LOCUS       NM_028149               8607 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 20 (Fbxl20),
            mRNA.
ACCESSION   NM_028149 XM_001000358 XM_126674 XM_895145 XM_903026 XM_903028
            XM_903031 XM_903032 XM_903033 XM_915017 XM_923494 XM_923501
            XM_923516 XM_923522 XM_923532 XM_923536 XM_982900 XM_982933
            XM_982970 XM_983008 XM_983045 XM_983087 XM_983129 XM_983157
            XM_992930
VERSION     NM_028149.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8607)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8607)
  AUTHORS   Eto,F., Sato,S., Setou,M. and Yao,I.
  TITLE     Region-specific effects of Scrapper on the abundance of glutamate
            and gamma-aminobutyric acid in the mouse brain
  JOURNAL   Sci Rep 10 (1), 7435 (2020)
   PUBMED   32366828
  REMARK    GeneRIF: Region-specific effects of Scrapper on the abundance of
            glutamate and gamma-aminobutyric acid in the mouse brain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8607)
  AUTHORS   Koga,K., Yao,I., Setou,M. and Zhuo,M.
  TITLE     SCRAPPER Selectively Contributes to Spontaneous Release and
            Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex
  JOURNAL   J Neurosci 37 (14), 3887-3895 (2017)
   PUBMED   28292828
  REMARK    GeneRIF: SCRAPPER plays a critical role in the anterior cingulate
            cortex pre-long term potentiation as well as synaptic transmission.
REFERENCE   4  (bases 1 to 8607)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 8607)
  AUTHORS   Takagi,H., Setou,M., Ito,S. and Yao,I.
  TITLE     SCRAPPER regulates the thresholds of long-term
            potentiation/depression, the bidirectional synaptic plasticity in
            hippocampal CA3-CA1 synapses
  JOURNAL   Neural Plast 2012, 352829 (2012)
   PUBMED   23316391
  REMARK    GeneRIF: SCRAPPER regulates the threshold of bidirectional synaptic
            plasticity and, therefore, metaplasticity.
REFERENCE   6  (bases 1 to 8607)
  AUTHORS   Yao,I., Takagi,H., Ageta,H., Kahyo,T., Sato,S., Hatanaka,K.,
            Fukuda,Y., Chiba,T., Morone,N., Yuasa,S., Inokuchi,K., Ohtsuka,T.,
            Macgregor,G.R., Tanaka,K. and Setou,M.
  TITLE     SCRAPPER-dependent ubiquitination of active zone protein RIM1
            regulates synaptic vesicle release
  JOURNAL   Cell 130 (5), 943-957 (2007)
   PUBMED   17803915
  REMARK    GeneRIF: SCRAPPER is synapse localized E3 ubiquitin ligase which
            binds/ubiquinates RIM1 to regulate synaptic transmission.
            Erratum:[Cell. 2007 Oct 5;131(1):190]
REFERENCE   7  (bases 1 to 8607)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 8607)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   9  (bases 1 to 8607)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 8607)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB656518.1, AK144786.1, AL591209.17, AK028535.1 and CX211402.1.
