LOCUS       NM_001368408            2321 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 9 (Fbxl9),
            transcript variant 1, mRNA.
ACCESSION   NM_001368408 XM_006530892
VERSION     NM_001368408.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2321)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2321)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124584.5.
            
            On Feb 12, 2019 this sequence version replaced XM_006530892.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4935658.1,
                                           SRR5189685.147742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC124584.5         67211-67252
            43-144              AC124584.5         70113-70214
            145-1137            AC124584.5         77411-78403
            1138-1353           AC124584.5         79583-79798
            1354-1497           AC124584.5         79915-80058
            1498-1715           AC124584.5         80217-80434
            1716-2321           AC124584.5         80534-81139
FEATURES             Location/Qualifiers
     source          1..2321
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..2321
                     /gene="Fbxl9"
                     /gene_synonym="A630024J02Rik; FBL9; Lrrc29"
                     /note="F-box and leucine-rich repeat protein 9"
                     /db_xref="GeneID:234684"
                     /db_xref="MGI:MGI:2443262"
     exon            1..42
                     /gene="Fbxl9"
                     /gene_synonym="A630024J02Rik; FBL9; Lrrc29"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1884
                     /gene="Fbxl9"
                     /gene_synonym="A630024J02Rik; FBL9; Lrrc29"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine rich repeat containing 29"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 29
                     isoform 1"
                     /protein_id="NP_001355337.1"
                     /db_xref="CCDS:CCDS90448.1"
                     /db_xref="GeneID:234684"
                     /db_xref="MGI:MGI:2443262"
                     /translation="MADSLPLEMLTYILSFLPLSDQKEASLVSRTWYCAAQNALRETN
                     VRYNIPVSSASLSAIKSLGLRGISCISLTNLDGSPASHQVLQSVAYHLGPHLESLCLG
                     GGSPTEASFLALILGCPVLRTLDLSGCNSLFTSGTLLAQPETAQCVREALSGLRDLNL
                     AGLRDLTDLSFNHLSSCFPSLERLSLAYCHLSFELSPTWGSISPQVSSPSQLSFHNLL
                     KFIKERAGTLRALDLSGTGLPPEALQALGQVTGLKLEELYLHSCRDLSSEAVTILCRQ
                     QPGLTSLDLSGCSDLTDGALLAVSRGLRHLRHLSLKKLQRLTDAGCAALGALRELQSL
                     DMAECCLVSGRELAQVLGSVRRAPRALTSLRLAYCSSLKDASVLSMIPALGPSLKVLD
                     LSSCMALTNQTMQAICTYLIHLSVLRLAWCKELQDWGLLGLKEPSDEPVLSPQLHQKV
                     DNEAPDPQEPSSEPQGSSLLMLQALQELDLTACSKLTDASLAKVLQFPQLRQLSLSLL
                     PAFTDTGLVAVARGCPSLERLTLSHCSHLSDEGWAQAARLWPRLQHLNLSSCSQLTEQ
                     TLDTIGQACKQLRVLDVAMCPGINMAAVRHFQAQLPQVTCIQSRFVGGADLTLTL"
     exon            43..144
                     /gene="Fbxl9"
                     /gene_synonym="A630024J02Rik; FBL9; Lrrc29"
                     /inference="alignment:Splign:2.1.0"
     exon            145..1137
                     /gene="Fbxl9"
                     /gene_synonym="A630024J02Rik; FBL9; Lrrc29"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1353
                     /gene="Fbxl9"
                     /gene_synonym="A630024J02Rik; FBL9; Lrrc29"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1497
                     /gene="Fbxl9"
                     /gene_synonym="A630024J02Rik; FBL9; Lrrc29"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1715
