LOCUS       NM_133940               4219 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 14 (Fbxl14),
            mRNA.
ACCESSION   NM_133940
VERSION     NM_133940.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4219)
  AUTHORS   Chen,F., Zhang,C., Wu,H., Ma,Y., Luo,X., Gong,X., Jiang,F., Gui,Y.,
            Zhang,H. and Lu,F.
  TITLE     The E3 ubiquitin ligase SCFFBXL14 complex stimulates neuronal
            differentiation by targeting the Notch signaling factor HES1 for
            proteolysis
  JOURNAL   J Biol Chem 292 (49), 20100-20112 (2017)
   PUBMED   29070679
  REMARK    GeneRIF: results suggest that SCF(FBXL14) promotes neuronal
            differentiation by targeting HES1 for ubiquitin-dependent
            proteolysis and that the C-terminal WRPW motif in HES1 is required
            for this process
REFERENCE   2  (bases 1 to 4219)
  AUTHORS   Vinas-Castells,R., Beltran,M., Valls,G., Gomez,I., Garcia,J.M.,
            Montserrat-Sentis,B., Baulida,J., Bonilla,F., de Herreros,A.G. and
            Diaz,V.M.
  TITLE     The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for
            proteasome degradation
  JOURNAL   J Biol Chem 285 (6), 3794-3805 (2010)
   PUBMED   19955572
  REMARK    GeneRIF: Data show that Twist1 small interfering RNA prevents
            hypoxia-induced Fbxl14 down-regulation and SNAIL1 stabilization.
REFERENCE   3  (bases 1 to 4219)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   4  (bases 1 to 4219)
  AUTHORS   Das,T., Purkayastha-Mukherjee,C., D'Angelo,J. and Weir,M.
  TITLE     A conserved F-box gene with unusual transcript localization
  JOURNAL   Dev Genes Evol 212 (3), 134-140 (2002)
   PUBMED   11976951
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126607.7.
            
            On Mar 21, 2009 this sequence version replaced NM_133940.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK084506.1, AK036124.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4219              AC126607.7         117354-121572
FEATURES             Location/Qualifiers
     source          1..4219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 56.86 cM"
     gene            1..4219
                     /gene="Fbxl14"
                     /gene_synonym="Fbx14l"
                     /note="F-box and leucine-rich repeat protein 14"
                     /db_xref="GeneID:101358"
                     /db_xref="MGI:MGI:2141676"
     exon            1..4219
                     /gene="Fbxl14"
                     /gene_synonym="Fbx14l"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1395
                     /gene="Fbxl14"
                     /gene_synonym="Fbx14l"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 14"
                     /protein_id="NP_598701.2"
                     /db_xref="CCDS:CCDS20475.1"
                     /db_xref="GeneID:101358"
                     /db_xref="MGI:MGI:2141676"
                     /translation="METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSV
                     WRGVEAKLHLRRANPSLFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYN
                     LTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTG
                     LLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDL
                     SLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAM
                     GSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVRQMHGLRT
                     LNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPCLKVLNLGLWQ
                     MTDSEKVR"
     polyA_site      2967
                     /gene="Fbxl14"
                     /gene_synonym="Fbx14l"
                     /note="major polyA site"
     regulatory      3177..3182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl14"
                     /gene_synonym="Fbx14l"
                     /note="hexamer: TATAAA"
     polyA_site      3202
                     /gene="Fbxl14"
                     /gene_synonym="Fbx14l"
                     /note="major polyA site"
     regulatory      3220..3225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl14"
                     /gene_synonym="Fbx14l"
                     /note="hexamer: AATGAA"
     polyA_site      3226
                     /gene="Fbxl14"
                     /gene_synonym="Fbx14l"
     polyA_site      3252
                     /gene="Fbxl14"
                     /gene_synonym="Fbx14l"
ORIGIN      
        1 gcggccgcgc gggggcggga agggcggcag gaaggaagcg ccgctcggac gcgccgggag
       61 gaggagcggc ggcccggccg gaaggcgggg aggggcggcc gttggcccgc ggcgggccgc
      121 tctcggcgcc tcccggggcg gcggcggcgc ccgcgcctcc tgcacccggc gcggcgtagc
      181 ggcgggagga agatggagac ccacatctcg tgcctgttcc ccgagctgct ggccatgatc
      241 ttcggctact tggacgtccg agacaagggt cgcgcggcgc aggtgtgcac ggcctggcgg
      301 gacgccgcct accacaagtc ggtgtggcgg ggcgtggagg ccaagctgca cctgcgccgg
      361 gcgaacccgt cgctgttccc cagcctgcag gcccggggca tccgccgcgt gcagatcctc
      421 agcctccgcc gcagcctcag ctacgtgatc cagggcatgg cgaacatcga gagcctcaac
      481 ctcagcggct gctacaacct caccgacaac ggcctgggcc acgcgttcgt gcaggagatc
      541 ggctcgctgc gcgctctcaa cttgagcctt tgcaagcaga tcaccgacag cagcctgggc
      601 cgcatagccc agtacctcaa gggcctggag gtgctggagc tggggggctg cagcaacatc
      661 accaacaccg gccttctgct cattgcctgg gggctgcagc gcctcaagag ccttaatctc
      721 cgcagctgtc gccacctctc ggatgtgggc atcgggcacc tggccggcat gacgcgcagc
      781 gctgccgagg gctgcctggg cctggagcag ctcactcttc aggactgcca gaaactcacg
      841 gatctttccc tgaagcacat ctcgcgaggg ctgacgggcc tccggctcct caacctcagc
      901 ttctgcggcg gcatctcgga cgcgggcctt ctgcacctgt cgcacatggg cagcctgcgc
      961 agcctgaacc tgcgctcctg cgacaacatc agcgacaccg gcatcatgca tctggccatg
     1021 ggcagcctgc gcctttccgg tctggatgtg tcgttctgtg acaaggtggg agatcagagt
     1081 ctggcgtaca tagcccaggg actggacggc ctcaagtccc tctccctttg ctcttgccat
     1141 atcagtgacg atggcatcaa ccgcatggtg cggcagatgc acgggctgcg cacgctcaac
     1201 attggacagt gtgtgcgcat cacggacaag ggcctggagc tgatcgctga gcacctgagc
     1261 cagctcacgg gcatagatct gtacggctgc accaggatca ccaagcgcgg cctggagcgc
     1321 atcacgcagc tgccctgcct caaggtactt aacctgggac tttggcagat gacggacagt
     1381 gagaaggtca ggtgagggcg gcagttccag ttcccccgcc ccgccctgtt catcccagga
     1441 ccaccactgt tccgcacact cacgcgcgca cttacacgtt cagggcagtg gccgcggtgg
     1501 ggcgatgacg gaagcctggg ctctcttctc ctagtctggc gcccctctcc actgcgtctg
     1561 gagttgttct gctccctcta cccactctcc tttcccagtg aggggagaga tggaccctgc
