LOCUS       NM_007994               1325 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus fructose bisphosphatase 2 (Fbp2), mRNA.
ACCESSION   NM_007994
VERSION     NM_007994.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1325)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1325)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. doi:
            10.1038/s41586-023-06316-w.. PMID: 37322272]
REFERENCE   3  (bases 1 to 1325)
  AUTHORS   Duda,P., Budziak,B. and Rakus,D.
  TITLE     Cobalt Regulates Activation of Camk2alpha in Neurons by Influencing
            Fructose 1,6-bisphosphatase 2 Quaternary Structure and Subcellular
            Localization
  JOURNAL   Int J Mol Sci 22 (9), 4800 (2021)
   PUBMED   33946543
  REMARK    GeneRIF: Cobalt Regulates Activation of Camk2alpha in Neurons by
            Influencing Fructose 1,6-bisphosphatase 2 Quaternary Structure and
            Subcellular Localization.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1325)
  AUTHORS   Hajka,D., Duda,P., Wojcicka,O., Drulis-Fajdasz,D., Rakus,D. and
            Gizak,A.
  TITLE     Expression of Fbp2, a Newly Discovered Constituent of Memory
            Formation Mechanisms, Is Regulated by Astrocyte-Neuron Crosstalk
  JOURNAL   Int J Mol Sci 21 (18), 6903 (2020)
   PUBMED   32962293
  REMARK    GeneRIF: Expression of Fbp2, a Newly Discovered Constituent of
            Memory Formation Mechanisms, Is Regulated by Astrocyte-Neuron
            Crosstalk.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1325)
  AUTHORS   Duda,P., Wojtowicz,T., Janczara,J., Krowarsch,D., Czyrek,A.,
            Gizak,A. and Rakus,D.
  TITLE     Fructose 1,6-Bisphosphatase 2 Plays a Crucial Role in the Induction
            and Maintenance of Long-Term Potentiation
  JOURNAL   Cells 9 (6), 1375 (2020)
   PUBMED   32492972
  REMARK    GeneRIF: Fructose 1,6-Bisphosphatase 2 Plays a Crucial Role in the
            Induction and Maintenance of Long-Term Potentiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1325)
  AUTHORS   Lee,C.K., Klopp,R.G., Weindruch,R. and Prolla,T.A.
  TITLE     Gene expression profile of aging and its retardation by caloric
            restriction
  JOURNAL   Science 285 (5432), 1390-1393 (1999)
   PUBMED   10464095
REFERENCE   7  (bases 1 to 1325)
  AUTHORS   Cloix,J.F., Beaulieu,E. and Hevor,T.
  TITLE     Various fructose-1,6-bisphosphatase mRNAs in mouse brain, liver,
            kidney and heart
  JOURNAL   Neuroreport 8 (3), 617-622 (1997)
   PUBMED   9106734
REFERENCE   8  (bases 1 to 1325)
  AUTHORS   Nomura,M., Takihara,Y., Yasunaga,T. and Shimada,K.
  TITLE     One of the retinoic acid-inducible cDNA clones in mouse embryonal
            carcinoma F9 cells encodes a novel isoenzyme of fructose
            1,6-bisphosphatase
  JOURNAL   FEBS Lett 348 (2), 201-205 (1994)
   PUBMED   8034042
REFERENCE   9  (bases 1 to 1325)
  AUTHORS   Nomura,M., Takihara,Y. and Shimada,K.
  TITLE     Isolation and characterization of retinoic acid-inducible cDNA
            clones in F9 cells: one of the early inducible clones encodes a
            novel protein sharing several highly homologous regions with a
            Drosophila polyhomeotic protein
  JOURNAL   Differentiation 57 (1), 39-50 (1994)
   PUBMED   8070621
REFERENCE   10 (bases 1 to 1325)
  AUTHORS   Nash,H.R. and Challinor,P.R.
  TITLE     Fructose bisphosphatase isozymes of the mouse. I. Inheritance
  JOURNAL   Biochem Genet 23 (7-8), 499-510 (1985)
   PUBMED   2996484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146946.1.
