LOCUS       NM_001164225            3482 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 16 (Fbxl16),
            transcript variant 1, mRNA.
ACCESSION   NM_001164225 XM_001479823 XM_001479825 XM_128530
VERSION     NM_001164225.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3482)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3482)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 3482)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3482)
  AUTHORS   Araujo,D.J., Anderson,A.G., Berto,S., Runnels,W., Harper,M.,
            Ammanuel,S., Rieger,M.A., Huang,H.C., Rajkovich,K., Loerwald,K.W.,
            Dekker,J.D., Tucker,H.O., Dougherty,J.D., Gibson,J.R. and
            Konopka,G.
  TITLE     FoxP1 orchestration of ASD-relevant signaling pathways in the
            striatum
  JOURNAL   Genes Dev 29 (20), 2081-2096 (2015)
   PUBMED   26494785
REFERENCE   5  (bases 1 to 3482)
  AUTHORS   Honarpour,N., Rose,C.M., Brumbaugh,J., Anderson,J., Graham,R.L.,
            Sweredoski,M.J., Hess,S., Coon,J.J. and Deshaies,R.J.
  TITLE     F-box protein FBXL16 binds PP2A-B55alpha and regulates
            differentiation of embryonic stem cells along the FLK1+ lineage
  JOURNAL   Mol Cell Proteomics 13 (3), 780-791 (2014)
   PUBMED   24390425
  REMARK    GeneRIF: FBXL16 negatively regulates the activity of B55alpha-PP2A
            to modulate the genesis of FLK1+ progenitor cells.
REFERENCE   6  (bases 1 to 3482)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 3482)
  AUTHORS   Liu,T., Ma,Z., Que,H., Li,X., Ni,Y., Jing,S. and Liu,S.
  TITLE     Identification and characterization of scirr1, a novel gene
            up-regulated after spinal cord injury
  JOURNAL   Exp Mol Med 39 (3), 255-266 (2007)
   PUBMED   17603280
  REMARK    GeneRIF: SCIRR1 ise involved in the succeeding injury and/or repair
            processes of the injured spinal cord.
REFERENCE   8  (bases 1 to 3482)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134908.5 and AC159277.3.
            
            On Apr 1, 2020 this sequence version replaced NM_001164225.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3543007.1,
                                           SRR7974084.3138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               AC134908.5         183034-183321
            289-935             AC159277.3         216305-216951       c
            936-1444            AC159277.3         215180-215688       c
            1445-1529           AC159277.3         214786-214870       c
            1530-1593           AC159277.3         214409-214472       c
            1594-3482           AC159277.3         212106-213994       c
FEATURES             Location/Qualifiers
     source          1..3482
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.91 cM"
     gene            1..3482
                     /gene="Fbxl16"
                     /gene_synonym="Scirr1"
                     /note="F-box and leucine-rich repeat protein 16"
                     /db_xref="GeneID:214931"
                     /db_xref="MGI:MGI:2448488"
     exon            1..288
                     /gene="Fbxl16"
                     /gene_synonym="Scirr1"
                     /inference="alignment:Splign:2.1.0"
     exon            289..935
                     /gene="Fbxl16"
                     /gene_synonym="Scirr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..1742
