LOCUS       NM_001159963            2855 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 5 (Fbxl5),
            transcript variant 1, mRNA.
ACCESSION   NM_001159963
VERSION     NM_001159963.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2855)
  AUTHORS   Wang S, Wu X, Wang H, Song S, Hu Y, Guo Y, Chang S, Cheng Y and
            Zeng S.
  TITLE     Role of FBXL5 in redox homeostasis and spindle assembly during
            oocyte maturation in mice
  JOURNAL   FASEB J 37 (8), e23080 (2023)
   PUBMED   37462473
  REMARK    GeneRIF: Role of FBXL5 in redox homeostasis and spindle assembly
            during oocyte maturation in mice.
REFERENCE   2  (bases 1 to 2855)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2855)
  AUTHORS   Gerez JA, Prymaczok NC, Rockenstein E, Herrmann US, Schwarz P,
            Adame A, Enchev RI, Courtheoux T, Boersema PJ, Riek R, Peter M,
            Aguzzi A, Masliah E and Picotti P.
  TITLE     A cullin-RING ubiquitin ligase targets exogenous alpha-synuclein
            and inhibits Lewy body-like pathology
  JOURNAL   Sci Transl Med 11 (495) (2019)
   PUBMED   31167929
REFERENCE   4  (bases 1 to 2855)
  AUTHORS   Muto Y, Moroishi T, Ichihara K, Nishiyama M, Shimizu H, Eguchi H,
            Moriya K, Koike K, Mimori K, Mori M, Katayama Y and Nakayama KI.
  TITLE     Disruption of FBXL5-mediated cellular iron homeostasis promotes
            liver carcinogenesis
  JOURNAL   J Exp Med 216 (4), 950-965 (2019)
   PUBMED   30877170
  REMARK    GeneRIF: FBXL5-deficient mice are the first genetically engineered
            mouse model of liver carcinogenesis promoted by iron overload.
REFERENCE   5  (bases 1 to 2855)
  AUTHORS   Das NK, Sandhya S, G VV, Kumar R, Singh AK, Bal SK, Kumari S and
            Mukhopadhyay CK.
  TITLE     Leishmania donovani inhibits ferroportin translation by modulating
            FBXL5-IRP2 axis for its growth within host macrophages
  JOURNAL   Cell Microbiol 20 (7), e12834 (2018)
   PUBMED   29470856
  REMARK    GeneRIF: Increased intracellular growth due to compromised
            expressions of Fpn and FBXL5 by specific siRNAs reveals that
            Leishmania donovani uses a novel strategy of manipulating
            IRP2-FBXL5 axis to inhibit host Fpn expression.
REFERENCE   6  (bases 1 to 2855)
  AUTHORS   Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB,
            Heard E, Lao K and Surani MA.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   7  (bases 1 to 2855)
  AUTHORS   Ching YH, Munroe RJ, Moran JL, Barker AK, Mauceli E, Fennell T,
            Dipalma F, Lindblad-Toh K, Abcunas LM, Gilmour JF, Harris TP, Kloet
            SL, Luo Y, McElwee JL, Mu W, Park HK, Rogal DL, Schimenti KJ, Shen
            L, Shindo M, Shou JY, Stenson EK, Stover PJ and Schimenti JC.
  TITLE     High resolution mapping and positional cloning of ENU-induced
            mutations in the Rw region of mouse chromosome 5
  JOURNAL   BMC Genet 11, 106 (2010)
   PUBMED   21118569
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2855)
  AUTHORS   Wilson L, Ching YH, Farias M, Hartford SA, Howell G, Shao H, Bucan
            M and Schimenti JC.
  TITLE     Random mutagenesis of proximal mouse chromosome 5 uncovers
            predominantly embryonic lethal mutations
  JOURNAL   Genome Res 15 (8), 1095-1105 (2005)
   PUBMED   16024820
REFERENCE   9  (bases 1 to 2855)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   10 (bases 1 to 2855)
  AUTHORS   Hurle B, Lane K, Kenney J, Tarantino LM, Bucan M, Brownstein BH and
            Ornitz DM.
  TITLE     Physical mapping of the mouse tilted locus identifies an
            association between human deafness loci DFNA6/14 and vestibular
            system development
  JOURNAL   Genomics 77 (3), 189-199 (2001)
   PUBMED   11597144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY245949.1, AK159744.1 and AK150664.1.
