LOCUS       NM_028049               2117 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus F-box protein 22 (Fbxo22), mRNA.
ACCESSION   NM_028049 NM_030170
VERSION     NM_028049.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2117)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2117)
  AUTHORS   Zhang,Y., Li,W., Guo,S., Wu,Z., Zhang,L., Liu,Y., Li,X., Guo,X.,
            Cao,J., Yang,C. and Wang,Z.
  TITLE     FBXO22 Mediates the NGF/TRKA Signaling Pathway in Bone Metastases
            in Prostate Cancer
  JOURNAL   Am J Pathol 193 (9), 1248-1266 (2023)
   PUBMED   37301536
  REMARK    GeneRIF: FBXO22 Mediates the NGF/TRKA Signaling Pathway in Bone
            Metastases in Prostate Cancer.
REFERENCE   3  (bases 1 to 2117)
  AUTHORS   Zhu,X.N., He,P., Zhang,L., Yang,S., Zhang,H.L., Zhu,D., Liu,M.D.
            and Yu,Y.
  TITLE     FBXO22 mediates polyubiquitination and inactivation of LKB1 to
            promote lung cancer cell growth
  JOURNAL   Cell Death Dis 10 (7), 486 (2019)
   PUBMED   31217475
  REMARK    GeneRIF: Study present evidence that FBXO22 interacts with and
            promotes polyubiquitination of LKB1. More intriguingly, FBXO22
            mediates Lys-63-linked LKB1 polyubiquitination and inhibits kinase
            activity of LKB1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2117)
  AUTHORS   Johmura,Y., Sun,J., Kitagawa,K., Nakanishi,K., Kuno,T.,
            Naiki-Ito,A., Sawada,Y., Miyamoto,T., Okabe,A., Aburatani,H.,
            Li,S., Miyoshi,I., Takahashi,S., Kitagawa,M. and Nakanishi,M.
  TITLE     SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and
            regulates senescence
  JOURNAL   Nat Commun 7, 10574 (2016)
   PUBMED   26868148
  REMARK    GeneRIF: Results indicate that SCF(Fbxo22)-KDM4A is an E3 ubiquitin
            ligase that targets methylated p53 and regulates key senescent
            processes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2117)
  AUTHORS   Lagirand-Cantaloube,J., Cornille,K., Csibi,A., Batonnet-Pichon,S.,
            Leibovitch,M.P. and Leibovitch,S.A.
  TITLE     Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents
            skeletal muscle atrophy in vivo
  JOURNAL   PLoS One 4 (3), e4973 (2009)
   PUBMED   19319192
REFERENCE   6  (bases 1 to 2117)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ078336.1, AK005473.1 and AW490772.1.
            
            On Apr 4, 2007 this sequence version replaced NM_028049.1.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by available transcript
            and homology data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018273.1, SRR1660811.196018.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               CJ078336.1         12-368
            358-2100            AK005473.1         186-1928
            2101-2117           AW490772.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2117
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.86 cM"
     gene            1..2117
                     /gene="Fbxo22"
                     /gene_synonym="0610033L19Rik; 1600016C16Rik"
                     /note="F-box protein 22"
                     /db_xref="GeneID:71999"
                     /db_xref="MGI:MGI:1926014"
     exon            1..254
                     /gene="Fbxo22"
                     /gene_synonym="0610033L19Rik; 1600016C16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1326
                     /gene="Fbxo22"
                     /gene_synonym="0610033L19Rik; 1600016C16Rik"
                     /codon_start=1
                     /product="F-box only protein 22"
                     /protein_id="NP_082325.2"
                     /db_xref="CCDS:CCDS23202.2"
                     /db_xref="GeneID:71999"
                     /db_xref="MGI:MGI:1926014"
                     /translation="MEPAGGGGGVSSSTDPRSTYVLSNLAEVVERVFTFLPAKALLRV
                     AGVCRLWRECVRRVLRTHRSVTWISAGVAEAGHLEGHCLVRVVAEALENVRILPQTVL
                     YMADSETFISLEECRGHKRARKRTTMETACALEKLFPKQCQVLGIVTPGIVVTPMGSG
                     SNRPQEIEIGESGFALLFPQIEGIKIQPFHFIKDSKNLTLERHQLTEVGLLDNPELRV
                     VLVFGYNCCKVGASNYLHRVVSTFSDMNIILAGGQVDNLSSLTCEKNPLDIDATGVVG