                     /gene="Fbxl16"
                     /gene_synonym="Scirr1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     F-box/LRR-repeat protein 16"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 16 isoform 1"
                     /protein_id="NP_001157697.1"
                     /db_xref="CCDS:CCDS50036.1"
                     /db_xref="GeneID:214931"
                     /db_xref="MGI:MGI:2448488"
                     /translation="MSSPGIDGDPKPPCLPRNGLVKLPGQPNGLGAASITKGTPAAKN
                     RPCQPPPPPTLPPPSLATPLSRVALAGGPCPPASGPASGPVSGPPVERPPLATDEKIL
                     NGLFWYFSACEKCILAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVNL
                     QGFAARGFEGFCLVGVSDLDICEFIDNYSLSKKGVKAMSLKRSTITDAGLEVMLEQMQ
                     GVVRLELSGCNDFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQ
                     AYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTSLSLSGCSKVT
                     DDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTGLSY
                     LSTMSSLRSLYLRWCCQVQDFGLKHLLAMRNLRLLSLAGCPLLTTTGLSGLVQLQELE
                     ELELTNCPGATPELFKYFSQHLPRCLVIE"
     exon            936..1444
                     /gene="Fbxl16"
                     /gene_synonym="Scirr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1529
                     /gene="Fbxl16"
                     /gene_synonym="Scirr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1593
                     /gene="Fbxl16"
                     /gene_synonym="Scirr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..3482
                     /gene="Fbxl16"
                     /gene_synonym="Scirr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3449..3454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl16"
                     /gene_synonym="Scirr1"
                     /note="hexamer: TATAAA"
     regulatory      3462..3467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl16"
                     /gene_synonym="Scirr1"
                     /note="hexamer: ATTAAA"
     polyA_site      3470
                     /gene="Fbxl16"
                     /gene_synonym="Scirr1"
                     /note="major polyA site"
     polyA_site      3482
                     /gene="Fbxl16"
                     /gene_synonym="Scirr1"
                     /note="major polyA site"
ORIGIN      
        1 aggaggcgcc cgccgggttc cctgcaaagc ggccttattt atctgggcac agcctcagcc
       61 tccccggtgg gaggctcagg gcggcagatc ctctcccacc ggggagctcc gctcggaact
      121 ctgcggagag ggccctggcg cggggcgccg ggcgcggggc gcagtcgggc cctgctagcc
      181 agtccagcac ctcggccgcc tccgcgctag gcggctcggg tgctgagctc cccatgacgc
      241 gaggtcgccc ggcggacagc gtggcatgag ccagaagccc tggccgagag cgtgcaagaa
      301 aaatgtcgag ccccggtatc gatggtgacc ccaagcctcc atgcttgcct cgaaacggtc
      361 tggtgaagct gcctggccag cccaacggcc taggtgcagc cagcatcacc aagggcacac
      421 ctgctgccaa gaaccgtcct tgccagccac cacccccacc gaccctccca cctccaagcc
      481 tggctacacc actatcccgg gttgctctgg ccggggggcc atgcccccca gccagtggac
      541 cagcctcggg tccagtgtct ggacccccag tggagcggcc accactggcc acagacgaga
      601 agatccttaa tgggcttttc tggtatttct cagcatgtga gaagtgcata ctagctcagg
      661 tgtgcaaggc ttggcggcgt gtgctctacc agcccaagtt ctgggcgggc ctcacgcctg
      721 tgctgcatgc caaggagctg tacaacgtgc tgcctggagg cgagaaggag tttgtgaacc
