LOCUS       NM_175206               3935 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 22 (Fbxl22),
            mRNA.
ACCESSION   NM_175206
VERSION     NM_175206.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3935)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3935)
  AUTHORS   Hughes,D.C., Baehr,L.M., Driscoll,J.R., Lynch,S.A., Waddell,D.S.
            and Bodine,S.C.
  TITLE     Identification and characterization of Fbxl22, a novel skeletal
            muscle atrophy-promoting E3 ubiquitin ligase
  JOURNAL   Am J Physiol Cell Physiol 319 (4), C700-C719 (2020)
   PUBMED   32783651
  REMARK    GeneRIF: Identification and characterization of Fbxl22, a novel
            skeletal muscle atrophy-promoting E3 ubiquitin ligase.
REFERENCE   3  (bases 1 to 3935)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3935)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3935)
  AUTHORS   Spaich,S., Will,R.D., Just,S., Spaich,S., Kuhn,C., Frank,D.,
            Berger,I.M., Wiemann,S., Korn,B., Koegl,M., Backs,J., Katus,H.A.,
            Rottbauer,W. and Frey,N.
  TITLE     F-box and leucine-rich repeat protein 22 is a cardiac-enriched
            F-box protein that regulates sarcomeric protein turnover and is
            essential for maintenance of contractile function in vivo
  JOURNAL   Circ Res 111 (12), 1504-1516 (2012)
   PUBMED   22972877
REFERENCE   6  (bases 1 to 3935)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003404.1 and AK052175.1.
            
            On Oct 22, 2009 this sequence version replaced NM_175206.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052175.1, AK084845.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AK003404.1         19-35
            18-1364             AK052175.1         4-1350
            1365-3935           AK052175.1         1352-3922
FEATURES             Location/Qualifiers
     source          1..3935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.96 cM"
     gene            1..3935
                     /gene="Fbxl22"
                     /gene_synonym="1110004B15Rik"
                     /note="F-box and leucine-rich repeat protein 22"
                     /db_xref="GeneID:74165"
                     /db_xref="MGI:MGI:1921415"
     exon            1..375
                     /gene="Fbxl22"
                     /gene_synonym="1110004B15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..751
                     /gene="Fbxl22"
                     /gene_synonym="1110004B15Rik"
                     /EC_number="3.4.19.12"
                     /note="F-box/LRR-repeat protein 22"
                     /codon_start=1
                     /product="F-box and leucine-rich protein 22"
                     /protein_id="NP_780415.1"
                     /db_xref="CCDS:CCDS23304.1"
                     /db_xref="GeneID:74165"
                     /db_xref="MGI:MGI:1921415"
                     /translation="MHITQLNRECLLCLFSFLDKDSRRSLSRTCSQLRDVFEDPTLWP
                     LLHFHSLAELKKDNFRLSPALRSLSICWHSSRVQVCSIEDWLKSALQRSICSQHESLV
                     NDFLLQVCNRCPNLTSVTLSGCGHVTDDCLARLLLSCPRLRTLRLENCARVTNRTLAA
                     VAAHGRALQTLHVDFCRNVSAAGLLRLRAACPNLRLSAERSAAMIPDQPPRARVCAAS
                     AFSAAPGRQSMPHPTGSY"
     exon            376..3935
                     /gene="Fbxl22"
                     /gene_synonym="1110004B15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      769..774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl22"
                     /gene_synonym="1110004B15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      793
                     /gene="Fbxl22"
                     /gene_synonym="1110004B15Rik"
                     /note="major polyA site"
     regulatory      2868..2873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl22"
                     /gene_synonym="1110004B15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2897
                     /gene="Fbxl22"
                     /gene_synonym="1110004B15Rik"
     regulatory      3691..3696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl22"
                     /gene_synonym="1110004B15Rik"
                     /note="hexamer: AATATA"
     polyA_site      3713
                     /gene="Fbxl22"
                     /gene_synonym="1110004B15Rik"
ORIGIN      
        1 cagacccttt ctgggcattc acgtgcggcc accactcacc atgcacataa cccagctcaa
       61 tcgggagtgt ctgctgtgtc tcttctcctt cctggacaag gacagccgga ggagcctctc
      121 caggacttgc tcccagctcc gagatgtgtt tgaggacccc accctctggc ccctgctgca
      181 cttccattct ctcgcagagc tcaagaaaga caacttccgg ctgagccctg cgctgcgcag
