LOCUS       NM_010181              10480 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus fibrillin 2 (Fbn2), mRNA.
ACCESSION   NM_010181
VERSION     NM_010181.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10480)
  AUTHORS   Wang,M., Liu,H., Zhang,M., Niu,X., Sun,M., Wang,F., Ni,Y., Hong,T.,
            Zhang,W. and Dang,S.
  TITLE     The secreted protease ADAMTS18 links early isoform transformation
            and maturation of glomerular basement membrane macromolecules to
            the integrity of the glomerular filtration barrier
  JOURNAL   Biochem Biophys Res Commun 750, 151386 (2025)
   PUBMED   39879696
REFERENCE   2  (bases 1 to 10480)
  AUTHORS   Neupane,S., Williamson,D.B., Roth,R.A., Halabi,C.M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     Poglut2/3 double knockout in mice results in neonatal lethality
            with reduced levels of fibrillin in lung tissues
  JOURNAL   J Biol Chem 300 (7), 107445 (2024)
   PUBMED   38844137
REFERENCE   3  (bases 1 to 10480)
  AUTHORS   Wang,L., He,L., Yi,W., Wang,M., Xu,F., Liu,H., Nie,J., Pan,Y.H.,
            Dang,S. and Zhang,W.
  TITLE     ADAMTS18-fibronectin interaction regulates the morphology of liver
            sinusoidal endothelial cells
  JOURNAL   iScience 27 (7), 110273 (2024)
   PUBMED   39040056
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10480)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 10480)
  AUTHORS   Jacobson,K.R., Saleh,A.M., Lipp,S.N., Tian,C., Watson,A.R.,
            Luetkemeyer,C.M., Ocken,A.R., Spencer,S.L., Kinzer-Ursem,T.L. and
            Calve,S.
  TITLE     Extracellular matrix protein composition dynamically changes during
            murine forelimb development
  JOURNAL   iScience 27 (2), 108838 (2024)
   PUBMED   38303699
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10480)
  AUTHORS   Ramirez,F.
  TITLE     Fibrillln mutations in Marfan syndrome and related phenotypes
  JOURNAL   Curr Opin Genet Dev 6 (3), 309-315 (1996)
   PUBMED   8791520
  REMARK    Review article
REFERENCE   7  (bases 1 to 10480)
  AUTHORS   Zhang,H., Hu,W. and Ramirez,F.
  TITLE     Developmental expression of fibrillin genes suggests heterogeneity
            of extracellular microfibrils
  JOURNAL   J Cell Biol 129 (4), 1165-1176 (1995)
   PUBMED   7744963
REFERENCE   8  (bases 1 to 10480)
  AUTHORS   Goldstein,C., Liaw,P., Jimenez,S.A., Buchberg,A.M. and
            Siracusa,L.D.
  TITLE     Of mice and Marfan: genetic linkage analyses of the fibrillin
            genes, Fbn1 and Fbn2, in the mouse genome
  JOURNAL   Mamm Genome 5 (11), 696-700 (1994)
   PUBMED   7873879
REFERENCE   9  (bases 1 to 10480)
  AUTHORS   Li,X., Pereira,L., Zhang,H., Sanguineti,C., Ramirez,F., Bonadio,J.
            and Francke,U.
  TITLE     Fibrillin genes map to regions of conserved mouse/human synteny on
            mouse chromosomes 2 and 18
  JOURNAL   Genomics 18 (3), 667-672 (1993)
   PUBMED   8307578
REFERENCE   10 (bases 1 to 10480)
  AUTHORS   Duchet-Suchaux,M., Le Maitre,C. and Bertin,A.
  TITLE     Differences in susceptibility of inbred and outbred infant mice to
            enterotoxigenic Escherichia coli of bovine, porcine and human
            origin
  JOURNAL   J Med Microbiol 31 (3), 185-190 (1990)
   PUBMED   2179554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102317.7 and AC127358.3.
            
            On Nov 17, 2006 this sequence version replaced NM_010181.1.
