LOCUS       NM_178674               2113 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 21 (Fbxl21),
            transcript variant 1, mRNA.
ACCESSION   NM_178674 XM_891254 XM_899486 XM_899495 XM_899501 XM_899507
            XM_915729 XM_923901 XM_923905 XM_923909 XM_923913
VERSION     NM_178674.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2113)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2113)
  AUTHORS   Lim,J.Y., Kim,E., Douglas,C.M., Wirianto,M., Han,C., Ono,K.,
            Kim,S.Y., Ji,J.H., Tran,C.K., Chen,Z., Esser,K.A. and Yoo,S.H.
  TITLE     The circadian E3 ligase FBXL21 regulates myoblast differentiation
            and sarcomere architecture via MYOZ1 ubiquitination and NFAT
            signaling
  JOURNAL   PLoS Genet 18 (12), e1010574 (2022)
   PUBMED   36574402
  REMARK    GeneRIF: The circadian E3 ligase FBXL21 regulates myoblast
            differentiation and sarcomere architecture via MYOZ1 ubiquitination
            and NFAT signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2113)
  AUTHORS   Wirianto,M., Yang,J., Kim,E., Gao,S., Paudel,K.R., Choi,J.M.,
            Choe,J., Gloston,G.F., Ademoji,P., Parakramaweera,R., Jin,J.,
            Esser,K.A., Jung,S.Y., Geng,Y.J., Lee,H.K., Chen,Z. and Yoo,S.H.
  TITLE     The GSK-3beta-FBXL21 Axis Contributes to Circadian TCAP Degradation
            and Skeletal Muscle Function
  JOURNAL   Cell Rep 32 (11), 108140 (2020)
   PUBMED   32937135
  REMARK    GeneRIF: The GSK-3beta-FBXL21 Axis Contributes to Circadian TCAP
            Degradation and Skeletal Muscle Function.
REFERENCE   4  (bases 1 to 2113)
  AUTHORS   Hirano,A., Yumimoto,K., Tsunematsu,R., Matsumoto,M., Oyama,M.,
            Kozuka-Hata,H., Nakagawa,T., Lanjakornsiripan,D., Nakayama,K.I. and
            Fukada,Y.
  TITLE     FBXL21 regulates oscillation of the circadian clock through
            ubiquitination and stabilization of cryptochromes
  JOURNAL   Cell 152 (5), 1106-1118 (2013)
   PUBMED   23452856
  REMARK    GeneRIF: Study shows that FBXL21 ubiquitinates CRY1 and CRY2 and
            that, surprisingly, FBXL21 stabilizes CRYs. FBXL21 localizes
            predominantly in the cytosol, whereas FBXL3 is present in the
            nucleus.
REFERENCE   5  (bases 1 to 2113)
  AUTHORS   Yoo,S.H., Mohawk,J.A., Siepka,S.M., Shan,Y., Huh,S.K., Hong,H.K.,
            Kornblum,I., Kumar,V., Koike,N., Xu,M., Nussbaum,J., Liu,X.,
            Chen,Z., Chen,Z.J., Green,C.B. and Takahashi,J.S.
  TITLE     Competing E3 ubiquitin ligases govern circadian periodicity by
            degradation of CRY in nucleus and cytoplasm
  JOURNAL   Cell 152 (5), 1091-1105 (2013)
   PUBMED   23452855
  REMARK    GeneRIF: FBXL21 plays a dual role: protecting CRY from FBXL3
            degradation in the nucleus and promoting CRY degradation within the
            cytoplasm.
REFERENCE   6  (bases 1 to 2113)
  AUTHORS   Dardente,H., Mendoza,J., Fustin,J.M., Challet,E. and Hazlerigg,D.G.
  TITLE     Implication of the F-Box Protein FBXL21 in circadian pacemaker
            function in mammals
  JOURNAL   PLoS One 3 (10), e3530 (2008)
   PUBMED   18953409
REFERENCE   7  (bases 1 to 2113)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK079800.1, AK085598.1 and AK035290.1.
