LOCUS       NM_172988               2563 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 4 (Fbxl4),
            transcript variant 1, mRNA.
ACCESSION   NM_172988
VERSION     NM_172988.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2563)
  AUTHORS   Alsina D, Lytovchenko O, Schab A, Atanassov I, Schober FA, Jiang M,
            Koolmeister C, Wedell A, Taylor RW, Wredenberg A and Larsson NG.
  TITLE     FBXL4 deficiency increases mitochondrial removal by autophagy
  JOURNAL   EMBO Mol Med 12 (7), e11659 (2020)
   PUBMED   32525278
  REMARK    GeneRIF: FBXL4 deficiency increases mitochondrial removal by
            autophagy.
REFERENCE   2  (bases 1 to 2563)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY128470.1, AK051429.1 and AI836810.1.
            
            [WARNING] On Oct 20, 2023 this sequence was replaced by
            NM_172988.5.
            
            On Oct 25, 2013 this sequence version replaced NM_172988.3.
            
            Transcript Variant: This variant (1) encodes the supported protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032391.1, AK051429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BY128470.1         2-51
            51-2541             AK051429.1         2-2492
            2542-2563           AI836810.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..2563
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 9.69 cM"
     gene            1..2563
                     /gene="Fbxl4"
                     /gene_synonym="FBL4; FBL5"
                     /note="F-box and leucine-rich repeat protein 4"
                     /db_xref="GeneID:269514"
                     /db_xref="MGI:MGI:2140367"
     exon            1..139
                     /gene="Fbxl4"
                     /gene_synonym="FBL4; FBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            140..249
                     /gene="Fbxl4"
                     /gene_synonym="FBL4; FBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            250..831
                     /gene="Fbxl4"
                     /gene_synonym="FBL4; FBL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..2185
                     /gene="Fbxl4"
                     /gene_synonym="FBL4; FBL5"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 4"
                     /protein_id="NP_766576.1"
                     /db_xref="CCDS:CCDS18004.1"
                     /db_xref="GeneID:269514"
                     /db_xref="MGI:MGI:2140367"
                     /translation="MSPVFPMLTVLTMFYYMCLRRRARTATRGDMMNSHRTIVSNSRT
                     SPLNAEVVQYAKEVVDFSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYGT
                     WWDQCPSASLPFRRTPSSFQSQDYVELTFEQQVYPTAVHVLETYHPGAVIRILACSAN
                     PYSPNPPAEVRWEILWSERPMKVNASQARQFKPCIKQINFPTNLIRLEVNSSLLDYYT
                     ELDAVVLHGTKDKPLLSLKTALVDMNDLEDDDYEEKDGCEMDALNKKFSSAALGDGPH
                     NGYFDKLPYELIQLILNHLSLPDLCRLAQTCRLLHQHCCDPLQYIHLNLQPYWARLDD
                     TSLEFLQARCVLVQWLNLSWTGNRGFISVSGFSRFLKVCGSELVRLELSCSHFLNDTC
                     LEVISEMCPNLQDLNLSSCDKLPPQAFGHIAKLCSLKRLVLYRTKVEQTALLSILNFC
                     AELQHLSLGSCVMIEDYDVIASMIGAKCKNLRTLDLWRCKNITENGIAELASGCVLLE
                     ELDLGWCPTLQSSTGCFVRLARQLPNLQKLFLTANRSVCDTDIEELASNCTRLQQLDI
                     LGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNKAVLELNASFPKVFIKKSFTQ"
     exon            832..1177
                     /gene="Fbxl4"
                     /gene_synonym="FBL4; FBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1422
                     /gene="Fbxl4"
                     /gene_synonym="FBL4; FBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1636
                     /gene="Fbxl4"