            
            Sequence Note: This RefSeq record was created using sequence from
            the reference genome strain C57BL/6J because transcripts from the
            reference strain were not available for the full length of the
            gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               AC102317.7         45920-46294
            376-458             AC102317.7         47164-47246
            459-557             AC102317.7         52002-52100
            558-653             AC102317.7         55141-55236
            654-749             AC102317.7         65510-65605
            750-947             AC102317.7         101889-102086
            948-1073            AC102317.7         106730-106855
            1074-1199           AC102317.7         131505-131630
            1200-1352           AC102317.7         140116-140268
            1353-1565           AC102317.7         141257-141469
            1566-1703           AC102317.7         142462-142599
            1704-1823           AC102317.7         149433-149552
            1824-1949           AC102317.7         150625-150750
            1950-2072           AC102317.7         151745-151867
            2073-2195           AC102317.7         153394-153516
            2196-2348           AC102317.7         159784-159936
            2349-2402           AC102317.7         160611-160664
            2403-2528           AC102317.7         162427-162552
            2529-2654           AC127358.3         464-589
            2655-2774           AC127358.3         6437-6556
            2775-2912           AC127358.3         9688-9825
            2913-2963           AC127358.3         10359-10409
            2964-3089           AC127358.3         10862-10987
            3090-3317           AC127358.3         14294-14521
            3318-3443           AC127358.3         15028-15153
            3444-3572           AC127358.3         18451-18579
            3573-3698           AC127358.3         19215-19340
            3699-3824           AC127358.3         21060-21185
            3825-3947           AC127358.3         21604-21726
            3948-4073           AC127358.3         21880-22005
            4074-4199           AC127358.3         22742-22867
            4200-4322           AC127358.3         25017-25139
            4323-4445           AC127358.3         27504-27626
            4446-4571           AC127358.3         29370-29495
            4572-4694           AC127358.3         31676-31798
            4695-4817           AC127358.3         32657-32779
            4818-4979           AC127358.3         34777-34938
            4980-5048           AC127358.3         35651-35719
            5049-5174           AC127358.3         36182-36307
            5175-5300           AC127358.3         37359-37484
            5301-5453           AC127358.3         38038-38190
            5454-5522           AC127358.3         40854-40922
            5523-5648           AC127358.3         42207-42332
            5649-5774           AC127358.3         42473-42598
            5775-5900           AC127358.3         43083-43208
            5901-6017           AC127358.3         45748-45864
            6018-6146           AC127358.3         46806-46934
            6147-6266           AC127358.3         47521-47640
            6267-6392           AC127358.3         50934-51059
            6393-6545           AC127358.3         51673-51825
            6546-6611           AC127358.3         52868-52933
            6612-6737           AC127358.3         53306-53431
            6738-6857           AC127358.3         54052-54171
            6858-6980           AC127358.3         55164-55286
            6981-7112           AC127358.3         55729-55860
            7113-7238           AC127358.3         63191-63316
            7239-7445           AC127358.3         64595-64801