     1621 tgtttctctg cccactcttc tgcagggtat ggagactttc agccaccgac aactgtatcc
     1681 tggggcactg catttggaaa tggggtgggg gcggggaggg actagtcgtt tcaaccccga
     1741 ggagttgagg aaagatgcct gccttcactt acactttcat ttggatactg tgatctggct
     1801 tttaattcca aacgtgtaga aagcaagccc gacttgaaca gccttctcat ccactttgta
     1861 gccagtctcc tctcatcgct gcccctttgg tatctgcaac tcacttcggt tctggttttg
     1921 ttcttgttct gtttttttgt tttgtttttt atctgcttcc tttttagttt tcaaagaaat
     1981 ttgaaatcat tgttcttttt tctttctgct gagtatattc tcatatatat atatatatat
     2041 atatgtgtgt gtgtgtgtgt gtatgtatat atatatatgt ctggctacct cgttttagtt
     2101 tacttttttc tcttaagccc tggaattcta caagagagat attttgagat tgaaacattt
     2161 ttgtgcctag actggaaaga tgcccactgg gtttgtatct gtttttggtt ttggcttctt
     2221 cccaacctcc ctgtacccaa tgtgccccac ttccgcatcc tggctacgac cccacccccc
     2281 accccacccc cagtctattg ggctttgatg acccaaccat gtttctatat tgatttaatt
     2341 tatagcacaa atgtatggga gaaatgagag cagaatttcc tttttgtttg tttgtttgag
     2401 atgcagattt gagtcttgaa gaggagtatt atatatgcaa attatgcccc accccaaccc
     2461 tcttgcaagt cttcccaccg agaggttagc tagtgaggct gttagctagt gaggcttccc
     2521 gtcctgtcgg ggagtgagcc gtgtcagcag agagcctgag gctatgtgaa tgaagggagg
     2581 aggctgaact tcatgtcctg tctgagttct gttctcgaaa cgggagcttg tgggtttgaa
     2641 aacttttgtt tctaaatgga ggaatagatg actttatttt ggtggggggt tgggactgtg
     2701 gctttaaaac aaatcgcttt tgagtaggat gtatattttt gttggatatt ttgtttgttt
     2761 atttttttag agtcctccac agcaacatga gagaccatgg agaaacccag agacctttat
     2821 caattaattg tactgtttgt gaatttgtat aaataacaaa gatcctctta aaacgtttat
     2881 attcttacag caaaaggtta aactgatatt tatataataa aagaggaaat atgaagtatg
     2941 tttttgaaaa aaaaagcaca aaatcccccc cttgtatctg tgaattattt ttaaggcatt
     3001 gtgtgtcggg tacatgctca ggtgggaggt gttaggagtg cacagaaact ggaactaagg
     3061 tggagttcag ctggctcatg tgctgtaagt ttatggttga gaatttcttt tgtgtaagat
     3121 ttaccactga catccaaatg ttctgtctct agaaatgtga tcagactgga gagttctata
     3181 aattttggtt ttaaactgtc aacatggaaa ctgaaagaaa atgaaacttt tttttttttt
     3241 taagagacca gacttggaag agtcagagtg gccagtttct ttttgggaat ggtggtggta
     3301 gaggtgagat ccagggtaac tgtgaagaag ccggtcctga gctctggaaa tgcgagagta
     3361 ggaggggtgt cctcacattg ggtgcacagt gagggacacg cagtaagacg cagagggagc
     3421 cagccattgt tccggggaag ttgaaagtgc tgtcctagct ggctggccca gtcctgcgtg
     3481 ctcctgtgtg tgtgcaggtc cagcggaagg gggcagcagt gctctttaac atcccccttc
     3541 aggcctgcct gcatgcagac cctttgctgg ggcttagact ggtcaaagtt aaggcacact
     3601 ttcgtttgga gcccttctag tgcccaggct ggccactgag ccattggtaa gggtacaggc
     3661 tggattaagg gcggatagat ggataccagc aatgttagca tagttctcct acatagacaa
     3721 gcagcactgt gacttctgta agccgaggga cagaggcggg agtgagcgag tcgcagccct
     3781 gggttcacgt tggtgggctt tgtttctgag gtcactttct ccactagaaa cccaggtttc
     3841 ctaggtcaac ccatctttcc taggtcaacc catctttccc ggcagacagc tggaacccag
     3901 gttgttgcag ggtgtgacgg tcctgtacac tttctaagct ttaagcctga acaacagaaa
     3961 agctgtgccg ttcctttctc aagtcaccaa aacctgctct gagtcccaca ctagatctat
     4021 cttccctttc tttagggaca atacagattt ctattcccta aagacaaagc atgcaacaac
     4081 aaaaagtagg aatcctggag agcagtctga atcaggcctg cttcctagga atctcaccca
     4141 gctcccaggg tcccgctgtg gtccggtctg taagtcacgc cgcgatacca gtctccatcg
     4201 gataagcaaa taatcccac
//
