LOCUS       NM_013909               1750 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 6 (Fbxl6), mRNA.
ACCESSION   NM_013909
VERSION     NM_013909.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1750)
  AUTHORS   Zhang,J., Lin,X.T., Yu,H.Q., Fang,L., Wu,D., Luo,Y.D., Zhang,Y.J.
            and Xie,C.M.
  TITLE     Elevated FBXL6 expression in hepatocytes activates
            VRK2-transketolase-ROS-mTOR-mediated immune evasion and liver
            cancer metastasis in mice
  JOURNAL   Exp Mol Med 55 (10), 2162-2176 (2023)
   PUBMED   37653031
  REMARK    GeneRIF: Elevated FBXL6 expression in hepatocytes activates
            VRK2-transketolase-ROS-mTOR-mediated immune evasion and liver
            cancer metastasis in mice.
            Erratum:[Exp Mol Med. 2023 Oct;55(10):2281-2286. doi:
            10.1038/s12276-023-01116-8.. PMID: 37783772]
REFERENCE   2  (bases 1 to 1750)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   3  (bases 1 to 1750)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040458.1, AF176522.1 and BC054377.1.
            
            On Dec 12, 2009 this sequence version replaced NM_013909.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF176522.1, SRR7345562.2263030.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AK040458.1         2-54
            54-1681             AF176522.1         42-1669
            1682-1750           BC054377.1         1503-1571
FEATURES             Location/Qualifiers
     source          1..1750
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.04 cM"
     gene            1..1750
                     /gene="Fbxl6"
                     /gene_synonym="Fbl6"
                     /note="F-box and leucine-rich repeat protein 6"
                     /db_xref="GeneID:30840"
                     /db_xref="MGI:MGI:1354705"
     exon            1..422
                     /gene="Fbxl6"
                     /gene_synonym="Fbl6"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1638
                     /gene="Fbxl6"
                     /gene_synonym="Fbl6"
                     /note="F-box protein containing leucine repeats 6; F-box
                     protein FBL6"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 6"
                     /protein_id="NP_038937.2"
                     /db_xref="CCDS:CCDS49653.1"
                     /db_xref="GeneID:30840"
                     /db_xref="MGI:MGI:1354705"
                     /translation="MAPVASRRVRRRVRSSKRPDARGRSAEDWWWDRLAPRGSGYHLL
                     QADSMLLVLPDLEPPRARAHRRARRRAPRSLARGPTAVAKPRTKPRPEPSLDQGLDSG
                     WGDRIPLEVLVHIFGLLVAAHGPMPFLGRAARVCRHWHEATSHPSLWHTVTLSPSLVG
                     RAGKGNLKGEKKLLACLEWLVPNRFSQLQSLTLIHWKSQVHSVLELVSKFCPRLTFLK
                     LSDCHTVTAETLVMLARACCQLHSLDLHHSMVESTAVVSFLEEAGSRMRKLWLTYSSQ
                     TTAILGALLDNCCPQLQVLQVSTGMNCNNTPLQLPVEALQKGCPQLQVLRLLNLIWLP
                     KPCGRGVPQGPGFPSLEELCLAGSTCNFVSNEVLGRLLHRSPKLRMLDLRGCARVTPS
                     GLCHLPCQELEQLYLGLYGISDGLTLAKDGSPLLTRKWYHTLRELDFSGQGFSEKDLE
                     QALAVFSGTPGGLHPALCSLNLRGTRVTPSTVSSVISGCPGLLYLNLESCRCLPRGLK
                     RVYRGLEEVQWCLEQLLTSPPSAKEPT"
     exon            423..581
                     /gene="Fbxl6"
                     /gene_synonym="Fbl6"
                     /inference="alignment:Splign:2.1.0"
     exon            582..645
                     /gene="Fbxl6"
                     /gene_synonym="Fbl6"
