LOCUS       NM_001367965            1654 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus F-box protein 15 (Fbxo15), transcript variant 2, mRNA.
ACCESSION   NM_001367965
VERSION     NM_001367965.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1654)
  AUTHORS   Zhang,Z., Wang,Y., Shan,Y., Zhou,R. and Yin,W.
  TITLE     Oroxylin A alleviates immunoparalysis of CLP mice by degrading CHOP
            through interacting with FBXO15
  JOURNAL   Sci Rep 10 (1), 19272 (2020)
   PUBMED   33159144
  REMARK    GeneRIF: Oroxylin A alleviates immunoparalysis of CLP mice by
            degrading CHOP through interacting with FBXO15.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1654)
  AUTHORS   Donato,V., Bonora,M., Simoneschi,D., Sartini,D., Kudo,Y., Saraf,A.,
            Florens,L., Washburn,M.P., Stadtfeld,M., Pinton,P. and Pagano,M.
  TITLE     The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in
            mouse embryonic stem cells
  JOURNAL   Nat Cell Biol 19 (4), 341-351 (2017)
   PUBMED   28319092
  REMARK    GeneRIF: TDH, responsible for mitochondrial production of
            acetyl-CoA in mouse embryonic stem cells, and the acetyltransferase
            GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its
            recognition by and degradation via Fbxo15, an F-box protein
            transcriptionally controlled by the pluripotency core factors and
            repressed following differentiation.
REFERENCE   3  (bases 1 to 1654)
  AUTHORS   Boroviak,T., Loos,R., Bertone,P., Smith,A. and Nichols,J.
  TITLE     The ability of inner-cell-mass cells to self-renew as embryonic
            stem cells is acquired following epiblast specification
  JOURNAL   Nat Cell Biol 16 (6), 516-528 (2014)
   PUBMED   24859004
REFERENCE   4  (bases 1 to 1654)
  AUTHORS   Chen,B.B., Coon,T.A., Glasser,J.R., Zou,C., Ellis,B., Das,T.,
            McKelvey,A.C., Rajbhandari,S., Lear,T., Kamga,C., Shiva,S., Li,C.,
            Pilewski,J.M., Callio,J., Chu,C.T., Ray,A., Ray,P., Tyurina,Y.Y.,
            Kagan,V.E. and Mallampalli,R.K.
  TITLE     E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin
            synthase 1 stability and mitochondrial function in pneumonia
  JOURNAL   Cell Rep 7 (2), 476-487 (2014)
   PUBMED   24703837
  REMARK    GeneRIF: Fbxo15 mediates degradation of cardiolipin synthase1 in
            pneumonia.
REFERENCE   5  (bases 1 to 1654)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   6  (bases 1 to 1654)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   7  (bases 1 to 1654)
  AUTHORS   Mitsui,K., Tokuzawa,Y., Itoh,H., Segawa,K., Murakami,M.,
            Takahashi,K., Maruyama,M., Maeda,M. and Yamanaka,S.
  TITLE     The homeoprotein Nanog is required for maintenance of pluripotency
            in mouse epiblast and ES cells
  JOURNAL   Cell 113 (5), 631-642 (2003)
   PUBMED   12787504
REFERENCE   8  (bases 1 to 1654)
  AUTHORS   Tokuzawa,Y., Kaiho,E., Maruyama,M., Takahashi,K., Mitsui,K.,
            Maeda,M., Niwa,H. and Yamanaka,S.
  TITLE     Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic
            stem cell self-renewal and mouse development
  JOURNAL   Mol Cell Biol 23 (8), 2699-2708 (2003)
   PUBMED   12665572
  REMARK    GeneRIF: Fbx15 is a novel target of Oct3/4 but is dispensable for
            embryonic stem cell self-renewal, development, and fertility.
REFERENCE   9  (bases 1 to 1654)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1654)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134545.5 and AC128672.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AC134545.5         19497-19639         c
            144-254             AC134545.5         14325-14435         c
            255-359             AC134545.5         13379-13483         c
            360-602             AC134545.5         12444-12686         c
            603-812             AC134545.5         11536-11745         c
            813-939             AC134545.5         9035-9161           c
            940-1022            AC134545.5         7564-7646           c
            1023-1177           AC134545.5         6170-6324           c
            1178-1302           AC128672.4         38581-38705
            1303-1654           AC128672.4         42336-42687
FEATURES             Location/Qualifiers
     source          1..1654
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 57.53 cM"
     gene            1..1654
                     /gene="Fbxo15"
                     /gene_synonym="ecat3; Fbx15"
                     /note="F-box protein 15"
                     /db_xref="GeneID:50764"
                     /db_xref="MGI:MGI:1354755"
     exon            1..143
                     /gene="Fbxo15"
                     /gene_synonym="ecat3; Fbx15"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1557
                     /gene="Fbxo15"
                     /gene_synonym="ecat3; Fbx15"
                     /note="isoform 2 is encoded by transcript variant 2; F-box
