LOCUS       NM_178624               3203 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 2 (Fbxl2), mRNA.
ACCESSION   NM_178624
VERSION     NM_178624.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3203)
  AUTHORS   Das A, Wang X, Wei J, Hoji A, Coon TA, Popescu I, Brown M, Frizzell
            S, Iasella CJ, Noda K, Sembrat JC, Devonshire K, Hannan SJ, Snyder
            ME, Pilewski JM, Sanchez PG, Chandra D, Mallampalli RK, Alder JK,
            Chen BB and McDyer JF.
  TITLE     Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-alpha
            during Acute and Chronic Lung Allograft Rejection
  JOURNAL   J Immunol 209 (9), 1788-1795 (2022)
   PUBMED   36113884
  REMARK    GeneRIF: Cross-Regulation of F-Box Protein FBXL2 with T-bet and
            TNF-alpha during Acute and Chronic Lung Allograft Rejection.
REFERENCE   2  (bases 1 to 3203)
  AUTHORS   Zhao X, Zhao G, Shi Z, Zhou C, Chen Y, Hu B and Yan S.
  TITLE     Low-intensity pulsed ultrasound (LIPUS) prevents periprosthetic
            inflammatory loosening through FBXL2-TRAF6 ubiquitination pathway
  JOURNAL   Sci Rep 7, 45779 (2017)
   PUBMED   28378753
  REMARK    GeneRIF: Study demonstrated that TRAF6 plays an important role in
            the process of aseptic inflammatory loosening caused by
            periprosthetic debris, and Low intensity pulsed ultrasound was
            found to inhibit such inflammation through increasing the level of
            FBXL2, and further increasing ubiquitination of TRAF6.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3203)
  AUTHORS   Chen BB, Glasser JR, Coon TA and Mallampalli RK.
  TITLE     Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B
            to inhibit tumorigenesis
  JOURNAL   Cell Death Dis 4 (8), e759 (2013)
   PUBMED   23928698
  REMARK    GeneRIF: FBXL2 mediates Aurora B ubiquitination and degradation
            within the midbody, which is sufficient to induce mitotic arrest
            and apoptosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3203)
  AUTHORS   Chen BB, Coon TA, Glasser JR, McVerry BJ, Zhao J, Zhao Y, Zou C,
            Ellis B, Sciurba FC, Zhang Y and Mallampalli RK.
  TITLE     A combinatorial F box protein directed pathway controls TRAF
            adaptor stability to regulate inflammation
  JOURNAL   Nat Immunol 14 (5), 470-479 (2013)
   PUBMED   23542741
REFERENCE   5  (bases 1 to 3203)
  AUTHORS   Chen BB, Glasser JR, Coon TA and Mallampalli RK.
  TITLE     FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest
  JOURNAL   Cell Cycle 10 (20), 3487-3494 (2011)
   PUBMED   22024926
  REMARK    GeneRIF: FBXL2 is a ubiquitin E3 ligase subunit that triggers
            mitotic arrest.
REFERENCE   6  (bases 1 to 3203)
  AUTHORS   Chen BB, Coon TA, Glasser JR and Mallampalli RK.
  TITLE     Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase
            subunit, FBXL2, to regulate surfactant homeostasis
  JOURNAL   Mol Cell Biol 31 (9), 1905-1920 (2011)
   PUBMED   21343341
REFERENCE   7  (bases 1 to 3203)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK039010.1 and AK141177.1.
            
            [WARNING] On Jan 12, 2024 this sequence was replaced by
            NM_178624.7.
            
            On Sep 19, 2009 this sequence version replaced NM_178624.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK039010.1, AK141177.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3084              AK039010.1         1-3084
            3085-3203           AK141177.1         3075-3193
FEATURES             Location/Qualifiers
     source          1..3203
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 64.17 cM"
     gene            1..3203
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /note="F-box and leucine-rich repeat protein 2"
                     /db_xref="GeneID:72179"
                     /db_xref="MGI:MGI:1919429"
     exon            1..59
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
     exon            60..121
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
     exon            122..176
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
     exon            177..251
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
     exon            252..346
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
     exon            347..415
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
     exon            416..511
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
     exon            512..638
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
     exon            639..713
