LOCUS       NM_007993               9900 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus fibrillin 1 (Fbn1), mRNA.
ACCESSION   NM_007993
VERSION     NM_007993.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9900)
  AUTHORS   Wang,M., Liu,H., Zhang,M., Niu,X., Sun,M., Wang,F., Ni,Y., Hong,T.,
            Zhang,W. and Dang,S.
  TITLE     The secreted protease ADAMTS18 links early isoform transformation
            and maturation of glomerular basement membrane macromolecules to
            the integrity of the glomerular filtration barrier
  JOURNAL   Biochem Biophys Res Commun 750, 151386 (2025)
   PUBMED   39879696
REFERENCE   2  (bases 1 to 9900)
  AUTHORS   Dinesh,N.E.H., Baratang,N., Rosseau,J., Mohapatra,R., Li,L.,
            Mahalingam,R., Tiedemann,K., Campeau,P.M. and Reinhardt,D.P.
  TITLE     Fibronectin isoforms promote postnatal skeletal development
  JOURNAL   Matrix Biol 133, 86-102 (2024)
   PUBMED   39159790
REFERENCE   3  (bases 1 to 9900)
  AUTHORS   Mishra,I., Feng,B., Basu,B., Brown,A.M., Kim,L.H., Lin,T.,
            Raza,M.A., Moore,A., Hahn,A., Bailey,S., Sharp,A., Bournat,J.C.,
            Poulton,C., Kim,B., Langsner,A., Sathyanesan,A., Sillitoe,R.V.,
            He,Y. and Chopra,A.R.
  TITLE     The cerebellum modulates thirst
  JOURNAL   Nat Neurosci 27 (9), 1745-1757 (2024)
   PUBMED   38987435
REFERENCE   4  (bases 1 to 9900)
  AUTHORS   Neupane,S., Williamson,D.B., Roth,R.A., Halabi,C.M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     Poglut2/3 double knockout in mice results in neonatal lethality
            with reduced levels of fibrillin in lung tissues
  JOURNAL   J Biol Chem 300 (7), 107445 (2024)
   PUBMED   38844137
REFERENCE   5  (bases 1 to 9900)
  AUTHORS   Wang,L., He,L., Yi,W., Wang,M., Xu,F., Liu,H., Nie,J., Pan,Y.H.,
            Dang,S. and Zhang,W.
  TITLE     ADAMTS18-fibronectin interaction regulates the morphology of liver
            sinusoidal endothelial cells
  JOURNAL   iScience 27 (7), 110273 (2024)
   PUBMED   39040056
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9900)
  AUTHORS   Romere,C., Duerrschmid,C., Bournat,J., Constable,P., Jain,M.,
            Xia,F., Saha,P.K., Del Solar,M., Zhu,B., York,B., Sarkar,P.,
            Rendon,D.A., Gaber,M.W., LeMaire,S.A., Coselli,J.S., Milewicz,D.M.,
            Sutton,V.R., Butte,N.F., Moore,D.D. and Chopra,A.R.
  TITLE     Asprosin, a Fasting-Induced Glucogenic Protein Hormone
  JOURNAL   Cell 165 (3), 566-579 (2016)
   PUBMED   27087445
REFERENCE   7  (bases 1 to 9900)
  AUTHORS   Longhurst,P.A., Eika,B., Leggett,R.E. and Levin,R.M.
  TITLE     Urinary bladder function in the tight-skin mouse
  JOURNAL   J Urol 148 (5), 1611-1614 (1992)
   PUBMED   1433576
REFERENCE   8  (bases 1 to 9900)
  AUTHORS   Muryoi,T., Andre-Schwartz,J., Saitoh,Y., Daian,C., Hall,B.,
            Dimitriu-Bona,A., Schwartz,R.S., Bona,C.A. and Kasturi,K.N.
  TITLE     Self-reactive repertoire of tight skin (TSK/+) mouse:
            immunochemical and molecular characterization of anti-cellular
            autoantibodies
  JOURNAL   Cell Immunol 144 (1), 43-54 (1992)
   PUBMED   1382866
REFERENCE   9  (bases 1 to 9900)
  AUTHORS   Yao,J. and Eghbali,M.
