LOCUS       NM_019395               1479 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus fructose bisphosphatase 1 (Fbp1), mRNA.
ACCESSION   NM_019395
VERSION     NM_019395.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1479)
  AUTHORS   Bornstein,M.R., Neinast,M.D., Zeng,X., Chu,Q., Axsom,J.,
            Thorsheim,C., Li,K., Blair,M.C., Rabinowitz,J.D. and Arany,Z.
  TITLE     Comprehensive quantification of metabolic flux during acute cold
            stress in mice
  JOURNAL   Cell Metab 35 (11), 2077-2092 (2023)
   PUBMED   37802078
REFERENCE   2  (bases 1 to 1479)
  AUTHORS   Li,P., Li,K., Yuan,W., Xu,Y., Li,P., Wu,R., Han,J., Yin,Z., Lu,L.
            and Gao,Y.
  TITLE     1alpha,25(OH)2D3 ameliorates insulin resistance by alleviating
            gammadelta T cell inflammation via enhancing
            fructose-1,6-bisphosphatase 1 expression
  JOURNAL   Theranostics 13 (15), 5290-5304 (2023)
   PUBMED   37908738
  REMARK    GeneRIF: 1alpha,25(OH)2D3 ameliorates insulin resistance by
            alleviating gammadelta T cell inflammation via enhancing
            fructose-1,6-bisphosphatase 1 expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1479)
  AUTHORS   Bai,Q., Liu,Y., Wang,C.M., Wang,J.R., Feng,Y., Ma,X., Yang,X.,
            Shi,Y.N. and Zhang,W.J.
  TITLE     Hepatic but not Intestinal FBP1 Is Required for Fructose Metabolism
            and Tolerance
  JOURNAL   Endocrinology 164 (6) (2023)
   PUBMED   36964915
  REMARK    GeneRIF: Hepatic but not Intestinal FBP1 Is Required for Fructose
            Metabolism and Tolerance.
REFERENCE   4  (bases 1 to 1479)
  AUTHORS   Xiong,X., Lai,X., Zhang,J., Meng,Q., Wang,P., Qin,S., Liu,W.,
            Wang,Y., Yao,Z., Wang,D., Li,X., Liu,Z. and Miao,H.
  TITLE     FBP1 knockdown decreases ovarian cancer formation and cisplatin
            resistance through EZH2-mediated H3K27me3
  JOURNAL   Biosci Rep 42 (9) (2022)
   PUBMED   36000567
  REMARK    GeneRIF: FBP1 knockdown decreases ovarian cancer formation and
            cisplatin resistance through EZH2-mediated H3K27me3.
REFERENCE   5  (bases 1 to 1479)
  AUTHORS   Mizuno,H., Koya,J., Masamoto,Y., Kagoya,Y. and Kurokawa,M.
  TITLE     Evi1 upregulates Fbp1 and supports progression of acute myeloid
            leukemia through pentose phosphate pathway activation
  JOURNAL   Cancer Sci 112 (10), 4112-4126 (2021)
   PUBMED   34363719
  REMARK    GeneRIF: Evi1 upregulates Fbp1 and supports progression of acute
            myeloid leukemia through pentose phosphate pathway activation.
REFERENCE   6  (bases 1 to 1479)
  AUTHORS   Allen-Jennings,A.E., Hartman,M.G., Kociba,G.J. and Hai,T.
  TITLE     The roles of ATF3 in glucose homeostasis. A transgenic mouse model
            with liver dysfunction and defects in endocrine pancreas
  JOURNAL   J Biol Chem 276 (31), 29507-29514 (2001)
   PUBMED   11371557
REFERENCE   7  (bases 1 to 1479)
  AUTHORS   Stein,S., Liehr,T. and Eschrich,K.
  TITLE     Characterization of the mouse liver fructose-1,6-bisphosphatase
            gene
  JOURNAL   Gene 264 (2), 215-224 (2001)
   PUBMED   11250076
REFERENCE   8  (bases 1 to 1479)
  AUTHORS   Tillmann,H., Stein,S., Liehr,T. and Eschrich,K.
  TITLE     Structure and chromosomal localization of the human and mouse
            muscle fructose-1,6-bisphosphatase genes
  JOURNAL   Gene 247 (1-2), 241-253 (2000)
   PUBMED   10773464
REFERENCE   9  (bases 1 to 1479)
  AUTHORS   Cloix,J.F., Beaulieu,E. and Hevor,T.
  TITLE     Various fructose-1,6-bisphosphatase mRNAs in mouse brain, liver,
            kidney and heart
  JOURNAL   Neuroreport 8 (3), 617-622 (1997)
   PUBMED   9106734
REFERENCE   10 (bases 1 to 1479)
  AUTHORS   Nash,H.R. and Challinor,P.R.
  TITLE     Fructose bisphosphatase isozymes of the mouse. I. Inheritance
  JOURNAL   Biochem Genet 23 (7-8), 499-510 (1985)
   PUBMED   2996484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171004.2, AK149527.1 and AC156572.3.
            
            [WARNING] On Apr 4, 2024 this sequence was replaced by NM_019395.4.