            
            On or before Aug 9, 2006 this sequence version replaced
            XM_915017.2, XM_923536.2, XM_992930.1, XM_923501.2, XM_923494.2,
            XM_923522.2, XM_923532.2, XM_923516.2, XM_895145.2, XM_126674.7,
            XM_001000358.1, XM_903028.2, XM_903026.2, XM_903032.2, XM_903033.2,
            XM_903031.2, XM_983087.1, XM_983129.1, XM_983008.1, XM_983157.1,
            XM_982933.1, XM_982970.1, XM_983045.1, XM_982900.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144786.1, AK220232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BB656518.1         3-28
            27-2895             AK144786.1         1-2869
            2896-5185           AL591209.17        166697-168986       c
            5186-8605           AK028535.1         3-3422
            8606-8607           CX211402.1         300-301
FEATURES             Location/Qualifiers
     source          1..8607
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.69 cM"
     gene            1..8607
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /note="F-box and leucine-rich repeat protein 20"
                     /db_xref="GeneID:72194"
                     /db_xref="MGI:MGI:1919444"
     exon            1..301
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1570
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /note="scrapper"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 20"
                     /protein_id="NP_082425.1"
                     /db_xref="CCDS:CCDS25339.1"
                     /db_xref="GeneID:72194"
                     /db_xref="MGI:MGI:1919444"
                     /translation="MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRIFSFLDVVT
                     LCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCL
                     GVGDNALRTFAQNCRNIEVLSLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMS
                     LKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGA
                     HCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLR
                     ILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSH
                     CELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQI
                     TRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL"
     exon            302..363
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     exon            364..418
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     exon            419..493
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     exon            494..588
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     exon            589..657
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     exon            658..753
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     exon            754..880
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     exon            881..955
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1086
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1147
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1192
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1249
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1462
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..8607
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2437..2442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /note="hexamer: AATAAA"
     polyA_site      2458
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /note="major polyA site"
     regulatory      3723..3728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /note="hexamer: ATTAAA"
     polyA_site      3744
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
     regulatory      8586..8591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /note="hexamer: ATTAAA"
