LOCUS       NM_172748               4462 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 19 (Fbxl19),
            transcript variant 1, mRNA.
ACCESSION   NM_172748 XM_917072 XM_924650 XM_924655
VERSION     NM_172748.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4462)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4462)
  AUTHORS   Chen,Z., Zheng,B., Zhang,Z. and Huang,Z.
  TITLE     Protective role of FBXL19 in Streptococcus pneumoniae-induced lung
            injury in pneumonia immature mice
  JOURNAL   J Cardiothorac Surg 18 (1), 92 (2023)
   PUBMED   36964598
  REMARK    GeneRIF: Protective role of FBXL19 in Streptococcus
            pneumoniae-induced lung injury in pneumonia immature mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4462)
  AUTHORS   Feldmann,A., Dimitrova,E., Kenney,A., Lastuvkova,A. and Klose,R.J.
  TITLE     CDK-Mediator and FBXL19 prime developmental genes for activation by
            promoting atypical regulatory interactions
  JOURNAL   Nucleic Acids Res 48 (6), 2942-2955 (2020)
   PUBMED   31996894
  REMARK    GeneRIF: FBXL19 and CDK-Mediator support long-range interactions
            between silent gene promoters that rely on FBXL19 for their
            induction during differentiation and gene regulatory elements.
REFERENCE   4  (bases 1 to 4462)
  AUTHORS   Acharya,A., Berry,D.C., Zhang,H., Jiang,Y., Jones,B.T.,
            Hammer,R.E., Graff,J.M. and Mendell,J.T.
  TITLE     miR-26 suppresses adipocyte progenitor differentiation and fat
            production by targeting Fbxl19
  JOURNAL   Genes Dev 33 (19-20), 1367-1380 (2019)
   PUBMED   31488578
  REMARK    GeneRIF: these data validate Fbxl19 as a direct miR-26 target and
            support its role as a regulator of adipogenesis that functions
            downstream from the miR-26 familywithin the APC lineage
REFERENCE   5  (bases 1 to 4462)
  AUTHORS   Dimitrova,E., Kondo,T., Feldmann,A., Nakayama,M., Koseki,Y.,
            Konietzny,R., Kessler,B.M., Koseki,H. and Klose,R.J.
  TITLE     FBXL19 recruits CDK-Mediator to CpG islands of developmental genes
            priming them for activation during lineage commitment
  JOURNAL   Elife 7, e37084 (2018)
   PUBMED   29809150
  REMARK    GeneRIF: Removing the CpG island-binding domain of FBXL19 results
            in a failure to induce developmental genes during ES cell
            differentiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4462)
  AUTHORS   Choi,M.Y., Romer,A.I., Hu,M., Lepourcelet,M., Mechoor,A.,
            Yesilaltay,A., Krieger,M., Gray,P.A. and Shivdasani,R.A.
  TITLE     A dynamic expression survey identifies transcription factors
            relevant in mouse digestive tract development
  JOURNAL   Development 133 (20), 4119-4129 (2006)
   PUBMED   16971476
REFERENCE   7  (bases 1 to 4462)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4462)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of FBXL19 gene in silico
  JOURNAL   Int J Mol Med 14 (6), 1109-1114 (2004)
   PUBMED   15547684
REFERENCE   9  (bases 1 to 4462)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   10 (bases 1 to 4462)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149222.4.
