LOCUS       NM_013911               2126 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus F-box and leucine-rich repeat protein 12 (Fbxl12),
            transcript variant 1, mRNA.
ACCESSION   NM_013911
VERSION     NM_013911.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2126)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2126)
  AUTHORS   Zhao,B., Yoganathan,K., Li,L., Lee,J.Y., Zuniga-Pflucker,J.C. and
            Love,P.E.
  TITLE     Notch and the pre-TCR coordinate thymocyte proliferation by
            induction of the SCF subunits Fbxl1 and Fbxl12
  JOURNAL   Nat Immunol 20 (10), 1381-1392 (2019)
   PUBMED   31451788
REFERENCE   3  (bases 1 to 2126)
  AUTHORS   Nita,A., Nishiyama,M., Muto,Y. and Nakayama,K.I.
  TITLE     FBXL12 regulates T-cell differentiation in a cell-autonomous manner
  JOURNAL   Genes Cells 21 (5), 517-524 (2016)
   PUBMED   26999371
  REMARK    GeneRIF: Study investigated the role of FBXL12 in T-cell
            development by examination of FBXL12-null mice, finding that the
            FBXL12-ALDH3 axis plays a key role in regulation of the positive
            selection of T cells.
REFERENCE   4  (bases 1 to 2126)
  AUTHORS   Nishiyama,M., Nita,A., Yumimoto,K. and Nakayama,K.I.
  TITLE     FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast
            Differentiation During Placental Development
  JOURNAL   Stem Cells 33 (11), 3327-3340 (2015)
   PUBMED   26124079
REFERENCE   5  (bases 1 to 2126)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   6  (bases 1 to 2126)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164565.1, AI430452.1, AF313405.1, AK030910.1 and AK031262.1.
            
            On Nov 8, 2013 this sequence version replaced NM_013911.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054471.1, AF176525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC164565.1         54553-54667
            116-512             AI430452.1         1-397
            513-1498            AF313405.1         1-986
            1499-2086           AK030910.1         1469-2056
            2087-2126           AK031262.1         4143-4182
FEATURES             Location/Qualifiers
     source          1..2126
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.59 cM"
     gene            1..2126
                     /gene="Fbxl12"
                     /gene_synonym="3110048D16Rik; Fbl12"
                     /note="F-box and leucine-rich repeat protein 12"
                     /db_xref="GeneID:30843"
                     /db_xref="MGI:MGI:1354738"
     exon            1..603
                     /gene="Fbxl12"
                     /gene_synonym="3110048D16Rik; Fbl12"
                     /inference="alignment:Splign:2.1.0"
     CDS             518..1498
                     /gene="Fbxl12"
                     /gene_synonym="3110048D16Rik; Fbl12"
                     /note="isoform a is encoded by transcript variant 1; F-box
                     protein containing leucine repeats 12; F-box/LRR-repeat
                     protein 12; F-box protein FBL12"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 12 isoform a"
                     /protein_id="NP_038939.2"
                     /db_xref="CCDS:CCDS22880.1"
                     /db_xref="GeneID:30843"
                     /db_xref="MGI:MGI:1354738"
                     /translation="MATLFDLPDLVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLW
                     RHVDLTLYTMRPKVMWHLLRRYMASRLYSLRMGGYLFSGSQAPQLSPALMRALGQKCP
                     NLKRLCLHVADLSMVPITSLPSTLRTLELHSCEISMIWLQKEQDPTVLPLLECIVLDR
                     VPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDASLQELSYLQRLEVLGCTLSADS
                     TLLAISRHLRDVRKIRLTVGGLSAQGLVFLEGMPVLESLCFQGPLITPDMPTPTQIVS