            7446-7571           AC127358.3         65982-66107
            7572-7694           AC127358.3         67838-67960
            7695-7811           AC127358.3         69943-70059
            7812-7940           AC127358.3         70635-70763
            7941-8060           AC127358.3         72277-72396
            8061-8292           AC127358.3         77250-77481
            8293-8470           AC127358.3         78742-78919
            8471-10480          AC127358.3         80501-82510
FEATURES             Location/Qualifiers
     source          1..10480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 32.15 cM"
     gene            1..10480
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /note="fibrillin 2"
                     /db_xref="GeneID:14119"
                     /db_xref="MGI:MGI:95490"
     exon            1..375
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..8845
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /note="syndatyly ems"
                     /codon_start=1
                     /product="fibrillin-2 precursor"
                     /protein_id="NP_034311.2"
                     /db_xref="CCDS:CCDS37827.1"
                     /db_xref="GeneID:14119"
                     /db_xref="MGI:MGI:95490"
                     /translation="MGRRRRLCLQPYFVWLGCVALWAQGTDGQPQPPPPKTLRPQPPP
                     QQVRPAVAGSEGGFMGPEYRDEGAVAASRVRRRGQQEILRGPNVCGSRFHSYCCPGWK
                     TLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISPTCGAKSIQQCSVRCMNGGTCA
                     DDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFT
                     QVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQD
                     VDECQAIPGLCQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSVIPGVCETGDC
                     SNTVGSYFCLCPRGFVTSTDGSRCIDQRAGTCFSGLVNGRCAQELPGRMAKAQCCCEP
                     GRCWSIGTIPEACPVRGSEEYRRLCLDGLPMGGIPGSSVSRPGGTGSTGNGYGPGGTG
                     FLPIPGDNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVS
                     SYRCECNMGYKQDANGDCIDVDECTSNPCSNGDCVNTPGSYYCKCHAGFQRTPTKQAC
                     IDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGM
                     CINEDGSFKCVCKPGFILAPNGRYCTDVDECQTPGICMNGHCINNEGSFRCDCPPGLA
                     VGVDGRVCVDTHMRSTCYGEIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAK
                     NSAEFHGLCSSGIGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASG
                     RNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDVNECESNPCVN
                     GACRNNLGSFHCECSPGSKLSSTGLICIDSLKGTCWLNIQDNRCEVNINGATLKSECC
                     ATLGAAWGSPCERCELDAACPRGFARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFH
                     CECPEGLTLDGTGRVCLDIRMEHCFLKWDEDECIHPVPGKFRMDACCCAVGAAWGTEC
                     EECPKPGTKEYETLCPRGPGFANRGDILTGRPFYKDINECKAFPGMCTYGKCRNTIGS
                     FKCRCNNGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMM
                     KNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLC
                     RNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCS
                     EGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVN
                     ECDLNPNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCL
                     NVPGSFKCSCREGWVGNGIKCIDLDECANGTHQCSINAQCVNTPGSYRCACSEGFTGD
                     GFTCSDVDECAENTNLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNIC
                     VFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCP
                     PDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEVGVGVSRSSCCCSLGKAWGNP
                     CETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQC
                     ECPQGYYLSEETRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCM
                     DMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC
                     GNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCE
