LOCUS       NM_001199632            2655 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 13 (Fbxl13),
            transcript variant 1, mRNA.
ACCESSION   NM_001199632
VERSION     NM_001199632.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2655)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2655)
  AUTHORS   Morohoshi,A., Miyata,H., Shimada,K., Nozawa,K., Matsumura,T.,
            Yanase,R., Shiba,K., Inaba,K. and Ikawa,M.
  TITLE     Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is
            required for sperm flagellum formation and male fertility in mice
  JOURNAL   PLoS Genet 16 (1), e1008585 (2020)
   PUBMED   31961863
  REMARK    GeneRIF: Deletion of Fbxl13 has no observable effect on sperm
            function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2655)
  AUTHORS   Castaneda,J.M., Hua,R., Miyata,H., Oji,A., Guo,Y., Cheng,Y.,
            Zhou,T., Guo,X., Cui,Y., Shen,B., Wang,Z., Hu,Z., Zhou,Z., Sha,J.,
            Prunskaite-Hyyrylainen,R., Yu,Z., Ramirez-Solis,R., Ikawa,M.,
            Matzuk,M.M. and Liu,M.
  TITLE     TCTE1 is a conserved component of the dynein regulatory complex and
            is required for motility and metabolism in mouse spermatozoa
  JOURNAL   Proc Natl Acad Sci U S A 114 (27), E5370-E5378 (2017)
   PUBMED   28630322
REFERENCE   4  (bases 1 to 2655)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2655)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB614373.1, BC145291.1 and CO797010.1.
            
            Transcript Variant: This variant (1) is the longer transcript and
            it encodes the longer protein (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145291.1, SRR5189685.195845.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                BB614373.1         2-93
            93-2607             BC145291.1         19-2533
            2608-2655           CO797010.1         628-675
FEATURES             Location/Qualifiers
     source          1..2655
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 9.83 cM"
     gene            1..2655
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /note="F-box and leucine-rich repeat protein 13"
                     /db_xref="GeneID:320118"
                     /db_xref="MGI:MGI:2443416"
     exon            1..144
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..2541
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     F-box/LRR-repeat protein 13; dynein regulatory complex
                     subunit 6"
                     /codon_start=1
                     /product="F-box and leucine-rich repeat protein 13 isoform
                     a"
                     /protein_id="NP_001186561.1"
                     /db_xref="GeneID:320118"
                     /db_xref="MGI:MGI:2443416"
                     /translation="MASLRSATPRLRSYFRDKYIPQICEALLCGLLVTCPEDPLKYLE
                     HMILAIIKRGLENLLWDTCIHPSLKSRVRRLSETYLDELFGLDDQLVTPELMIKACTF
                     YTGHLVKTHFSGWKKVAIPRANQEEIMAEKMDKAIAHDNFRCQKYIFNRWFAYTVMSR
                     ERLITTLLRLRHLFYMQRQRIILAKWKERARHKSKTREDDLISKHELQLKKWKFKLGK
                     PISLEGSLSDIAVENRRIAFDISVLPEQAILQIFLYLTFKDMMACSRVNRSWMAMIQR
                     GSLWNSIDFSTVKNIADKCVVTTLQKWRLNVLRLNFRGCDFRTKTLKAVSHCKNLQEL
                     NVSDCQSFTDESMRHISEGCPGVLYLNLSNTTITNRTMRLLPRYFHNLQNLSLAYCRK
                     FTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRNIASSCTGIVHLTINDMPTLTDN
                     CVKVLVEKCPRISSVVLIGSPHISDSAFKALSSCDLKKIRFEGNKRISDACFKSIDRN
                     YPGINHIYMVDCKGLTDSSLKSLSLLKQLTVLNLTNCIRIGDIGLKHFFDGPASIRLR
                     ELNLTNCSLLGDSSVIRLSERCPNLHYLNLRNCEHLTDLAIEYIASMLSLISVDLSGT
                     LISNEGMTILSRHRKLREVSVSDCVNITDFGIRAYCKTSLLLEHLDVSYCSQLTDDII
                     KTIAIFCTRITSLNIAGCPKITDAGMEILSARCHYLHILDISGCIQLTDQIIQDLQIG
                     CKQLRILKMQFCKSISPAAAQKMSSVVQHQEYNSDNPPHWFGYDSEGNPLDKIHSRVQ
                     LRTYSKLIVKEPFSIDEEDPDSKHQ"
     exon            145..248
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            249..339
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            340..407
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            408..562
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            563..672
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            673..819
