LOCUS       NM_176959               4639 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 7 (Fbxl7), mRNA.
ACCESSION   NM_176959 XM_619306
VERSION     NM_176959.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4639)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4639)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4639)
  AUTHORS   Liu,Y., Lear,T., Iannone,O., Shiva,S., Corey,C., Rajbhandari,S.,
            Jerome,J., Chen,B.B. and Mallampalli,R.K.
  TITLE     The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial
            Function by Mediating the Ubiquitylation and Proteasomal
            Degradation of Survivin
  JOURNAL   J Biol Chem 290 (19), 11843-11852 (2015)
   PUBMED   25778398
  REMARK    GeneRIF: the Skp1.Cul1.F-box protein complex subunit Fbxl7
            modulates mitochondrial function by controlling the cellular
            abundance of survivin
REFERENCE   4  (bases 1 to 4639)
  AUTHORS   Coon,T.A., Glasser,J.R., Mallampalli,R.K. and Chen,B.B.
  TITLE     Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora
            A, causing mitotic arrest
  JOURNAL   Cell Cycle 11 (4), 721-729 (2012)
   PUBMED   22306998
  REMARK    GeneRIF: FBXL7 specifically interacts with Aurora A during mitosis
            but not in interphase, suggesting a regulatory role for FBXL7 in
            controlling Aurora A abundance during mitosis.
REFERENCE   5  (bases 1 to 4639)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   6  (bases 1 to 4639)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091646.1.
            
            On or before May 25, 2005 this sequence version replaced
            XM_619306.1, NM_176959.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091646.1, AK048688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 9.87 cM"
     gene            1..4639
                     /gene="Fbxl7"
                     /gene_synonym="D230018M15Rik; Fbl6; FBL7"
                     /note="F-box and leucine-rich repeat protein 7"
                     /db_xref="GeneID:448987"
                     /db_xref="MGI:MGI:3052506"
     exon            1..552
                     /gene="Fbxl7"
                     /gene_synonym="D230018M15Rik; Fbl6; FBL7"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..1991
                     /gene="Fbxl7"
                     /gene_synonym="D230018M15Rik; Fbl6; FBL7"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 7"
                     /protein_id="NP_795933.2"
                     /db_xref="CCDS:CCDS37052.1"
                     /db_xref="GeneID:448987"
                     /db_xref="MGI:MGI:3052506"
                     /translation="MGANNGKQYGSEGKGSSSVSSDVSSSTDHTPTKAQRNVATSEDS
                     DLSMRTLSTPSPALICPPTLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIR
                     LASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLT
                     GETINVDRALKVLTRRLCQDTPNVCLMLETVIVSGCRRLTDRGLYTIAQCCPELRRLE
                     VSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRY
                     LDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCTSIKELSVSDC
                     RFVSDFGLREIAKLESRLRYLSIAHCGRITDVGIRYVAKYCSKLRYLNARGCEGITDH
                     GVEYLAKNCTKLKSLDIGKCPLVSDTGLESLALNCFNLKRLSLKSCESITGQGLQIVA
                     ANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF"