                     DIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGL
                     CVDLQGSYQCICNNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFEL
                     THNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVAL
                     PGSCSPGTCQNLEGSFRCICPPGYEVRSENCIDINECDEDPNICLFGSCTNTPGGFQC
                     ICPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDP
                     CELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCE
                     CPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECTCNEGFEPGPMMNCEDIN
                     ECAQNPLLCAFRCMNTFGSYECTCPVGYALREDQKMCKDLDECAEGLHDCESRGMMCK
                     NLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQS
                     SSSGTECLDNRQGLCFAEVLQTMCQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPG
                     TAQYKKICPHGPGYATDGRDIDECKVMPSLCTNGQCVNTMGSFRCFCKVGYTTDISGT
                     ACVDLDECSQSPKPCNFICKNTKGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQF
                     LCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGF
                     SLDASGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYVQHYQWNQCVDENECSNP
                     GACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCSYGCSNTEGGYLC
                     GCPPGYFRVGQGHCVSGMGFNKGQYLSVDAEAEDDENALSPEACYECKINGYTKKDGR
                     RKRSAQEPEPASAEEQISLESVAMDSPVNMKFNLSGLGSKEHILELVPAIEPLNNHIR
                     YVISQGNEDGVFRIHQRNGLSYLHTAKKKLAPGTYTLEITSIPLYGKKELRKLEEHNE
                     DDYLLGVLGEALRMRLQIQLY"
     exon            376..458
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            459..557
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            558..653
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            654..749
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            750..947
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1073
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1199
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1352
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1565
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1703
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1823
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1949
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2072
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2195
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2348
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2402
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2528
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2654
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2774
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2912
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..2963
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3089
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3317
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            3318..3443
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            3444..3572
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            3573..3698
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3824
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..3947
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4073
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..4199
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            4200..4322
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            4323..4445
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            4446..4571
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            4572..4694
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            4695..4817
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            4818..4979