  TITLE     Decreased collagen mRNA and regression of cardiac fibrosis in the
            ventricular myocardium of the tight skin mouse following thyroid
            hormone treatment
  JOURNAL   Cardiovasc Res 26 (6), 603-607 (1992)
   PUBMED   1451140
REFERENCE   10 (bases 1 to 9900)
  AUTHORS   Green,M.C., Sweet,H.O. and Bunker,L.E.
  TITLE     Tight-skin, a new mutation of the mouse causing excessive growth of
            connective tissue and skeleton
  JOURNAL   Am J Pathol 82 (3), 493-512 (1976)
   PUBMED   176891
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ044840.1, AK046621.1 and
            AL844547.9.
            
            On Nov 21, 2006 this sequence version replaced NM_007993.1.
            
            Summary: This gene encodes a member of the fibrillin family of
            proteins. The encoded preproprotein is proteolytically processed to
            generate two proteins including the extracellular matrix component
            fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an
            extracellular matrix glycoprotein that serves as a structural
            component of calcium-binding microfibrils. Asprosin, secreted by
            white adipose tissue, has been shown to regulate glucose
            homeostasis. Homozygous knockout mice for this gene exhibit
            impaired aortic development and early postnatal death, which was
            attributed to a deficiency in the fibrillin-1 protein. Mice with a
            hypomorphic allele of this gene exhibit impaired glucose
            homeostasis, likely due to a reduction in serum asprosin levels.
            [provided by RefSeq, Apr 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U22493.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               CJ044840.1         2-101
            101-1433            AK046621.1         285-1617
            1434-1619           AL844547.9         174514-174699       c
            1620-1760           AL844547.9         173805-173945       c
            1761-1880           AL844547.9         171900-172019       c
            1881-2006           AL844547.9         168245-168370       c
            2007-2129           AL844547.9         166619-166741       c
            2130-2252           AL844547.9         163641-163763       c
            2253-2405           AL844547.9         162421-162573       c
            2406-2459           AL844547.9         158545-158598       c
            2460-2585           AL844547.9         157025-157150       c
            2586-2711           AL844547.9         155410-155535       c
            2712-2831           AL844547.9         154780-154899       c
            2832-2969           AL844547.9         154428-154565       c
            2970-3020           AL844547.9         153968-154018       c
            3021-3146           AL844547.9         152217-152342       c
            3147-3374           AL844547.9         150118-150345       c
            3375-3500           AL844547.9         148496-148621       c
            3501-3629           AL844547.9         148246-148374       c
            3630-3755           AL844547.9         147309-147434       c
            3756-3881           AL844547.9         147096-147221       c
            3882-4004           AL844547.9         145818-145940       c
            4005-4130           AL844547.9         144742-144867       c
            4131-4256           AL844547.9         143440-143565       c
            4257-4379           AL844547.9         136587-136709       c
            4380-4502           AL844547.9         136316-136438       c
            4503-4628           AL844547.9         134880-135005       c
            4629-4751           AL844547.9         132741-132863       c
            4752-4874           AL844547.9         130964-131086       c
            4875-5039           AL844547.9         130489-130653       c
            5040-5108           AL844547.9         128659-128727       c
            5109-5234           AL844547.9         128439-128564       c
