LOCUS       NM_015795               3799 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus F-box protein 16 (Fbxo16), transcript variant 1, mRNA.
ACCESSION   NM_015795
VERSION     NM_015795.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3799)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3799)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 3799)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   4  (bases 1 to 3799)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164657.1 and BC086690.1.
            
            On Feb 3, 2018 this sequence version replaced NM_015795.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164657.1, AK077043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1311              AK164657.1         1-1311
            1312-3799           BC086690.1         1229-3716
FEATURES             Location/Qualifiers
     source          1..3799
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.19 cM"
     gene            1..3799
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
                     /note="F-box protein 16"
                     /db_xref="GeneID:50759"
                     /db_xref="MGI:MGI:1354706"
     exon            1..166
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
                     /inference="alignment:Splign:2.1.0"
     exon            167..302
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1208
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     only protein 16"
                     /codon_start=1
                     /product="F-box only protein 16 isoform 1"
                     /protein_id="NP_056610.1"
                     /db_xref="CCDS:CCDS36956.1"
                     /db_xref="GeneID:50759"
                     /db_xref="MGI:MGI:1354706"
                     /translation="MMAFAPPKSIDGPKMQTKMSTWTPLNHQLLNDQVFEERRALLGK
                     WFDKWTDSQRRRILTGLLERCSLSQQKFCCRKLQEKIPAEALDFTTKLPRVLSVYIFS
                     FLDPRSLCRCAQVSWYWKSLAELDQLWMLKCLRFNWYISFSPTPFEQGVWKKHYIQMV
                     RELHVTKPKTPPKDEFTTADVQPIPGNSPDEKQSPSLAFRSSSSLRKKNNPGEKELPP
                     WRSSDKHPTDIIRFNYLDNCDPELFRLGRRKRSEVTPDFKRQLRDKKNKLQDRARLRK
                     AQSLISLSSPPKVPVRLAWPLHLPVAPSDREAATEALLEHLQKHPGLQSPSPRLQSQS
                     "
     exon            303..338
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
                     /inference="alignment:Splign:2.1.0"
     exon            339..545
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
                     /inference="alignment:Splign:2.1.0"
     exon            546..710
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
                     /inference="alignment:Splign:2.1.0"
     exon            711..940
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1043
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..3783
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1290..1295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
                     /note="hexamer: ATTAAA"
     polyA_site      1312
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
                     /note="major polyA site"
     regulatory      3441..3446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
                     /note="hexamer: AGTAAA"
     polyA_site      3462
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
     regulatory      3764..3769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
                     /note="hexamer: AATAAA"
     polyA_site      3783
                     /gene="Fbxo16"
                     /gene_synonym="4932435C24Rik; Fbx16"
ORIGIN      
        1 acattgttgc ctaagagacc ccggatgcca gcgacaggat ttatagatgg cgattggcct
       61 gctggaagca gtaaggtggg ggctgaaagg agtcaaagaa agctgcccta gtgcaacgat
      121 agcaacccca gaaccagagg cttgaagaag gaagccagct gctgaggtgt tgtctttctt
      181 atggaaaaat accagttcat ttcatgatgg cctttgcacc tccaaaaagc atcgatggcc
      241 ccaaaatgca gacaaagatg agtacctgga cacctctcaa ccatcagctt ctgaatgacc
      301 aggtatttga agaacgaaga gctctgctgg gaaaatggtt tgacaaatgg acagactctc
      361 aaaggagaag aattcttaca ggcctactag agcgctgttc cctgtcccag cagaagttct
      421 gttgtcgaaa gctgcaggaa aaaatcccag cagaggccct ggattttact accaagcttc
