LOCUS       NM_024237               2922 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus fibulin 7 (Fbln7), mRNA.
ACCESSION   NM_024237 XM_986761
VERSION     NM_024237.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2922)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2922)
  AUTHORS   Sugiura,H., Tsunezumi,J., Yanagisawa,H., Futaya,M., Nitta,K. and
            Tsuchiya,K.
  TITLE     Fibulin7 aggravates calcium oxalate-induced acute kidney injury by
            binding to calcium oxalate crystals
  JOURNAL   J Cell Physiol 238 (1), 165-178 (2023)
   PUBMED   36370444
  REMARK    GeneRIF: Fibulin7 aggravates calcium oxalate-induced acute kidney
            injury by binding to calcium oxalate crystals.
REFERENCE   3  (bases 1 to 2922)
  AUTHORS   Raja,E., Changarathil,G., Oinam,L., Tsunezumi,J., Ngo,Y.X.,
            Ishii,R., Sasaki,T., Imanaka-Yoshida,K., Yanagisawa,H. and Sada,A.
  TITLE     The extracellular matrix fibulin 7 maintains epidermal stem cell
            heterogeneity during skin aging
  JOURNAL   EMBO Rep 23 (12), e55478 (2022)
   PUBMED   36278510
  REMARK    GeneRIF: The extracellular matrix fibulin 7 maintains epidermal
            stem cell heterogeneity during skin aging.
REFERENCE   4  (bases 1 to 2922)
  AUTHORS   Chakraborty,P., Dash,S.P., Dalpati,N., Kumar,P., Jain,D. and
            Sarangi,P.P.
  TITLE     A C-terminal fragment of adhesion protein fibulin-7 inhibits growth
            of murine breast tumor by regulating macrophage reprogramming
  JOURNAL   FEBS J 288 (3), 803-817 (2021)
   PUBMED   32297473
  REMARK    GeneRIF: A C-terminal fragment of adhesion protein fibulin-7
            inhibits growth of murine breast tumor by regulating macrophage
            reprogramming.
REFERENCE   5  (bases 1 to 2922)
  AUTHORS   Ikeuchi,T., de Vega,S., Forcinito,P., Doyle,A.D., Amaral,J.,
            Rodriguez,I.R., Arikawa-Hirasawa,E. and Yamada,Y.
  TITLE     Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In
            Vivo Antiangiogenic Activity
  JOURNAL   Sci Rep 8 (1), 17654 (2018)
   PUBMED   30518776
  REMARK    GeneRIF: This study examined the in vivo antiangiogenic activity of
            recombinant full-length mouse Fbln7 (Fbln7-FL) and Fbln7-C-Terminal
            Fragment proteins using a rat corneal angiogenesis model. Both
            Fbln7-FL and Fbln7-C inhibited neovascularization.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2922)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   7  (bases 1 to 2922)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 2922)
  AUTHORS   Segade,F.
  TITLE     Molecular evolution of the fibulins: implications on the
            functionality of the elastic fibulins
  JOURNAL   Gene 464 (1-2), 17-31 (2010)
   PUBMED   20595023
REFERENCE   9  (bases 1 to 2922)
  AUTHORS   de Vega,S., Iwamoto,T., Nakamura,T., Hozumi,K., McKnight,D.A.,
            Fisher,L.W., Fukumoto,S. and Yamada,Y.
  TITLE     TM14 is a new member of the fibulin family (fibulin-7) that
            interacts with extracellular matrix molecules and is active for
            cell binding
  JOURNAL   J Biol Chem 282 (42), 30878-30888 (2007)
   PUBMED   17699513
  REMARK    GeneRIF: TM14 is a cell adhesion molecule that interacts with
            extracellular matrix molecules in teeth and suggest that TM14 plays
            important roles in both the differentiation and maintenance of
            odontoblasts as well as in dentin formation.
REFERENCE   10 (bases 1 to 2922)
  AUTHORS   Osipovich,A.B., Singh,A. and Ruley,H.E.