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
     exon            714..844
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
     exon            845..905
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
     exon            906..950
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1007
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1220
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..3203
                     /gene="Fbxl2"
                     /gene_synonym="2810423A21Rik; Fbl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacaacggg cgtcgccggc gccgtgtgac ttcaggctgt gggcgcgctc gcggccatgg
       61 ttttctcaaa cagtgatgat ggccttatca acaagaagct acccaaggag ctcctcttga
      121 gaatattctc cttcttggac atcgtaactc tatgccgatg tgcacagatc tccaaggcct
      181 ggaacatctt agccctggat ggcagcaact ggcaacgggt ggatcttttt aacttccaga
      241 cagatgtaga gggccgagtg gtggaaaaca tctccaagag gtgcggtggc ttccttagaa
      301 agctcagcct gcgtggctgc atcggagtcg gggactcctc tttgaagacc tttgcacaga
      361 actgccggaa cattgaacat ttaaacctca atggctgcac gaaaatcact gacagcacgt
      421 gttacagcct tagcagattc tgttccaagc tgaaacacct ggatctcacg tcctgcgtgt
      481 ctgttaccaa cagctcttta aagggcatca gcgagggctg ccggaacctg gaatatctga
      541 acctctcctg gtgtgaccag atcacaaagg aaggcattga ggcgctggtg cgggggtgcc
      601 ggggtttgaa agccctgctc ctgaggggtt gtacacagtt agaggacgaa gctctgaaac
      661 acattcagaa ccactgccac gagctggtga gcctcaacct gcagtcctgc tcacgcatca
      721 ctgatgatgg cgtggtgcag atctgcaggg gctgccaccg gctacaggct ctgtgcctct
      781 cgggttgtag caaccttacg gatgcatctc tcacagcctt gggcctgaac tgccccagac
      841 tacaagtttt ggaggctgcc cggtgctccc atctgaccga cgcaggcttt acactgctag
      901 ctcggaattg ccatgagctg gagaagatgg accttgaaga atgtgtcctg attaccgaca
      961 gcaccctcgt ccagctctcc atccactgtc ccaagctgca agccctgagc ttgtcccact
     1021 gtgagctcat cacagatgag gggatcctgc acctgagcag cagcacctgt gggcacgaga
     1081 gactccgggt gctggagctg gacaactgcc ttcttgtcac ggacgcctcg ctggagcacc
     1141 tggagaactg ccgaggcctg gagcgactgg agctttacga ctgccagcag gtcacccgtg
     1201 caggcatcaa gcgcatgcgg gctcagcttc ctcatgtcaa agtccatgcc tactttgctc
     1261 cagtcacccc tccaccagca gtggcaggaa gtggacatcg actgtgcaga tgctgtgtca
     1321 tactctgaca gcagctgctt aggccacggg ccccatcctc caggttagac cagtctcctg
     1381 gctgttccat cgtcacccta tctcgactct ccatggtgaa aacattacag gtaaaagact
     1441 tcagcacaga ttacagtacc tggtaatgct attcacctta acactgctag gatgcaagca
     1501 aatccaggtc tgtgtcatcc acagcaagag tggtgtggtg caacctagag cccatcagag
     1561 gtgggtacct atgtatacaa gtcccacctg gctttgtcag cattctatat atacaccttc
     1621 agtgttagca caacctgagc agagtaaaag agcctgctgg tttctacctg atccttaagc
     1681 cagtggccta atgtaattca cagcaatttc tgtccatctg caggacttgt ccactttaaa
     1741 gactaaatag cacctttatg aacgtgattg tactgcaaac tcagaatggc tggtagtttc
     1801 atatgtagaa gtgtgtgtga aaggcatgtt aacatacttc cataagacac caaagaaaca
     1861 aggcctctaa gctgggtggg gcaggatctt cacctttctg tttgtgtcaa ctcgtcatac
     1921 ccaactctag ggaccaaaac cacccccttt gcattgatcc gctgggaatt acaagctctg
     1981 ccagatgcca cagcacacag tgcatttctg ttaaaaggaa aaagccaatt atgtccatcc
     2041 acacttctca aaaaatttgc gggaacctta agcaaatcca gaattaaggc tcaagttatc
     2101 tataatcaag taaaaataac aaacagatgc atgtagaatg gatgtggttt ttatttactc
     2161 tgaattttta gaaatcataa ctgttttaaa gcttgtcaaa tgaatgacgt atttgcagct
     2221 tcagactcac aacacctcac cttgctcact ggagtcagat ttttgcaaat gcaggcactc
     2281 ctgtccctgt cccaggatgc tgtcttttac tattacggtg ctgctgctct gtgccactga
     2341 gacctcccac cttcaatatt aataatggta gctgaacctt ccagcaacca ccccaaccac
     2401 aactgcaaga aagagctttt tctgcctcgg tggacagcac tgaagcatct gcatagatgc
     2461 agtgtctccg atgcactctg ggagggaaag cagatacaca cacattccag agactcatca
     2521 ggcgaacggc tccttgtaag gagtactgtg atacgaaggg tacgactacc acaacagcta
     2581 cttaactgtg gcgctgtgtg gggggtgggg ggtggggcat ggctgctgga ggagctgcta
     2641 agtaagcact agacctgctc cagtgactcg tgagactcac ttctatgaaa tacccgagac
     2701 aactatggaa ttttttctga gctagaatga tgtggctcat tgcagatggt ggacttgatg
     2761 ctcagtgacc atgacttcga gcctgatctg tctcttctaa gtatgcagca ggcacttact
     2821 gtaactactt gtcttgagtt gcatcacctc tgtggaaatt gggatgaaca tcttacacca
     2881 tgcacatcga ggccaaccct tgagtccatg tgacttcaga tgacaacagt gcagcttaga
     2941 tttgaaatga gtgacacgtt tacaaaacaa tcagaaaaca tttattacac tgaactgtac
     3001 atcctataac caaagtagca gactgctggt gccatgggcc aggtatagtt tcactgagac
     3061 ggcctagcac tttgtgctgc tcagcacaag ttcaagtctg aggagcctgt aagtactttc
     3121 accccacttc taaaacctga taatgaattc aaaataatac acagcattaa atgacattta
     3181 ttgttccata aatcatgaga tcc
//