            
            On Jan 5, 2023 this sequence version replaced NM_172748.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059812.1, SRR13422586.288041.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-860               AC149222.4         206925-207784       c
            861-1061            AC149222.4         205612-205812       c
            1062-1205           AC149222.4         204209-204352       c
            1206-1292           AC149222.4         203995-204081       c
            1293-1511           AC149222.4         203696-203914       c
            1512-1673           AC149222.4         203036-203197       c
            1674-2185           AC149222.4         201541-202052       c
            2186-2349           AC149222.4         192647-192810       c
            2350-2511           AC149222.4         191461-191622       c
            2512-2730           AC149222.4         186399-186617       c
            2731-4462           AC149222.4         184579-186310       c
FEATURES             Location/Qualifiers
     source          1..4462
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.71 cM"
     gene            1..4462
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
                     /note="F-box and leucine-rich repeat protein 19"
                     /db_xref="GeneID:233902"
                     /db_xref="MGI:MGI:3039600"
     exon            1..860
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1061
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1205
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1292
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1511
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1673
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..2185
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2349
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2511
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2730
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..4462
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3915
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
     regulatory      4439..4444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
                     /note="hexamer: TATAAA"
     polyA_site      4462
                     /gene="Fbxl19"
                     /gene_synonym="6030430O11; Fbl19"
                     /note="major polyA site"
ORIGIN      
        1 aggaaggagg aaggagctga ggagggatga gagcggcgac ctgggcccag ggccgaagca
       61 gcgcgaggct aggggagtag gggtgctaag acatcccaac tgcccccacc cccttcctgc
      121 ctctgcccca tcctttcctt ataccctccc attttaggag tggatttatt caaattttat
      181 ttaaatcttt atatcttgag ggtcgcgcgt ttgaaggggg gagggcgggg gcgcgtgcag
      241 gctggggggg gcggggccgg agcagcttcc ttcacccccc tctgcgcgcc ctgtctctgt
      301 aggtcagggg gccgcagtac aggggcggac ccaggggagg ggggcaggtt gcagcgaccc
      361 ccccctcccc gggaaccggc ggtgggcggg gtttgaaccc cggaaacggt ggggggcccc
      421 tggtctttcc ctggacccct gggcagttgg agctgggaag gggccagtta agggtcgggg
      481 gctttgggga aaggtggggg tggggagctg agactcatac ccgggactga gtggggcccg
      541 ggcaaaagct gagcaccctg cgcccgagga gcccccgttg gcctgggggg gctgagggac
      601 tgagcccccc agagcaggac ctccccctgg aagggccgcg ccgcagcccg tgggagggcc
      661 tcgcccccgg cgctccccat ctccactcgc tgctgtcccg gcctccgccg gagggagggg
      721 ccgagcgccc tcggggggcc gtggaccccg gcgttctgag cgttcagcgc cccgcgccgc
      781 ccggcccccc cgccgccgat ggccgccgac ccgccgggag ctgccgagaa gggagagatg
      841 gctcccggga cacgtgtgag ccctcggcgt tgctgacgcc cccaatgtcg tcgagcagcc
      901 ggggaccggg ggccggagcg cgccgacgcc gaacccgctg ccgtcgttgc cgggcctgtg
      961 tgcgaactga gtgcggggac tgccatttct gccgagacat gaagaagttc ggggggcccg
     1021 ggcgcatgaa gcagtcgtgc ctgcttcggc agtgcaccgc gcccgtgctc ccacacacag
     1081 ctgtgtgcct cttgtgcggg gaggctggaa aggaggatac agtggaggga gaagacgaga
     1141 agtttagttt gagcctcatg gagtgtacaa tctgcaacga gatcgtccac cctggctgcc
     1201 tgaagatggg aaaggctgag ggtgttatca attccgagat acccaactgc tgggagtgcc