                     /gene_synonym="FBL4; FBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1708
                     /gene="Fbxl4"
                     /gene_synonym="FBL4; FBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..2021
                     /gene="Fbxl4"
                     /gene_synonym="FBL4; FBL5"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2546
                     /gene="Fbxl4"
                     /gene_synonym="FBL4; FBL5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcctcggtc ttccttccgg gtcgcgctgg gccgggcccg ccgccgcggc agcagcacgg
       61 gatactggga gccgtctcct gctgcccacg ctgcgggctt gcggcgaagc tctgttcgcc
      121 cagttccgga ccctgcaggg ctgtctcatc tcagcatctg taggtgaaag cagcatgcat
      181 gtttcagaca cgtggatggg caccaactcc tgtgcttccc gtgtgtgtca ggtgacctgt
      241 caagccagga ccatccttca gagttcatgc atctcaccga ggacacctga ccttttgaag
      301 cttcataatt cacgactaga tgtcaccagt ctttcccatg ttaacagttc tgaccatgtt
      361 ttattatatg tgccttcggc gtcgagccag gacagctaca agaggagata tgatgaacag
      421 ccataggact atagtgtcaa acagccggac ttcccctctc aatgcagagg tggtccagta
      481 tgctaaagaa gtggtggatt tcagttccca ttacggcagt gagaacagta tgtcctatac
      541 catgtggaat ttggcaggtg taccaaatgt cttcccaagt tctggtgact tcacgcagac
      601 ggctgtgttt cgaacttatg ggacgtggtg ggatcagtgt cctagtgctt ccttgccatt
      661 cagaaggaca ccgtccagtt tccagagcca ggactatgtg gaactgactt ttgagcagca
      721 agtgtacccc acggctgtcc atgtgctgga gacttaccat cctggagcag tcatcagaat
      781 tctggcctgc tcagcaaatc cctactcccc aaatcctcca gctgaagtaa gatgggagat
      841 tctttggtca gagagaccta tgaaggtgaa tgcttcccag gctcgtcagt ttaaaccttg
      901 tattaagcaa ataaatttcc ctacaaacct catacgactg gaagtcaata gttctcttct
      961 ggattattac accgaactag atgcagttgt gctgcatggt acgaaggaca agccactgct
     1021 ctctctcaag actgctcttg tagacatgaa tgatctagaa gatgacgact atgaagagaa
     1081 ggatggctgt gagatggatg ctcttaacaa aaagtttagc agtgctgccc ttggggatgg
     1141 gccacataat gggtattttg acaaactacc atatgagctc attcaactga ttctgaatca
     1201 tctttcacta ccagacctgt gtagattagc ccagacttgc aggcttctcc accagcattg
     1261 ctgtgatcct ctgcaatata tccacctcaa cctgcagcca tactgggccc ggctggacga
     1321 cacgtcactg gagttcctac aggctcgctg tgtgcttgtc cagtggctta atctgtcttg
     1381 gactggcaac agagggttca tctctgtatc aggatttagc aggtttctaa aggtgtgtgg
     1441 gtctgagtta gtacgccttg agttatcctg cagccacttt cttaatgaca cttgcttgga
     1501 ggttatttct gaaatgtgcc caaatctaca agacttaaat ctctcatcct gcgataaact
     1561 cccacctcag gcttttggcc atattgccaa gttatgcagc ctcaagaggc ttgttctcta
     1621 tcggacaaaa gtagagcaaa cagcactact gagcattttg aacttctgtg cagagcttca
     1681 gcacctcagc ctgggcagct gtgtgatgat tgaagattat gatgtgatag ccagcatgat
     1741 aggagccaag tgtaaaaacc tgcggacttt ggatctgtgg agatgcaaga atatcaccga
     1801 gaatgggata gcagagttgg cttctggctg tgttcttctt gaggaacttg accttggctg
     1861 gtgccccacc cttcagagca gcactgggtg ctttgtcaga ctggcacgcc agctcccaaa
     1921 cttgcagaaa ctctttctta cagctaacag gtctgtgtgt gacacagaca tagaagaact
     1981 ggcatctaat tgtaccagat tacagcaact ggacatatta ggaacaagaa tggtaagtcc
     2041 agcatccttg agaaaactcc tggaatcttg caaagatctt tccctacttg acgtgtcctt
     2101 ctgttcccag attgataaca aggctgtgtt agagctcaac gcgagctttc cgaaagtctt
     2161 cataaagaag agctttactc aatgagttca tactgctctg tcactacaat catgctttgg
     2221 tggcttcttg tgggggtggc tcttctgttt gtttggtttt tataatgatg agaattaaga
     2281 catttataga atttaaagga aaatgtaaaa ttgtccactg aatcaagtaa aaatgtaaag
     2341 aatgctctct aaaatattac agcacttttc tttaggaatg tgtaatctct gatattattt
     2401 cccattatgt tgatcagtgg tatgctttaa tcagtaattg tatgttaaag gaataatatg
     2461 gaaatattct aatttatttt aaaggaatac tttgaaaaat aaagtgatca taatatttat
     2521 gaaaaataaa gttgattttg cacatcaaaa aaaaaaaaaa aaa
//
