LOCUS       NM_015822               4287 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 3 (Fbxl3),
            transcript variant 1, mRNA.
ACCESSION   NM_015822 XM_975284
VERSION     NM_015822.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4287)
  AUTHORS   Wirianto M, Yang J, Kim E, Gao S, Paudel KR, Choi JM, Choe J,
            Gloston GF, Ademoji P, Parakramaweera R, Jin J, Esser KA, Jung SY,
            Geng YJ, Lee HK, Chen Z and Yoo SH.
  TITLE     The GSK-3beta-FBXL21 Axis Contributes to Circadian TCAP Degradation
            and Skeletal Muscle Function
  JOURNAL   Cell Rep 32 (11), 108140 (2020)
   PUBMED   32937135
REFERENCE   2  (bases 1 to 4287)
  AUTHORS   Correia SP, Chan AB, Vaughan M, Zolboot N, Perea V, Huber AL,
            Kriebs A, Moresco JJ, Yates JR 3rd and Lamia KA.
  TITLE     The circadian E3 ligase complex SCFFBXL3+CRY targets TLK2
  JOURNAL   Sci Rep 9 (1), 198 (2019)
   PUBMED   30655559
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4287)
  AUTHORS   Saran AR, Kalinowska D, Oh S, Janknecht R and DiTacchio L.
  TITLE     JMJD5 links CRY1 function and proteasomal degradation
  JOURNAL   PLoS Biol 16 (11), e2006145 (2018)
   PUBMED   30500822
  REMARK    Erratum:[PLoS Biol. 2019 Aug 21;17(8):e3000454. PMID: 31433800]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4287)
  AUTHORS   Maggi S, Balzani E, Lassi G, Garcia-Garcia C, Plano A, Espinoza S,
            Mus L, Tinarelli F, Nolan PM, Gainetdinov RR, Balci F, Nieus T and
            Tucci V.
  TITLE     The after-hours circadian mutant has reduced phenotypic plasticity
            in behaviors at multiple timescales and in sleep homeostasis
  JOURNAL   Sci Rep 7 (1), 17765 (2017)
   PUBMED   29259298
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4287)
  AUTHORS   Wegner S, Belle MDC, Hughes ATL, Diekman CO and Piggins HD.
  TITLE     Delayed Cryptochrome Degradation Asymmetrically Alters the Daily
            Rhythm in Suprachiasmatic Clock Neuron Excitability
  JOURNAL   J Neurosci 37 (33), 7824-7836 (2017)
   PUBMED   28698388
REFERENCE   6  (bases 1 to 4287)
  AUTHORS   Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa
            K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito
            R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T,
            Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe
            M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held
            WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA,
            Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts
            P, Muramatsu M, Okazaki Y, Kawai J and Hayashizaki Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   7  (bases 1 to 4287)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4287)
  AUTHORS   Peterson KA, King BL, Hagge-Greenberg A, Roix JJ, Bult CJ and
            O'Brien TP.
  TITLE     Functional and comparative genomic analysis of the piebald deletion
            region of mouse chromosome 14
  JOURNAL   Genomics 80 (2), 172-184 (2002)
   PUBMED   12160731
REFERENCE   9  (bases 1 to 4287)
  AUTHORS   Winston JT, Koepp DM, Zhu C, Elledge SJ and Harper JW.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
REFERENCE   10 (bases 1 to 4287)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY787665.1 and AK142007.1.
            
            [WARNING] On Oct 2, 2023 this sequence was replaced by NM_015822.4.
