LOCUS       NM_001413784            6092 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus fibulin 5 (Fbln5), transcript variant 11, mRNA.
ACCESSION   NM_001413784
VERSION     NM_001413784.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6092)
  AUTHORS   Ramachandra,A.B., Mikush,N., Sauler,M., Humphrey,J.D. and
            Manning,E.P.
  TITLE     Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice
  JOURNAL   J Biomech Eng 144 (8) (2022)
   PUBMED   35171214
  REMARK    GeneRIF: Compromised Cardiopulmonary Function in Fibulin-5
            Deficient Mice.
REFERENCE   2  (bases 1 to 6092)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (bases 1 to 6092)
  AUTHORS   Wu,Y., Zhou,Y., Huang,J., Ma,K., Yuan,T., Jiang,Y., Ye,M. and Li,J.
  TITLE     The Role of Sorting Nexin 17 in Cardiac Development
  JOURNAL   Front Cardiovasc Med 8, 748891 (2021)
   PUBMED   34988124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6092)
  AUTHORS   Negretti,N.M., Plosa,E.J., Benjamin,J.T., Schuler,B.A.,
            Habermann,A.C., Jetter,C.S., Gulleman,P., Bunn,C., Hackett,A.N.,
            Ransom,M., Taylor,C.J., Nichols,D., Matlock,B.K., Guttentag,S.H.,
            Blackwell,T.S., Banovich,N.E., Kropski,J.A. and Sucre,J.M.S.
  TITLE     A single-cell atlas of mouse lung development
  JOURNAL   Development 148 (24) (2021)
   PUBMED   34927678
REFERENCE   5  (bases 1 to 6092)
  AUTHORS   Clark-Patterson,G.L., Roy,S., Desrosiers,L., Knoepp,L.R., Sen,A.
            and Miller,K.S.
  TITLE     Role of fibulin-5 insufficiency and prolapse progression on murine
            vaginal biomechanical function
  JOURNAL   Sci Rep 11 (1), 20956 (2021)
   PUBMED   34697337
  REMARK    GeneRIF: Role of fibulin-5 insufficiency and prolapse progression
            on murine vaginal biomechanical function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6092)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   7  (bases 1 to 6092)
  AUTHORS   Schiemann,W.P., Blobe,G.C., Kalume,D.E., Pandey,A. and Lodish,H.F.
  TITLE     Context-specific effects of fibulin-5 (DANCE/EVEC) on cell
            proliferation, motility, and invasion. Fibulin-5 is induced by
            transforming growth factor-beta and affects protein kinase cascades
  JOURNAL   J Biol Chem 277 (30), 27367-27377 (2002)
   PUBMED   12021267
  REMARK    GeneRIF: FBLN-5 is a novel TGF-beta-inducible target gene that
            regulates cell growth and motility in a context-specific manner and
            affects protein kinase activation by TGF-beta.
REFERENCE   8  (bases 1 to 6092)
  AUTHORS   Nakamura,T., Lozano,P.R., Ikeda,Y., Iwanaga,Y., Hinek,A.,
            Minamisawa,S., Cheng,C.F., Kobuke,K., Dalton,N., Takada,Y.,
            Tashiro,K., Ross,J. Jr., Honjo,T. and Chien,K.R.
  TITLE     Fibulin-5/DANCE is essential for elastogenesis in vivo
  JOURNAL   Nature 415 (6868), 171-175 (2002)
   PUBMED   11805835
REFERENCE   9  (bases 1 to 6092)
  AUTHORS   Yanagisawa,H., Davis,E.C., Starcher,B.C., Ouchi,T., Yanagisawa,M.,
            Richardson,J.A. and Olson,E.N.
  TITLE     Fibulin-5 is an elastin-binding protein essential for elastic fibre
            development in vivo
  JOURNAL   Nature 415 (6868), 168-171 (2002)
   PUBMED   11805834
  REMARK    GeneRIF: Fibulin-5 is a calcium-dependent, elastin-binding protein
            that localizes to the surface of elastic fibres in vivo.
REFERENCE   10 (bases 1 to 6092)
  AUTHORS   Nakamura,T., Ruiz-Lozano,P., Lindner,V., Yabe,D., Taniwaki,M.,
            Furukawa,Y., Kobuke,K., Tashiro,K., Lu,Z., Andon,N.L., Schaub,R.,
            Matsumori,A., Sasayama,S., Chien,K.R. and Honjo,T.