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            4980..5048
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            5049..5174
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            5175..5300
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            5301..5453
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            5454..5522
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            5523..5648
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            5649..5774
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            5775..5900
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            5901..6017
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            6018..6146
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            6147..6266
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            6267..6392
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            6393..6545
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            6546..6611
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            6612..6737
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            6738..6857
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            6858..6980
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            6981..7112
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            7113..7238
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            7239..7445
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            7446..7571
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            7572..7694
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            7695..7811
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            7812..7940
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            7941..8060
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            8061..8292
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            8293..8470
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     exon            8471..10480
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10460..10465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /note="hexamer: AATAAA"
     polyA_site      10480
                     /gene="Fbn2"
                     /gene_synonym="Fib-2; mKIAA4226; sne; sy"
                     /note="major polyA site"
ORIGIN      
        1 gagccccgcg agctgacgaa gggtggtcag accctgactt tatttttagt gggccgtgcg
       61 gatttggtct ccgacagtgc tctctccgcg ggcctccttc tgtgcgctct tggcgccggc
      121 gatggggaga cggcggcggt tgtgtctcca gccctacttc gtgtggctgg gttgcgtggc
      181 gctctgggcg cagggcacag atggccagcc ccagcctcct ccaccaaaga cgctccggcc
      241 ccagccgccc ccgcaacagg tccgacccgc agtagcgggc tccgaaggtg gcttcatggg
      301 gcctgagtat cgggacgagg gcgcggtagc agcgagccgg gtccgcaggc gaggacagca
      361 ggaaatactc cgagggccca acgtgtgcgg ttctagattc cactcctatt gctgcccagg
      421 atggaagacg ctccctggag gaaatcaatg cattgtcccc atttgcagga acagttgtgg
      481 agatggattc tgttcccgcc ccaacatgtg tacttgttcc agtggacaaa tatccccgac
      541 atgcggagcc aaatcaattc agcagtgtag cgtgaggtgc atgaacggcg ggacctgtgc
      601 agacgaccac tgtcagtgcc agaagggata catcggaact tactgtggac aacctgtctg
      661 tgagaatgga tgccagaacg gggggcgttg tatcggccct aaccgctgtg cttgcgttta
      721 tggattcacc gggccgcagt gcgaaagaga ttacaggaca ggcccgtgtt tcactcaagt
      781 caataatcag atgtgccagg ggcagctgac aggcatcgtc tgcacaaaga cactgtgttg
      841 tgccaccatc ggacgagcct ggggccatcc ttgtgagatg tgtccagccc agcctcagcc
      901 ctgccgccgg ggcttcattc ctaacatccg cactggagca tgtcaagatg ttgacgaatg
      961 ccaggcgatt ccaggactgt gccagggggg aaactgtatc aacacagtgg gctcgtttga
     1021 gtgcagatgc cctgctggtc acaagcagag tgaaaccaca cagaaatgtg aagacattga
     1081 tgagtgcagt gtgattcctg gggtctgtga gactggcgac tgttccaaca ccgtgggaag
     1141 ctatttttgt ctctgtcccc gtggcttcgt aacctcaaca gatggctcgc gttgcattga