     exon            553..642
                     /gene="Fbxl7"
                     /gene_synonym="D230018M15Rik; Fbl6; FBL7"
                     /inference="alignment:Splign:2.1.0"
     exon            643..1254
                     /gene="Fbxl7"
                     /gene_synonym="D230018M15Rik; Fbl6; FBL7"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..4616
                     /gene="Fbxl7"
                     /gene_synonym="D230018M15Rik; Fbl6; FBL7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4596..4601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl7"
                     /gene_synonym="D230018M15Rik; Fbl6; FBL7"
                     /note="hexamer: AATAAA"
     polyA_site      4616
                     /gene="Fbxl7"
                     /gene_synonym="D230018M15Rik; Fbl6; FBL7"
                     /note="major polyA site"
ORIGIN      
        1 cgcaggcgag cagcgccggg ccacaagtct ctgctcactc ggggcaccgc aacaagtggc
       61 cgccgcgccc tccccgggga agccgcggac gcacgggggc gcagggcgga ggcggaggcc
      121 gaggagccgg acagcctggg gcaggcgcgg ctcggctcgc acggctgggg accgcggagg
      181 cgcatgggga ccccacggcg gtggagcggc gagtctaggg gcggcacccg ggcgcgggct
      241 gtgcttcgcg ctgctcccac tcgcccggag cgcggaatct gagagctccg gtggttgctc
      301 tggagctggc tcgccaccct cgggggtgcc aggagcggac ctagtcccac ccctccggtc
      361 gcagagcact gcggaccccc aagcccaaat cggcccttgg aaggggcatg tgcagctaag
      421 ggtccggtcc tgcccgcttt cctctgcccc gccgcctggg aggtgcgccc cagctatgca
      481 gtgtccaggg aggaggcggg catgacggcg acaggatggg cgcgaacaat ggcaaacagt
      541 acggcagtga gggcaaaggc agctcaagcg tctcatccga cgtgagttca agcacagatc
      601 atacaccaac caaagcccag aggaatgtgg ccaccagcga agattctgac ttgagcatgc
      661 gcacactgag cacgcccagc ccagccttga tatgcccacc gactttgcca ggatttcaga
      721 atggaagggg ttcgtccaca tcttcatcct ccatcaccgg ggagacagtg gctatggttc
      781 actccccgcc cccgacccgc ctcactcacc cactcattcg gctcgcctcc agaccccaga
      841 aagagcaagc cagcatagac aggctcccgg accactccat ggtgcagatc ttctccttcc
      901 tgcccaccaa ccagctatgt cgctgtgcac gtgtgtgccg ccgctggtac aacctggcct
      961 gggacccgcg cctctggagg actatccgtc tcactggaga gaccatcaat gtggaccgtg
     1021 ccctgaaagt actgacccgc aggctttgcc aggacacccc caatgtgtgt ctcatgctgg
     1081 agactgtcat tgtcagtggc tgccggcggc tcacagaccg ggggctttat accattgcac
     1141 agtgctgtcc agaactgagg cgcctggaag tctcaggatg ttacaatatc tcgaacgagg
     1201 ctgtctttga tgtggtgtca ctctgtccca acctggagca tctggatgtg tcagggtgct
     1261 ccaaagtgac ctgcatcagc ttgacccggg aggcctccat taaactgtcc cccttacatg
     1321 gcaaacagat ttccatccga taccttgata tgacggactg cttcgtgctg gaggacgaag
     1381 gcttacacac catcgcagct cactgcacgc agctcactca cctctatctg cgccgctgcg
     1441 tccgcctcac agatgagggt ctccgctacc tggtgatcta ctgcacttcc atcaaggagc
     1501 tgagtgtcag cgactgccgc tttgtcagtg actttggcct gcgggagatt gctaaactgg
     1561 agtcccgctt gaggtacctc agcatcgccc actgcggccg catcacggat gtgggcattc
     1621 gttatgtggc taaatactgc agcaaattac gctacctcaa tgcgaggggc tgcgagggca
     1681 tcacggacca tggtgtggag tacctcgcca agaactgtac aaaacttaag tcgctggaca
     1741 ttggtaaatg tcccctggtc tccgacacgg gcctggaatc cctggctttg aactgcttca
     1801 atctcaagag gctaagcctc aagtcctgtg agagcatcac cggccagggc ctgcagatcg
     1861 tggctgccaa ctgcttcgac ctgcagatgt taaatgtcca ggactgtgaa gtttccgtgg
     1921 aggccctgcg gtttgtgaag cgccattgca agcgctgtgt cattgagcat accaaccccg