  TITLE     DANCE, a novel secreted RGD protein expressed in developing,
            atherosclerotic, and balloon-injured arteries
  JOURNAL   J Biol Chem 274 (32), 22476-22483 (1999)
   PUBMED   10428823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122473.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.2596742.1,
                                           SRR17253013.3680708.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               AC122473.4         147798-148152       c
            356-581             AC122473.4         147297-147522       c
            582-636             AC122473.4         143606-143660       c
            637-688             AC122473.4         141218-141269       c
            689-943             AC122473.4         138780-139034       c
            944-1066            AC122473.4         100309-100431       c
            1067-1183           AC122473.4         97457-97573         c
            1184-1303           AC122473.4         94220-94339         c
            1304-1426           AC122473.4         90866-90988         c
            1427-1553           AC122473.4         89765-89891         c
            1554-1749           AC122473.4         86320-86515         c
            1750-6092           AC122473.4         75625-79967         c
FEATURES             Location/Qualifiers
     source          1..6092
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 51.29 cM"
     gene            1..6092
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /note="fibulin 5"
                     /db_xref="GeneID:23876"
                     /db_xref="MGI:MGI:1346091"
     exon            1..355
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            356..581
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..1911
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 11; FIBL-5; developmental arteries and neural
                     crest EGF-like protein"
                     /codon_start=1
                     /product="fibulin-5 isoform 1 precursor"
                     /protein_id="NP_001400713.1"
                     /db_xref="GeneID:23876"
                     /db_xref="MGI:MGI:1346091"
                     /translation="MGPRSFEPMHSGLCRQRRMILTVTILALWLPHPGNAQQQCTNGF
                     DLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTSYS
                     GPYPAAAPPVPASNYPTISRPLVCRFGYQMDEGNQCVDVDECATDSHQCNPTQICINT
                     EGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNDDGRSC
                     QDVNECETENPCVQTCVNTYGSFICRCDPGYELEEDGIHCSDMDECSFSEFLCQHECV
                     NQPGSYFCSCPPGYVLLDDNRSCQDINECEHRNHTCTSLQTCYNLQGGFKCIDPISCE
                     EPYLLIGENRCMCPAEHTSCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYY
                     IFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVI
                     RLRIYVSQYPF"
     exon            582..636
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            637..688
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            689..943
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1066
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1183
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1303
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1426
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1553
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1749
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..6092
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2699..2704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /note="hexamer: ATTAAA"