                     LSFSGHRIQSATVLLTEDVNDAKTVEAAMQRLKAANIPEQNTIGFMFACVGRGFQYYR
                     AKGNVEADAFRKFFPSVPLFGFFGNGEIGCDRIVTGNFILRRCNEVKEEDLFHSYTTI
                     MALVHLGTSK"
     exon            255..393
                     /gene="Fbxo22"
                     /gene_synonym="0610033L19Rik; 1600016C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            394..481
                     /gene="Fbxo22"
                     /gene_synonym="0610033L19Rik; 1600016C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            482..577
                     /gene="Fbxo22"
                     /gene_synonym="0610033L19Rik; 1600016C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            578..742
                     /gene="Fbxo22"
                     /gene_synonym="0610033L19Rik; 1600016C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            743..908
                     /gene="Fbxo22"
                     /gene_synonym="0610033L19Rik; 1600016C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            909..2102
                     /gene="Fbxo22"
                     /gene_synonym="0610033L19Rik; 1600016C16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2080..2085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo22"
                     /gene_synonym="0610033L19Rik; 1600016C16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2102
                     /gene="Fbxo22"
                     /gene_synonym="0610033L19Rik; 1600016C16Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggaagcggcc caccggaagt ggcgcgcgcc tgctcaggga gctcgggttg taggtggtgc
       61 gccggccgct ccggtacccc tgagactctg tagggccttc gggccggtag gcgaggaatg
      121 gagccggcag gcggcggtgg cggcgtctcc tcctccacag atccgcgaag cacctacgtg
      181 ctgagtaacc ttgcggaggt ggtggagcgt gtgtttacct tcctgccggc caaagcgctg
      241 cttcgggtag ccggagtatg ccgcctgtgg agggagtgtg tacgcagagt gctgcggacc
      301 catcgcagcg tgacctggat ctccgcgggt gtggctgaag cgggccacct ggagggacat
      361 tgcttggtgc gcgtggtagc tgaggcgctt gagaatgttc gaatcttacc acagacagtt
      421 ctctacatgg cagattctga aactttcatc agcctggaag agtgtcgtgg ccataaaaga
      481 gcgaggaaga gaactactat ggagacagca tgtgccctgg agaagctttt ccccaagcag
      541 tgccaagtcc ttgggattgt gaccccggga attgtggtga ctccaatggg atcaggtagc
      601 aatcgacctc aggaaataga aattggagaa tctggttttg ctttattatt ccctcaaatt
      661 gaaggaataa aaattcaacc ctttcatttt attaaggact ccaagaattt aacactcgaa
      721 agacaccagc ttactgaagt aggtcttctg gacaaccctg aacttcgtgt ggtccttgtc
      781 tttggctata actgctgtaa ggtgggagcc agtaattacc tgcatcgggt agtcagcact
      841 ttcagcgata tgaatatcat cttggctgga ggccaggtgg acaatttgtc ttcacttact
      901 tgtgagaaga accctctgga tattgatgcc acaggtgtgg ttggactgtc atttagtggg
      961 caccgaatcc agagtgccac agttctcctc actgaggatg taaatgatgc caagaccgtc
     1021 gaggctgcta tgcagcgcct caaagcagcc aacatccctg aacagaacac cattggcttc
     1081 atgtttgcat gcgttggccg aggctttcag tactacagag ccaaggggaa tgttgaagct
     1141 gatgcattta gaaagttctt tcccagtgtc cccttatttg gcttctttgg aaatggggag
     1201 attggctgcg accggatagt cactgggaac tttatactga ggagatgtaa tgaggtaaag
     1261 gaagaggacc tgttccatag ctacacaacc atcatggctc tcgttcacct gggaacctct
     1321 aaatgagccg cctcgctgag agcacctttc acaccatgta actttggggg tttctctttt
     1381 ttaggaaaat ggaaactcgg gatccaaata ttttaagcaa aactagctat gtgtgttttg
     1441 tagctttggg tgacgctctg aggtcacttt gggatgattt ttttaataca tagatgaagg
     1501 acagcattaa cattgtaagc acacaagtca agaagtgagg ctgtggttag gcgcaagcaa
     1561 agctgccggg gctgaactgc cccagattct gtagccactg cataagcgcc ctgcgaggtt
     1621 gagggccacc aggaaggtgg aggtttaaat agtgcttgat gaacttttag cagaatcatg
     1681 acttaagaaa ggagaaaatt gccaggcgtg gtgatgcgca cctttaatcc cagcactcgg
     1741 gaggcagagg caggcagatt tctgagttgg aggccagcct ggtctataga gtgagttcca
     1801 ggacagccag ggctacagag aaaccctgtc tcgaaacccc cacacacccc ccctaaaaaa
     1861 aagaagaaag gagaattaaa gaactggttt gagaagtttt gcagaagctg taacaaatat
     1921 tactgacttt ttacttttct gatgaacagt ctgttttgtt actgtataaa gtcgttcttt
     1981 ttgtgagtta gctttttcct cttcatagta aagagactgc aagggaacag cctttatcac
     2041 acagttctga aaatcatcac catattttgt ttgtacacca ataaaacata cttcccactc
     2101 aaaaaaaaaa aaaaaaa
//