  TITLE     Post-entrapment genome engineering: first exon size does not affect
            the expression of fusion transcripts generated by gene entrapment
  JOURNAL   Genome Res 15 (3), 428-435 (2005)
   PUBMED   15741512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB867118.1, CK023294.1, BM936626.1, AL808104.14 and BX520805.1.
            
            On Apr 28, 2007 this sequence version replaced NM_024237.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005465.1, BC095941.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                BB867118.1         15-72
            59-774              CK023294.1         1-716
            775-1380            BM936626.1         36-641
            1381-2855           AL808104.14        178320-179794
            2856-2922           BX520805.1         272-338
FEATURES             Location/Qualifiers
     source          1..2922
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.63 cM"
     gene            1..2922
                     /gene="Fbln7"
                     /gene_synonym="1600015H20Rik; TM14"
                     /note="fibulin 7"
                     /db_xref="GeneID:70370"
                     /db_xref="MGI:MGI:1917620"
     exon            1..216
                     /gene="Fbln7"
                     /gene_synonym="1600015H20Rik; TM14"
                     /inference="alignment:Splign:2.1.0"
     exon            217..376
                     /gene="Fbln7"
                     /gene_synonym="1600015H20Rik; TM14"
                     /inference="alignment:Splign:2.1.0"
     exon            377..547
                     /gene="Fbln7"
                     /gene_synonym="1600015H20Rik; TM14"
                     /inference="alignment:Splign:2.1.0"
     exon            548..673
                     /gene="Fbln7"
                     /gene_synonym="1600015H20Rik; TM14"
                     /inference="alignment:Splign:2.1.0"
     exon            674..814
                     /gene="Fbln7"
                     /gene_synonym="1600015H20Rik; TM14"
                     /inference="alignment:Splign:2.1.0"
     exon            815..952
                     /gene="Fbln7"
                     /gene_synonym="1600015H20Rik; TM14"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1091
                     /gene="Fbln7"
                     /gene_synonym="1600015H20Rik; TM14"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..2909
                     /gene="Fbln7"
                     /gene_synonym="1600015H20Rik; TM14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1657..1662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbln7"
                     /gene_synonym="1600015H20Rik; TM14"
                     /note="hexamer: AACAAA"
     polyA_site      1679
                     /gene="Fbln7"
                     /gene_synonym="1600015H20Rik; TM14"
                     /note="major polyA site"
     regulatory      2891..2896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbln7"
                     /gene_synonym="1600015H20Rik; TM14"
                     /note="hexamer: ATTAAA"
     polyA_site      2909
                     /gene="Fbln7"
                     /gene_synonym="1600015H20Rik; TM14"
                     /note="major polyA site"
ORIGIN      
        1 ggctggcgcc tccccgcgtc gtcgggacag tcccgtgcag gcggctgcgg actagtggcc
       61 ttggaagctg caagggaccc gcgcactgcg gccagagaac agcgacctgc cttccccagc
      121 agcaaggctg tgagtggcaa gatgggaccg ggctcacagc gcgcgctttt cctcctcttg