      781 tgcagggctt tgctgctaga ggttttgagg gcttctgcct agttggtgtc tccgacttag
      841 acatctgcga gttcatcgac aactattctc tctctaagaa gggagtcaag gccatgagtc
      901 tcaagcgctc caccatcact gacgctggtc tagaggtgat gctggagcag atgcagggag
      961 tggtgcgtct ggagctgtca ggctgcaacg atttcaccga ggctggcctg tggtccagcc
     1021 tcagtgcccg tatcacctcc ctgagcgtca gtgactgcat caatgtggca gatgatgcaa
     1081 tcgctgccat ctcacaactt ctacccaacc tggcagagct aagccttcag gcctatcacg
     1141 tgactgacac ggccctggcc tacttcacag cacgccaggg ccacagcacc cacacgctgc
     1201 gcctgctttc ctgctgggag ataaccaacc atggggtggt caatgtggtg cacagtctgc
     1261 ccaacctcac ctcactcagc ctctcaggct gctctaaggt cactgatgat ggagtggagc
     1321 ttgtagctga gaacctgcgc aaattgcgca gccttgacct ttcctggtgc cctcggatca
     1381 ccgatatggc actggagtat gtggcctgcg acttgcaccg actggaggag ctcgtgctgg
     1441 acaggtgtgt acgcatcacg gacactggtc tcagctattt gtccaccatg tcgtctctcc
     1501 gcagcctcta cctgcgatgg tgctgccagg tgcaggactt cgggttgaag cacctcttag
     1561 ccatgagaaa tttgcgactc ttgtctctag caggctgccc gctcctaact accaccgggc
     1621 tatctggcct cgtgcaactg caagagctgg aggagctgga gctgaccaac tgccctggag
     1681 ccacacccga gctcttcaag tacttctcgc agcacctgcc gcgctgcctc gtcattgaat
     1741 agcgcaggct tcccgacccg gccgcgggaa ccggccacgc cctgggcagt agcccttctt
     1801 ccatccctgc cggagcatct cttctccgcc ctgcgctgga ggcggggcaa gctgagggaa
     1861 atcccgcccc gtgcctccct tgctcctctg ctcaactgct ccttccctgt ctggggcaag
     1921 aggcagaggg gccagcccca cgcacgcacg cacactcggg gactttgtgc atgcccctcg
     1981 tgcccgcact gcacgcccgc cctccaccat gccacagccg ccgccatcac tcgcccgcct
     2041 tctgggggtc taggtccttt tggggatgct ttgagtgcat atgccctcac tggcttcccc
     2101 acttcattct gctctctgcc tcccctcgct gtccccccat cccgggcagg gcccaagggg
     2161 atggagggat tggtccccca ggacttaggg gcctggaaga gcccccaagg gcctcccaca
     2221 tcttccactg caccgcgcct ggagccctcc aaagggtatg aggcgccaca ggccactgcc
     2281 aaagccatgg ccccctgagg agcccaactc cccatgccca cctgacctag tggcttccct
     2341 tcttccttgt tgccatatag gtcagttctt gtcctctgta tcctgcgccc ctacccccgt
     2401 atctccttct ttccccctgg cctacagatc cttgggccct ggccaggttg ggacagcttt
     2461 aggaggacgc agaccttgga acaatcaaca ttagcctaac cggtgcccat ccacctaagt
     2521 gcaagggtgg aataggcacc tggcagaccc caatctggag ccacccacag ggctatcagg
     2581 ccttgggatc agcccaccca tttgagcccc taccccagct gagctcaggc ctctcagcac
     2641 tgtgcttctc cctggatagg tctcctcagg tggaatctgc agagggcctg gccatgagtc
     2701 agggtcagta ctgaccagcg attctgatct cccagtggcc agcaccccct tcacacccca
     2761 gggaaggagg gctccttccc agtcctcctt tagttctccc agcttccaaa acctttgcct
     2821 gcccaaaggg tttgtgacca tgttctgtca ggtctcaaga aatttggaag tcctagggga
     2881 tcctggcata taggtgacaa taccgaggaa gggactggga accttccctc ccaaccttga
     2941 accccaggag acacagcacc cacaactaat cttgggacac ccctatctgg ttggaagaga
     3001 gtaaactaat tcccagagag ccagagggag agagagagag agagagagag agagagagag
     3061 agagagagag agagaggaga gagagagatg ctgttgacga aaagtaaaga ttcaacagcc
     3121 caaagagttc cctgcccctg cagtgttggc cagggaggcc ccaggctgaa gtggtcagga
     3181 gccagatttg tcagcccctc ttcccacagt cccccaacag ggagggggaa gctgtccatt
     3241 tgcccaaagt attaatgcaa ctgaagctgt gatatttcca atgactgtag gaggaaaatt
     3301 taaggggaga gaggaacaca aacaaaacca accaacccct aaaatcattt tcttattgta
     3361 cataacgacc tcattctcct gtatatgcgg aagatataac cttatatttg gtaagtgttt
     3421 cttgtgctat tttatcacgt gacctgttta taaaaatata tattaaaaaa gttgtaaaaa
     3481 ca
//