     polyA_site      8607
                     /gene="Fbxl20"
                     /gene_synonym="2610511F20Rik; 4632423N09Rik; Fbl2;
                     mKIAA4147; Scr"
                     /note="major polyA site"
ORIGIN      
        1 gagtgttttt gttttgggtt gaagttgagg ctttggagag gaccgagcta gcgactggca
       61 gtcgtcgcgg ccgcggacgc cgcgggcggt ggtggaggcc cccgcgggac tcgagcggtc
      121 gctcctccgc gtcggccggg cgagcctcgc cttgctgccg ccgccgcctc ccgctcccgg
      181 aactccgggg cctgccctgg cccctatctt tgcactccgc acgccgcagc gccctgcccg
      241 ggccgcaccc gccggcccca tgaggaggga cgtgaacgga gtgaccaaga gcaggtttga
      301 gatgttctca aacagtgatg aggctgtaat caataaaaaa cttcccaaag aactcctgtt
      361 gaggatattt tctttcctgg atgttgttac cctgtgtcgc tgtgctcagg tctccagggc
      421 ctggaatgtc ctagctctgg atggcagtaa ctggcaacgg atagacctgt ttgatttcca
      481 gagggacatt gagggccggg tagtggaaaa tatttcaaaa cgatgtggag gctttttacg
      541 aaagttaagt cttcgtgggt gtcttggagt aggagacaat gcattaagga cctttgcaca
      601 aaactgtagg aatattgaag tactaagtct caacggatgt acaaagacaa cagatgctac
      661 ctgcactagc cttagcaagt tctgctccaa actcagacac ctcgacttgg cttcctgtac
      721 gtcaataaca aacatgtctc taaaagctct gagtgagggc tgtccactgt tggagcagtt
      781 gaacatttcc tggtgtgacc aagtaaccaa ggatggcatt caagcactag tgagaggctg
      841 tgggggtctc aaggccttat tcttaaaagg ctgcactcag ctagaagatg aagctctcaa
      901 gtacataggt gcacactgcc ctgagctagt gactttaaac ctgcaaactt gcttacaaat
      961 cacagatgaa ggtctcatta ccatatgcag agggtgtcat aagttgcagt ccctctgtgc
     1021 ctctgggtgc tccaatatca cagatgccat cctgaacgct ctaggtcaga actgccctcg
     1081 acttagaata ttagaagtgg ccagatgttc ccagttaaca gatgtgggct tcactaccct
     1141 agccaggaat tgccatgagc ttgagaagat ggacctagaa gaatgtgtgc agatcacgga
     1201 tagcacatta atccagcttt ccattcactg tcctcggctt caagtgttga gtctttctca
     1261 ctgtgagctg atcacagacg atggaatccg tcacctaggg aacggggcct gtgcccatga
     1321 ccagctggag gtgatagagc tggacaactg cccactaatc accgatgcat ccctggagca
     1381 cttgaagagc tgtcacagcc ttgagcgaat agaactctat gactgccagc agatcacccg
     1441 ggctggcatc aagagactca ggacccattt acccaacatt aaagtccacg cctacttcgc
     1501 ccctgtcact ccgcccccat cagtcggggg cagcagacag cgcttctgca ggtgctgcat
     1561 catcctatga cagcggggtg gcccaccatg ttgaactgag tatttaatga cacttctaga
     1621 cataccgtgg agtctctccg gtggaagcga ccccagcatt ctgggcaagg gttacaaagt
     1681 gagggcagcg tccagatccc cagagccgca catacacagg cacaggcgtc ctcaccccat
     1741 ctgctgtggt tctgggacca tggctctgaa gttcatgccg gctgtaacaa gtgggttggt
     1801 aaaacctaag cattcctgtt ggacatgccc agaaacaatc gcaggccacg gtagagggag
     1861 gggacattcc agcagagccc agtgttactg cttctgtggt ttcttcattt tattaagggg
     1921 tttctgtggg gggtttggaa cagtaactat gatcctccaa ggtgagaggt agcatggaaa
     1981 acaatatatg atttatccag ggaccagaaa gaaaacttct ccacatccta gaaatggtag
     2041 ccatccattg ggagactcgt gggcttcctt gttcccgtgc tgacatgctg agcatgttca
     2101 cagagaaact catcctttca tctggtgttt gagtatttga cccagaggtt tttttagcgg
     2161 ctgcattgaa atcactgggg tccaaataga attccttttc ttatctgctc agtttgtcac
     2221 tgtatgtcac tgcacccggt tctctcgctc actgccaccc gcgctcgctc gcgctctctc
     2281 tgtctctctc tctgtctctc tctccctccc cctctccttc agtctgtcct caggatgctg
     2341 cccactcgat tgttactatg ttgctatttg ttgtgtttac agtttgcatt ttggatgaat
     2401 tagttggggt caccaaacat ttttaaaaga aacatcaata aatatttttt taatctaact
     2461 tttaccatca ggggaccctg cctgaatctt tgccagtctg gaaagaaatt ctaacaaaag
     2521 caggaaagtt atgataagaa atagtcggac tgtttggatg gaaaaaaact ttccttaggg
     2581 tttctgttgt atcctatgct gtatgctggt ttgcacgctg tgcgctgtcc cccacgtgct
     2641 gccccacccc acccccacat ttccttcctt ctaaactcac tgagcttaca agagaagtgc