            
            [WARNING] On Sep 29, 2023 this sequence was replaced by
            NM_001159963.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085100.1, AK159744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BY245949.1         3-14
            13-2848             AK159744.1         2-2837
            2849-2855           AK150664.1         2806-2812
FEATURES             Location/Qualifiers
     source          1..2855
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 23.81 cM"
     gene            1..2855
                     /gene="Fbxl5"
                     /gene_synonym="Fbl4; Fir4"
                     /note="F-box and leucine-rich repeat protein 5"
                     /db_xref="GeneID:242960"
                     /db_xref="MGI:MGI:2152883"
     exon            1..185
                     /gene="Fbxl5"
                     /gene_synonym="Fbl4; Fir4"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2174
                     /gene="Fbxl5"
                     /gene_synonym="Fbl4; Fir4"
                     /note="isoform A is encoded by transcript variant 1;
                     F-box/LRR-repeat protein 5"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 5 isoform A"
                     /protein_id="NP_001153435.1"
                     /db_xref="CCDS:CCDS51489.1"
                     /db_xref="GeneID:242960"
                     /db_xref="MGI:MGI:2152883"
                     /translation="MAPFPDEVDVFTAPHWRMKQLVGRYCDKLSKTNFSNNNDFRALL
                     QSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNE
                     YEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCS
                     QKDTAELLRGLSLWNQAEERQKVLKYSVDEKADTEAEVSEHSTGITHLPPEVMLSIFS
                     YLNPQELCRCSQVSTKWSQLAKTGSLWKHLYPVHWARGDWYSGPATELDTEPDEEWVR
                     NRKDESRAFQEWDEDADIDESEESAEESVAISIAQMEKRVLHGLIHNVLPYVGTSVKT
                     LVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSG
                     CEKITDMALEKISRALGVLTSHQSGFLKSAGKAASTPWTSKDITMPSTTQYACLHNLT
                     DKGIGEEIDNEHSWTEPVSSESLTSPYVWMLDAEDLADIEDAVEWRHRNVESLCVMET
                     ASNFGCSSSGCYSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMTTLPATS
                     AMCRKALRTTLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRALTLGGGL
                     PYLEHLNLSGCLTVTGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGF
                     RACCRSGE"
     exon            186..401
                     /gene="Fbxl5"
                     /gene_synonym="Fbl4; Fir4"
                     /inference="alignment:Splign:2.1.0"
     exon            402..497
                     /gene="Fbxl5"
                     /gene_synonym="Fbl4; Fir4"
                     /inference="alignment:Splign:2.1.0"
     exon            498..684
                     /gene="Fbxl5"
                     /gene_synonym="Fbl4; Fir4"
                     /inference="alignment:Splign:2.1.0"
     exon            685..867
                     /gene="Fbxl5"
                     /gene_synonym="Fbl4; Fir4"
                     /inference="alignment:Splign:2.1.0"
     exon            868..993
                     /gene="Fbxl5"
                     /gene_synonym="Fbl4; Fir4"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1142
                     /gene="Fbxl5"
                     /gene_synonym="Fbl4; Fir4"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1225
                     /gene="Fbxl5"
                     /gene_synonym="Fbl4; Fir4"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1948
                     /gene="Fbxl5"
                     /gene_synonym="Fbl4; Fir4"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2097
                     /gene="Fbxl5"