     1201 tcagagggct ggaacatgct tctccggcct ggtgaatggc cgttgtgccc aagaactccc
     1261 gggccgaatg gcaaaagctc aatgttgttg tgagcccggc cgttgctgga gcatcgggac
     1321 cattccggag gcctgtcctg tcagaggttc cgaggaatat cgtagactgt gcctggatgg
     1381 tcttccgatg ggtggcattc cagggagctc ggtttctagg cctgggggca cggggagcac
     1441 cggcaatggc tatggccccg gtggaacagg cttcctcccc atccctggag acaatggctt
     1501 ttctccgggt gttgggggag ctggagtagg agctggggga cagggaccca tcatcacggg
     1561 actaacaatt ctcaaccaga caatagacat ctgtaagcac catgccaatc tctgtttgaa
     1621 tggacggtgt atacctactg tttctagcta cagatgcgag tgtaatatgg gctacaagca
     1681 ggatgctaat ggagattgta tagatgttga tgaatgtaca tccaatccct gcagtaatgg
     1741 agattgtgtt aacacacctg gatcctatta ctgtaaatgt cacgctggat tccagaggac
     1801 tcctacgaaa caagcgtgca tcgatatcga tgagtgcatc cagaatggag ttctgtgtaa
     1861 gaatggccga tgtgtgaaca cagatggcag tttccagtgc atttgtaatg ctggctttga
     1921 attaaccaca gacggaaaaa actgtgttga ccatgatgaa tgtacaacga ccaacatgtg
     1981 cttgaatgga atgtgtatca acgaagatgg cagcttcaag tgcgtgtgca agccaggctt
     2041 catcctggct ccaaacggcc gctactgcac agacgtggac gaatgccaga ccccaggaat
     2101 ctgcatgaac gggcactgca tcaacaacga aggatccttc cgctgtgact gtcctcccgg
     2161 cctggctgtg ggtgtggacg gacgtgtatg tgttgacact catatgcgta gcacctgcta
     2221 cggggaaatc aagaaaggag tgtgtgtgcg tccattcccg ggtgcggtga ccaagtctga
     2281 atgctgctgt gctaatccag actatggttt tggagagcct tgccagcctt gccccgctaa
     2341 aaattcagct gagttccatg gcctctgtag cagtggcatc ggcatcactg tggatggaag
     2401 agatattaac gagtgtgcct tggaccctga catatgtgcc aatgggatct gtgaaaacct
     2461 gcgaggcagc taccgctgta actgcaacag tggctatgaa ccagatgcct caggaagaaa
     2521 ttgcattgac attgatgaat gcctggttaa taggctgctt tgtgacaacg gcctatgcag
     2581 aaatacccct ggcagttaca gctgcacgtg tccccctggc tatgtgttcc ggacggagac
     2641 agagacctgc gaagatgtaa atgaatgtga gagcaacccg tgtgtcaatg gagcctgcag
     2701 gaacaacctg ggctctttcc attgcgagtg ctcgcccggc agcaagctca gctccaccgg
     2761 actcatctgc atcgacagcc tgaaaggaac ctgctggctc aacatccagg acaaccgctg
     2821 tgaggtgaac attaatggag ccaccctgaa atccgaatgc tgtgccacac ttggagccgc
     2881 ttgggggagc ccctgtgagc gctgtgagct agatgcagct tgcccaagag ggtttgccag
     2941 gatcaaaggt gtgacttgcg aagacgttaa tgaatgcgag gtgtttcctg gcgtctgtcc
     3001 aaatggacgc tgtgtcaaca gcaaaggctc tttccactgt gaatgccctg aaggtcttac
     3061 tctggatggt accggccggg tgtgtttgga tatccgtatg gagcactgct tcctgaagtg
     3121 ggatgaggat gagtgcatcc accctgtccc tgggaagttc cgcatggacg cctgctgctg
     3181 tgcagtcggg gcagcttggg gcacagagtg tgaagaatgt cctaagcctg gcaccaagga
     3241 atatgagacc ctgtgcccgc ggggcccagg ctttgctaac agaggggaca tcctcactgg
     3301 gcgtccattt tacaaagata tcaacgagtg caaagccttt cctgggatgt gcacctatgg
     3361 gaagtgcaga aacacaattg gaagcttcaa gtgccgttgc aataatggct tcgccctgga
     3421 catggaggaa agaaactgta ctgacattga tgagtgcagg atctcccccg acctctgcgg
     3481 cagcggcatc tgtgtcaaca cgccaggcag ctttgaatgc gagtgctttg agggctacga
     3541 gagcggcttc atgatgatga agaattgcat ggacattgac gaatgtgaac gtaaccctct
     3601 cctttgtagg ggtggcacct gcgtgaacac tgagggaagc tttcagtgtg actgcccact
     3661 gggacacgag ctgtcaccgt cccgtgagga ctgtgtagat attaacgagt gctccttgag
     3721 cgacaacctc tgtagaaatg gcaaatgtgt gaacatgatc ggaacttacc agtgctcttg
     3781 caatcctgga taccaggcca cgccagaccg ccagggctgt acagatatcg acgagtgtat
     3841 gataatgaat gggggctgcg acacccagtg caccaactcc gaaggaagct acgagtgcag
     3901 ctgcagcgag gggtacgcac tgatgccaga cggacggtcg tgcgcagata ttgatgagtg
     3961 tgaaaataac cccgatatct gtgacggcgg ccagtgtacc aacattcctg gggagtatcg
     4021 ctgtctctgt tatgatggct tcatggcttc gatggacatg aagacatgca tcgatgtgaa
     4081 cgagtgtgac ctgaatccca acatctgcat gtttggggaa tgtgagaaca cgaagggctc
     4141 tttcatttgc cactgccagc tgggctactc ggtgaagaag gggaccacag gatgcacaga
     4201 cgtggacgag tgtgagattg gcgcccataa ctgcgacatg cacgcctcat gtctgaatgt