            
            On Feb 1, 2018 this sequence version replaced NM_015822.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142007.1, AK080863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY787665.1         2-24
            24-4287             AK142007.1         2-4265
FEATURES             Location/Qualifiers
     source          1..4287
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 51.73 cM"
     gene            1..4287
                     /gene="Fbxl3"
                     /gene_synonym="FBK; Fbl3a; Fbxl3a; Ovtm; Play68"
                     /note="F-box and leucine-rich repeat protein 3"
                     /db_xref="GeneID:50789"
                     /db_xref="MGI:MGI:1354702"
     exon            1..371
                     /gene="Fbxl3"
                     /gene_synonym="FBK; Fbl3a; Fbxl3a; Ovtm; Play68"
                     /inference="alignment:Splign:2.1.0"
     exon            372..720
                     /gene="Fbxl3"
                     /gene_synonym="FBK; Fbl3a; Fbxl3a; Ovtm; Play68"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..1659
                     /gene="Fbxl3"
                     /gene_synonym="FBK; Fbl3a; Fbxl3a; Ovtm; Play68"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     and leucine-rich repeat protein 3a; F-box/LRR-repeat
                     protein 3; F-box/LRR-repeat protein 3A; protein overtime;
                     protein after-hours"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 3 isoform 1"
                     /protein_id="NP_056637.1"
                     /db_xref="CCDS:CCDS27315.1"
                     /db_xref="GeneID:50789"
                     /db_xref="MGI:MGI:1354702"
                     /translation="MKRGGRDSDQDSAEEGTAEKPKRPRTTQERSQPCDWGNLLQDIV
                     LHVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQI
                     IKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHF
                     ISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILC
                     VADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSS
                     WDAFIKHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRL
                     VELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSI
                     MEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW"
     exon            721..843
                     /gene="Fbxl3"
                     /gene_synonym="FBK; Fbl3a; Fbxl3a; Ovtm; Play68"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1015
                     /gene="Fbxl3"
                     /gene_synonym="FBK; Fbl3a; Fbxl3a; Ovtm; Play68"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..4287
                     /gene="Fbxl3"
                     /gene_synonym="FBK; Fbl3a; Fbxl3a; Ovtm; Play68"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attttggatt ccctaactgg gccgaagctt cgggctcgct gctgtcgatc gctgctcgcc
       61 tagggcgtct cgggcgggcg acgaggaggt gccggggcga aggacacaga ccgcgcggga
      121 cagagaaggg acgcgacgct ctcctcccca cacaccgggg cagccggagc cgcaaaggtg
      181 gagccgcgtc ggcgcccgcc gcgggaccag cgtctcggat gcgggcggag cgcggggggc
      241 cgcgacggcg ggagctcgga gacggggccc cgggaggcct catgtgagag gcgcgggagc
      301 cgccgccgcc gctgccgccg tcgtccgcgc ggcccggggt gctgtgtggg ggaagccgcc
      361 cccggcagca ggatgaaacg aggaggaaga gatagtgacc aggactctgc tgaggaaggc
      421 actgccgaga agcccaagag accgaggacg acacaggagc gctcgcagcc ttgtgactgg
      481 ggtaacctcc tgcaggacat cgtcctccat gtttttaagt atttgcctct tcttgaccgg
      541 gctcatgctt cccaagtgtg ccggaattgg aatcaggtat ttcacatgcc tgacttgtgg
      601 cgatgttttg aatttgaact gaatcagcca gcgacatctt acttgaaagc cacacaccca
      661 gagctgatca aacagattat caaaaggcac tcaaaccacc tacagtatgt cagcttcaag
      721 gtggacagca gcaaagaatc agctgaagct gcttgtgaca tactgtcgca gcttgtgaat
      781 tgctctttaa aaactctcgg acttatctcg actgcccggc caagctttat ggatctacca
      841 aagtctcact ttatctctgc actgacagtt gtgtttgtaa actccaagtc cctgtcctca
      901 cttaagatag acgacacccc agtcgatgac ccatccctta aagtcctcgt ggccaacaac
      961 agcgacacac tcaagctgtt gaaaatgagc agctgtcctc acgtctctcc agcaggcatt