      241 cctgtccatc tgttggcatt ccagccgtgt gcaggtgtgc agcatcgagg actggctcaa
      301 gagcgccctc cagaggagca tctgcagcca gcacgagagc ctggttaatg atttcctcct
      361 gcaggtgtgc aacaggtgcc ccaacctgac gtccgtcacg ctgtcgggct gcggccacgt
      421 cacggacgac tgcctggcgc gcttgctgct cagctgcccg cgcctgcgta cgctgcgcct
      481 cgagaactgc gcgcgcgtta ccaaccgcac gctggcggcc gtggccgcgc acgggcgcgc
      541 gctgcagact ctgcacgtgg acttctgccg caacgtgagc gccgccggcc tgctccgcct
      601 ccgcgccgcc tgcccgaacc tgcgcctcag cgccgaacgc agcgcggcca tgatacccga
      661 tcagccgccg cgcgcacgcg tgtgcgctgc ctcagctttc tcggctgcac cggggagaca
      721 aagcatgcct caccccacgg gctcctactg aggatgcgcg cgcgcgctat taaaggagag
      781 gatgcatgta aaactctggg tttctcttta aacgtctgcc ccgtcgcggc gcgctgactc
      841 gccgtagcgc cggggctgct ttctaagctg gcgaggaacc tgcgaatggc tgaggggaga
      901 acccgaaatg agagtctccc tggctgctca ctgccagacc gtgcgagatg cacaagccat
      961 tctagaaaac tcactcctgt ccctgcatga ctgatagtta ctattatttc tcctgtttct
     1021 cacaagggaa aaaaaagcat cacttttaaa aagccagtat ttaaagtagt agccatagtt
     1081 aaaagtgctt agatagggaa ccatttttac ttgatgcaaa aaatgagact agtttttctg
     1141 gcctgagtct ggacttctag gtcaacttca ctttagttgc caagaccctg tggccacggc
     1201 cctctcagtt cacccagcag cctccctctc taggcagggg atgggcaagc aggttaaatg
     1261 agcacagcta gggggtgggg aagctcagcc aggcttctct ggctgccatc tataatcaag
     1321 actccttcgt ttatctgcag ccagattctt tttttttttt ttttctttca gatttctgtg
     1381 acatggtttc ccaatcccta tccacaggtt ccttaattta ttgcccaaat ggaaaacaag
     1441 aaaaagacaa ttttctgttc tgttcgcgtg gaacccctat tctagggaga caataattgg
     1501 tacaaaagaa ggcttgtggg gtgggtgggg ataaccaaac taaatgtcat ggagaaggtt
     1561 gacacttgag ccatgaaacc agccagggag ccaagcaagc catatggaaa gtgctacagt
     1621 ccaagaaact gcagggcacc atactggaag cattcgaggg atgtgcgaca gcagtgagat
     1681 cagcatggct gaagcaggga gaggagtaga gaaccagatg gagggaagtg taaaggacag
     1741 attatgagga ggataaaatg agcccttgga ggtaaccgca tgccagcagg agccagacca
     1801 ccaaacagcg aaagtgtgtg aagttccact gaacaacatt caggcacgtg tggcaggcat
     1861 agcctccaag gccctgggga ctgctgaggg actttcctgc tgctgccagg ttctgagctg
     1921 tggcagtgcc tcacccagaa tcagggtaca caagtcgtgg cctggtgtaa tgccttctaa
     1981 tctttgggaa agctcccagt ggagtgttcc aactgtgctg acgatgttcc cactggcagg
     2041 catagctcag caagcacatg ccaccttcag ggaaggtggg taagccacta accctttact
     2101 gacagcaaaa ccagagaaaa ctgggctcta atttcccaga tctgtaaagg gaagaccaaa
     2161 tggtccccag gccccttttt gcctgctctc ccaataaatg tccaacacat acttttttgc
     2221 taaatactga gcttggcaga cacagagctt catctgacaa aggtcacatg ttcatggaca
     2281 tctgggaaaa gcttggtttt tgaaggtaga gggtttatgt tttcttgaga ctgattaagg
     2341 acataagttg gcaagtattt gttaactgaa cgaggccagc aattaaggaa atacacaagt
     2401 ctctacaagg caaaccaaat ccctgccctg agacccaatg gctggctgct ctacagataa
     2461 ggaacactag tcttcaagaa tcaagaagag gaaaataaaa acacaaacaa acaaaaactc
     2521 aaagcaagca tgcaggtttc cagctaagag gcagcatcac catgctatct gcatctctgc
     2581 agacctgaga caagtgggtt tgtcgggcac catcttacta gagtgctccc acagtctcca
     2641 ggcagagcaa atcttctgtc aaaggcccag atccggttaa ggcattattc tcaatggcaa
     2701 taaactgaag cctgcagact gcttgtcact aggacaaagc ctagaggcac aagcagggcc
     2761 ttcctacctc aagtccagaa ttaagggcat atctttattt agaagtctcc ggtgcccccc
     2821 agagacttga atctttttct agggaaccaa ttccatatga aaacttcaat aaaatgatgc
     2881 ctggattctc agctttatca gggatgttcc ttcagatttg gaaagacaag cactcgcctt
     2941 tccactggta aacttgcctt cccgtttctc tgcctggtac cttatttgag caggctgtca
     3001 gcaatggcct tttcattgag tccacaggaa gcagcctgtg acacagatta gatgggagga
     3061 aaagagacaa gctgcctact gacctccaat gctttctggt acactgcagc aggagcctca
     3121 cagcaagggg gctcctcttt cccaccaccc ggcatactca gctggcactc ttggacagat
     3181 gagcaactgc cactgaccac aagggctggg ttaaacacca agtggggctc tgtctcagtc
     3241 cctcatccac acactaaccc ttgtatgaat gtacactgtc agccacccat ccactcactg
     3301 atgcatgtgc acagctgtct cttttggacc actgtcccct ttgctgtcct ttggtacatt
     3361 ggcacagagg tgctgcctca caccagccat gcttgaggct ctgctgtagg ccgggatgcc
     3421 agcagcacaa ggggagggag gtgtgagagc cccggctcct cctcggtagg tatccttttc
     3481 agaagaaatc tgtccccagt ttctgaatgg cccagagagc aaggtgacac tggcagactg
     3541 caaagctcac tctgtttggg ctcatgtctg cttcaacttc tagcctaggc acccctggat
     3601 caacaacagc ggccccactc tgattcctga atctgcttta tttctctgca taaggaaccc
     3661 tgcacaggcg aatcaaacta aaacaaaata aatatatgaa tattcatgta aaactgtcct
     3721 ttctaatgaa caattataca caatgtacaa tttcatgttc actgggtggg cttacaaaaa
     3781 tgtatcattc tcaactaaaa atacaccaaa atggctccat gcaaacttat ccacagtgac
     3841 caaaaaatac agaggaaaac ctgactgagc agtttctgct ctttgttttg tacaatcaca
     3901 gaaaaataaa accatctaat ttctttgttt cattt
//
