LOCUS       NM_015821               1901 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 8 (Fbxl8), mRNA.
ACCESSION   NM_015821
VERSION     NM_015821.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1901)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
REFERENCE   2  (bases 1 to 1901)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   3  (bases 1 to 1901)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124584.5 and CX222518.1.
            
            On Aug 8, 2009 this sequence version replaced NM_015821.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155194.1, AK170367.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC124584.5         128800-128831       c
            33-736              CX222518.1         1-704
            737-1901            AC124584.5         124153-125317       c
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..1901
                     /gene="Fbxl8"
                     /gene_synonym="FBL8"
                     /note="F-box and leucine-rich repeat protein 8"
                     /db_xref="GeneID:50788"
                     /db_xref="MGI:MGI:1354697"
     exon            1..113
                     /gene="Fbxl8"
                     /gene_synonym="FBL8"
                     /inference="alignment:Splign:2.1.0"
     exon            114..584
                     /gene="Fbxl8"
                     /gene_synonym="FBL8"
                     /inference="alignment:Splign:2.1.0"
     CDS             433..1557
                     /gene="Fbxl8"
                     /gene_synonym="FBL8"
                     /note="F-box protein FBL8"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 8"
                     /protein_id="NP_056636.2"
                     /db_xref="CCDS:CCDS22595.1"
                     /db_xref="GeneID:50788"
                     /db_xref="MGI:MGI:1354697"
                     /translation="MGELVDNLPEEVLALIFRDLPLRDLAVATRVCRAWAAAAANSTV
                     WSDKSISCDCELEDLLPPYLSSCLDHIHNLRLEYEPSKKPSRGTATELLTALASRAPR
                     LRGLRLECRGEKPLFDAGQDILGAVHAVCGAAHQLRHLDLRHLPYTLDDTLVLKAAAG
                     CPELRSLFLDNHALVNSVQPTSVLKLLEACPHLRALGLHLASMSRAALELLAAPHRSP
                     FALLALRCACPEDARASPLPDEAWATLSCRHPGLEVELELEPVLPDEAVTRILQPAVP
                     VAVLRLNLSGDTVGPVRFATRHYAETLRALEVRASASPELHTALEELAARCAGLREIH
                     CFCVVRPSVLDAFRAHCPRLRSYTLKLKREPHPWRPTLVR"
     exon            585..1901
                     /gene="Fbxl8"
                     /gene_synonym="FBL8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1877..1882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl8"
                     /gene_synonym="FBL8"
                     /note="hexamer: AATAAA"
     polyA_site      1898
                     /gene="Fbxl8"
                     /gene_synonym="FBL8"
                     /note="major polyA site"
ORIGIN      
        1 gggtccgccc gcgcgtcccg ccttctccgc ccagggcctc tccttcctgc cctagctgtc
       61 ctccgtggcc agtcccctgt ctccgggtaa agcccaccta gtccgctgag caggtatgtg
      121 tgtggaagtg ctccaatcag ggtacacatg cattcttgga gatcagagga caactttcag
      181 aagtcagttc ttctgaaaga gttctgaccc cgggacagaa ctcaggtcgt ccgtgtttgg
      241 ggcaaatgcc tttatctgct aagccatctc acagcctggg atctctgcct tctctacaaa
      301 ccacatagcg cttcctgggc tcccagtatt actgtgcaca agcatccatc cgcccctctg
      361 acccagggga ctccctcttt cactttagtc acagcagctg ggagcagcag gcccctcccc
      421 tccagccgca ccatggggga gctggtcgac aatctgccag aggaagtgtt ggcgctcatc
      481 ttccgtgacc tgcctctcag ggaccttgct gtagccacca gagtctgcag ggcctgggcg
      541 gcggctgccg ccaacagcac cgtgtggtct gataaaagca tcagttgtga ctgtgagctg
      601 gaagacttgt tgccaccata tctgtcctcc tgcctggacc acattcacaa cctaaggctg
      661 gaatatgagc catcaaagaa gcccagccgc ggaacggcca ccgagctgct gaccgctctg
      721 gccagccgag ccccaaggct ccgaggcctg cgcttggagt gccgcggaga gaaaccgctt
      781 tttgatgcgg gccaggacat cctgggagct gtgcacgcag tctgcggagc tgctcaccaa
      841 cttcgccacc tcgacctgcg ccacttgccc tacacgctgg acgacactct ggtgcttaag
      901 gctgctgctg gctgtcccga gctccgcagt cttttcctgg acaaccatgc actggtgaac
      961 agcgtgcagc ccacttctgt gctcaaacta ctggaggcct gtcctcactt gcgcgccctt
     1021 ggactgcacc ttgctagtat gtcgcgcgcc gcgctggaat tgctagccgc tccgcatcgc
     1081 tccccttttg cacttctggc actgaggtgc gcgtgccccg aagatgctcg tgcttcccct
     1141 ctgcctgatg aagcctgggc gacgctgagt tgccgccatc ctgggctgga ggtggagctg
     1201 gagctggagc ctgtgcttcc agatgaggcc gtgacgcgca tcctgcaacc agcagtacca
     1261 gtggctgtgc tgcgtctcaa cctctccggt gacactgtag gacccgtgcg cttcgcaacg
     1321 cgccactacg ctgaaacttt gcgcgccctc gaggtgcgcg cgtccgcatc cccggagttg
     1381 cacaccgcgc tggaggagct ggcggcgcgc tgcgcgggct tgagagaaat acactgcttc
     1441 tgcgtggtga gaccctcggt actggacgcc ttccgagcgc actgtccgcg cctgcgcagc
     1501 tatacgctca agctaaagcg tgagccgcat ccctggcggc ccacactggt gcggtgattg
     1561 ggcaatctag cccccccagg gccgcgcgaa ccccaagcct cgggaaggcc taagcaagtt
     1621 gcgcaggcac gccccagttg ctagtctctt taggggctcc gttgactaag gcgcttttgg
     1681 ggaactgggg gtctatgaaa gcatccagac caatctcagg caccataaat tcagcgagcc
     1741 ctctcaacct ctgtgtctct gtctattctg ggccctccgt cccctctgta cactcgcact
     1801 agctctagct caggtccaga gctgggggga gggcaggcac aagtaggagc caagagtcaa
     1861 gggtgagtgt aaagtaaata aatcctttaa tattcctgcg t
//