     1021 ctgtgtgtgg ctgaccagtg tcatggctta cgagaactgg ccctgaacta ccatttgcta
     1081 agtgatgagt tgttgctcgc actgtcttct gaaaagcatg ttcgcttaga acatttgcgc
     1141 attgatgttg tcagtgagaa cccgggacag acacacttcc acactatcca gaagagcagc
     1201 tgggatgcct tcatcaaaca ctcaccgaaa gtcaacctag tgatgtattt ttttttatac
     1261 gaagaggaat ttgacccatt ctttcgttat gaaatacctg ctacgcatct ttactttggg
     1321 agatcagtca gcaaagatgt gcttggccgt gtgggcatga cctgcccgag actagtggaa
     1381 ctggtagtgt gtgccaatgg gttgcggcct cttgatgaag agttaattcg cattgcggaa
     1441 cgttgcaaaa atttgtcagc tattgggctg ggggaatgtg aagtctcatg tagtgccttt
     1501 gttgagtttg tgaagatgtg tgggggccgc ctgtctcagt tatccattat ggaagaagtg
     1561 ttaattcctg accaaaagta tagtttggaa caaattcatt gggaagtgtc taagcatctt
     1621 ggcagggtat ggttcccaga catgatgcct acttggtaag ggactgcatg acacaggaca
     1681 taatgagtga gtagtacctt cattcaagaa acgtattcta actaaaagtt tatctgctct
     1741 aaagctgata caatgctact gttctgtggc acagaaattt gatatctttg agctatgaat
     1801 gatgtttgtc agaagactta tagtttggtt cagataactc cttttttgta gcctaatagc
     1861 aatcatatgt ttaaaaatta aaaatgtggt ttcatatttg aaagtaatat ccaattatga
     1921 aattgagata attcagtctg aaggaagcaa cctgtatatt gtaatatctc agaaatgtac
     1981 taataggttt tctgaaatgt tctctatgca ttttttaaaa aaatgtaaac ttgacatttt
     2041 agggtcttca gttataaata cacctgttat aaggtgttta acatagctca ggaaagtgag
     2101 cattttgtga gagaaatgta tgatagtgct cgtaagacct tggttgaatg ttttcaaacg
     2161 ttatgaagct gttttaaaaa taaagatata actatcaaag tacttagaac gttgatgaat
     2221 gttgaagtgg ctgttaagga gggcacacag agccaggatc caatctggag agatccgtgg
     2281 agtaggagag gtagcactca gccttgtgta actctaggtt tcttgtgtga tatgctaaac
     2341 acatgcattc tcttttgtta tattactaat gtctgtggtg cctgaggcat cgtgtgtaaa
     2401 ggaatgcttt gctctctcta agtctttatt taaactatta gtaattattt aaattaaaat
     2461 tttacttaaa aaccaaattg aaataattaa aagtagaact ttataaattg tttatgaaca
     2521 gtttcatgaa aggatattag tctccagtga actttagtga tggctcatgc tttaagtttg
     2581 gaattacata gctacaataa atacaacttt aaaaatcaaa gagcatctgt acagtttaga
     2641 aacactaaat ttaaaagaag atatatttca taatgatttg cataaatatt actcagtgaa
     2701 ctggaacatt ttaataggaa aatatctata gttttgtgat tgtcagtttg gttgaaactg
     2761 gtattttata ttaagttatg tagcttttca tattacttta atatgaataa aggtaaattc
     2821 tagtctttgt agaatataaa aatactaagt tttggttata ttatagtttt gggtttttgg
     2881 ttttcatttt tttagatcct gtatgagctt ggattctggg cactagtgct aacagatgtc
     2941 tctcctgaga gaagttagta gtgacttacc ccacaggatg cttcagagcc tgaaatggct
     3001 cttcagtagt agtgggactt ttacaaagta ccttgataat tatggaagct aacagtctta
     3061 aaaatagata aacttactga gactaaaaca gaatggctgt ccacacagtg catgcttttc
     3121 aagagtggtg gtgttctttc aggcacgtag ggatgagaag gaaaagaccg acccagagct
     3181 ccacactaaa ggcaactatt agaatatttc actcttaaac agtaagaagc tttgactgta
     3241 caggaaatac ttgtgctgtt ttgtgttttg tttttctttt taattttttt gaacaacatt
     3301 gaaaaatgga gttgatggta tatagtcagt tttactaacc aaagctttat ttgaaaactt
     3361 ttgtacaaat tgaattatat gcttgaatac tttaagtcac tttataagca aaatgcatag
     3421 cacttaattt gtttatactg taaaatatat gttaaatggt tttatgaatt tgagaataaa
     3481 gatagttact aatgtggttg tatttttata actttagaga actaatcaaa catacattac
     3541 aaagctatga ctttagtttc agagctatta tttggtagtc ttttaaacac cggaggattt
     3601 ttagtctttt aaaaagtagc tatggccggg cggtggtggc gcacgccttt aatcccagca
     3661 cttgggaggc agagacaggc ggatttctga gtttgaggcc agcctggtct acaaagtgag
     3721 ttccaggaca gccaagacta tacagagaaa tcctgtctcg aaaaaccaaa aaaaaaaaag
     3781 tagcttgaag atacaaaact aggcacatta attctgttct gatgctctaa tacctgtgaa
     3841 acttaccatg aaatgtaaat tcttttatga ttagaaataa ggcataggtt ctttatgtat
     3901 tcagaatgaa ccccaagagt tgaggagatg ctcaggctaa gctggtgaac actcttggca
     3961 gttttcagtt gcacgtcctt ccgggactgc ttgtaactgc agtcccagca gatctgttgc
     4021 ctttgacatc catggcacct gcactcattt gcatacacat acctagacac ccacgcataa
     4081 ttaaaacaga aggatacata tgttttaaaa accattctta gagtttccta agcaagcttt
     4141 tattagaaat ctttaaccta gcaagccata ttagaaatct gtattagaat agttttaaaa
     4201 caatagaaat taatttatct taaataggtt tcaggaaaca tccaatttgt tgtaataggc
     4261 cttgctaaac aataaataag ttactgc
//