            
            On Feb 15, 2013 this sequence version replaced NM_019395.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011480.1, AJ132693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC171004.2         111783-111903
            122-1470            AK149527.1         3-1351
            1471-1479           AC156572.3         12851-12859
FEATURES             Location/Qualifiers
     source          1..1479
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.74 cM"
     gene            1..1479
                     /gene="Fbp1"
                     /gene_synonym="Fbp-2; Fbp2; Fbp3"
                     /note="fructose bisphosphatase 1"
                     /db_xref="GeneID:14121"
                     /db_xref="MGI:MGI:95492"
     exon            1..409
                     /gene="Fbp1"
                     /gene_synonym="Fbp-2; Fbp2; Fbp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1256
                     /gene="Fbp1"
                     /gene_synonym="Fbp-2; Fbp2; Fbp3"
                     /EC_number="3.1.3.11"
                     /note="fructose-1,6-bisphosphatase isozyme 3;
                     D-fructose-1,6-bisphosphate 1-phosphohydrolase 1;
                     D-fructose-1,6-bisphosphate 1-phosphohydrolase 3; FBPase
                     liver; liver FBPase"
                     /codon_start=1
                     /product="fructose-1,6-bisphosphatase 1"
                     /protein_id="NP_062268.1"
                     /db_xref="CCDS:CCDS26590.1"
                     /db_xref="GeneID:14121"
                     /db_xref="MGI:MGI:95492"
                     /translation="MANHAPFETDISTLTRFVMEQGRKAQGTGELTQLLNSLCTAIKA
                     ISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEENTN
                     AIIIEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKKSTDEPSEKDALQPGRDL
                     VAAGYALYGSATMLVLAMDCGVNCFMLDPSIGEFIMVDRDVKMKKKGNIYSLNEGYAK
                     DFDPAINEYLQRKKFPPDGSAPYGARYVGSMVADIHRTLVYGGIFLYPANKKSPSGKL
                     RLLYECNPIAYVMEKAGGLATTGDKDILDIVPTEIHQKAPVVMGSSEDVQEFLEIYRK
                     HKAK"
     exon            410..572
                     /gene="Fbp1"
                     /gene_synonym="Fbp-2; Fbp2; Fbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            573..665
                     /gene="Fbp1"
                     /gene_synonym="Fbp-2; Fbp2; Fbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            666..806
                     /gene="Fbp1"
                     /gene_synonym="Fbp-2; Fbp2; Fbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            807..944
                     /gene="Fbp1"
                     /gene_synonym="Fbp-2; Fbp2; Fbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1064
                     /gene="Fbp1"
                     /gene_synonym="Fbp-2; Fbp2; Fbp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1479
                     /gene="Fbp1"
                     /gene_synonym="Fbp-2; Fbp2; Fbp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaggacct tggccagcgg gcagaatggc agttggtaga ggaagggagc aagggggtgt
       61 ttcctgggac aggggggcgg agacctggag actataggct cccccaggac tcaagttcat
      121 tgagtttctg cagacactga acggctttca gtcttcccgc tgtgactatc acctgtgggc
      181 tccacctgcc tgcaccttta gtcagcacct ttagccagca cctgcgccag accccagcaa
      241 tggcgaacca tgcgcccttc gaaacggata tcagcaccct gacccgcttc gtcatggagc
      301 agggcaggaa ggctcagggc acgggggagt tgacccagct gctgaattcg ctctgcaccg
      361 cgatcaaagc catctcgtct gcggtgcgcc aggcgggcat cgcacagctc tatggtatcg
      421 ctggctcaac caatgtgact ggggatcaag taaagaagct ggacatactt tccaatgacc
      481 tggtgatcaa tatgctgaag tcgtcctacg ctacctgtgt tcttgtgtct gaagaaaaca
      541 caaatgccat cataatcgaa cctgagaaga ggggcaaata tgttgtctgt ttcgatcccc
      601 ttgatggctc atccaacatt gactgccttg tgtccatcgg aaccattttt ggcatttaca
      661 gaaagaaaag tactgatgag ccttctgaga aggatgctct gcagcccggc cgggacctgg
      721 tggcagccgg gtatgcgctc tatggcagtg ccaccatgtt ggtccttgcc atggattgtg
      781 gtgtcaactg cttcatgctg gacccgtcca ttggagaatt cattatggtg gacagggacg
      841 tgaagatgaa gaagaaaggt aacatctaca gccttaatga gggttatgcc aaggactttg
      901 accctgccat caatgagtat ctccagagga aaaagttccc tccggatggt tcagccccct
      961 atggtgcccg gtatgtgggg tccatggtgg ctgatattca ccgcactctg gtatatggag
     1021 ggatcttttt ataccccgcc aacaagaaaa gcccaagtgg aaagctgcgg ctgctgtatg
     1081 agtgcaaccc catagcttat gtcatggaga aggccggtgg gctcgccacc acgggggaca
     1141 aagatatatt agacatcgtt cccaccgaga tccaccagaa ggcaccagtc gtcatggggt
     1201 cctctgaaga tgtgcaggag ttcctggaga tctacaggaa gcacaaagcc aagtgaaggc
     1261 cagccttgcc cctgccccag agcagagctc aagtgacgct actccattct gcatgttgta
     1321 cattcctaga aacaaaccta acagcgtgga tagtttcaca gcttaatgct ttgcaatgcc
     1381 caaggtcact tcatcctcat gctataatgc cactgtatca ggtaatatat attttgagta
     1441 ggtgaaggag aaataaacac atctttcctt tataaatta
//