            
            On Feb 4, 2019 this sequence version replaced NM_007994.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168374.1, AK146946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1325              AK146946.1         24-1348
FEATURES             Location/Qualifiers
     source          1..1325
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.74 cM"
     gene            1..1325
                     /gene="Fbp2"
                     /gene_synonym="Fbp-1; Fbp1; Rae-30"
                     /note="fructose bisphosphatase 2"
                     /db_xref="GeneID:14120"
                     /db_xref="MGI:MGI:95491"
     exon            1..273
                     /gene="Fbp2"
                     /gene_synonym="Fbp-1; Fbp1; Rae-30"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1123
                     /gene="Fbp2"
                     /gene_synonym="Fbp-1; Fbp1; Rae-30"
                     /EC_number="3.1.3.11"
                     /note="D-fructose-1,6-bisphosphate 1-phosphohydrolase 2;
                     FBPase 2; FBPase muscle; muscle FBPase"
                     /codon_start=1
                     /product="fructose-1,6-bisphosphatase isozyme 2"
                     /protein_id="NP_032020.2"
                     /db_xref="CCDS:CCDS36698.1"
                     /db_xref="GeneID:14120"
                     /db_xref="MGI:MGI:95491"
                     /translation="MTDRSPFETDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKA
                     ISSAVRKAGLANLYGISGSVNVTGDEVKKLDVLSNSLVINMLQSSYSTCVLVSEENKE
                     AVITAQERRGKYVVCFDPLDGSSNIDCLASIGTIFAIYRKTTEDEPSEKDALQPGRNI
                     VAAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEKDVRIKKKGKIFSLNEGYAK
                     YFDAATAEYVQKKKFPEDGSEPYGARYVGSMVADVHRTLVYGGIFMYPANQKSPNGKL
                     RLLYECNPVAYIIEQAGGMATTGTQPVLDVKPESIHQRVPLILGSPEDVQEYLSCVQR
                     NQAGR"
     exon            274..436
                     /gene="Fbp2"
                     /gene_synonym="Fbp-1; Fbp1; Rae-30"
                     /inference="alignment:Splign:2.1.0"
     exon            437..529
                     /gene="Fbp2"
                     /gene_synonym="Fbp-1; Fbp1; Rae-30"
                     /inference="alignment:Splign:2.1.0"
     exon            530..670
                     /gene="Fbp2"
                     /gene_synonym="Fbp-1; Fbp1; Rae-30"
                     /inference="alignment:Splign:2.1.0"
     exon            671..808
                     /gene="Fbp2"
                     /gene_synonym="Fbp-1; Fbp1; Rae-30"
                     /inference="alignment:Splign:2.1.0"
     exon            809..928
                     /gene="Fbp2"
                     /gene_synonym="Fbp-1; Fbp1; Rae-30"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1325
                     /gene="Fbp2"
                     /gene_synonym="Fbp-1; Fbp1; Rae-30"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtgcaggt gtgtcttcaa cgagtaggct gtgaggctgc tgccttgaga gagcaaggat
       61 ttctacaagg agcaaaggga ggctttggga tctcatttgc acaatgacgg acagaagccc
      121 ctttgagaca gacatgctga ccctgacccg ttacgttatg gaaaaggggc gacaggccaa
      181 agggaccgga gaactcaccc agctgctcaa ctcgatgctg actgccatca aagccatctc
      241 ttccgcagtg cgcaaggccg gcctggccaa cctgtatggg atttcgggga gcgtgaatgt
      301 gacaggagat gaggtgaaga aactggacgt gctgtccaac tccctggtca tcaacatgct
      361 tcagtcctcc tacagcacct gtgtgctcgt ctccgaagag aataaagagg cggtgatcac
      421 agcccaggag aggaggggga aatatgtggt ttgctttgac cctctggatg gatcttcaaa
      481 cattgactgc ctggcctcca tcggaactat atttgctatt tacagaaaga ccacggagga
      541 tgagccttct gagaaggatg ccttgcagcc tggccgcaac atcgtggctg cgggttatgc
      601 actgtatggt agtgcaaccc tggtcgctct ttccacagga caaggagtag atctcttcat
      661 gctggacccg gctcttggag aattcgtgct agtggaaaaa gatgtccgga ttaagaagaa
      721 agggaaaatt tttagcctca acgagggcta tgccaagtat tttgatgctg ctactgctga
      781 gtatgtacag aaaaagaaat tccccgagga tggcagtgag ccttatggag ccaggtacgt
      841 gggttccatg gtggctgatg tgcatcgcac cttggtctat ggaggaatct tcatgtaccc
      901 agccaaccag aagagtccta atggcaagct ccggctcctg tatgaatgca atcctgtggc
      961 ctatatcatc gagcaagcag gaggtatggc aaccacaggc acccagccag tactggatgt
     1021 gaaacctgag agtattcacc agcgagtccc cctcattctg gggtcccctg aggatgtgca
     1081 agagtatctc agctgtgtgc agagaaacca ggcaggcagg tagtgagcct gaacccatga
     1141 gcccgcttcc ctttgtcttt gtcaattgaa aaactagatg aatgagctat ggagatggga
     1201 ggaaaggcaa agaagtcaag tgacacaggt cacggtcaga acagcgccct gctgctaagg
     1261 acagggttag aagccagggg taaagaaaga tacagtcaaa ggactaaaat aaaaatatga
     1321 atctg
//