                     SCLTMPKLRVLEVQGLGWEGQEAEKILCKGLPHCIVIVRACPKESMDWWM"
     exon            604..676
                     /gene="Fbxl12"
                     /gene_synonym="3110048D16Rik; Fbl12"
                     /inference="alignment:Splign:2.1.0"
     exon            677..2126
                     /gene="Fbxl12"
                     /gene_synonym="3110048D16Rik; Fbl12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2068..2073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl12"
                     /gene_synonym="3110048D16Rik; Fbl12"
                     /note="hexamer: AAGAAA"
     regulatory      2074..2079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbxl12"
                     /gene_synonym="3110048D16Rik; Fbl12"
                     /note="hexamer: AATAAT"
     polyA_site      2089
                     /gene="Fbxl12"
                     /gene_synonym="3110048D16Rik; Fbl12"
                     /note="major polyA site"
     polyA_site      2108
                     /gene="Fbxl12"
                     /gene_synonym="3110048D16Rik; Fbl12"
ORIGIN      
        1 cttcagcctt ctggatttgc tgttagcctt cctcttggcc ctggccacgc ctcgtgcccc
       61 ctcctccacc aagccacatc caggttttcc tagagtcacg ccttctgggt tgtctgcgga
      121 ccccttttgg gtttgctgct tatacttagc tccaccttat ggccacgccc ccgaggcact
      181 cgtcacctcc agccttctgg gtttgctgtt cgtcttcctc ttggccctgg ccacgcctcg
      241 tgccccctcc tctcccaagc cacatccagg ttttcctatt tccagttcca tccgctagcc
      301 aagccagtca ggcctagtca gtctctagtc ttgacctcta aacggtcgtc agcccgcgcc
      361 tgtccagtcc cggggcctcg ggcactttcc tagaaaagta gggattctcg gcgggcctct
      421 gaaagtcgcg ccggtttggc cagtccgacc accccagcgc tgtccaggga acgcggcctc
      481 gccgccaccg gaaacggaag cgtgcgacag ctggaccatg gcgactctgt ttgacctccc
      541 agacttggtg ctcttggaga tcttctctta cctccctgtc cgggaccgga tccgcatctc
      601 cagggtctgt caccgctgga agaggctagt ggatgaccgg tggctatggc gacacgtcga
      661 cctgacgctc tacacgatgc ggccgaaagt catgtggcac ctcctgcgcc ggtacatggc
      721 gtcccggctc tactcgttgc gcatgggcgg ctacctgttt tctggctctc aggccccaca
      781 gctgtccccc gccttgatga gggccctggg tcagaaatgc cccaatctga agcgcctgtg
      841 cctgcacgtg gctgacctga gcatggtgcc tatcaccagc cttcctagca cactgaggac
      901 cctggagctg cacagctgcg aaatctccat gatctggttg cagaaagagc aggaccccac
      961 ggtgctgcct ctgctggaat gcatcgtgct ggaccgagtg ccggcctttc gcgatgagca
     1021 tctgcagggc cttacccgat tccgagccct gcgctcgctg gtgctgggcg gcacctaccg
     1081 ggtcactgag accgggctag atgccagcct gcaggagctc agctacctgc aaaggcttga
     1141 ggtgctgggc tgcaccctgt cagctgacag cacgctgctg gccatcagcc gccaccttcg
     1201 agatgtgcgc aagattcggc tgaccgttgg gggcctctca gcccagggcc tggtcttcct
     1261 ggagggaatg cctgtcctgg agagtttgtg cttccagggt ccccttatca ccccagacat
     1321 gcccacaccc actcagattg tgtcctcctg cctcaccatg ccgaagctca gagtgcttga
     1381 ggtgcaaggg ctgggctggg agggtcagga agcagagaaa atcctgtgca agggcctgcc
     1441 ccactgcata gttattgtta gggcttgtcc caaagaatcc atggattggt ggatgtgagg
     1501 gcatcaccca tccatctctg gaacctagcc tagcttggag agtgacctta taagcaaact
     1561 gaagcatgta aattcatcag gcgtgaggga actggaggtg tcaaggaaag gaagctagga
     1621 ccttggggct tcctgagctg gggttatctg taatctgggt cacctcagac ttgtcatcaa
     1681 gcctctggaa gaccccgttc acacatttag gaataggcat catagctacc tcatgattca
     1741 ttttaaaatc tttaacaccc cttcccctct ttcttttcca gtacctggga ctcaaaccca
     1801 tggccttagg tctggtagag aagcactgct gtgctgctga gccaccccag agaccttaga
     1861 gagggctcat tttcaagtgg aggtgtgtgg agttcagggc tccgaggttg gcctggtttt
     1921 ctacatacat ggttgagagg catagagggc aggggcaagg gagcatgctg ttggattgtc
     1981 ctagttttct agaaggttct cagtcatatt tactgtattt tgtatcctgt ctttttcaag
     2041 ttttctacag catatatttt actattaaag aaaaataatg tttttcaaag tgtgttgcac
     2101 ttatttaaca agagttgttc cttgcc
//