                     /gene="Fbxl9"
                     /gene_synonym="A630024J02Rik; FBL9; Lrrc29"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..2321
                     /gene="Fbxl9"
                     /gene_synonym="A630024J02Rik; FBL9; Lrrc29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2302..2307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl9"
                     /gene_synonym="A630024J02Rik; FBL9; Lrrc29"
                     /note="hexamer: ATTAAA"
     polyA_site      2321
                     /gene="Fbxl9"
                     /gene_synonym="A630024J02Rik; FBL9; Lrrc29"
                     /note="major polyA site"
ORIGIN      
        1 ggagacggca gaactgcgat ggcggactcg ctgcctctgg agatgctcac atatatcctg
       61 agcttcctgc ctctgtcaga tcagaaagag gcctcccttg tgagtcggac ctggtactgt
      121 gcagcccaga atgcccttcg ggagacaaat gtgcgctaca acattcccgt gtcctctgcc
      181 tcactctcag ccatcaagag tttgggcctc aggggcattt catgcatcag cttgaccaac
      241 ttggacggct cgccagcttc gcaccaggta ctgcagtctg ttgcttacca cttaggccca
      301 cacctggaaa gcttgtgcct gggtgggggc agccccacag aggcgtcctt cttggccctg
      361 atcctgggat gcccagtcct tcgtacgctt gatctcagtg gctgcaacag tctcttcaca
      421 tcaggcactc tgctggccca gcctgagaca gcacagtgtg tccgagaggc attgagtggc
      481 ctccgtgatc ttaacctggc tggcctacgt gacctgactg acctcagctt caaccatctc
      541 agtagttgtt tccccagcct ggagcgcctc tccttggctt actgccatct ttcctttgag
      601 ttaagcccaa cctggggctc catcagcccc caggtttcct ctccctccca gctttccttc
      661 cacaacttgc tgaagttcat caaggagcga gctggtacgc tgcgtgccct agacctcagt
      721 ggtactggtt tgccaccgga ggccctacaa gccctgggcc aagtgactgg attgaagttg
      781 gaggagctgt atctgcacag ctgcagagac ctctcctcag aggctgtgac catcctgtgc
      841 cgccagcagc ctggtcttac ttccctagac cttagtggct gctcagacct gaccgatggg
      901 gcactcttgg ctgtgagccg aggcctacgc cacctgcggc acttgagtct gaagaaactg
      961 cagagactga cagatgcagg gtgtgcagcc ctaggggccc tgcgtgaatt gcagagccta
     1021 gacatggctg aatgctgtct ggtgagcggt cgggagctgg cccaggtcct aggctcagtt
     1081 cgcagagctc cacgtgcact gacttccctc aggctggctt actgctcttc actgaaggat
     1141 gcctcggtgc tctccatgat cccagcattg ggtccaagcc tcaaggtgct agacttgtcc
     1201 tcctgcatgg ccctcactaa ccagaccatg caggccattt gcacctacct cattcacctg
     1261 tcggtcctgc gcctggcttg gtgcaaggag ctccaggatt gggggctttt ggggttgaag
     1321 gagccaagtg atgagcctgt gctaagtccc cagctacacc agaaggtgga caatgaggct
     1381 ccagaccctc aggagcccag ttctgagcca cagggctcct ccctgctcat gcttcaggcc
     1441 ctgcaggagt tggatctcac agcctgcagt aagctgactg atgccagttt ggccaaggtg
     1501 ctccagttcc ctcagctgag gcagttatca ttgagcttgt tgccagcttt cacagacacg
     1561 ggcttggtgg ctgtggctag gggctgtcct agcctggagc gcttgacatt gagtcactgc
     1621 agccacctca gtgacgaggg atgggcccag gcagccaggt tgtggccaag gctacaacat
     1681 ctcaacctgt ccagctgcag tcagctcaca gagcaaactc tggatacaat tgggcaggca
     1741 tgcaagcagc ttcgagtgtt ggacgtggcc atgtgtcctg gtatcaacat ggcagccgtc
     1801 agacactttc aggcacagct acctcaggtg acctgcatcc agtctcgctt cgtgggaggg
     1861 gctgacctga ccctaacact ttgaggccag gtcagtaact agccctgaag ctcatcttcc
     1921 cctcaccact gtagtcctag gccagccagg cctgtggacc tgagtttgcc ccagtgcctc
     1981 ctgcctgcct tcccctgttc tagaaccttt tctaagactc tggacggaac caatccaggg
     2041 ctcttgcagc actagtgtac cccacagatg gcagccacca cttcccagct acacttgctg
     2101 ccacgagccc ctctaaaggt cagacccaca ggtgagctgg gcctggtgct ggggatggcc
     2161 agactctgcc tcctgccagc cacctactta gactaaaacc tttgttctgc ctgctcccag
     2221 gtgtagggtg atggtggggt ctcttccagt ccttcagagt tttagcagcc agccaccaac
     2281 ttcattgtaa acccaaacaa gattaaaaat tccagatctt a
//