                     /inference="alignment:Splign:2.1.0"
     exon            646..777
                     /gene="Fbxl6"
                     /gene_synonym="Fbl6"
                     /inference="alignment:Splign:2.1.0"
     exon            778..885
                     /gene="Fbxl6"
                     /gene_synonym="Fbl6"
                     /inference="alignment:Splign:2.1.0"
     exon            886..999
                     /gene="Fbxl6"
                     /gene_synonym="Fbl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1231
                     /gene="Fbxl6"
                     /gene_synonym="Fbl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1478
                     /gene="Fbxl6"
                     /gene_synonym="Fbl6"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1719
                     /gene="Fbxl6"
                     /gene_synonym="Fbl6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1696..1701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl6"
                     /gene_synonym="Fbl6"
                     /note="hexamer: AATAAA"
     polyA_site      1719
                     /gene="Fbxl6"
                     /gene_synonym="Fbl6"
                     /note="major polyA site"
ORIGIN      
        1 cttccgcttt tagttcagct cccgggggct atggctcccg tggcctctag gcgagttaga
       61 cgtcgagttc gaagctccaa gcggcccgat gcgcggggcc gctcggcgga ggactggtgg
      121 tgggaccgcc tggcacctcg cggctctggg taccacctgc tgcaagcgga cagcatgttg
      181 ctcgtgctgc cggacctgga gcctccccgc gctcgtgcgc accggcgcgc ccgtcgccgc
      241 gctccgaggt cactggctcg tggccccacg gctgtcgcca agcccaggac caaaccccga
      301 ccggagccgt cgctcgatca gggcctggac tctggttggg gagaccgtat tcccttagaa
      361 gtcctggtgc atattttcgg gttgttggtt gcggctcatg ggcccatgcc gtttcttggc
      421 agggctgcac gcgtttgccg tcactggcac gaagccacct cccatccttc actctggcat
      481 actgtgaccc tgtcaccctc gctggttggc cgggctggca agggcaacct taagggagag
      541 aagaagctcc ttgcttgcct ggagtggctc gtacccaatc ggttctctca gctccagagc
      601 ttgaccctca tccactggaa gtctcaagta cactctgtgt tggagctggt tagcaagttc
      661 tgccctcggc tcaccttcct caagctttca gactgccaca ctgtgactgc tgaaactctg
      721 gtcatgttag cgagagcctg ctgccagctc cacagcctgg acctacatca ttccatggtg
      781 gagtccacag ctgtggtgag cttcttggag gaggccgggt cccgaatgcg taaactgtgg
      841 ctgacctaca gttcccagac gacggccatc ttgggcgcac tgctggacaa ctgctgccca
      901 cagctccaag tcctccaggt cagcactggc atgaactgca acaacacacc cctgcagctg
      961 cctgtggaag ccctgcagaa aggctgcccc cagctgcagg tgctgcggct gctgaatctg
     1021 atttggcttc ccaagccgtg tggccgaggc gtgccccagg gaccaggctt ccccagtctt
     1081 gaggagctct gtttggctgg ctccacctgc aactttgtga gcaatgaggt tctgggccga
     1141 ttgctccatc gctccccgaa actgcgcatg ctggaccttc gaggctgcgc tagggtcact
     1201 cctagcggtc tgtgtcatct gccatgtcaa gagctggagc aactctacct gggcctgtat
     1261 ggcatatctg atggcttgac cctggctaag gatggcagcc ccctgttgac ccggaagtgg
     1321 tatcacaccc tgagggagct ggacttcagt ggccaaggct tcagcgagaa ggacttggaa
     1381 caggccctgg ctgttttctc gggcacccct gggggcttac acccagcctt gtgctccctc
     1441 aacctgaggg gtacccgagt taccccaagc acggtcagtt ctgtgattag tggttgcccg
     1501 gggctgctgt atcttaacct ggagtcctgt cgttgcctcc cccgaggtct gaagcgcgtc
     1561 taccggggcc tggaggaagt ccagtggtgt ctagagcagc tacttaccag cccgccctct
     1621 gccaaagagc ccacttagag ggcagccagg tttaccctgc tcattttcac tttgaaatgt
     1681 tggaggtttt gttacaataa aggttttttt ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1741 aaaaaaaaaa
//