                     /gene_synonym="Fbl4; Fir4"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2855
                     /gene="Fbxl5"
                     /gene_synonym="Fbl4; Fir4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgcatgc gcaggggggc gcgccgcctc tgccccgcgg cgagggtgtc tatggagagg
       61 cggcggccgc ggctgctgag gcggacgctg aggcagtggc gatggcgccc ttccccgatg
      121 aagtggacgt cttcaccgcc ccgcactggc ggatgaagca gctggtgggg cgctactgcg
      181 acaagctttc taaaaccaac ttttccaaca acaatgactt ccgtgctctt ctccagtctt
      241 tatatgctac tttcaaggag tttaaaatgc atgaacaaat tgaaaatgaa tacattatcg
      301 gtttacttca gcagcgcagt cagaccatat ataatgtaca ctctgacaat aagctctccg
      361 agatgctgag tctctttgaa aaggggctga agaatgtcaa gaatgagtac gaacagttaa
      421 attatgcaaa acagctgaaa gagagattgg aggcttttac aagagatttt cttcctcaca
      481 tgaaagagga agaagaggtt tttcagccca tgttaatgga atattttacc tacgaggagc
      541 ttaaagatat caaaaagaaa gtgattgcac agcactgctc acagaaggac acggcagagc
      601 tcctcagagg gctcagtctg tggaaccaag ctgaggagcg acagaaagtt ctcaagtact
      661 ctgtggatga gaaggcagat acagaagcgg aagtgtcaga acactccaca ggtataaccc
      721 atcttcctcc tgaggtaatg ctgtccattt tcagttacct taatcctcaa gaattgtgtc
      781 ggtgtagtca agtcagtact aagtggtctc agctggcaaa aacaggatct ttgtggaaac
      841 atctttaccc tgttcattgg gcaagaggtg actggtatag tggtcctgcc actgaacttg
      901 atactgagcc tgatgaggaa tgggtgagaa ataggaaaga tgaaagtcgt gctttccagg
      961 agtgggatga agatgccgat atagatgaat ctgaagagtc tgcagaggaa tcggttgcta
     1021 tcagcattgc acaaatggaa aaacgtgtac tccatggctt aattcataat gttctgccat
     1081 atgttggtac ctctgtaaaa actttagtgt tagcgtacag ctctgcagtc tccagcaaaa
     1141 tggttaggca gattttagag ctttgtccta acctggaaca tctggatctt acccagaccg
     1201 acatttctga ttctgcattt gacagttggt cttggctcgg ttgctgccag agtcttcggc
     1261 atcttgatct gtctggatgt gaaaaaatca cagacatggc tctagagaag atttctagag
     1321 ctcttggagt tctgacatct catcagagtg gctttctgaa aagtgcaggc aaggctgctt
     1381 caactccatg gacaagtaaa gacattacca tgccatccac cacgcagtat gcctgtttgc
     1441 acaatttaac tgacaaaggc attggtgaag aaatagacaa cgagcactct tggactgaac
     1501 ctgtgtcttc tgaaagtttg acttctcctt atgtgtggat gctagatgct gaagatttgg
     1561 ctgatattga agatgctgta gagtggagac acagaaatgt tgagagtctc tgtgtgatgg
     1621 aaacagcctc caactttggt tgttcctcat ctggttgtta cagtaaggac attgtgggat
     1681 taaggactag tgtctgttgg cagcagcatt gtgcttctcc agcctttgca tattgtggtc
     1741 attcattctg ttgtacaggg acagctttaa gaactatgac tacactccca gcgacttctg
     1801 caatgtgtag aaaagcatta aggactacat tgcccagggg gaaagactta atttattttg
     1861 ggagtgaaaa gtctgaccaa gagactggac gagtactttt gttcctcagt ctgtctggat
     1921 gttaccagat cacagaccat ggtctcaggg ctctgactct gggaggaggg ctgccttacc
     1981 tggagcacct gaatctctct ggctgtctga ctgtaactgg tgcagggctg caggatttgg
     2041 tctcagcgtg tccttcccta aatgacgaat acttttacta ctgtgacaac attaacggtc
     2101 ctcatgctga caccgccagt ggatgccaga atttgcagtg tggttttcga gcctgctgcc
     2161 gctctggcga atgacccctg acttctgacc tttgtctact tcatttagct gagcaggctt
     2221 cctttcatgc actttactta tagcacattt cttgtgttaa caacccattt tgggtgtgtc
     2281 ttgtttggcc ccatttctta cagtctcaga aatttaattt agcagtgaac tgtacaatgt
     2341 tgtttaccct tgcaaaatat atttttgttt tagaaaaggt ttaggatttt ttgttagggt
     2401 gagaacagtc tttctggttt cttttcaatg aaatgcttta aaaaatatca ctaataccat
     2461 gctatttaaa gtttttctag attatttgca ttttagtcaa tgggggttat tggttctctt
     2521 atgtgtaaac actgtaccaa gttttgcaga ttctttcaaa tccacatttc tgaagtttta
     2581 ttttcaaaga ctgaacattt tagaaaggaa tctcttttcc cctaacgttt tctttatttg
     2641 aacaattctg aggggccaat tcaaacacac ttagaagcga gattctttaa gattatagga
     2701 taaattggtc tcttggtgca gcagtctgtt gtttgctgta gacaccagct tccactgctg
     2761 tccctaaact gttgaattct agaaggattt ttaaaaattc cacaattgtt tgaagaaatg
     2821 tataaataaa atctactttg agaactttac caagc
//
