LOCUS       NM_001346588            3916 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus F-box protein 21 (Fbxo21), transcript variant 2, mRNA.
ACCESSION   NM_001346588 XM_006530297
VERSION     NM_001346588.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3916)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3916)
  AUTHORS   Wittorf,K.J., Weber,K.K., Swenson,S.A. and Buckley,S.M.
  TITLE     Ubiquitin E3 ligase FBXO21 regulates cytokine-mediated signaling
            pathways, but is dispensable for steady-state hematopoiesis
  JOURNAL   Exp Hematol 114, 33-42 (2022)
   PUBMED   35987460
  REMARK    GeneRIF: Ubiquitin E3 ligase FBXO21 regulates cytokine-mediated
            signaling pathways, but is dispensable for steady-state
            hematopoiesis.
REFERENCE   3  (bases 1 to 3916)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3916)
  AUTHORS   Yu,Z., Chen,T., Li,X., Yang,M., Tang,S., Zhu,X., Gu,Y., Su,X.,
            Xia,M., Li,W., Zhang,X., Wang,Q., Cao,X. and Wang,J.
  TITLE     Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase
            complex is required for antiviral innate response
  JOURNAL   Elife 5, e14087 (2016)
   PUBMED   27063938
  REMARK    GeneRIF: Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21
            ubiquitin ligase complex is required for antiviral innate response.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3916)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   6  (bases 1 to 3916)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   7  (bases 1 to 3916)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3916)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049723.1, AK048131.1, BY478760.1, BE954194.1 and BP754360.1.
            
            On Oct 21, 2016 this sequence version replaced XM_006530297.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. It
            encodes isoform 2, which lacks an internal in-frame segment and is
            shorter, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB093270.1, AK048131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK049723.1         2-25
            25-1215             AK048131.1         4-1194
            1216-1224           AK049723.1         1217-1225
            1225-3492           AK048131.1         1204-3471
            3493-3716           BY478760.1         125-348
            3717-3862           BE954194.1         53-198              c
            3863-3916           BP754360.1         15-68               c
FEATURES             Location/Qualifiers
     source          1..3916
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 57.73 cM"
     gene            1..3916
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /note="F-box protein 21"
                     /db_xref="GeneID:231670"
                     /db_xref="MGI:MGI:1924223"
     exon            1..270
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1894
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /note="isoform 2 is encoded by transcript variant 2; F-box
                     only protein 21"
                     /codon_start=1
                     /product="F-box only protein 21 isoform 2"
                     /protein_id="NP_001333517.1"
                     /db_xref="CCDS:CCDS84947.1"
                     /db_xref="GeneID:231670"
                     /db_xref="MGI:MGI:1924223"
                     /translation="MASVAGDSAMEVVPALAEEAAAEATGPSCLVQLPGEVLEYILCS