                     only protein 15"
                     /codon_start=1
                     /product="F-box only protein 15 isoform 2"
                     /protein_id="NP_001354894.1"
                     /db_xref="CCDS:CCDS89296.1"
                     /db_xref="GeneID:50764"
                     /db_xref="MGI:MGI:1354755"
                     /translation="MASGRGRMLRGCFGLQAQRGSLHGGGATWGSAGQAAGRSGFSFR
                     SKFVRGSSVTKQHAWRNQHSEKRCSSSISSISLDRMPSEILVKILSYLDAVTLVCIGC
                     VSRRFYHLADDNLIWVRKYAAAFRSKRSRWKATSVEETATSLSLLSVWDKEDGYWKKE
                     YITKQISSVKAALTNSLSPVKRRTSLPSKTKESLRISGLGWTIILREASGKEHIMQHS
                     NLSVNDNSVTVFWHDKNWPHVDTLSTLDLYGATPIFMEQYKGPNTSCPRWLSLIEKYD
                     LSNLRKSAMIGCDRHVRVFCVNPGLLVGLWQENGGLAFVMANIHSHGLFERSIMGSDT
                     IPYTLPPDTTFVDNYPDSMTFYGDKGFQLHIDIHGSKTYFLCSTFHNLFCRRAGINNG
                     YVKFLMINLKNNREHLPLVGKVGLEWRTDCLNGRIESCIVVDMTLLDEDKKPIWYVSS
                     PVCLRSACLPDFPQPAYSFEYMDSVGGVCADLGWFENTDEYFIVRLDIYLSVAKLQQW
                     FGRQ"
     exon            144..254
                     /gene="Fbxo15"
                     /gene_synonym="ecat3; Fbx15"
                     /inference="alignment:Splign:2.1.0"
     exon            255..359
                     /gene="Fbxo15"
                     /gene_synonym="ecat3; Fbx15"
                     /inference="alignment:Splign:2.1.0"
     exon            360..602
                     /gene="Fbxo15"
                     /gene_synonym="ecat3; Fbx15"
                     /inference="alignment:Splign:2.1.0"
     exon            603..812
                     /gene="Fbxo15"
                     /gene_synonym="ecat3; Fbx15"
                     /inference="alignment:Splign:2.1.0"
     exon            813..939
                     /gene="Fbxo15"
                     /gene_synonym="ecat3; Fbx15"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1022
                     /gene="Fbxo15"
                     /gene_synonym="ecat3; Fbx15"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1177
                     /gene="Fbxo15"
                     /gene_synonym="ecat3; Fbx15"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1302
                     /gene="Fbxo15"
                     /gene_synonym="ecat3; Fbx15"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1654
                     /gene="Fbxo15"
                     /gene_synonym="ecat3; Fbx15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1635..1640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo15"
                     /gene_synonym="ecat3; Fbx15"
                     /note="hexamer: AATAAA"
     polyA_site      1654
                     /gene="Fbxo15"
                     /gene_synonym="ecat3; Fbx15"
                     /note="major polyA site"
ORIGIN      
        1 aggtgtcttt gggtctccat ggcgagcgga cgcggtcgga tgctgagggg atgttttggc
       61 ctccaggcgc agcgagggtc acttcatggt gggggcgcta cctggggcag cgcgggacag
      121 gccgcggggc gctccgggtt cagttttaga agtaagtttg ttagaggctc atctgtcacg
      181 aagcagcatg cctggcgaaa ccagcacagc gagaagcgtt gctcttcctc catcagttct
      241 atatccctgg acagaatgcc atcggaaatc ttggtgaaga tactttctta cttggatgcg
      301 gtgaccttgg tgtgcattgg atgtgtgagc agacgctttt atcatttggc tgatgacaat
      361 cttatttggg tcaggaagta cgcagctgca tttagatcaa aaagatcacg ttggaaagct
      421 acttcagtgg aggaaacagc cacaagtctg agcttgctgt cagtttggga taaagaagat
      481 ggatactgga agaaagaata tattacaaag cagatctcat ctgtgaaagc agccctcacc
      541 aacagcctca gtcctgtcaa acgccgcaca agccttcctt cgaaaaccaa agagtccctc
      601 agaatatctg gcttaggttg gacaatcatc ttaagagaag ccagtggcaa agaacacatc
      661 atgcagcatt cgaatctttc cgtaaatgac aactctgtca ctgttttttg gcatgacaaa
      721 aattggccac atgtagacac gttgtccacc ctggatttgt atggtgccac accaattttt
      781 atggagcagt ataaaggccc taacacaagt tgtccacgat ggctgtcttt aattgaaaag
      841 tacgatctga gtaatttacg caagtctgct atgattggct gcgacagaca tgttcgggta
      901 ttctgtgtaa atcctggcct cctggtgggg ctgtggcagg agaatggtgg actagctttt
      961 gtcatggcaa atattcattc ccatggcctt ttcgagagaa gcataatggg ctcagacact
     1021 attccctata cattgcctcc cgacactaca tttgtggata actacccaga ctcaatgacc
     1081 ttttatggag ataaaggctt tcagctgcat atcgacattc atggcagtaa gacttacttc
     1141 ctgtgtagca ccttccacaa tctcttctgc aggagagcgg gcattaacaa tggatatgtg
     1201 aagttcttga tgataaactt aaaaaataac agagaacacc tacctcttgt tggaaaagtt
     1261 ggccttgaat ggagaactga ctgtttaaat ggccgtattg agagttgcat tgtagtggat
     1321 atgaccttgc tggatgagga caagaagccc atctggtatg tgagttctcc agtgtgcttg
     1381 agatctgcct gccttcctga tttcccgcag ccggcttact ctttcgagta catggacagc
     1441 gtaggaggag tgtgcgcaga cctagggtgg tttgaaaata ccgatgaata cttcattgtc
     1501 agactggaca tttacctcag tgtagcaaaa ttacaacaat ggtttgggag gcaataaatg
     1561 ctgagttagc agtagggagt cttgttatta gtaagctgtt tgttttttac aactttgttt
     1621 ttattgaaag ttaaaataaa gcatatttgt ggta
//