     1261 cccgatgtac ccaggaagga cggacaagca aggatgcagg tgagggtcca gggcgccgca
     1321 gggctgacaa tggtgaggaa ggcgctaacc tagggggtgg atggaagctg acagaggaac
     1381 caccacctcc accacccctg cccagaagaa agggaccctt acctgctggc cctacccctg
     1441 acgatgtgcc tgggcccccc aaacggaagg agagggaggg ggggaatgag ccccccaccc
     1501 caaggaaaaa ggtgaaagga ggccgagaga ggcacttgaa gaaggtgggt ggagatgcct
     1561 gcctcctccg aggagcggac ccaggcagcc ccggccttct gccccccagg gttctgaatc
     1621 cgagccaggc attctcatcc tgccaccctg ggctccctcc cgagaactgg gagaaaccaa
     1681 agccacctat agcttctgct gagggcccgg cagtgccatc tccatcacca cagagggaga
     1741 aactggagcg tttcaagcgc atgtgccagc tgctggagcg ggtgcccgat acctcttctt
     1801 cctcctcgga ctcggactcg gattcagact catccggcac atcactcagt gaggatgaag
     1861 ctcctggaga ggcccggaat gggcggcggc cagcacgggg cagctccggc gagaaggaga
     1921 accgtggggg acggcgggct atacgccctg gcactggggg gccactgctc agctggcccc
     1981 tgggccctgc cccaccacca cggcctccac agttggagcg acatgtcgtg cggcccccgc
     2041 ctcgaagccc tgagcctgat actctgcctt tggctgctgg atccgaccac cctctgcctc
     2101 gggctgcctg gcttcgtgtt ttccagcacc ttggaccccg tgagctatgt gtctgcatga
     2161 gagtttgccg gacttggagc cgctggtgct acgacaagcg tctgtggcct aggatggacc
     2221 taagccggag aaagtcactg accccaccca tgcttagtgg ggtggttcgc cgccagcccc
     2281 gtgctctgga cctcagctgg acaggtgtct ccaaaaagca gctcatgtgg ctcctgaacc
     2341 gactgcaagg cctgcaggag ttggtgcttt ctgggtgctc ctggctctct gtctctgccc
     2401 tgggctcggc cccactgcca gcgctgcggc tcttggacct ccgctggatt gaagatgtta
     2461 aagactccca gcttcgggag ctgctgctgc ctccaccaga caccaaacca gggcaaactg
     2521 agagtcgagg ccgactgcag ggggtggcag aacttcgcct agctggtctg gagctcacag
     2581 atgcctccct gaggctcctg ttgcgccacg ctccccagct cagtgccctg gacctgagtc
     2641 actgcgccca cgttggggac cccagtgtcc acctcctcac ggctcctact tcccctcttc
     2701 gagaaacact ggtgcacctc aatctcgctg ggtgccaccg cctcacggac cactgccttc
     2761 cactgttccg tcgatgccca cgtcttcgcc gcctggacct acgctcctgc cgccagctct
     2821 cacctgaagc ttgtgcccgg ttggcggctg ctgggccccc tggccccttt cgctgcccag
     2881 aagagaaact gcttctcaag gacagctagt tgggtgccga tgcccccttc ccttcccttc
     2941 cccaggactc agccagagaa cctggacctc ttgccttcat ttcaccccct gttgggaggc
     3001 caggttattt tcttcatgac ttggcactcc tcagtttaat gacttgggat tcctgcccag
     3061 ggacttgagc cagccttccc tctctcccac ctgcactgat atctctgggg gtctttgctt
     3121 cccatctctc cctttcacct gcttcattgt ccatcccctc tggggagtgg gtcaagaggt
     3181 actggggagg tgctgagcca aagggatggt gggagggagg ggcggtgaag gtgcaagtct
     3241 ggagtaggga aaatgaggtg acatggtatc ttgtacacag gatactgggg gctgggggag
     3301 gcgatggatg ggtgtgggga gggcagaaat cagaccaaca agggttcagg gaacaaagac
     3361 cagttgggtg ggatgggggg ccaaaaaggg aaaacagagg agcaattggg gatccgagtg
     3421 tcaagacagg gggcgctaca agccaggtaa tgccaggact gggggctggg agaggagcag
     3481 atgtggggat agtaccctct gcgtagggtt gcctctctcc ccttccctct acccagattt
     3541 cagttttccc cgaccttgac tccttgaacg tcactgaaaa tggcagctat tgcaaggagt
     3601 aggggccgcg ggtctacctg ctgttaagct cggtggccca ggggagtggt gaggggtagc
     3661 ccagacccct gcctggctct ctacacaata cttgaacatt catctgtact gaagtgttac
     3721 ttgaaccggg ggaatctcgg acttggggga gtgtgatgtg aggggaccag cttgaccgag
     3781 actgggctat gggtacccag tttggactgt cccaccccta gctctcttgc attactgtct
     3841 tgaacagctc cacccttcac ttgagttggg gtggggaaat gtcagcttaa agatgggcaa
     3901 gatgggactc ctccagtttg gctcttccca ttctttcatc gtcatggaaa ctcgtgtccc
     3961 atttgcccag ggaactgcca ctcctggttg ccatggaaat agcagccaat ggacacctcc
     4021 ggaaatcagt gctaagactg gaaacggtcc ctcttagttg ctgtgggaac ttagtaacag
     4081 actcttggca cctcccctct tcccacccct ttccttcttc cagtgtgggg gtggggtctc
     4141 aagagcctga gggaggagtc aggtctaggt cccactcaac ttaggccagg gggaactgga
     4201 ttgtactaca tgggggtggg gggaggggaa tctatccaca tacctcaggt aacaggaagg
     4261 tgcgcgggtt gggggcgggg gctgggcgga ccaaaggcag gagggggggc ctggggttgg
     4321 agaaaggctt gacggtgggg ccgcttgcgg gaggggagga ggcaccccgg cgagggacaa
     4381 gtggggcacc cagccgggct ggacccctaa ccccacaagt ctgtacaata aggtttgcta
     4441 taaaactcag aatctagccg gg
//