                     GSLTALDIGRVSSTCRRLREVCQSSGQVWKEQFRVRWPSLMKHYSPTDYVNWLEEYKV
                     RQKAGLEARKIVASFSKRFFSEHVPCNGFSDIENLEGPEIFFEDELVCILNMEGRKAL
                     TWKYYAKKILYYLRQQKILNNLKAFLQQPDDYESYLEGAVYIDQYCNPLSDISFRDIQ
                     AQIHSIVELVCKTLRGINSRHPSLTFRAGESSMIMEIELQSQVLDAINYVLYDQLKFK
                     GNRMDYYNALNLYMHQVLTRRTGIPISMSLLYLTVARQLGVPLEPVNFPSHFLLRWCQ
                     GAEGATLDIFDYIYIDAFGKGKQLTVKECEYLIGQHVTAALYGVVNVKKVLQRMVGNL
                     LSLGKREGIDQSYQLLRDSLDLYLAMYPDQVQLLLLQARLYFHLGIWPEKVLDILQHI
                     QTLDPGQHGAVGYLVQHTLEHIERKKEEVGVEVKLRSEEKHRDVCYSIGLVMKHKRYG
                     YNCVIYGWDPTCMMGHEWIRNMNVHSLPHGHHQPFYNVLVEDGSCRYAAQENLEYNVE
                     PQEISHPDVGRYFSEFTGTHYIPNAELEIRYPEDLEFVYETVQNIYSAKEDTAE"
     exon            271..406
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            407..501
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            502..623
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            624..770
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            771..907
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1044
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1224
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1357
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1548
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1706
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..3895
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2364..2369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /note="hexamer: AATACA"
     polyA_site      2388
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /note="major polyA site"
     regulatory      3679..3684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3705
                     /gene="Fbxo21"
                     /gene_synonym="2810425J22Rik"
ORIGIN      
        1 gcacagcggc cccctcaggt acgcggacaa gatggcgtcg gtagcggggg acagcgctat
       61 ggaggtggtg ccggcgctgg ccgaggaggc cgcggctgag gcgacgggcc ccagctgcct
      121 ggtgcagctg ccgggcgagg tgctggagta catcctgtgc agcggctcgc tcacggcgct
      181 ggacatcggc cgcgtgtcca gcacctgccg ccgcctgcgc gaggtgtgcc agagcagcgg
      241 gcaggtgtgg aaggagcagt tccgggtgag gtggccctcc ctgatgaagc actacagccc
      301 caccgactac gtcaattggt tagaggaata taaagttcgg cagaaagctg ggttagaagc
      361 ccggaagatt gtagcttcct tctccaagcg gttcttttca gagcacgtcc cctgtaatgg
      421 cttcagtgac attgaaaacc ttgagggccc agagatcttt tttgaggatg agctggtgtg
      481 tatcctaaac atggaaggaa ggaaagcttt gacctggaaa tactacgcaa agaaaattct
      541 ctactacctg cggcagcaga aaatcctcaa taacctcaag gcgttcctgc agcagcccga
      601 cgattacgag tcctatctcg aaggtgccgt ttacatcgac cagtactgca acccactctc
      661 cgacatcagc ttcagagaca tccaggccca gatccacagc attgtggagc ttgtgtgcaa
      721 aaccctccgt ggcatcaaca gccgccaccc cagcctgacc ttcagggcag gtgagtcctc
      781 tatgataatg gagatagaac ttcagagcca agtgctggac gctatcaact atgtcctgta
      841 tgaccagctg aagttcaaag ggaaccgcat ggactactat aatgccttga acctctacat
      901 gcaccaggtg ttgacccgca gaacaggaat ccccatcagc atgtctctgc tctacctgac
      961 cgtcgcccgg cagctggggg ttcccctgga gcctgtcaac ttcccaagcc acttcctgct
     1021 gcggtggtgc caaggtgcag aaggggcaac cctggacatc tttgactaca tctacataga
     1081 tgcttttggg aagggcaagc agctgacagt gaaagagtgt gagtacctga ttggccagca
     1141 cgtgacggca gcactctacg gcgtggtgaa tgtgaagaag gtgctacagc ggatggtggg