      181 ctgctcctcg ccagccccgg agcgcgggct ttccagagct gtctcaacaa acagcagctc
      241 ctcaccacca tccgccagct gcagcagctg ctgaaaggcc aggagacccg cttcaccgaa
      301 ggcatccgaa acatgaagag ccggctggct gcactgcaaa acacggttaa caaaatgacc
      361 ccggatgcac caccagtttc ctgcccagct ctggaggccc ctccggatgg caagaagttt
      421 ggaagcaagt acttagtgga ccatgaagtc tattttacct gcaaccctgg gttccagctg
      481 gttgggccca gcagcgtggt gtgtcttgct aatggtagct ggacaggaga gcagccccgc
      541 tgcagagata tcagtgaatg ctccagccag ccttgtcaca atggagggac gtgtgtggaa
      601 ggcatcaacc actacagatg catctgtcct ccaggaaaaa ctgggaaccg ctgtcagcat
      661 cagacccagg ctgcggcccc agatggcggc gaggccggtg accccgcctt cagccgcgca
      721 ccccgctgcg cgcaggtgga gcgggaacag cattgcagct gcgaggcggg attccacctg
      781 agcagcacca cgggcggcca cagcgtctgc caggatgtga atgagtgtga gatctatggg
      841 cagaaaggac gcccccggct ctgcatgcat gcctgtgtga acacccctgg ttcctaccga
      901 tgtacctgcc cgagtggata ccggatcctg gctgatggga agagctgtga ggatgttgat
      961 gagtgtgcag gcccacagca catgtgcccc cgggggacca catgcatcaa cactggagga
     1021 ggcttccagt gtgtcaaccc tgagtgtcct gagggcagcg gcaatataag ctacgtgaag
     1081 acatctccct ttcagtgcga gcgaaaccct tgtcccatgg acagcaggcc atgccgccac
     1141 ctgcccaaga ccatctcctt ccattacctc tctctccctt ccaagttgaa gacacccatc
     1201 acgctcttcc gcatggccac agcctcaatt cctggccatc ctgggcccaa cagcctgcgc
     1261 tttgggatcg tgggtgggaa cagccgtggc cacttcgtaa tgcagcgctc agaccggcag
     1321 acaggagagc tcatccttac acagaccctg gaggggcctc agactctgga ggttgacgta
     1381 gacatgtcgg aatacctgga gcgctccttc caggccaacc atgtatccaa ggtcaccatc
     1441 tttgtttctc gctatgactt ctgaggatgc catggcagtc gggaggctgg ggtttgagat
     1501 ctgggctgat ttcacttccc caaggacaca ttgtgggcaa gagctgtggt ggtcattctt
     1561 ttcttggtca tgttcttacc tactctgctt gttcattcag gcttctagat caatgctgtg
     1621 ttctgaccca ggggctgcca cagaagggaa gccacaaaca aatgctgttt ctaccatcac
     1681 attacttgtt ttttgttttt gtttttgttt ttttgttttt ttgttttctt tctgctttaa
     1741 gccccactcc taccctgtta ggagacagca cagaatttca aaatactatg tgagtgacca
     1801 tgtgagtttg aaccagctga ggtgggggag aagctcacgg tgtgtacttg agacaatggc
     1861 caacggttct gcattgaggc tgccaaggct tttctggctg agcgtgttct agctctgcag
     1921 atgctctaat ggccctgtga gctacctacc agggtacttt accctgtgac attccagcca
     1981 accttttcgt cagcaagctg taagggagcc tagcaacccc gagtggatcc ttctagacca
     2041 aggtgtcaac attaaatcat ggattttgtc agagtttctt cacttgagag aaaacatgtc
     2101 tcaaaaacat gacctggctt tatggctgtg gaaacagact ctgtattctc tgcccatctg
     2161 acttctccct gggtgtgaga gcaccttcta ggaagggata gtcctcttcc tgcccaggtt
     2221 ggacttggag gatggagagg tgatgtgtga gatagctcca atagtttcaa tatggattgg
     2281 tcacatggga gcccagtaag gatggcatct ggccatggga tgtttaggag aatactcaaa
     2341 ttgtcttcca ttccatggtt tcttctttag ttgaaagaac taaagaagag ttgacgcctt
     2401 ccacatgaat gaatcaggaa cactccattg agcactgaga gcttgctggg accatcgagt
     2461 tagaacttaa aagctggatg gggtgagttg agaggagttt cgatgtccaa atgataatct
     2521 atggcgagcg ttgcttcata cacattttat cttaaaaatt atttctagag gatgggacag
     2581 gctgactgag tttgagggca gtatggatga catagtaaga ctgtttccaa caaaataaga
     2641 caagaagagg actagagctg tagcttagta gaagagttat tgtccagcat gcataaagcc
     2701 ccaaggtcat ttccttgcac tgcataaaac tgggtgcagt tgtccgtttc tctgctatat
     2761 agccagtttg agagtttgta catggcttct tttgtgagac aaagaccggg ggtcctccca
     2821 tggcttcagc tgcagtttct aacaacaata agggcctgag gatttgcttt tccaggttgt
     2881 tacatgactc attaaaacaa tgttcagaaa aaaaaaaaaa aa
//
