LOCUS       NM_015796               1984 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus F-box protein 17 (Fbxo17), transcript variant 1, mRNA.
ACCESSION   NM_015796 XM_001001221 XM_001001233 XM_993759 XM_993780
VERSION     NM_015796.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1984)
  AUTHORS   Suber,T., Wei,J., Jacko,A.M., Nikolli,I., Zhao,Y., Zhao,J. and
            Mallampalli,R.K.
  TITLE     SCFFBXO17 E3 ligase modulates inflammation by regulating
            proteasomal degradation of glycogen synthase kinase-3beta in lung
            epithelia
  JOURNAL   J Biol Chem 292 (18), 7452-7461 (2017)
   PUBMED   28298444
  REMARK    GeneRIF: identified FBXO17 as an F-box protein subunit that
            recognizes and mediates GSK3beta polyubiquitination.
REFERENCE   2  (bases 1 to 1984)
  AUTHORS   Kurogi,S., Sekimoto,T., Funamoto,T., Ota,T., Nakamura,S., Nagai,T.,
            Nakahara,M., Yoshinobu,K., Araki,K., Araki,M. and Chosa,E.
  TITLE     Development of an efficient screening system to identify novel bone
            metabolism-related genes using the exchangeable gene trap
            mutagenesis mouse models
  JOURNAL   Sci Rep 7, 40692 (2017)
   PUBMED   28106071
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1984)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   4  (bases 1 to 1984)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   5  (bases 1 to 1984)
  AUTHORS   Kuninger,D., Kuzmickas,R., Peng,B., Pintar,J.E. and Rotwein,P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   6  (bases 1 to 1984)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   7  (bases 1 to 1984)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY145793.1, AF176532.1 and AC171210.1.
            
            On Apr 1, 2008 this sequence version replaced NM_015796.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026470.1, SRR7652917.349290.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                BY145793.1         2-84
            84-1166             AF176532.1         1-1083
            1167-1521           AC171210.1         152860-153214       c
            1522-1984           AF176532.1         1112-1574
FEATURES             Location/Qualifiers
     source          1..1984
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.9 cM"
     gene            1..1984
                     /gene="Fbxo17"
                     /gene_synonym="Fbg4; Fbx17; Fbxo26"
                     /note="F-box protein 17"
                     /db_xref="GeneID:50760"
                     /db_xref="MGI:MGI:1354707"
     exon            1..249
                     /gene="Fbxo17"
                     /gene_synonym="Fbg4; Fbx17; Fbxo26"
                     /inference="alignment:Splign:2.1.0"
     exon            250..362
                     /gene="Fbxo17"
                     /gene_synonym="Fbg4; Fbx17; Fbxo26"
                     /inference="alignment:Splign:2.1.0"
     exon            363..822
                     /gene="Fbxo17"
                     /gene_synonym="Fbg4; Fbx17; Fbxo26"
                     /inference="alignment:Splign:2.1.0"
     CDS             450..1310
                     /gene="Fbxo17"
                     /gene_synonym="Fbg4; Fbx17; Fbxo26"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     only protein 17; F-box only protein 26"
                     /codon_start=1
                     /product="F-box only protein 17 isoform 1"
                     /protein_id="NP_056611.2"
                     /db_xref="CCDS:CCDS39863.2"
                     /db_xref="GeneID:50760"
                     /db_xref="MGI:MGI:1354707"
                     /translation="MGARPSRRQMTEARRLALTKLPPELLVQVLSHVPPRALVTRCRP
                     VCRAWRDLVDGPSIWLLQLARDRSAEGRALYALAQRCPADADADADADGNRHDEFPFC