            5235-5357           AL844547.9         127434-127556       c
            5358-5516           AL844547.9         126637-126795       c
            5517-5588           AL844547.9         125890-125961       c
            5589-5714           AL844547.9         123067-123192       c
            5715-5837           AL844547.9         119999-120121       c
            5838-5963           AL844547.9         116892-117017       c
            5964-6080           AL844547.9         115167-115283       c
            6081-6209           AL844547.9         113625-113753       c
            6210-6329           AL844547.9         112727-112846       c
            6330-6455           AL844547.9         109460-109585       c
            6456-6605           AL844547.9         106250-106399       c
            6606-6671           AL844547.9         105830-105895       c
            6672-6788           AL844547.9         105497-105613       c
            6789-6908           AL844547.9         103631-103750       c
            6909-7031           AL844547.9         102046-102168       c
            7032-7163           AL844547.9         101601-101732       c
            7164-7289           AL844547.9         99993-100118        c
            7290-7496           AL844547.9         99228-99434         c
            7497-7622           AL844547.9         97473-97598         c
            7623-7745           AL844547.9         97134-97256         c
            7746-7862           AL844547.9         94391-94507         c
            7863-7991           AL844547.9         94015-94143         c
            7992-8111           AL844547.9         93104-93223         c
            8112-8343           AL844547.9         90904-91135         c
            8344-8518           AL844547.9         87720-87894         c
            8519-9900           AL844547.9         85228-86609         c
FEATURES             Location/Qualifiers
     source          1..9900
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.38 cM"
     gene            1..9900
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /note="fibrillin 1"
                     /db_xref="GeneID:14118"
                     /db_xref="MGI:MGI:95489"
     exon            1..100
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            101..450
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..8908
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /note="tight skin"
                     /codon_start=1
                     /product="fibrillin-1 preproprotein"
                     /protein_id="NP_032019.2"
                     /db_xref="CCDS:CCDS16676.1"
                     /db_xref="GeneID:14118"
                     /db_xref="MGI:MGI:95489"
                     /translation="MRRGGLLEVALAFALLLESYTSHGADANLEAGSLKETRANRAKR
                     RGGGGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCTC
                     PSGQISPSCGSRSIQHCSIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGRC
                     VAPNRCACTYGFTGPQCERDYRTGPCFTVVSNQMCQGQLSGIVCTKTLCCATVGRAWG
                     HPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGMCQGGNCINTVGSFECKCPAG
                     HKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCVDVRPG
                     YCYTALANGRCSNQLPQSITKMQCCCDLGRCWSPGVTVAPEMCPIRSTEDFNKLCSVP
                     LVIPGRPEYPPPPIGPLPPVQPVPPGYPPGPVIPAPRPPPEYPYPSPSREPPRVLPFN
                     VTDYCQLVRYLCQNGRCIPTPGSYRCECNKGFQLDIRGECIDVDECEKNPCTGGECIN
                     NQGSYTCHCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVT
                     RDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGI
                     CMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYRRGQCVKPLFGAVTK
                     SECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGTDINECALDPDICPNGI
                     CENLRGTYKCICNSGYEVDITGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGF
                     VYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSPESTLDPTKTICIETIKGTCW
                     QTVIDGRCEININGATLKSECCSSLGAAWGSPCTICQLDPICGKGFSRIKGTQCEDIN
                     ECEVFPGVCKNGLCVNSRGSFKCECPNGMTLDATGRICLDIRLETCFLKYDDEECTLP
                     IAGRHRMDACCCSVGAAWGTEECEECPLRNSREYEELCPRGPGFATKDITNGKPFFKD
                     INECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQC
                     VNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGICHNTEGSYRCECPPGH
                     QLSPNISACIDINECELSANLCPHGRCVNLIGKYQCACNPGYHPTHDRLFCVDIDECS
                     IMNGGCETFCTNSDGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGE
                     YRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKT
                     GCTDINECEIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQ
                     HADCKNTMGSYRCLCKDGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMG
                     FVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECL
                     DPTTCISGNCVNTPGSYTCDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACS
                     NEIGVGVSKASCCCSLGKAWGTPCELCPSVNTSEYKILCPGGEGFRPNPITVILEDID
                     ECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNT
                     VGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYN
                     IGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVC
                     INMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGYR
                     LTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNVDQTMCLDINECERD
                     ACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECATGNGNLCRNGQCVNTVGSFQC
                     RCNEGYEVAPDGRTCVDINECVLDPGKCAPGTCQNLDGSYRCICPPGYSLQNDKCEDI
                     DECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSTGRRCQDLRMSYCYAKFEGGKCSS
                     PKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPFGSGIIVGPDDSAVDMDE
                     CKEPDVCRHGQCINTDGSYRCECPFGYILEGNECVDTDECSVGNPCGNGTCKNVIGGF
                     ECTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCK
                     DEDECAEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCIDENECQTKPGICEN
                     GRCLNTLGSYTCECNDGFTASPTQDECLDNREGYCFSEVLQNMCQIGSSNRNPVTKSE
                     CCCDGGRGWGPHCEICPFEGTVAYKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVN
                     DRGSYHCICKTGYTPDITGTACVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQE
                     DGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTACIDNNECTSDINLCG
                     SKGVCQNTPGSFTCECQRGFSLDQSGASCEDVDECEGNHRCQHGCQNIIGGYRCSCPQ
                     GYLQHYQWNQCVDENECLSAHVCGGASCHNTLGSYKCMCPTGFQYEQFSGGCQDINEC
                     GSSQAPCSYGCSNTEGGYLCGCPPGYFRIGQGHCVSGMGMGRGGPEPPASSEMDDNSL
                     SPEACYECKINGYPKRGRKRRSTNETDASDIQDGSEMEANVSLASWDVEKPASFAFNI
                     SHVNNKVRILELLPALTTLMNHNRYLIESGNEDGFFKINQKEGVSYLHFTKKKPVAGT
                     YSLQISSTPLYKKKELNQLEDRYDKDYLSGELGDNLKMKIQILLH"
     exon            451..533
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            534..632
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            633..728
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            729..824
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1022
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1148
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1274
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1433
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1619
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1760
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1880
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2006
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2129
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2252
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2405
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2459
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2585
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2711
