LOCUS       NM_001081034            4773 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus F-box protein 11 (Fbxo11), transcript variant 1, mRNA.
ACCESSION   NM_001081034 XM_001004113
VERSION     NM_001081034.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4773)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4773)
  AUTHORS   Kasuga,Y., Ouda,R., Watanabe,M., Sun,X., Kimura,M., Hatakeyama,S.
            and Kobayashi,K.S.
  TITLE     FBXO11 constitutes a major negative regulator of MHC class II
            through ubiquitin-dependent proteasomal degradation of CIITA
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2218955120 (2023)
   PUBMED   37279268
  REMARK    GeneRIF: FBXO11 constitutes a major negative regulator of MHC class
            II through ubiquitin-dependent proteasomal degradation of CIITA.
REFERENCE   3  (bases 1 to 4773)
  AUTHORS   Huang,H., Lu,J., Aukhil,I., Yu,C., Bhut,B., Marchesan,J., Pirih,F.
            and Chang,J.
  TITLE     FBXO11 regulates bone development
  JOURNAL   Bone 170, 116709 (2023)
   PUBMED   36863499
  REMARK    GeneRIF: FBXO11 regulates bone development.
REFERENCE   4  (bases 1 to 4773)
  AUTHORS   Azar,A., Bhutta,M.F., Del-Pozo,J., Milne,E. and Cheeseman,M.
  TITLE     Trans-cortical vessels in the mouse temporal bulla bone are a means
            to recruit myeloid cells in chronic otitis media and limit
            peripheral leukogram changes
  JOURNAL   Front Genet 13, 985214 (2022)
   PUBMED   36246635
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4773)
  AUTHORS   Del-Pozo,J., Headon,D.J., Glover,J.D., Azar,A.,
            Schuepbach-Mallepell,S., Bhutta,M.F., Riddell,J., Maxwell,S.,
            Milne,E., Schneider,P. and Cheeseman,M.
  TITLE     The EDA-deficient mouse has Zymbal's gland hypoplasia and acute
            otitis externa
  JOURNAL   Dis Model Mech 15 (3) (2022)
   PUBMED   35107126
REFERENCE   6  (bases 1 to 4773)
  AUTHORS   Hardisty,R.E., Erven,A., Logan,K., Morse,S., Guionaud,S.,
            Sancho-Oliver,S., Hunter,A.J., Brown,S.D. and Steel,K.P.
  TITLE     The deaf mouse mutant Jeff (Jf) is a single gene model of otitis
            media
  JOURNAL   J Assoc Res Otolaryngol 4 (2), 130-138 (2003)
   PUBMED   12943368
REFERENCE   7  (bases 1 to 4773)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 4773)
  AUTHORS   Nolan,P.M., Peters,J., Strivens,M., Rogers,D., Hagan,J., Spurr,N.,
            Gray,I.C., Vizor,L., Brooker,D., Whitehill,E., Washbourne,R.,
            Hough,T., Greenaway,S., Hewitt,M., Liu,X., McCormack,S.,
            Pickford,K., Selley,R., Wells,C., Tymowska-Lalanne,Z., Roby,P.,
            Glenister,P., Thornton,C., Thaung,C., Stevenson,J.A., Arkell,R.,
            Mburu,P., Hardisty,R., Kiernan,A., Erven,A., Steel,K.P.,
            Voegeling,S., Guenet,J.L., Nickols,C., Sadri,R., Nasse,M.,
            Isaacs,A., Davies,K., Browne,M., Fisher,E.M., Martin,J., Rastan,S.,
            Brown,S.D. and Hunter,J.
  TITLE     A systematic, genome-wide, phenotype-driven mutagenesis programme
            for gene function studies in the mouse
  JOURNAL   Nat Genet 25 (4), 440-443 (2000)
   PUBMED   10932191
REFERENCE   9  (bases 1 to 4773)
  AUTHORS   Mounier,C.M., Luchetta,P., Lecut,C., Koduri,R.S., Faure,G.,
            Lambeau,G., Valentin,E., Singer,A., Ghomashchi,F., Beguin,S.,
            Gelb,M.H. and Bon,C.