            
            On Jan 13, 2018 this sequence version replaced NM_178674.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085598.1, BC138941.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AK079800.1         2-37
            37-2001             AK085598.1         2-1966
            2002-2113           AK035290.1         1854-1965
FEATURES             Location/Qualifiers
     source          1..2113
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.07 cM"
     gene            1..2113
                     /gene="Fbxl21"
                     /gene_synonym="D630045D17Rik; FBL3B; FBXL3B; Psttm"
                     /note="F-box and leucine-rich repeat protein 21"
                     /db_xref="GeneID:213311"
                     /db_xref="MGI:MGI:2442921"
     exon            1..151
                     /gene="Fbxl21"
                     /gene_synonym="D630045D17Rik; FBL3B; FBXL3B; Psttm"
                     /inference="alignment:Splign:2.1.0"
     exon            152..245
                     /gene="Fbxl21"
                     /gene_synonym="D630045D17Rik; FBL3B; FBXL3B; Psttm"
                     /inference="alignment:Splign:2.1.0"
     exon            246..376
                     /gene="Fbxl21"
                     /gene_synonym="D630045D17Rik; FBL3B; FBXL3B; Psttm"
                     /inference="alignment:Splign:2.1.0"
     exon            377..743
                     /gene="Fbxl21"
                     /gene_synonym="D630045D17Rik; FBL3B; FBXL3B; Psttm"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..1682
                     /gene="Fbxl21"
                     /gene_synonym="D630045D17Rik; FBL3B; FBXL3B; Psttm"
                     /note="isoform 1 is encoded by transcript variant 1;
                     F-box/LRR-repeat protein 21; F-box/LRR-repeat protein 3B;
                     F-box and leucine-rich repeat protein 3B"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 21 isoform 1"
                     /protein_id="NP_848789.2"
                     /db_xref="CCDS:CCDS26563.1"
                     /db_xref="GeneID:213311"
                     /db_xref="MGI:MGI:2442921"
                     /translation="MKRNNFSAVNKVVQSSPVVKQPKRGLCSSLRQTHALSVLLDWGT
                     LPHHVILQIFQYLPLIDRARASSVCRRWNEVFHIPDLWRKFEFELNQSATSYFKSTHP
                     DLIQQIIKKHAAHLQYVSFKVDSSTESAEAACDILSQLVNCSIQTLGLISTAKPSFMN
                     VPKSHFVSALTVVFVNSKSLSSIKIEDTPVDDPSLKILVANNSDTLRLLKMSSCPHVS
                     SDGILCVADHCQGLRELALNYYILSDEILLALSSETHVNLEHLRIDVVSENPGQIKFH
                     SIKKRSWDALIKHSPRVNVVMYFFLYEEEFEAFFKEETPVTHLYFGRSVSRAILGRIG
                     LNCPRLIELVVCANGLLPLDSELIRIAKHCKNLTSLGLSECEVSCSAFVEFVRLCGRR
                     LTQLSIMEEVLVPDDRYTPDEVHTEVSKHLGRVWFPDVMPIW"
     exon            744..866
                     /gene="Fbxl21"
                     /gene_synonym="D630045D17Rik; FBL3B; FBXL3B; Psttm"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1038
                     /gene="Fbxl21"
                     /gene_synonym="D630045D17Rik; FBL3B; FBXL3B; Psttm"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..2113
                     /gene="Fbxl21"