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2831
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2969
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3020
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3146
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3374
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3500
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            3501..3629
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3755
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            3756..3881
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            3882..4004
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            4005..4130
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            4131..4256
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            4257..4379
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            4380..4502
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            4503..4628
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            4629..4751
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            4752..4874
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            4875..5039
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            5040..5108
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            5109..5234
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            5235..5357
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            5358..5516
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            5517..5588
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            5589..5714
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            5715..5837
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            5838..5963
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            5964..6080
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            6081..6209
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            6210..6329
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            6330..6455
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            6456..6605
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            6606..6671
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            6672..6788
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            6789..6908
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            6909..7031
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            7032..7163
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            7164..7289
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            7290..7496
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            7497..7622
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            7623..7745
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            7746..7862
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            7863..7991
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            7992..8111
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            8112..8343
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            8344..8518
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     exon            8519..9900
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9876..9881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /note="hexamer: AATAAA"
     polyA_site      9900
                     /gene="Fbn1"
                     /gene_synonym="B430209H23; Fib-1; Tsk"
                     /note="major polyA site"
ORIGIN      
        1 agagttgggg cagagactgt gggtgccaca ggcggccaca gctgggacag ctgcggagca
       61 gagcagccac cgccgcctga gagtccgagc cgctagtcca gacaggcagg gactacccga
      121 agtgggagca gtccctggag aagaaagctg taggacccag gccggggacc tctctgcatc
      181 aggacagccg gacagtgaga cagcgggacc ccggagactc gggccgctgg aaggcgcggc
      241 ggcggcggcg gcggcggcgg cggagcgagt ggcggccggc ggcaccatgc ggcgaggagg