     regulatory      2711..2716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /note="hexamer: AAGAAA"
     polyA_site      2716
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /note="major polyA site"
     polyA_site      2732
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
     regulatory      3714..3719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /note="hexamer: ATTAAA"
     polyA_site      3738
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
     regulatory      6069..6074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /note="hexamer: AATACA"
     polyA_site      6092
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
ORIGIN      
        1 agacgcccca agattgttgt gaggagtcta gccagttggt gagcgctgta atctgaacca
       61 gctgtgtcca gaccgaggcc ccatttgcat tgtttaacat acttagaaaa tgaagtgttc
      121 atttttaaca ttcctcctcc aattggctta atgctgaatt actgaagggg gttaagcgaa
      181 accaggtgcc ggcggcgagg gctctgcagt ggctcccagc acccggcact gtcccggccc
      241 tccgcgctgc ccgctcggcc cctccggaac caagccgccc cagtcccacc gcagagcctg
      301 ccttcctcgc gtcgcttctc ctcccgcgca tcttggatat gccaggatta aaaagggcag
      361 caacgttgtg cgcagtttat aaactatcac actacatgtt ttttaaattt gggagactgc
      421 tgactacggc accagcaatt gctttgctgc aacggctgtg agacaagcag aagtctccga
      481 acacttctgt ctgcgtttgc tctatgtgtg tgatttacag agggaatggg acctagaagt
      541 ttcgagccaa tgcacagtgg actctgcaga cagagacgca tgatactcac tgttaccatc
      601 ttggcactct ggcttccaca tcctgggaat gcacagcagc agtgcacaaa cggctttgac
      661 ctggaccgcc agtcaggaca gtgtctagat attgatgaat gccggaccat ccctgaggct
      721 tgtcgtgggg acatgatgtg tgtcaaccag aatggcgggt atttgtgcat ccctcgaacc
      781 aacccagtgt atcgagggcc ttactcaaat ccctactcta catcctactc aggcccatac
      841 ccagcagcgg ccccaccagt accagcttcc aactacccca cgatttcaag gcctcttgtc
      901 tgccgctttg ggtatcagat ggatgaaggc aaccagtgtg tggatgtgga cgagtgtgca
      961 acagactcac accagtgcaa ccctacccag atctgtatca acactgaagg aggttacacc
     1021 tgctcctgca ccgatgggta ctggcttctg gaagggcagt gcctagatat tgatgaatgt
     1081 cgctatggtt actgccagca gctctgtgca aatgttccag gatcctattc ctgtacatgc
     1141 aaccctggtt tcaccctcaa cgacgatgga aggtcttgcc aagatgtgaa cgagtgcgaa
     1201 actgagaatc cctgtgttca gacctgtgtc aacacctatg gctctttcat ctgccgctgt
     1261 gacccaggat atgaacttga ggaagatggc attcactgca gtgatatgga cgagtgcagc
     1321 ttctccgagt tcctctgtca acacgagtgt gtgaaccagc cgggctcata cttctgctcg
     1381 tgccctccag gctacgtcct gttggatgat aaccgaagct gccaggatat caatgaatgt
     1441 gagcaccgaa accacacgtg tacctcactg cagacttgct acaatctaca agggggcttc
     1501 aaatgtattg atcccatcag ctgtgaggag ccttatctgc tgattggtga aaaccgctgt
     1561 atgtgtcctg ctgagcacac cagctgcaga gaccagccat tcaccatcct gtatcgggac
     1621 atggatgtgg tgtcaggacg ctccgttcct gctgacatct tccagatgca agcaacaacc
     1681 cgataccctg gtgcctatta cattttccag atcaaatctg gcaacgaggg tcgagagttc
     1741 tatatgcggc aaacagggcc tatcagtgcc accctggtga tgacacgccc catcaaaggg
     1801 cctcgggaca tccagctgga cttggagatg atcactgtca acactgtcat caacttcaga
     1861 ggcagctccg tgatccgact gcggatatat gtgtcgcagt atccgttctg agcctctggc
     1921 taaggcctct gacactgcct ttcaccagca ccgagggacg ggaggagaaa ggaaaccagc
     1981 aagaatgaga gcgagacaga cattgcacct ttcctgctga atatctcctg ggggcatcag
     2041 cctagcatct tgacccatat ctgtactatt gcagatggtc actctgaagg acaccctgcc
     2101 ctcagttcct atgatgcagt tatccaaaag tgttcatctt agcccctgat atgaggttgc
     2161 cagtgactct tcaaagcctt ccatttattt ccatcgtttt ataaaaaaga aaatagatta
     2221 gatttgctgg ggtatgagtc ctcgaaggtt caaaagactg agtggcttgc tctcacctct
     2281 tcctctcctt cctccatctc ttgctgcatt gctgctttgc aaaagtcctc atgggctcgt