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            820..915
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1045
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1098
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1199
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1329
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1428
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1546
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1709
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1829
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1956
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2040
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2175
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2339
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2630
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2630
                     /gene="Fbxl13"
                     /gene_synonym="4921539K22Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgtctc tcctcctcaa cgtgaacagc agtaacctat gaaacgcatt ctgagtcctg
       61 cttctgacca tggcttcact acgcagtgcc acccccaggc taaggagcta cttcagggac
      121 aagtacattc ctcaaatctg tgaggcgctg ttatgtggtt tacttgtgac atgtcctgag
      181 gacccactga aatatttaga gcacatgatc ctagctatca ttaaaagagg tctggaaaac
      241 cttctttggg acacgtgcat ccatccatca ctgaagtcaa gagttcgaag actgtctgaa
      301 acttacttgg atgaactttt tggactggat gaccagctgg tgactccaga gttgatgata
      361 aaagcatgca cattttacac tggacattta gtaaagacac atttcagtgg ttggaaaaaa
      421 gttgcaatac ctcgtgcaaa tcaagaggag atcatggctg aaaaaatgga caaggcaata
      481 gcacatgaca attttagatg ccaaaaatac atttttaatc gctggttcgc ctacacggtt
      541 atgagtagag aaagacttat aactacactg cttcggttgc gacatttgtt ctatatgcaa
      601 agacaaagaa ttatactagc aaaatggaag gagagagcca gacacaagag taaaacaaga
      661 gaagacgact tgatttcaaa acatgaactt cagttgaaaa aatggaagtt caagttaggg
      721 aagccgatta gccttgaggg gagcctctct gacatcgctg ttgagaacag gcgcatagca
      781 tttgacattt cagtgctacc ggagcaagca atactccaga ttttcttgta cctcaccttt
      841 aaagacatga tggcgtgcag tcgagtcaac cgctcctgga tggcgatgat tcagagaggc
      901 tccttgtgga actctattga tttttccaca gttaaaaaca ttgcagataa atgtgtggtg
      961 accactttac aaaagtggcg gctaaacgtg ctgcgtttaa acttccgagg ctgcgacttc
     1021 cgaacaaaaa ccttgaaagc tgtcagccac tgtaaaaact tgcaagagtt gaacgtctct
     1081 gactgccagt ctttcacaga tgaatccatg aggcacattt ctgagggctg tcctggggtc
     1141 ctgtatctca atctatccaa cacaaccatc accaacagga ccatgcgact cctacccagg
     1201 tacttccaca acttacagaa cctcagtctg gcttactgcc gaaagttcac cgacaaaggc
     1261 ttacagtacc tgaacttggg gaacggatgc cacaagctca tctatctgga cctttccggc
     1321 tgcacccaga tctcagtcca aggcttcagg aacatcgcca gcagctgcac ggggattgtg
     1381 caccttacta tcaacgacat gcccactctg acggacaact gcgtaaaagt tttggttgag
     1441 aagtgtcccc gtatttcgtc ggtggtttta attggttcac cacacatctc tgactctgct
     1501 ttcaaagctc tttcctcctg cgacctcaaa aagattcgat ttgaaggaaa caaaaggatt
     1561 tctgatgcgt gctttaagtc gatagacagg aattatccag gcatcaatca catttacatg
     1621 gtggactgca aagggctaac agacagcagc ctcaagtcac tttcactttt gaagcaattg
     1681 acagtgttga acttgacaaa ttgcataagg attggtgata tcggcctgaa gcattttttt
     1741 gatggtcctg cgagtatcag gctaagagag ctcaatttga ctaactgctc actgctgggc
     1801 gattcctctg tcatcagact gtcagagcgt tgccctaatt tacactactt gaatttacga
     1861 aattgtgaac atctgactga cttggcaatt gaatatattg caagcatgtt atccttgata
     1921 tcagtagatc tttctggaac actcatctca aatgagggca tgaccatact ttccagacac
     1981 agaaaactga gggaagtttc tgtgtctgac tgtgtcaaca tcactgactt tggaattcgg
     2041 gcatactgca aaacctcgct gttgttggaa cacttggacg tctcctactg ctcccaactg
     2101 acagatgaca tcataaagac tatagccatt ttctgtactc gaattacatc tcttaacatc
     2161 gctggatgcc caaagattac cgatgcaggg atggagatat tatctgcaag gtgccattat
     2221 ctgcacattt tggatatctc tggctgtatc caacttacag accagatcat tcaggacctt
     2281 caaataggct gcaaacaact ccggatcctc aagatgcaat tctgcaagtc catctctccg
     2341 gcagcggctc agaaaatgtc ctctgtggtc cagcatcagg aatacaactc cgacaaccct
     2401 ccacattggt ttggctacga ctctgaaggc aaccctcttg acaagattca tagtcgagta
     2461 caacttagaa cttactcaaa actgatagtc aaagagccat tcagcatcga cgaggaggat
     2521 ccagactcca aacaccaata ggaaaacaaa acatctacaa caatttccct tcatttgatg
     2581 taaatattgt gagttgctgg ttctcaataa caatgtcaaa aagcagtgca aaaaaaaaaa
     2641 aaaaaaaaaa aaaaa
//
