LOCUS       NM_001033312            2831 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 18 (Fbxl18),
            mRNA.
ACCESSION   NM_001033312 XM_485692
VERSION     NM_001033312.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2831)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2831)
  AUTHORS   Yu,H.Q., Li,F., Xiong,H., Fang,L., Zhang,J., Bie,P. and Xie,C.M.
  TITLE     Elevated FBXL18 promotes RPS15A ubiquitination and SMAD3 activation
            to drive HCC
  JOURNAL   Hepatol Commun 7 (7), e00198 (2023)
   PUBMED   37378633
  REMARK    GeneRIF: Elevated FBXL18 promotes RPS15A ubiquitination and SMAD3
            activation to drive HCC.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2831)
  AUTHORS   Ding,X., Barodia,S.K., Ma,L. and Goldberg,M.S.
  TITLE     Fbxl18 targets LRRK2 for proteasomal degradation and attenuates
            cell toxicity
  JOURNAL   Neurobiol Dis 98, 122-136 (2017)
   PUBMED   27890708
  REMARK    GeneRIF: Study showed that LRRK2 phosphorylation is required for
            LRRK2 to bind to Fbxl18, and that this interaction is important for
            regulating the amount of LRRK2 via ubiquitination of LRRK2 by the
            SCFFbxl18 ubiquitin ligase and subsequent proteasomal degradation
            of LRRK2. We also show that LRRK2 can induce caspase 8 mediated
            cell death and that the degradation of LRRK2 mediated by Fbxl18 can
            prevent LRRK2-mediated toxicity.
REFERENCE   4  (bases 1 to 2831)
  AUTHORS   Yoon,J., Feng,X., Kim,Y.S., Shin,D.M., Hatzi,K., Wang,H. and
            Morse,H.C. 3rd.
  TITLE     Interferon regulatory factor 8 (IRF8) interacts with the B cell
            lymphoma 6 (BCL6) corepressor BCOR
  JOURNAL   J Biol Chem 289 (49), 34250-34257 (2014)
   PUBMED   25331958
REFERENCE   5  (bases 1 to 2831)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   6  (bases 1 to 2831)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144757.1 and AK049302.1.
            
            On Jul 26, 2007 this sequence version replaced NM_001033312.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144757.1, AK049302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-955               AK144757.1         2-956
            956-1328            AK049302.1         909-1281
            1329-2810           AK049302.1         1283-2764
            2811-2831           AK144757.1         2813-2833
FEATURES             Location/Qualifiers
     source          1..2831
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 81.79 cM"
     gene            1..2831
                     /gene="Fbxl18"
                     /gene_synonym="B130019G13Rik; C330021B20Rik"
                     /note="F-box and leucine-rich repeat protein 18"
                     /db_xref="GeneID:231863"
                     /db_xref="MGI:MGI:2444450"
     exon            1..129
                     /gene="Fbxl18"
                     /gene_synonym="B130019G13Rik; C330021B20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            130..336
                     /gene="Fbxl18"
                     /gene_synonym="B130019G13Rik; C330021B20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            337..1880
                     /gene="Fbxl18"
                     /gene_synonym="B130019G13Rik; C330021B20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2099
                     /gene="Fbxl18"
                     /gene_synonym="B130019G13Rik; C330021B20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2831
                     /gene="Fbxl18"