     2701 agcagtgtgt agggtgggtg atgaatccca agctgagcct ggattcccgg ctacccaagc
     2761 tccagcacaa atgaccagta tcctgtgcca gcaggcggtg ggtgtgtcct gtgccagcag
     2821 gcggtgggtg tggcctctgc ctgtctgagt tacttgagtt acttgctttg cagcagtgct
     2881 gggggggggg ggggggctgc ttttggtttc ttggtctcct cccacaacta atcccaggag
     2941 ggatacaaga agagtcctgt aatagctggc tgctgtgtta acgttaatag aagacctaag
     3001 catctccgct gtctctgcag acttcctcag aaaggggaca tgaaagcagc cagctaggag
     3061 cactggggca gccagagagc ccagagaggg agtgggggct cagagtctac caaggctgga
     3121 gagggagtgg ggggctcaga gtctaccaag gctggagagg gagtgggggg ctcagagtct
     3181 accaaggctg gagagggagt ggggggctca gagtctacca aggctggaga gggagtgggg
     3241 ggctcagtct accaaggctg gagagggagt ggggggctca gagtctacca aggctggaga
     3301 gggagtgggg ggctcagagt ctaccaaggc tggagaggga gtggggggct cagagtctac
     3361 caagcctgag cacctgacac cagagcagag ggaacaaggt tagtacctat ggctcagtca
     3421 agaaaaagcc tcttcagaga aacacacaga gaatgggaga aatgagatga gttttaaggc
     3481 atatttctaa accccgatgg tagaagcttt gtgtgtgttc attagagtat tgggagaggg
     3541 gcttttggga cctgagtgtg caagcctgtg accctggcat gttaaaaggg agggctgttt
     3601 catgccatag gtgcaggttc tgtcagaata tataggaaga aagtctgatg gatttctcat
     3661 tactgtagaa aacaatcaga tggaaggccc tcgaacgcta tactcccaca tttatttatt
     3721 gtattaaact tattgaaaat cttattttat tatgctcttt tgaaagctaa attacttgtg
     3781 tttttattcc ttttcccctt tatgttcaaa ttaccttgag agaaatctcc tttttcctct
     3841 gagaccgtct tgttacattg ctcacctgac tggtctcagt cacctggact ccagttaccc
     3901 tccacttcag cggctgggac tcgtggctag tactgcttcc ccagactggg tacctcctac
     3961 cccccctccc ccccacacac accccatcgc cccagacaaa ggcttatact ctgtagctct
     4021 ggctggcctg gaatcttgtc ttggcctcct tactgctagg attataaagt taggcacact
     4081 agctcacata cacacttgca aatgtagata ccctaggtct ttcaaacaaa atcaaaagaa
     4141 ggtgagggac tatcagctct aaactatatc gtttggggtt tttttttttc ccctaagtgc
     4201 ctaataagtt gacagtaaga cctgaacact gaacaggtag cagactctga ttgccccagt
     4261 ctgagtcatt caggaactct ttggtatgca ttcaagtttg aatgagtttc ctaactacta
     4321 gtgtgtcaga agtcttgaaa acgctgtctg cctgctcaga gtgttgctac acgcaggttt
     4381 gttggctttg tcttggtgac ccctgctggt aaggcaaatc accacctttc taggccaaga
     4441 acacgagtca aaaggaggga tgaggggtct gctgatgcac agctctggcc gcacatggtc
     4501 aagcgggcgt catattcctt tcttaagtaa cgcaggccca tcatgcatag aggagcatag
     4561 agaagcactg acctctgaat ccaagtgcca gctcccacat gcggaatact tgtaagaatt
     4621 ggatagggtt ttggttgggt tgataggttt ggggttgttt taggacggac catgtgtgga
     4681 gcccggggcc ttctcaagca ttaagcagac gctgagctgt aatcatcagt tctagtaagg
     4741 attagcgtga aaagttcctt tttgagaaag ctgattgggg gctgtgagtc tgataccagc
     4801 actcctgttg gcagatgggt ggtgggcgga ggcaggaaaa tccgccagaa gcctgagggc
     4861 cctccatctc caacctggag cacataacac tgacaagcaa aacagacccc gccgtaccaa
     4921 ggtgtggagg gagaattgtc ctgtgacctc catacaaggt gtggcatgta cgtgcctgca
     4981 cttcacagta tggatataaa agagggagag tgaggtatag tggtttgtgc ctatatctcg
     5041 acacaggaga tgcagaggct ggagggctgc tgcctgtacc tgaccagatt ggagtacata
     5101 gcaaggaggt ggggggcggg gggaagcctg gtggtccatt tgtctcattt tacacccact
     5161 cccaaacatg ccttttacaa tggggaaaga aaaaaaatga ggcctgagtg agatcagcct
     5221 cagctacact gtgacactgc ttaagcaagc caagcaaaag gaagaataag gtaccctcaa
     5281 agatggtgcc ctaagcctcc aggtggccag gagggattgc taatatggag aaagatcttg
     5341 aatagacaac gtccattgta ggctccgctc ccctgcgtca tctggaatat cctgccccca
     5401 tttgctgctg ccgctttatt agacctgcaa atgtagccac tgatctctcc agttcttcca
     5461 gcacccgccc tgccctgtgt ctaaagcatt gtggcatcca gtctagcatc cttggattcc
     5521 tttccctgct cacagcaagc tgtcgtgggc agaactgagc acagcacagg ggagtggcag
     5581 tggcttggga tagttctcag gtgatggtcc gtggggttgg gggttggact tggagttgaa