      301 gctgctggag gtcgcgctgg cgttcgccct gctcctcgag tcctacacga gccatggggc
      361 ggacgccaat ttggaggctg ggagcctgaa ggagaccaga gccaatcggg ccaagagaag
      421 aggcggcgga ggacacgatg cgctgaaagg acccaatgtc tgtggatcac gttataatgc
      481 atactgttgt cctggatgga aaaccttacc tggtggaaat cagtgtattg ttcccatttg
      541 ccggcattcc tgtggggatg gattctgctc gaggccaaat atgtgcactt gcccgtctgg
      601 tcagatatct ccttcctgtg gctccagatc catccaacac tgcagcatcc gctgtatgaa
      661 tgggggcagc tgcagcgatg accactgtct gtgccagaaa gggtacatcg gcactcactg
      721 tggacagcct gtctgtgaaa gtggctgtct caacggaggg aggtgtgtgg ccccaaatcg
      781 gtgtgcttgc acgtacggct ttactggacc ccagtgtgaa agagattaca gaacaggccc
      841 atgttttact gtggtaagca accagatgtg ccagggacag ctcagcggga ttgtctgcac
      901 caaaacactt tgctgtgcca ccgtgggccg agcctggggc cacccctgtg agatgtgtcc
      961 tgcccagcct cacccctgcc gccgcggctt cattcccaac atccgcactg gagcttgtca
     1021 agatgtggat gaatgtcagg ccatcccagg gatgtgtcaa ggaggaaatt gcattaatac
     1081 cgttggatct tttgagtgca aatgccctgc tggacacaaa tttaatgaag tgtcacaaaa
     1141 atgtgaagat attgacgagt gcagcaccat tcctggagtc tgcgatggcg gggaatgtac
     1201 aaacactgtc agcagctact tctgcaaatg tccccctggt ttttacacct ctcctgatgg
     1261 caccagatgc gtagatgttc gccctggtta ctgctacaca gctctggcaa acgggcgctg
     1321 ctctaaccag ctgccacagt ccataaccaa aatgcagtgc tgttgcgatc ttggccggtg
     1381 ctggtctcca ggggttactg ttgctcccga gatgtgtccc atcaggtcaa ctgaggattt
     1441 caacaagctg tgctctgtcc ctctggtaat tcccgggaga ccagaatatc ctcccccacc
     1501 cattggcccc cttcctccag ttcagcccgt tcctcctggc tatcctcctg ggcctgtgat
     1561 tccagcccct cggccaccgc cagaatatcc atatccatct ccgtctcggg aaccaccaag
     1621 ggtgctgcct ttcaacgtta ctgactactg tcaactggtc cgctatctct gtcaaaatgg
     1681 gcgctgcatt ccaactcccg gtagctaccg ctgcgagtgc aacaagggct tccagctgga
     1741 tatccgtggc gaatgcatcg acgtggatga gtgtgagaag aacccatgca ctggtggcga
     1801 gtgcatcaac aaccagggct cctacacctg tcactgcaga gctggctacc agagcacact
     1861 caccagaact gagtgcagag acatagatga gtgtcttcag aatggccgga tctgcaacaa
     1921 tggtcgctgt atcaacacag acggcagctt ccactgcgta tgcaatgcgg gctttcatgt
     1981 cacgcgggac ggaaagaact gtgaagatat ggatgagtgc agcatccgaa acatgtgcct
     2041 aaacggaatg tgtattaatg aagatggcag tttcaagtgt atttgcaaac ctgggttcca
     2101 actggcatca gatggccgct actgcaaaga tatcaatgag tgtgagacac ctgggatctg
     2161 catgaacgga cgctgtgtga acacggatgg ctcctacaga tgcgaatgct tccccggatt
     2221 ggctgtgggt ctagacggac gtgtgtgtgt tgacacacac atgcggagca catgctatgg
     2281 aggatacagg agaggccagt gcgtgaagcc gttgtttggt gctgttacca aatcggaatg
     2341 ctgttgtgcc agcactgagt atgcctttgg ggaaccctgc cagccgtgtc ctgcacagaa
     2401 ttcagcggaa tatcaggcac tctgcagcag tggaccggga atgacatcag caggcactga
     2461 tataaacgaa tgtgcattag atcctgatat ttgcccaaat ggaatttgtg aaaatctccg
     2521 tgggacctac aaatgtatat gcaactcggg atatgaagta gacataactg ggaaaaactg
     2581 tgtcgatatt aatgagtgtg tgctgaacag tctactttgt gacaatggac aatgtcgaaa
     2641 cacacctgga agttttgtct gcacctgccc caaaggattt gtgtacaaac ctgacctaaa
     2701 aacctgtgaa gacattgatg aatgtgaatc gagtccttgc attaatggag tctgcaagaa
     2761 cagccctggc tccttcattt gtgaatgttc tcctgaaagt actctggacc caacaaaaac
     2821 catctgcata gaaaccatca agggcacttg ctggcagact gtcatcgacg ggcgctgtga
     2881 gatcaacatc aacggagcca ccttgaagtc cgagtgctgc tcctcccttg gtgctgcgtg
     2941 ggggagcccg tgcaccatct gtcaacttga tcccatttgt ggtaaagggt tctcaagaat
     3001 taaaggcacg caatgtgaag atatcaatga gtgtgaagtg ttcccgggag tatgcaagaa
     3061 cggcctgtgt gtcaactcca ggggttcatt caagtgcgag tgtcccaatg gaatgacttt
     3121 ggatgctaca ggaagaatct gtcttgacat ccgcctggag acctgcttcc tcaagtatga
     3181 cgatgaagag tgcaccttgc ccatcgctgg ccgccaccga atggatgcct gctgctgctc
     3241 tgttggggca gcctggggaa cggaagagtg tgaggagtgt ccattgagaa acagccggga
     3301 gtatgaggaa ctctgtcccc gaggacctgg gtttgccaca aaagacatta caaatgggaa
     3361 acctttcttc aaagatatca atgagtgcaa gatgataccc agcctctgta cccacggcaa
     3421 gtgcaggaac accattggca gcttcaagtg taggtgtgac agtggctttg ctctggattc