     4261 ccctggaagc ttcaagtgca gctgcagaga aggctgggtg ggaaatggca tcaaatgcat
     4321 tgatctggat gagtgcgcga atggaaccca ccagtgcagc ataaacgccc agtgtgtcaa
     4381 caccccaggc tcctaccggt gcgcctgctc ggagggcttc acgggagatg gctttacttg
     4441 ctcagatgtt gacgagtgtg cggaaaacac aaacctttgt gagaacggcc agtgcctgaa
     4501 tgtcccggga gcttaccgct gcgagtgtga gatgggcttc accccagcct cagacagcag
     4561 gtcctgccaa gatattgatg aatgctcctt ccaaaatatc tgtgtctttg gaacctgtaa
     4621 caacttgccc gggatgtttc actgtatctg tgatgatggt tatgaactgg acaggacagg
     4681 aggaaactgt acagatattg atgagtgcgc agaccccata aactgtgtca atggcctatg
     4741 tgtgaacacg cctggtcgct atgagtgtaa ctgcccgcct gacttccagc tgaaccccac
     4801 tggcgtgggt tgcgttgaca accgcgtggg caactgttac ctgaagtttg gtcctcgagg
     4861 agacgggagt ctgtcctgca acacagaggt cggcgtaggt gtcagtcgct cctcctgctg
     4921 ctgctccctg gggaaggcct ggggaaaccc ctgtgagaca tgccctcctg taaacagcac
     4981 tgagtattat accctgtgtc ctggaggcga aggctttaga cccaacccca tcacaatcat
     5041 cttagaagac attgatgaat gtcaggagtt accagggctc tgccagggtg gaaactgtat
     5101 caacactttt gggagtttcc agtgtgagtg cccacagggt tactacctca gtgaggaaac
     5161 ccgcatctgt gaagatatcg acgagtgctt tgcccatccc ggcgtctgtg gacctggcac
     5221 ctgctacaac accctgggaa attacacttg catttgcccg cctgagtaca tgcaagtcaa
     5281 tggaggacat aactgtatgg acatgaggaa aagcttctgc taccgaagct ataatgggac
     5341 cacatgtgaa aacgagctgc cttttaacgt gacaaagagg atgtgctgct gcacatacaa
     5401 tgtcggcaaa gcctggaaca aaccttgtga gccgtgccca accccaggga cagctgactt
     5461 taagaccata tgtggaaata ttcctggatt cacctttgac attcacacag gaaaagctgt
     5521 tgacattgac gagtgtaaag agattccggg catctgtgca aacggtgtgt gcattaacca
     5581 gatcggtagc ttccgctgcg aatgccccac aggcttcagc tacaacgacc tgctcttggt
     5641 ctgtgaagac atcgatgagt gtagcaacgg cgacaatcta tgccaacgaa acgcggactg
     5701 tatcaacagc cccggcagct accgctgcga gtgtgcggcc ggcttcaaac tctcccccaa
     5761 cggggcctgt gtagatcgca atgaatgctt ggaaattcct aatgtttgca gtcatgggtt
     5821 gtgtgttgat ctgcaaggga gttaccagtg tatctgcaac aatggcttta aggcttctca
     5881 agaccagacc atgtgcatgg atgtcgacga gtgtgagcgg cacccgtgcg gaaacgggac
     5941 ttgtaagaac actgtgggat cctacaactg tctgtgttac cctgggttcg agctcactca
     6001 caacaacgat tgcctagaca tagacgagtg cagctcgttt tttggccagg tgtgcagaaa
     6061 tgggcggtgc ttcaatgaaa tcggctcctt caagtgcctg tgcaacgagg gttacgaact
     6121 gactccagac ggcaaaaact gtatcgatac taatgagtgt gtcgcacttc ctggctcctg
     6181 ttctcctggg acctgtcaga atttggaggg ctccttcagg tgcatctgcc cccctggata
     6241 tgaagtgaga agcgaaaatt gcattgatat aaatgaatgc gatgaggacc ccaacatttg
     6301 cctttttggt tcctgcacca acaccccagg gggcttccag tgcatctgtc cccctggctt
     6361 tgtcttgtct gacaacgggc ggagatgctt cgatactcgc cagagcttct gcttcaccaa
     6421 ctttgaaaac ggaaagtgtt ctgtacccaa agccttcaac accaccaagg caaaatgctg
     6481 ttgcagcaag atgccaggcg agggctgggg ggacccgtgt gagctgtgcc ccaaagatga
     6541 tgaagttgcc ttccaggatc tatgtccata cggccacggg acagtcccta gtcttcatga
     6601 cacacgtgaa gatgtcaatg agtgtcttga gagcccaggc atttgctcaa atggtcagtg
     6661 catcaacact gatggatctt tccgatgtga gtgtccaatg ggctacaacc tggattacac
     6721 tggagtccgg tgtgtggaca ccgacgagtg ctccatcggc aacccctgcg ggaacgggac
     6781 gtgcaccaac gtgatcggga gcttcgaatg cacctgcaat gaaggctttg agccggggcc
     6841 catgatgaac tgcgaagaca tcaacgagtg tgcccagaac ccgctgctct gtgctttccg
     6901 atgcatgaac actttcggat cttatgaatg cacgtgccca gttggctacg ccctcaggga
     6961 agaccaaaag atgtgtaaag atctggacga gtgtgccgag gggctgcacg actgcgagtc
     7021 tagaggcatg atgtgcaaga acctgatcgg caccttcatg tgcatctgcc ccccaggcat
     7081 ggcccgcagg cccgatggcg agggctgtgt agatgagaac gaatgcagga ctaagccagg
     7141 catctgtgaa aatggacgct gcgttaacat cattgggagc tacaggtgtg agtgcaatga
     7201 gggattccag tcgagttcct ccggcactga atgcctcgac aaccgccagg gtctgtgctt
     7261 cgccgaggta ctgcagacaa tgtgtcagat ggcctccagt agccgcaacc tcgtcacaaa
     7321 gtcggagtgc tgctgtgacg gtggccgagg ctggggccac cagtgtgagc tgtgcccact