                     /gene_synonym="B130019G13Rik; C330021B20Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcgtgcgc cgcagccacg ccccttaccg gggtctctgt ggagctgtgg ccgcgccggc
       61 ttcgagcatc cctacgctgg caggctgggg gactgtgagg ctgcagctcc ggcggctagc
      121 tccggagagg acatgtccag tgaggaggag gcagcggcag aggcagcagg tgacacccac
      181 ctgcttggct tctccgatga gatcctccta cacatcctga gccatgtccc cagcacggac
      241 ctggttctca gtgtgcggcg cacctgcagg aaactggcag ccctgtgcct ggacaagagc
      301 ctggtgcaca ccgtgctgct gcagaaggac taccaggcca gtgaggagaa ggtgaagcaa
      361 ctggtgaagg agattggccg ggagatccaa cagctgaaca tggcaggctg ctattggttg
      421 tctggctcca ccatcgagca cgtggcccgg tgtcacagcc tggtgaaggt gaacttgtca
      481 ggttgccacc tcacctcgct gcggctgtcc aaggtgctct cggccctgca gcacctgcgc
      541 tcattggcca ttgacgtgag ccccggcttc gacgccagcc agctgagcag tgagtgcaag
      601 gccacgctaa gccgcgtgca ggagctcaag cagacactct tcacgccgtc ctacggggtg
      661 gtgccctgct gtgccagcct gcagaagctg ctgctctact tcgagatcct ggaccgcacc
      721 cgggaggggg ccgtcctctc gggccagctc atggtgggcc agagcaacgt gccccactac
      781 cagaacctgc gtgtcttcta tgcacgcctg gctcctggct acatcaacca ggaggtggtg
      841 agactctacc tggccgtgct cagcgaccgc acgcctgaga acctgcatgc cttcctcatc
      901 tccgtccctg gcagctttgc agagagcggg gccaccaaaa acttgctgga ctccatggcc
      961 cgcaacgtgg ccctggatgc actgcagctg cccaagtcct ggctcaatgg ctccaccctc
     1021 ctccagcata tgaaattcaa caatcccttc tacttcagct tcagccggtg tacgctgtca
     1081 gggggtcacc tgattcagcg gctcatcaat ggcgggaagg acctgcgtag cctggccagc
     1141 ctcaacctca gcggctgtgt gcattgcctg tctgcggact cgttgctgcg caaggccgag
     1201 gacgacattg acagcagcat cctggagact ctggtggagt cctgctgcaa cctgcaccac
     1261 ctcaatctct ctgccgccca tcaccacagc tccgacggcc tgggccgcca cctctgccag
     1321 ctcctggctc ggctctgcca cctgcgttcc ctgtccctgc ctgtctgctc tgtggctgac
     1381 tcggcaccca ggcctgaccg tgcgcccgcc ccgccagcca tgcacgcagt accccgtgga
     1441 tttggcaaga aggtgcgcat tggggtgcag acctgtccca accccttcgt gggccagtcg
     1501 gccccacagc ctgcctctgt gttctggtct ctgctgaaga agctcccatt tctggagcac
     1561 ctggaactga tcgggtccaa tttctcctca gccatgcccc gcaatgagcc tgccatccgc
     1621 aactccctcc caccctgcag tcgggcacag aacgtggggg actcagaggt ggccgccatt
     1681 ggccagctga ccttcctgcg gcacctgact ctagcccaac tgccaggcat gctcacgggc
     1741 tccggactcg tgagcatcgg tctccagtgc cagcacctgc agtctctatc gctggccaac
     1801 ctgggcatga tggggaaggt ggtgtacatg cctgctcttg ctgacatgct gaagcactgc
     1861 aagcggctga aggacctcag gttggagcag ccctacttca acgccaacgc tcagttcttc
     1921 caggcactgg gccagtgctc gtctctgcag cgcctgtgcc tggtatctcg cagcggcacc
     1981 ctgcagccag atgccgtgct ggcctttatg gcccgttgcc tgcaggtcgt catgtgtcac
     2041 atgttcaccg gagaatccct taccacctgc aagagcctgc agcagtcgct cctccggagt
     2101 ttccaggccg agaggcccgc gttgaacgtc gtcatcttcc ccctgctcca cgagggcctg
     2161 acagatgtca tccgagatgt ccccatgctg cacctggatg agatcacctt gttcaaaagc
     2221 cgtgtggctg aggaaccgcc caacctatgg tggtgagagg accctggcca gcccgcccac
     2281 cactcctgct accacgtcca ccactcctgt cgccagagcc tcttctgtct gagtctccac
     2341 gagggtgccc ggagccagca gacagtaagg ccttgttccg tgacaggaag aaagtttcca
     2401 gttctcctga gacactcacc ccagtccccc gggattctct ctgtcactct catgagtaca
     2461 gtgacaagaa gtaatctggt gagccatgga cgaatgggcc gtggatgagc caggctgccc
     2521 ttcagggcct ggctgtgctg ggggtggggg gaggatttgt gggctgcggt ccccagtcct
     2581 ctcgcttgct tcagcttggg gactctcgcc tgctcctttg ttcatggccg tctacactta
     2641 agctcagtca tgtgaccgca cccacgtgca gtcagggtgg gccgggctgt cactgtgaaa
     2701 ttctcgaatg ttgtctgtga gcctgtggct ccttttcctg ttgagctcca tttagggtgt
     2761 gggccagtgg cagagctagt gtgtgcgagg ccctggctgc catccccgcc acaaaaaaaa
     2821 aagtttaacc c
//