     3481 tgaagagagg aactgtacag acattgatga gtgccgcata tctcctgacc tctgtggccg
     3541 aggccagtgt gtgaacaccc cgggggactt tgaatgcaag tgtgatgaag gctatgaaag
     3601 tggcttcatg atgatgaaga actgcatgga tattgatgaa tgtcagagag atcctctcct
     3661 gtgtcgagga ggcatttgcc acaacacaga gggaagctat cgctgcgaat gtcctcctgg
     3721 tcaccaattg tccccaaaca tctctgcatg cattgacatc aacgagtgtg agctgagtgc
     3781 gaatctctgt ccccatgggc gttgtgtgaa cctcataggg aagtaccagt gtgcctgcaa
     3841 ccctggctac caccccactc atgacaggct cttctgtgtc gatattgatg aatgcagcat
     3901 aatgaacggt ggttgtgaga ccttctgcac aaactctgac gggagctatg aatgtagctg
     3961 tcagccaggc ttcgcgctaa tgccagacca gcgatcgtgc acagacattg atgagtgtga
     4021 agacaacccc aatatctgtg atggtggcca gtgcacaaac atacctgggg agtacaggtg
     4081 cctgtgctat gatgggttca tggcatctga agacatgaag acttgtgtgg atgtcaatga
     4141 gtgtgacctg aatccaaaca tctgccttag tgggacctgt gaaaatacta aaggctcgtt
     4201 catctgccac tgtgatatgg gatattcagg gaagaaagga aaaacgggct gtacagatat
     4261 caatgaatgt gagatcggag cacacaactg tggcagacat gctgtatgca caaatacagc
     4321 cgggagcttc aagtgcagct gcagtcccgg ctggattgga gacggcatta agtgcacaga
     4381 tctggatgaa tgctctaatg gaacccacat gtgcagccaa cacgcggact gcaagaacac
     4441 catggggtca tatcgctgtc tctgtaagga tggctataca ggggatggct tcacctgtac
     4501 agacctcgac gagtgctccg agaacctgaa cctctgtggc aatggccagt gcctcaacgc
     4561 ccctggcggg taccgctgtg aatgcgacat gggcttcgtg cccagtgctg acgggaaggc
     4621 ctgtgaagat atcgatgagt gctcccttcc aaacatctgt gtctttggaa cttgccacaa
     4681 cctcccgggc ctcttccgtt gcgagtgtga gattggctat gaactggacc gaagtggtgg
     4741 aaactgcaca gatgttaatg agtgtctgga tcccaccacc tgcatcagtg gaaactgtgt
     4801 caacactccc ggtagttaca catgcgattg tcctccggat tttgagctga atccaactcg
     4861 tgtcggctgt gtcgatactc gctctggaaa ctgctatctg gatatccgac cccggggaga
     4921 caatggagat acagcctgca gcaatgaaat tggagttggt gtctctaagg cttcctgctg
     4981 ttgttcactg ggtaaagctt ggggaacccc atgtgagctg tgtccttctg tgaacacatc
     5041 tgagtataaa attctttgcc ctggaggaga aggttttcgt ccaaatccca tcaccgttat
     5101 attggaagac atcgatgagt gccaggagct tccagggctg tgccaagggg ggaagtgcat
     5161 caataccttt ggcagcttcc agtgtcgctg tccaactggt tactacctga atgaagacac
     5221 tcgagtgtgt gatgatgtga acgaatgtga gactcctgga atctgtggtc cggggacctg
     5281 ttacaacacc gttggcaact atacctgcat ttgtcctcca gactacatgc aagtgaacgg
     5341 gggaaataat tgcatggaca tgagaagaag tctatgctac agaaactatt acgctgacaa
     5401 ccagacctgc gatggagaac tcctgttcaa catgaccaag aagatgtgct gttgctccta
     5461 caacatcggc agagcctgga acaaaccctg tgaacagtgc cccatcccaa gcacagatga
     5521 gtttgctacc ctctgtggga gccagaggcc cggcttcgtg attgacattt atacgggttt
     5581 acccgtggat attgatgaat gccgggagat ccctggggtc tgtgaaaatg gagtgtgcat
     5641 caacatggtt ggcagcttcc ggtgtgagtg tcccgtggga ttcttctata acgacaagtt
     5701 actggtttgt gaagatatcg acgagtgtca gaatggccct gtgtgccagc gaaatgcgga
     5761 atgcatcaac actgcaggca gctaccgctg tgactgtaag cccggctacc gccttacctc
     5821 cacaggtcaa tgcaacgatc gaaacgagtg ccaagaaatc ccgaacatat gcagtcatgg
     5881 ccagtgcatc gacaccgtgg gaagcttcta ctgcctttgt cacactggct tcaaaacaaa
     5941 tgtggatcag accatgtgct tagacataaa tgagtgtgag agagacgcct gtgggaacgg
     6001 gacttgcaga aacacgattg gctccttcaa ctgtcgctgt aaccatggct tcatactgtc
     6061 tcacaacaat gactgcatag atgttgatga gtgtgcaact ggaaacggga acctttgcag
     6121 aaatggccag tgtgtcaata ccgtgggctc ctttcagtgc aggtgcaatg aaggctatga
     6181 ggtggctccg gacggcagga cctgtgtgga tatcaacgag tgtgttctgg atcctgggaa
     6241 atgtgcacct ggaacctgtc agaacctgga tggctcctac agatgcattt gcccgcctgg
     6301 gtatagtcta cagaatgaca agtgtgaaga tattgatgag tgtgttgaag agccagaaat
     6361 ctgtgccttg gggacctgca gcaacactga gggtagcttc aaatgtctgt gtccagaggg
     6421 gttctccctg tcctccactg gaagaaggtg ccaagatttg cgaatgagct actgctatgc
     6481 gaagtttgaa ggtgggaagt gttcatcacc caaatccaga aaccattcca agcaggagtg
     6541 ctgctgtgct ttgaagggag aaggctgggg agatccttgt gagttgtgcc ccactgagcc
     6601 agatgaggct ttccgccaga tctgcccctt tggaagtggg atcattgtgg gccctgatga
     6661 ctcagcagtt gatatggacg aatgcaaaga acctgatgtc tgtagacatg ggcagtgcat