                     /gene_synonym="D630045D17Rik; FBL3B; FBXL3B; Psttm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1987..1992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl21"
                     /gene_synonym="D630045D17Rik; FBL3B; FBXL3B; Psttm"
                     /note="hexamer: ATTAAA"
     polyA_site      2010
                     /gene="Fbxl21"
                     /gene_synonym="D630045D17Rik; FBL3B; FBXL3B; Psttm"
                     /note="major polyA site"
ORIGIN      
        1 gatgcccatt tagtctctca ctgtccgcgg ctttatgcgg cgctggagcc cgcccacctg
       61 agaaggtagc tgctggcgtt cgtcacgcag agttctgcgc ttgaccggcg ggcctgcctg
      121 gggctggctg ccctcaggag cgcgttcgga gactggaagt gaagtcagat gggtgtcggt
      181 gattacccca tggcagtgtc atttcattgg ctcagcagta actgtaactt ggaagccacc
      241 ttcagtgatt ttataggtca gtcctgcttc tgggacccaa ctttatgttg tggttaagaa
      301 atgtttcacg tcactcagac tgaaccacaa gacagatgta cttatgttgt agataaatat
      361 ttcagtagct ttgaagaatg aagaggaata atttctctgc cgtgaataag gttgtccagt
      421 cgtcaccagt agtgaaacag cccaaacgtg ggctctgctc ttccctccgc cagacccatg
      481 cgctctctgt ccttctggac tgggggactt tacctcacca tgtcatatta cagatctttc
      541 agtaccttcc tttaatagat cgagcccggg cttcgtccgt gtgcaggaga tggaatgaag
      601 tattccacat ccctgatctt tggaggaagt ttgagtttga gctgaaccaa tcagcaactt
      661 cttatttcaa gtccactcat cccgacctca ttcaacagat catcaaaaag cacgctgcac
      721 atcttcagta tgtcagcttt aaggttgata gcagtactga gtcggcagaa gccgcctgtg
      781 atatcctttc tcagctggta aattgttcta tccagacctt gggattgatt tcaacagcca
      841 aaccaagttt catgaatgtg cccaagtctc actttgtgtc ggcacttacg gtcgtgtttg
      901 tcaactcaaa atcgttatca tcgattaaaa ttgaggacac gccagtggat gacccttccc
      961 tgaagattct tgtggctaac aacagtgaca cccttcgact cctcaaaatg agtagctgtc
     1021 ctcacgtttc atctgatggg atcctctgtg tggcggacca ctgtcagggc ctccgagagc
     1081 tggccctgaa ttactacatt ctgagcgacg aaattctcct tgcgctctcc agcgagactc
     1141 acgtgaacct cgaacatctc cggatagacg ttgtgagtga aaacccgggg cagatcaagt
     1201 tccattctat taagaaacgc agctgggacg cactgatcaa acactccccg agagtgaacg
     1261 tcgtcatgta cttcttcttg tatgaagaag agtttgaggc attcttcaaa gaggaaaccc
     1321 ccgtcactca cctttatttc ggacgttcag taagcagagc catcctgggc cggataggtc
     1381 ttaactgccc gaggctgatc gagttagtgg tgtgtgccaa tggccttctg cccctggaca
     1441 gtgaactcat ccgtattgcc aagcattgta aaaatctaac ctccttgggc ctgagtgagt
     1501 gtgaagtcag ctgcagcgca tttgtagagt ttgtgagact ctgtggcaga aggctcaccc
     1561 agctgtctat catggaggaa gttctggtcc ctgacgacag gtacacccca gatgaagtcc
     1621 acactgaagt ctctaagcac ctgggaagag tgtggtttcc ggatgtgatg cccatctggt
     1681 aaccagctac caaagatgct gaattttctg ttagtagggt tagctattgt ccgtgttaca
     1741 caaatgtaaa ttttgagagg agctgctcaa gtaatttagg ttaaatattt gctgtttgca
     1801 agttatctta attggttgct gcagaatcat ttgaaaacaa tataacaaat ttgaacagag
     1861 atctttgtca gtaggacaca gatactgtgt gtattagatg tttaataggg tagactacag
     1921 atgtctaaga tgtgtataga cttctcaacc tttacaagcc tattttagct tactaagtaa
     1981 atttacatta aacttataac taatatataa ttattatgta tggtattaga tccctttaaa
     2041 tgacatattt ttatgttaca accttattat tttaatttta tctggttcat ttgggtacca
     2101 atacatgttt tac
//