     7381 tccaggaacc gcccagtaca aaaagatatg tcctcacggc ccaggatacg ccactgatgg
     7441 aagagatatc gatgaatgta aggtgatgcc aagcctctgc actaatggcc agtgcgtcaa
     7501 caccatgggc tccttccggt gcttctgcaa agttggctac accacggaca tcagcggaac
     7561 agcttgtgta gacctcgatg aatgttcgca gtctccaaag ccatgcaact tcatctgcaa
     7621 gaacaccaag ggcagttacc agtgctcctg cccacggggg tacgtcctgc aggaggacgg
     7681 aaagacgtgc aaagacctcg acgaatgtca aaccaaacag cacaactgcc agttcctctg
     7741 tgtcaacacc ctggggggat tcacctgtaa atgtccgccc ggtttcaccc agcatcacac
     7801 ggcttgcatc gataacaatg aatgtgggtc tcagccttcc ctctgtggtg caaaggggat
     7861 ctgtcagaac actcctggga gcttcagctg cgaatgccaa agagggttct ctctggatgc
     7921 ctctgggctg aactgtgaag atgtcgatga gtgtgatggg aatcacaggt gccaacacgg
     7981 ctgccagaat atcctgggag gctatcggtg cggctgcccg cagggctacg tccagcacta
     8041 ccagtggaac cagtgtgttg atgagaatga atgttccaac ccaggtgcct gtggctccgc
     8101 ctcctgctac aacaccctgg ggagttacaa gtgcgcctgc ccctccgggt tctccttcga
     8161 ccagttctcc agcgcctgcc atgatgtgaa tgagtgttcc tcctccaaga acccatgcag
     8221 ctacggctgc tccaacacag aaggcggcta cctctgcggc tgcccaccag ggtacttcag
     8281 agtgggacag ggccactgtg tctcgggaat gggcttcaac aaaggacagt acctgtcggt
     8341 ggatgcggag gcagaggatg acgaaaacgc tctgtcccca gaagcatgct acgagtgcaa
     8401 aatcaatggc tacaccaaga aagatggccg acggaagagg agcgcgcagg agcctgagcc
     8461 cgcctcagcc gaggagcaaa tcagcctgga gagcgtagcc atggacagcc cagtcaacat
     8521 gaagttcaac ctctccggcc ttggctccaa ggagcacatc ctagaactgg tccccgccat
     8581 tgagcccctc aacaaccaca tccgttatgt catctcgcaa gggaacgagg atggcgtctt
     8641 ccgaatccac caaaggaacg ggctcagcta cctgcacacg gccaagaaga agctcgctcc
     8701 cggcacatac acactggaaa tcaccagcat ccccctctat gggaagaagg agctgaggaa
     8761 attggaggag cacaatgagg acgactacct tctgggggtg ctcggggagg ctctccgaat
     8821 gaggttgcag attcagttgt attagccctc tgcagacttg ggccttgggc cccagctcag
     8881 atcccagcac agccggcctt cagaagtgtt tggaacatca ctgactgatt ttgaagagga
     8941 aaaaaaacaa aaacaaacaa acaaacaaac aaaaaaaaaa aaacaaagaa ggccttctat
     9001 tcctttcctt cttcctgatt cagacttcgg aatgttgacc ctcgcaggga aggataattt
     9061 agactctggt atggccaaag atttgagtgc aaaggcaaac atagttactg tattttttat
     9121 ataacttcat ttttaaatat attaaaaaaa aaagcaaacc taaatgttca agagatcagc
     9181 gtatggcact aaatgcacaa aactaatgtg agccttcttc ctgttagcag tctataacac
     9241 tttgggtatt ttgctatagt tgctaattaa aaaaaatata gatgtttatt tattttaatg
     9301 cagtaatata tggagaaatg aacaaactat gtaaacaaaa agggaaactc gcttgttttt
     9361 cttagattta taaatttgag ctatttcttt tagaggtgct ttaaaaaaaa aatccaatac
     9421 attcaagaga tgttttcctt tagtttttcc gccagccctc caactggtgc gcacctgact
     9481 atttcaaaga aagtcttgcg gagctgaatg ggcggtgtaa tcagtaattt aaaaagatgt
     9541 ggaagtcgtt tgatcctgtc caaaggaaat gaaagccaga gcagctccta tgacaatatt
     9601 tcacatcagc agattcgcca ggcaacagga gaggaaacca ctgtagcaaa ataccttgac
     9661 tgcttgtgag accgttagca ttgcaggcca aactgtactg tatttcttcc tcgtaacctc
     9721 aaggacccac acgtgcctcc cacaacacct cattcttacc agggcgtgct gtgcacttgt
     9781 ggtcccctag gcagctgaag aacccgccgt tcctttgagc aggaacacct ggcgttctgt
     9841 cgagtttggt gctgtcgtag attaaatggt gcatttatta tgttcaagct atttcaggat
     9901 tgccatgtgt gcaaacaatc atgccatgca gccaaggaat atatgtcgat gttttttttt
     9961 ttaaacccat ggtttttatt tttattttat tttttagaat tttcattaat actgtagtta
    10021 tacaccatat gcctcatttt atcatagctt attgtgtatg aaatatgttt gtaaaatgaa
    10081 ttgatgttta gtttgcttta gccatttgaa aagatgccac accaggaggt aaccaataag
    10141 agcacagctc cacattcttc tccctggaga acccgttcct ggaagagtga tggaaaccgg
    10201 agatacaaaa tggccaaagc acacaccgtc attcctctcg cacctgtgtt gaccaaagag
    10261 tagtaaccag ttatagccaa tgttttgggg ttttttgttt tgttttgttt cgtttcgttt
    10321 tgtttgtttg tttttaataa ccaaaaagaa aaagagaaac agtgtaaatt tgtaatcaag
    10381 tgtttgtgag gaaaaacgta tgggttttgg ttatgtttgt ttttgtaggt ctatgtatca
    10441 aatatgacac ttttcttgca ataaagctta ttttggggta
//