  TITLE     Basic residues of human group IIA phospholipase A2 are important
            for binding to factor Xa and prothrombinase inhibition comparison
            with other mammalian secreted phospholipases A2
  JOURNAL   Eur J Biochem 267 (16), 4960-4969 (2000)
   PUBMED   10931177
REFERENCE   10 (bases 1 to 4773)
  AUTHORS   Van der Bliek,A.M., Van der Velde-Koerts,T., Ling,V. and Borst,P.
  TITLE     Overexpression and amplification of five genes in a
            multidrug-resistant Chinese hamster ovary cell line
  JOURNAL   Mol Cell Biol 6 (5), 1671-1678 (1986)
   PUBMED   2431283
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154673.2, AI853268.1, BY127063.1, CN533292.1, CN666984.1,
            CA557033.1, CF172333.1, CF169182.1, CA749247.1, AC087233.6 and
            BC055343.1.
            
            On Mar 30, 2020 this sequence version replaced NM_001081034.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777535.3654909.1,
                                           SRR14777530.687181.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-838               AC154673.2         38630-39467
            839-1002            AI853268.1         1-164
            1003-1117           BY127063.1         1-115
            1118-1650           CN533292.1         1-533
            1651-1907           CN666984.1         324-580
            1908-2323           CA557033.1         49-464
            2324-2648           CF172333.1         315-639
            2649-3262           CF169182.1         63-676
            3263-3850           CA749247.1         137-724
            3851-4592           AC087233.6         49861-50602
            4593-4773           BC055343.1         2574-2754
FEATURES             Location/Qualifiers
     source          1..4773
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 57.87 cM"
     gene            1..4773
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /note="F-box protein 11"
                     /db_xref="GeneID:225055"
                     /db_xref="MGI:MGI:2147134"
     exon            1..1037
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     CDS             794..3586
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     only protein 11"
                     /codon_start=1
                     /product="F-box only protein 11 isoform 1"
                     /protein_id="NP_001074503.1"
                     /db_xref="CCDS:CCDS37717.1"
                     /db_xref="GeneID:225055"
                     /db_xref="MGI:MGI:2147134"
                     /translation="MNSVRAANRRPRRVSRPRPVQQQQQQPPQQPPPQPPQQQPPPQP
                     PQQPPQQQPPPPPQQQPPPPPPPPPPPPQDRNNAGERDDVPADMVAEESGPGAQNSPY
                     QLRRKTLLPKRTACPTKSSMEGASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQE
                     KLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEP
                     GKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIE
                     DALGGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFV
                     FMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAV
                     CVSGQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIR
                     RNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGI
                     YVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEG
                     NDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVW
                     VTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRN
                     KIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICI
                     FNGGRGLLEENDIFRNAQAGVLISTNSHPVLRKNRIFDGFAAGIEITNHATATLEGNQ
                     IFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRC
                     HTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDT
                     LYDSAPPIESNTLQHN"
     exon            1038..1162
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1244
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1389
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1519
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1603
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1736
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1843
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1955
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2062
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2200
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2418
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2504
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2599
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2722
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2808
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2885
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..3029
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3140
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3248
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3357
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3456
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..4773
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4752..4757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /note="hexamer: AATAAA"
     polyA_site      4773
                     /gene="Fbxo11"
                     /gene_synonym="Jf"
                     /note="major polyA site"
ORIGIN      
        1 agggcttgag cggagaggct ccggcggtgt caatggctcc tcctgccacg gagcagcagc
       61 agcagcagca gcggcagcag cagcagcggc agcggcggcg gcggcgctgg ggctgaggag
      121 ggaaggttcc tttaaggagg aggaacgacg acgcctcttt tgcccctatc tcctcccttt
      181 tacactcatt tccccttcgc cgagggtggg ggtggggggg gcggaggaga gagaagaggc
      241 cgaagaaaga gaaaattcct cgcagggcgc tctttcaggg ggtgtggggg gaggacgagg
      301 aacggaggag ccgggcgccc cccgcgcgct cccgccccgc tcggctcgcc ctctccgaga
      361 tcgcccgtcc gcccactccc cccgccgccg ccgctgccgg agacgccgct cgggagtcgg
      421 cgggcccggc tcgtctgctc ggccgccgcc gcgcttcgcc tcgggctccc caggcggacg
      481 gacgcccttt ctttctttct cttgcccggc ccgtctctct gtctgcgtcc ctcgcggccg
      541 ccccgcccgg cggcctcggc cttgcccgtg cgccaggccc ggccggcggg cctcgctcaa
      601 gctccggtgg tgcccccagc ctccccgcgg agccggggga agctcacgcc cggtggcccc
      661 ccggtccccg cgtccccggc cgccccgctc cttcccgctc cccaccccct tcctccccgg
      721 ccccggagct cgcggtgcgt gtgcgcgtga gtgtgtgtgt ccctccgcca acgccgccac
      781 ctcagcccgg caaatgaact ccgtccgagc cgccaaccgg agacccaggc gagtgtcgcg
      841 gccgcgcccg gtgcaacagc agcagcagca gcccccgcag cagccgccgc cgcagccgcc
      901 tcagcaacag ccgccgccgc agccgcccca gcagccgccg cagcagcagc ccccgccgcc
      961 gccgcagcag cagcccccgc cgccgccccc gccgcctccg ccgccgcctc aggatcggaa
     1021 caacgccggc gagagggatg atgttcctgc agatatggtt gcagaagaat caggtcctgg
     1081 tgcacaaaat agtccatacc aacttcgcag aaaaactctt ttgccaaaaa gaacagcgtg
     1141 tcctacaaag agcagtatgg agggtgcctc tacttcgact acagaaaact ttggtcatcg
     1201 agcaaagcgt gcaagagtgt ctggaaagtc acaagatctt tcagcagcac ccgctgaaca
     1261 gtatcttcag gagaagctgc cagatgaagt agttttaaaa atattttctt atttgctgga
     1321 acaagacctt tgtagagctg cttgcgtgtg taaacgcttc agtgagcttg ctaatgatcc
     1381 aattttgtgg aaacgattat atatggaagt atttgaatat acccggccga tgatgcatcc
     1441 tgaacctggt aaattctacc agattaatcc agaagaatat gaacatccaa atccatggaa
     1501 agaaagtttt caacagttgt ataaaggtgc gcatgtaaag ccaggatttg cggaacattt
     1561 ctatagtaat cctgcaagat acaaaggaag agaaaacatg ttgtattatg atactattga
     1621 agatgccctt ggaggagtac aagaagcaca ttttgatggg cttatctttg ttcattctgg
     1681 aatatatact gatgaatgga tatatattga atctccaatt actatgattg gtgcagcacc