     1981 ctttcttctg aagggacagc tcccacggcg caatgagaac caaacagtgc tttgtaaaag
     2041 tgtcccatgt aagcacccat acccattcac agcagctatt tttctttctg taaggttctt
     2101 aggagtctgg cttttatttt attattttta atttctcatg agcaaaagag gtcaaataat
     2161 gaaggggagc cccaaatttc taccatggta aactcttcct agtcagttaa tttttagata
     2221 aatgtcacca aggctgcacc tcagcaggct ggttattgtg tctcagaaat gcaccttacc
     2281 cccctttccc tctcccctcc tgtccccaag ctacacccca gcgttccata ctctcttctt
     2341 ccaaccctga agcagctgca acattaagcg ttgaagaagg ctctctaaag ctcctcctta
     2401 aactatctga tgggcgtaag ccccacgcct aaatcccaca ccaagcaaat tatggttaaa
     2461 gtcctattaa cacttcgtat cagtgtgcaa agagcttccc tatgttaata cgttacggca
     2521 aaccatatgg agtaagagga gtcatgtttt ctcccctagc tctgccagta actagccttg
     2581 tcaccttggt caaaacccct cacctttctg agattgccac caccagagcc cagaggtgag
     2641 ggattagcct tcggcccatt ttcaaactga gagatgctct gctcagagat gctgctgagc
     2701 agaagagctc tgtataagtc acacacaggt ggcacttgtg agagaactgg atatgtaaat
     2761 gagttgtgcg ttcaggagtt tccatgggcg ctcggtaagt ccacactggg ttctgctcag
     2821 gtctcccttt gctctcatcc gagaaccagc acaactgtaa tggtgggctg ggcttctgaa
     2881 cgttctttgc cttgttggat gctcagactc acatccacac gtgctctcgc attccctcgc
     2941 ccttccacgc ccgactcaga caggagggcg cctcatcaca ggaagcctct atctctgtca
     3001 acttgcatcc tctgagcatt ttcaaaccca agtaagaacc cttataaatt ttaattaaca
     3061 agtgaggccc aagggaacac atgtccttaa aggttttcct aaaccttctc agtgcacatc
     3121 tgctatgctt taggcacatc tgtcctgcag ccatcgggga caggtgccgt ggttctttgt
     3181 tatccacgtt tcattgtgac ttctctcttc tatttatttc tccatcacac aaagcctcct
     3241 ggggttaagt ttgtaagtgt ttaattgtac gaatgccgcc cagcccgctg tcttcatgtt
     3301 ttctactaag ggatgtgaaa cagatgtcca ggtgtttcaa tattgttcat tcaagatgcc
     3361 aggcacagag aagaggcgac acactggtga gacagaagct gatccaccca ccacagtctt
     3421 ggaacagaat attacaatca tttcaaattt tgaattttta agttgatggg ctcttaagtg
     3481 gtccgttctg aatagaaacc aatttgctag tttcggtttt gttttgtttt gttttgtttt
     3541 gttttgtttt gtttttttaa ggaatcagat agccagaaaa aaaaatgcta ttgcttgttt
     3601 tcatgaactt cagttgtctc tttttagtaa acccagtact ttccacaaag tcttctctga
     3661 ccttccccat cactggacgg ttcacccatc ttcttctcca agtgtttatc ccccagccca
     3721 agcctttcct gctgcaagcc aagcctgcta catttgttac agaccaagct tatacacagc
     3781 tcgacaactg cactcccact gtaggctccg gtgtgtactc ttgtcttgtg ttgggaaggg
     3841 gaagtgaagt gataagccag aatttttttc aggaggtttc tgtcattgat cctgtgagtc
     3901 acagtttact cttcagttca caccatcatc aggacagatg gctgttcaca ggtatcagaa
     3961 aagaaagtga aaagttttgg ctgggggcag aatctaggga cagccaccaa gattagaatc
     4021 ataaaagata ttgaaagtag cacccctctg ctctctggcc ttggctttac ctaaatcttg
     4081 tgatttggag agtcacaata gcttatctgt aacccttgac actgggactt gccaaatgat
     4141 ctggttcaat actcccagaa tgagcagagg gtccaaagtg gatccctgag ccattttgaa
     4201 taattttatc accactgaca gagtacatca cctgagctgt ctgtcatgtg agacccaagg
     4261 gacatttcca acttgctgcc tgcccagcac atatgtcttt cccagtttct tccttcccca
     4321 tcttcttcgt gctctctgct ctccaccagg gtggaggtat ggatctgtga cagaggttct
     4381 tgggaacagc tcagcagatt tttgagacca atcaaatggc ctcattaaga actttatctg
     4441 tttggaaaca tggcttcctt cctggctctg ctaaactgaa agctcatttg ttgttgctgt
     4501 tgttgttgtt tgtttgtcca tttctcttta attctaatgt tcacatcatg tcgtgctgta
     4561 tgactctaga aagccttaat ttacttccac caagaaataa agcaatatgt tggtaaaaaa
     4621 aaaaaaaaaa aaaaaaaaa
//