     6721 taacacagac ggctcctatc gatgcgagtg tccttttggt tatattctgg aagggaatga
     6781 gtgtgtggat accgatgaat gctctgtggg caatccttgt ggaaatggga cctgcaagaa
     6841 tgtgattgga ggttttgaat gtacctgtga ggaggggttc gagcctggcc caatgatgac
     6901 ttgtgaagat ataaatgaat gtgcccagaa tcctctgctc tgcgccttcc gctgtgtaaa
     6961 tacctacggg tcctatgaat gcaaatgccc tgttggatac gttctccgag aagacaggag
     7021 gatgtgtaaa gatgaggatg agtgtgcaga gggaaaacac gactgtactg agaagcaaat
     7081 ggagtgtaag aacctcattg gtacctacat gtgcatctgc ggccctgggt accagcgcag
     7141 acccgatgga gagggctgca tagatgagaa tgagtgtcag accaagcccg ggatctgtga
     7201 gaatgggcgt tgcctcaaca ccctgggtag ctacacttgt gagtgtaacg atggcttcac
     7261 agccagcccc actcaggatg agtgcttgga caaccgggaa gggtactgct tttcggaggt
     7321 cttgcaaaac atgtgccaga ttggctcaag caacaggaac cccgtcacca agtccgagtg
     7381 ctgctgtgat ggagggagag gctggggacc ccactgtgag atctgccctt tcgagggcac
     7441 agtggcttac aagaagctct gtccccacgg ccgaggattc atgaccaacg gagcagatat
     7501 tgatgagtgc aaggttattc atgatgtttg ccgaaatggg gagtgtgtca acgacagagg
     7561 gtcctatcac tgcatctgta aaactggcta cactccggat ataacaggga ccgcctgtgt
     7621 agatctgaat gaatgcaacc aggctcccaa accctgcaat tttatatgca aaaacacaga
     7681 agggagttac cagtgttcct gcccgaaggg ctacattctg caagaggatg gaaggagctg
     7741 caaagatctt gacgagtgtg caaccaagca gcataactgt cagttcctgt gtgttaacac
     7801 catcggtggc ttcacatgca aatgccctcc tgggtttacc cagcatcaca ctgcctgcat
     7861 tgataacaat gagtgcacgt ctgatatcaa cctgtgtggg tccaagggtg tttgccagaa
     7921 cactccagga agcttcacct gtgaatgcca acgggggttc tcactcgatc agagtggtgc
     7981 cagctgtgaa gatgtggacg agtgtgaggg taaccaccgc tgtcaacatg gctgccagaa
     8041 catcatcgga ggctataggt gtagctgccc ccagggctac ctccagcact accaatggaa
     8101 ccagtgtgta gatgaaaacg agtgcctgag tgcacatgtc tgtggaggag cctcctgcca
     8161 caacaccctg gggagttaca agtgcatgtg tcccaccggc ttccagtacg aacagttcag
     8221 tggaggctgc caagacatca atgagtgtgg ctcatcccag gccccctgca gttacggttg
     8281 ctctaatact gagggtggct acctgtgtgg ctgtccacca ggatacttcc ggataggcca
     8341 agggcattgt gtttctggaa tgggcatggg ccgaggcggc ccagagccac ctgccagcag
     8401 cgagatggac gacaactcac tgtccccaga ggcctgctat gagtgtaaga tcaacggcta
     8461 cccaaaacga ggccggaaac ggagaagcac gaacgaaacg gatgcctccg acatccagga
     8521 cgggtctgag atggaagcca acgtgagcct cgccagctgg gatgtggaga agccggctag
     8581 ctttgctttc aatatttccc atgtcaataa caaggtccga atcctagagc tcctgccggc
     8641 cctcacaact ctgatgaacc acaacagata cttgattgaa tctggaaatg aagatggctt
     8701 ctttaaaatc aaccagaaag aaggggtcag ctacctccac ttcacgaaga agaagccggt
     8761 ggctgggacc tactccttac aaatcagcag caccccactt tataaaaaga aagaacttaa
     8821 ccagttagaa gacagatatg acaaagacta cctcagtggt gaactgggcg ataacctgaa
     8881 gatgaaaatt cagatcttgc tgcattaatt caccatccag agaccaaata attaaatgaa
     8941 aaagcaacct taggcaggta gaattatatt ttccccaagc cagaaccttc acatcatggt
     9001 acaattgttc accgagtcga tctgtataaa tgagcaccac tcttgaatgg caacacccag
     9061 gtacagtgat gatcctagtt caaccaacca ctttctcagg cttctcgtga gtagctcagc
     9121 taccctgtca tgcgtattga ttcctgaaaa ctgggacatg aatatccgct gaggttggcc
     9181 attcacgccg atgggctatc ttcccagcct ccgcacagga acgcgcttcc atctgatgga
     9241 ctgttccgcg ttggtcttca gatcttgaaa ctttgcttct ccgagtgcaa gcagtaggtt
     9301 tctgttgtct gtttggtgct agtaaattct caaaatagat ttattgatgc actgtaataa
     9361 agacacgagt taggaaccaa attgccaagt actcagttca aatacttcat ttcaatcaac
     9421 caaagttagt tcagtagctt atctcactta tgagtatggt gcagtacatg taaattaagt
     9481 gtgtgtacac tgtaacgtgc tatttttatc attgaaacat ttataaacta caataataaa
     9541 gcccttaatg tgagggtttg taatggtgct tattaagacc aaagacttgt taaacatcta
     9601 caccaaatgg tagtggattc tctgagactg gcccacttgt gcactgaggt tggggaggac
     9661 aaggaagcag cctcagccac cagaggatca ccaccgcatc ctccatcaca cagcatgtgc
     9721 aatacgccaa aatcactctc agtcattcct gtcaacaagg ggttaatgtc atgatgtcac
     9781 aataaagtga tcctcccctc cctccccatt ttagtttaca ccttggtttt atgttcttgt
     9841 gtggattaag gctggagggg cctttctgga ggtgaaataa agtctcctgg gtttaaagta
//