                     ALARFCLRAPFGRNLIHNSCGEQGFRGWEVEHGGNGWAVEKNLTLVPGAPSQTCFVTS
                     FEWCSKRQLVDLVKEGVWQELLDSGQIEICIADWWGARENCGCIYRLRVRLLDEYENE
                     VVKFSASPNPVLQWTERSCRQVSHVFTNFGKGIRYVSFEQYGRDTRSWVGHYGALVTH
                     SSVRVRIRLS"
     exon            823..934
                     /gene="Fbxo17"
                     /gene_synonym="Fbg4; Fbx17; Fbxo26"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1030
                     /gene="Fbxo17"
                     /gene_synonym="Fbg4; Fbx17; Fbxo26"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1166
                     /gene="Fbxo17"
                     /gene_synonym="Fbg4; Fbx17; Fbxo26"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1972
                     /gene="Fbxo17"
                     /gene_synonym="Fbg4; Fbx17; Fbxo26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1956..1961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo17"
                     /gene_synonym="Fbg4; Fbx17; Fbxo26"
                     /note="hexamer: AATACA"
     polyA_site      1972
                     /gene="Fbxo17"
                     /gene_synonym="Fbg4; Fbx17; Fbxo26"
                     /note="major polyA site"
ORIGIN      
        1 aggggattgg cagccacgtt tcagggacag gcggcctagc tcggcggccc tgggccgggc
       61 tcactcaggc tgcaacgttg cccggtggcc ccgggatcct gagcatagaa gaagacggtc
      121 cactaggacc ccagatcacg gggctgactt cccggacctc gggttactct tcgactgcct
      181 ccagcgccgg gtagggattg gatcttcccc gccaactcag agcaggccgc ccggtgagct
      241 cccggacagg tatttactca agagaatgca acctgtgcct acatagacct tcatacatga
      301 acaatcatag cagcttcatt cataacagct ccaagtgggg agcagctcaa gtgcccatca
      361 aggtatcctg acctcctgac cgggtccgtg accttgggaa gctgaacacc aacccctctt
      421 cacccagagg acgacgccag cggcaggtca tgggagcgcg gccctcgcga cggcagatga
      481 ctgaagctcg gcgcctggct ctaaccaagc tgccccctga gctgctggtg caggtgctga
      541 gccacgtgcc gcctcgcgcg ttagtgaccc gctgccggcc agtgtgccgg gcctggcgcg
      601 acctggtaga tggcccaagt atatggctgc tgcaactggc tcgcgaccgc agcgcggagg
      661 gcagagccct ctacgccttg gcccagcgct gtcccgccga cgccgacgcc gacgccgacg
      721 ccgacggcaa ccgccacgac gagttcccat tctgcgctct ggcccgattc tgcctgagag
      781 cgccgtttgg ccgcaacctc atccacaact cctgcggaga acagggcttc agaggttggg
      841 aagtggagca cggcggaaat ggttgggccg tggaaaagaa tttgacgctg gtaccagggg
      901 ctccttccca gacctgcttt gtgacttctt ttgagtggtg ctccaagagg cagcttgtag
      961 acctggtgaa ggaaggagta tggcaggagc tgttggacag tggccagatt gagatctgca
     1021 tagctgactg gtggggcgcc cgtgagaact gcggctgcat ctaccggctt cgagttcgcc
     1081 tactggatga atatgaaaac gaagtggtca agttctctgc ctcacccaac ccagtccttc
     1141 agtggactga gaggagctgc cgacaagtct ctcacgtctt cactaacttt ggcaagggca
     1201 tccggtatgt gtcttttgag cagtatggga gagacacgcg ttcctgggtg ggacactacg
     1261 gtgcccttgt aactcactcc agtgtgcggg tcaggatccg tctgtcctag ccgaccagtc
     1321 tgattgggac ttccaggaca cactgccttc tcccggatgg tgttaaaacc aaaggtgact
     1381 ttgcagtccc cagctgatgg gtatctgggg aaaaaaggag accctgtgtg tccctcctgc
     1441 tgtgacaaac cagggactgc cagcttgttc atagcttctg tctctcaagc agggactacc
     1501 atgatgtgat gcagacatct ctaggttgct atgcctgagg actactccat gtgtggaggc
     1561 caagccagac ctgagagcac acacttctgg tccccacatc aaggtaaacg gaggaggatc
     1621 tggagttcaa ggtcatcccc agctgtatac tgacttcaag gccagcctga gctacatgag
     1681 gccctgtcaa aaaagagaga atatccaata gaccaagctt gggatcataa caaaaggaga
     1741 aagctactta taagaagaca gtgactttaa aaattttctt aatccggggc tggagagatg
     1801 gctcagcggt taagagcact gactgctctt ccagagtcct gagttcaatt cccagcaacc
     1861 acatggtggc tcacaaccat ctacaatgtg atctgatgcc ctcttctgga gtgactgaag
     1921 atagcaacag tatactcaaa gacatacgat aaataaatac atctttaaaa aaaaaaaaaa
     1981 aaaa
//