     5641 tttgagatct aactggctct gaggagtaaa gggacctaac atgacctctc ccccagtgtt
     5701 tgaagtatta aaccgctctg ctctgcttaa tgttttagaa atgcggtgac tggccctgcc
     5761 ctcaccctga cagcctttct ggaggtgaaa gtatccctca gtttgttttt gtagatttcc
     5821 agtgagattt ctgtgtctac taggtaggta gcaggcatgt aagtccgaga tggtgtttta
     5881 agcgtttccc agggaatgtt gttgagtgac ttaccatgct ttgtttgggg tgttctgtac
     5941 cgtttggaat gtttgttgta gctgtgggcc actgacgtcc agtctggact atttgtagct
     6001 gtgtagacta tttgaagtct atttgatatt ttcagttgtc ttctaaaatg tgtttgaaaa
     6061 catgccttga cttggcattg ttagggcgta ggagagttgt cactgaaaag aagagagaga
     6121 ctccctgcct gtccgtgggc attgagactt ggaaggcctc atagatcatg actgaccttg
     6181 gactgttgag atggctcggc aggtaagcac tgtttgcagg ccaagtctga caacctgttt
     6241 gtgatggtga aggagcggta atgccggctg ggaattgttg tgacttccac ggatgtacca
     6301 tgggatccat gtgcgttaat agaaaggatt atgtaaaatc caaggctgat ggctctaaag
     6361 tcaggcagct catggagtca taagtgagag ggtagacaag gaatgagccc tgaaccttct
     6421 ctgagttgta caggtgggtt tctgtgctgt ggtttctgct gacagaccag aggataagcc
     6481 cagccttctt gaagacttga agacaaacaa gtcttaagtt agagggatga ggggaagtag
     6541 gagtcacaaa cctgctcaca tttatttttg tcttaagtct gcatcagaag atgcagaaag
     6601 cagtgttatc tatcaatagg gcatgattag ccctgctgat ttgagaataa aatctggctg
     6661 taaatacaat atccaaaaga cctgactcta catcttcatt ctccagcaag aaaaaaaatt
     6721 aaatatatat atatgctatt taagcactgg ctgctgtaac cctgccttat tctttttacc
     6781 tgctggaaac cacaggagac aggagacaga gcttctgggg tttcccattg gagcctggtt
     6841 cacagtgttg tgcgctctga tttctctgca catcgtttct gcatctctgg aaaactctca
     6901 gttatttagc atcctctccc ttgaatggga gtttaagaaa gttatttgag agggaaaagc
     6961 ttttgttaca caaaccatgc gtggaaggtt cgaggagaac atcctcctgc aggtctttgg
     7021 tctctgccac aggagtgttt gatctaaggc tttgtggagt caagtttaca aagatgtcag
     7081 tacttctcag ccagagtggc tcgtagaaca agaaccatga gcaggcagaa acctagtgtc
     7141 gctttccact gtatggcatg ggcaggcaag gctcgtgagg agatgctttg cctcaggaag
     7201 cgcatctgtc ctgtgctcat aagacttcct ttccatggga cacatttact tcgttttttt
     7261 catggtatca actccatgcc ctttggtggc aagaagggct tccttacttc tggggacagc
     7321 attagtacca agacaggagt gtggacagtg gacaacagtc ctcccccttg gaaggggtgg
     7381 tgatagacag gtgtcctctg ccaggtccca ggagatcttt gaagttacat ccttttgctc
     7441 cgtttgtcgt gttatctcca atctgccctg gtttgctgct tacatatgtt tcttcctgta
     7501 ccctaacatt ttcctctcag ctccacaaaa cattcaacca ctcactgttt atagccctgg
     7561 agaccaggga cctctaaatg actgcgtggc gtggctcatt agttagacag gagtgccctg
     7621 gctctgcagc agtgagaagg gccttgctgt ctgtcgccat ctgggtgtcc ataggaaggc
     7681 ttgctccttg taaggatctt ttcttacata tttctgacga ctgttaatct ctaacaagtg
     7741 ctgagcccga ttcctgtgac ccatccctgc cacactccta cctgacacac tgacacctag
     7801 atcctgttgg cacgtcccaa aatctttagg ccagccagct cttcctccct gctgtaaccc
     7861 cagaactgac cccaagaacc aggacaaccc cgaggggaat ctgggagagg ctcgaggtca
     7921 cttttccgtt ggttttatcc actctggcca cctctgttct tcctcccagg aactctttgc
     7981 ggttactgtt tcctggtgtt cagcttagcc ttgcccacct tccagtgacc ctgagggcac
     8041 agacctgagt atcccatgtg gcctgtgcag agctcagagc actgtgagga ccaccccctt
     8101 ccggtcaggc cgctcaggga cagatggatg ggtacctggt gctgtctgca gaactcagtc
     8161 tccagtcctg cacccccact ccgctgactc cctgaggggt agcagggcag tcacggtgtg
     8221 atccctgtgc ctagctgctg ggcctgacct ggacttcgct gtatgggggc tgctgcttgc
     8281 ttgttttctc accaggcctg tgccaacact tggccactcc ccaggccctg aactgttccc
     8341 cagtggggac ttcacgccac ctttcactag ctaagtgact gtatgtacac ctcgtacttc
     8401 cagcatctga ggatgtgggg gtgaggattg ttttcaataa ataaaatcca aggaggcagt
     8461 agacgattct ttttgcttta aaaatctttg gactaaagat atgtttttat atatataaat
     8521 atataaagta aattgttatg taactattat tgttcctgta tgttctaatt ttgttttatg
     8581 atgtaattaa aggaaatcag ctgtgaa
//