      481 caagggtgtt atctgtctac atcttttcct tcctggatcc ccggagtctt tgccgttgtg
      541 cacaggtgag ctggtactgg aagagcttgg ctgagttgga ccagctctgg atgctcaagt
      601 gcctgcgctt caactggtac atcagcttct ccccaacgcc ctttgaacag ggcgtctgga
      661 aaaagcacta catccagatg gtgagagaac ttcacgtcac caagcccaag acacctccaa
      721 aggatgaatt cacaactgcc gatgttcagc caattcctgg caattctcca gatgagaagc
      781 agtccccttc cttagctttt cggtcctcct cctccttaag aaagaagaat aaccccgggg
      841 agaaagagct tccaccttgg cgatcgtcag ataagcatcc cactgacatc atccgcttta
      901 attatctaga caactgtgac cctgagctct tcaggctagg aagaagaaaa agaagcgaag
      961 tgaccccaga cttcaagcgc cagctgcgag ataagaaaaa taagcttcaa gacagagcca
     1021 ggctcaggaa agcacagtca ttgatctccc tgagttcccc tccaaaagtt ccagttcgtc
     1081 tcgcctggcc tctgcatctg ccagtggcac cctcagaccg tgaagcagca acggaagcac
     1141 tcctggagca tcttcagaaa caccccgggc ttcagtcacc ctcaccgagg ctccagagtc
     1201 aaagctgatt aaaggattgg aaaaggactt tttctagaaa cgacaaggtg ttcttcacag
     1261 ctgagagttg gattctagct agtccctcca ttaaactctt ttggcttaag tatcttactg
     1321 tgaaaggtcc tgcgagtttg tgtatctcag gaaaagagaa tgaacagcag aaatggtgac
     1381 aaacgcagac tcttggaaat atggcaatag acatcttggg tttgatgggg ggatgtctaa
     1441 tgtcctcgtt ggtagtacta ggaaaatcag gcctgggaag ggaatgacac ccccaggctc
     1501 cttcagaagt tggtaaagga gatgcttagg gcgttagcta tagcacagat cgagtggttt
     1561 ctgcaataga agtgcattag ctcacagtct gaatactgga agtctgaggt gatgtgtcag
     1621 caagtgacac caaggtctcg aggtctctct ccattggcca tcttcctgtc tttacatgag
     1681 tctcctcttc taagtcaaat gcaggccctt tataagatat cgaagttagg agttcagcgt
     1741 gtagctttac aagagacatg gttcagccag aaacacatgc tatggggcag gattaagaaa
     1801 atcaagatag gatgctgaag cccctggacc tggcagcagt gagaaacttt atcatccttt
     1861 gtgccaaaga gatgaaggga gcagggagag tggaggtctt gggtccagct tctgcggcgg
     1921 ccttcagaga gaggctggca gacatggtgt gttggaggtg gcagaggaat gtggggaggg
     1981 aagtagtgat acccaactct tcttctctct tacactctcc cacactcctg gcgtcaccca
     2041 tctggaacta gaagaaaaga tactagtgat tctgtcctta gctgccagcc tcctgaggca
     2101 agagagcaga actggcaagg ctgagcagta agtctaggca gaaccatgga aaataaccag
     2161 catcatggag ggaaagagta cagggctggt accagggaga tgcctcagcc aaagaaagca
     2221 tcctgtgtag gcctgatgag ttccgttctc agaaaccatg gtggaaggag agaacttaac
     2281 tcctgaaagg tgacctctgg ccgccgcatg caccaacttc ccactccagc aataatagag
     2341 cacatgtcta aaggagtgac aatgggcatg taagcaattt aaaagagctt tggagtagct
     2401 ggaaaacaga acaaaatcac ttagtgtagc gggagtagat taatctactc ttatctcccc
     2461 tgtggtggaa cacatgctcc ttgctaccca ccccaatgct ctggattcta ggaatgaaag
     2521 acacacacac agagccttat atttaatatg ccttaatctg ctcagtggct gggccacatc
     2581 agtcctccat gtcgctaaca cactcttccc tcccattctc ctgatttatt acttaccaaa
     2641 acctgtattc catcctggcc accctggatc caggcctgca gctctcctgg gccatgatcc
     2701 atgactctta catgttggta gtctacctgt ctctctgtcc tacacttctc aggcctggtc
     2761 cttctccttc cccaacatgt cacattcccc ccctgccccc tcccctttcc ctggagtcct
     2821 gtctctgtct ccctgcccaa ccattggcca ctggcatctt tatttagcaa tcaaagccaa
     2881 ctgggggtag ggaccctcag catttacatg cagacatgcg ggttctgtga ttctggaaac
     2941 ccaaataaca taatgcaagc atgaaaacca aatccacaac aactcagtac agacgtgaat
     3001 gttcatgtaa caggctccca gaccttaaca caactcatga atgttagagg caccattttg
     3061 atcttaaaac ccaacacaca ggccccagta cctgccaaca tggaaacaaa gacctaacac
     3121 atccagcacc taggcgcagt tccaggaaag tccgtgcacg tactcacctt gcttttcggc
     3181 ttctgtcttt ctgctccttg ctaagtcgac tgtgacaacc aggatgtggt tttggtacat
     3241 aacttggggt cgcatggtta tggcaagttc cctgtgcagg cactggccag ccataatacc
     3301 tttctttttt tgtctttcta agtgtccttg tggtggtctc tgatgggctt acttcaaaac
     3361 atttctttct acaatcaacc atctacccat atacccatct cagttcccca gaaactgctg
     3421 ttctgcgatg tagttaccta agtaaagtag aataatggaa aagcagtgtt tgctgttatt
     3481 gtctgaatat gaaggaaccc acgagaggct gatgcattga aagcttggtc tctaggtgac
     3541 aaatccaatc actgtgggat gattacacca tgagggttct gacgtcatca gtacattaat
     3601 tcattataga gttacaccaa gtaagatttt aggaggtgag gctggttgga gggagtaggt
     3661 cccagagttc gtcctctgaa gagtctgtct tattcttggc cccttcctat ctaacgctcc
     3721 accccgtttg caacaaagtg agctctggtt tcttctgtgg ccaaataaat ccttcctcag
     3781 caaaaaaaaa aaaaaaaaa
//