     1741 tggcaaggtt gcagacaagg tcatcattga gaacactaga gattcgacct tcgtgttcat
     1801 ggaaggctct gaagatgctt atgttggata catgacgata agattcaacc ctgatgacaa
     1861 atctgctcag catcacaacg cacaccactg cttagagatc acagtcaact gcagccctat
     1921 tattgaccac tgtataatcc gcagcacatg cacagttggt tctgcagtgt gtgtcagtgg
     1981 ccagggggcg tgtcccacta tcaagcattg taacatcagt gactgtgaaa acgtcggact
     2041 ttatataaca gatcatgcac agggaatata tgaagataat gaaatttcta ataatgcgtt
     2101 agctgggatt tgggttaaaa atcatggaaa tccaattatt agacggaatc acattcatca
     2161 tggacgtgat gttggtgtgt tcacatttga tcatggcatg ggctactttg aaagttgcaa
     2221 catacacaga aacaggatag caggctttga ggtaaaagcc tatgccaatc ccacagtggt
     2281 tcgatgtgag attcaccacg ggcagactgg aggaatatac gtccacgaga aaggaagagg
     2341 acagttcata gagaacaaga tctatgcaaa caatttcgca ggcgtgtgga ttacctcaaa
     2401 tagtgaccca acaataaggg ggaattctat atttaatgga aatcaaggag gagtttacat
     2461 ctttggtgac ggacgaggcc ttatagaagg aaatgacatt tatggtaatg cgttagcagg
     2521 aattcagatc aggacaaaca gttgtcctat tgttcgacat aacaaaattc atgatggaca
     2581 gcatggtggg atttatgtgc atgaaaaggg gcaaggagta atagaagaga atgaagttta
     2641 cagcaacact ctggctggcg tctgggtgac aactggcagc acaccagttc taagaagaaa
     2701 ccggatacac agtggcaagc aggttggtgt ttatttctat gacaatggac atggtgttct
     2761 agaagataac gacatctaca atcacatgta ttcaggggtt cagataagaa ctggaagcaa
     2821 ccccaaaatt agacgcaaca aaatttgggg aggacagaat ggtggaattc tagtttataa
     2881 ttctggtcta ggctgtatag aagacaatga aatatttgac aacgcgatgg ctggagtctg
     2941 gattaaaaca gatagtaatc ctacgctaag aagaaataaa atccatgatg gaagagatgg
     3001 tggcatctgt atatttaatg ggggtcgagg tctccttgaa gaaaatgata ttttcaggaa
     3061 cgctcaagca ggtgtcctca tcagcactaa cagtcatcca gtattaagga aaaacagaat
     3121 atttgatgga tttgctgcag gtattgaaat tacaaatcat gcaactgcaa cactcgaagg
     3181 caatcagatc tttaacaacc gatttggagg cttattttta gcatctggtg ttaatgtgac
     3241 aatgaaagat aacaaaataa tgaacaatca agatgccata gaaaaggctg ttagtagagg
     3301 acaatgtcta tataaaatat caagttatac cagctacccc atgcatgact tctacagatg
     3361 tcatacttgt aacaccacag atcgaaatgc catatgtgtg aactgcatta agaagtgcca
     3421 tcagggacat gatgtagagt tcattagaca tgataggttt ttctgtgact gtggtgctgg
     3481 aacgctgtct aatccttgta ccttagctgg cgagcctaca cacgacacag acacactcta
     3541 tgactctgcc ccacctatag aatctaatac gttgcagcac aactgaattc cttccctaaa
     3601 gaaaaagtcc tgccattcta acataactta aaacatcttt tggaagataa aatacttgcc
     3661 catgctacag aaagagactg tactgaaaaa atggacacac aaggtcagtt gacactagga
     3721 agctcaagct accaaaaagg aagtggcaat agattgactc aggatgtcag agctcgggat
     3781 tttagcatta ctgcgtaaag acttttgaag ggacagaagt gaagaaataa gctgcaattt
     3841 tgtacagata ccaacttctg aaaaagctgg tgtttttaca acgagcattg aatgcagtct
     3901 gatttgcagt agtcatcttc cacagacaag cagctttgtt gctgccttta tggacatggg
     3961 taccaattgc tttttgtaat atggtaaaaa tgtgagctag cacttctgca ttgatttttt
     4021 tttttttgtt taacatgtat tcagattgag aatatgattt taatgcttta atctcatgta
     4081 gttcgttttt aatttcaagc aaatcttatt gtacttgaat gtgccctgtt ttgttagcac
     4141 acctagactt gctgtaactg tactcatgtc ccagtatgta ccttctttct atgaaagaga
     4201 aaaacactaa ccttaagtta tatccagcaa tgtttctggt atcctttaag aaaagttaag
     4261 actattatct ccttcccttt cctgtgcagc attcaaaatc acccctagaa aaagtgagtg
     4321 ttttaatgag acttcctagg aagggatgca ctgtaaaaca aaagtattct tgtatctcag
     4381 ttttgtgaaa ggtaaaaact actatgtttt aaagtacact ttagaaagtc tcttcaaaac
     4441 agtcctgtat ttgaactctg ttcatagttt ttatttgaac agttaagaca aaacagctgg
     4501 aaattacagc aatttcctgc attaagctga gaccagtata tatacagctc tatacagttt
     4561 catagcgccc ctccccccat ttatgtgtat tggtgacagt gggtataaac agcctgaaag
     4621 tgtatgcatg taccataaca tctagactta atatattgtg gagtattcaa taaccattat
     4681 gtagaaggta gataagaatt aaaagggttt aatttcctag aaagaaaatg gaaaaatggt
     4741 cattttttaa aaataaagtt tattagatca taa
//