     1201 caacttgctg agcctgggca agagggaagg cattgaccag tcctaccagc tcctcagaga
     1261 ctccttggac ctgtacctgg cgatgtaccc ggaccaggtg cagctcctgc tcctccaagc
     1321 cagactctac ttccacctgg gcatctggcc agagaaggtg cttgacatcc tccagcacat
     1381 ccagaccctg gaccccgggc agcacggggc ggtgggctat ctcgtgcagc ataccttaga
     1441 gcacattgag cgtaagaagg aggaggtggg cgtggaggtg aagctgcgct ccgaggagaa
     1501 gcacagggat gtctgctact ccatcgggct tgtgatgaag cataagaggt acggctacaa
     1561 ctgtgtgatc tacggctggg accctacgtg catgatgggg catgagtgga tccgaaacat
     1621 gaatgtgcac agcctgcctc atggccacca tcagcccttc tacaacgtcc tggtggagga
     1681 tggctcctgc agatatgcag cccaagaaaa cctggaatac aacgtggagc ctcaggaaat
     1741 ctcgcaccca gatgtggggc gctacttctc ggagttcaca ggcacacact acatcccaaa
     1801 tgcagagctg gagatccggt accccgagga cctggagttt gtgtacgaga cagtgcagaa
     1861 tatttacagt gcaaaggagg acacagccga gtaaactcag ggggtgtcac atctgtgctg
     1921 ctgctgctgc tgctgctgct accttctagg ggaccaggat tcctgaagga cgtgtgctgc
     1981 ccctggagtc agcacaggac agccacttca ccagcagcct ggctgcctcc ccactttaga
     2041 tggtgtgcgc tcctccagcc acagacagcg ttgctctccg ctacactagt gaatcagttg
     2101 aaaggcaccg tgtcccgtgg catggctcgt gtgcttgtcc cgtggtgaca gtgtgtgaca
     2161 ttctgtcctc tcaccccctt cccatccctg tctccatcta ccttgtgtca gtctctcccg
     2221 ctggacagtc agtcggggcc atatttcctc atctctggaa caaggtcgct gagtcaggcc
     2281 tgccgccctc tgccttccgt tagattgtac ttggagaagg gcatggaggt gggagtcaga
     2341 atgatcacgg ttcaggtttt gctaatacag aaacacagat ttcaagtatt cccttttttt
     2401 gttgttgtta tttttaattt aatttgggag aacagtgtct cccttctctc actgggtctg
     2461 tgcacatttc tgcctgttgt gagctcctgt cttgttacgt tggttctctg agcaaatgca
     2521 cagcaatggc ctttccgagt gagctgctcc tttaagatga ctactccttg gttaacttta
     2581 agatctactc cagtatcctg agcagatctt aagtcggtca tgggcccgct tcagtagcaa
     2641 agcctgcaga tcaaaggaaa atggctctta aaacttgtac ctcctggtcc ccaaaccaag
     2701 agaacgggtc tgttcttctg atcaggaaaa tgaactgatg aagcctaacc aggggagaca
     2761 ggtgtcatgt tccctgtcac tcctgagtca cacatccaga ccctccattt tgagagtgtt
     2821 gggcttacgg gaagcggagc acatgctctg ggcttcaagc tgcctgtctg aaggctccag
     2881 gacgctgact cttggatgag gtctggcctc aggtcaccct tggcttctgc ctgatgctgt
     2941 ctgtgagtga ggagcaagcc tttaccagat cctagtgggt gctacctggt cctcagacaa
     3001 gcagtcccat aagtaaaact acccactggg ccaatggcac atctgtcctg tgttgctgta
     3061 gtgagcggag ctttaggggg ccgcctgcca gccttgccca cccgcctgcc tgccgcatgt
     3121 gtatcctcac accacaccgc tcgctccaaa tgagcgctcc ctcttccatt gcccttcacc
     3181 agccccagga tgatgggatg aggcagttac tagaagggca ggaagcttga agctcttgca
     3241 gctgaaaagg ttcctgccca gcctgtgcct caccaggcag aaccagtcag aggcgggtcc
     3301 agacttacat ttggaaactt aactcctcag agcttctgcc cgcggttggg ggattttaca
     3361 cctgctcatt caaaggtgag aaccgcccgc cccacgagga ctcacaccct tgcaccccag
     3421 tactaagcag cctcggagca tggtgggagt ctccattgct gggtttctgc ttcgatttcc
     3481 tttttcctgt agagaaacgt caaagctgag aaagatggct tccctccctg acctgactgt
     3541 aaataatgta cttagactgt ttttaaatgt gtttcttcac gaaggcttcg tttggctgag
     3601 ggagcctata tcactcgtgt aagttggtat ttgggcactt tatatttttc taaaaatgtg
     3661 ttttggatcc tgtactctaa taaatcataa gtttcttttt aaaaattttt ccaaaagttt
     3721 tctccatttt caaaaaccct gttataaaaa gtagaacttt cacaatgtta aaatactaaa
     3781 tatttggtta tagcaacttc tcttctaatg aatgccaagg gtcttttttt tttcttttct
     3841 tttctttttc tttttctttt gtacaacaat taataaacga acttgccgag agaaaaaaaa
     3901 aaaaaaaaaa aaaaaa
//