     2341 gggaaatgct gggaatagct agtttgcttc ttgcatgttc tgagaaggct atgggaacac
     2401 accacagcag gatcgaaggt ttttatagag tctattttaa aatcacatct ggtattttca
     2461 gcataaaaga aattttagtt gtctttaaaa tttgtatgag tgtttaacct tttcttattc
     2521 attttgaggc ttcttaaagt ggtagaattc cttccaaagg cctcagatac atgttatgtt
     2581 cagtctttcc aacctcatcc tttcctgcat cttagcccag tttttacata gaccccttaa
     2641 tcatgctttc ttaagagttt ttacccaact gtgttggaag acagaggtat ccagactgat
     2701 taaatatttg aagaaatctt gtgtttggtt aattatgact ccatggataa tttagtgctt
     2761 ggggttggtt ttgatctatg cagtggcttg gaaagttctc tgaggggctg aaacctcctt
     2821 cataactgaa tcaagatggc aaaagatggg gaactgagaa atgaggatgg tggagaagtg
     2881 agggccagca tccaccccaa gattttttat agatgctttc ttatgtggtc tgttgtgggt
     2941 tgtctccaag ggcagagggc agagggcaga ggacacagga cacagggcca aggatactaa
     3001 ggatacaggc cagaacatac tcaaatccct gtaaaccagt gagtggcccc tgaccctctg
     3061 tagagggaag cctgattaag caggaaccat ccccagaaac tgttgctatt gatcctgggt
     3121 ggggcctgag aatcaagatt tgttaaagag gaataaatag caaagttgag gatgaaatgt
     3181 cagaggtggg gggaagtggc tagtgtggcc caagtttggg ttaccttgcc ttcagcacct
     3241 gtatagtttc ttccagaact tttaaatctt gtcatccctt cgatggtcag gagctccggg
     3301 tttctcccca ggcagatgta aagagcacaa ggcacagaga agagatcagg ttagatggct
     3361 gcccacatga cattctcagg aatggatagg agacaacagg aggagaaaat gtgttcctta
     3421 agacccgaag acacacctga aggaccaggc tcctatccta cctcttggtg ataaattcct
     3481 ccaagatacc caggtctgta ccctggaccc ccaggctagt aggcaacaga ttaggttttt
     3541 ttttgtgtgt gtgtgttttg atggtaggca tagactgtgt gtgtgtgttt tgtttatttg
     3601 gtttttttga gacagaatct ttctatgtat ccttgattgg cctcaaattc actatgtaga
     3661 ctaggttggt cttgagttta gagatctgat ttcgtttacc tccttgtgct gggattaaaa
     3721 gtgtatacta cccccaaatc cataggcttt cttcagcaga ggcaaaaaag cattaccacc
     3781 tacatctgag cagccccagc ctttcttaac cagagtgtgt ctcacgccac aacacatctc
     3841 tgcctcactt ttccccccta actaaaacca agtccattct aaaccatgtc catcagtgag
     3901 ccttctggca ggctcaggta acattagtaa cacctaccca ggtggcggag aggattctat
     3961 ttggaagctt ggagaaaggg acaaatccct tcagctaggc tttctagagc tcaaggctag
     4021 aaggcaccct ctaattcagg catcctgagt ttgaggagtc ttaggagtta aggacagggc
     4081 agagtagaga cgctaagtgc cagcactcag agcatccaca accattggcc caggctcagc
     4141 acagcatggg ctcaacttgc gtcacacaga ggctgaggag cttggccttg tagtttctga
     4201 acccattgct ttccaaggtg ctatatttgg aactagactc cgagtaagtc cttagggttt
     4261 actttttagt tgtcattgtc taaatgtggc ttcctgcttc gaagaaaaaa ggcacccaaa
     4321 ggctccacaa aagcaggctc aaaaggcctc ttggccattg gattgctctt tcaaaacatc
     4381 actgatgagt tcagtttaaa tgaataagaa gcatgtagga tgaatttatc ttaagataca
     4441 cttgggccta gaagttcaag aggagaatgg cctgtggcag agtgtgtact ggaggaccaa
     4501 acccaaaata ttcagaatgg ttctagaggc tcccagaacc caaaaggctg cttgttttac
     4561 ccacttgttg gaaacagttg gatttttttt tcctcccatg gctaaggggg cggaggttgg
     4621 cctgctggca gaattacagc attgtactct aaagtggggt ctagtggatt ggctgttttg
     4681 gaagccctaa tatatcaggg ctctccaggc tcgtctcttg tcagtatggc tgcatcctgg
     4741 agctgaagtc ttccaagtca accctggttc catcagatcc caaagaatga agcaatctat
     4801 gaagagaggg taccagacaa agatccaaga caccagccca aatcctgtgt tcccaccacc
     4861 tgactgactg agttccccac aggtgaatac ttccatttag ctgcttctga ctctaacgtt
     4921 ctcagaggcc ccaggatgta ctttggggat gacagccagc atttccatta aagtgcagtt
     4981 ttggagtttc acagaagcgt gccaatctta acacacttcc taattggcac agaatccttc
     5041 tacctgttac ccttcaggct ccggtaacac actcagtttt tctttaggta acagtcttgg
     5101 actcaggagt gttatttgcc cagatggtga aatgtttaag gaggtctgat tatttcattt
     5161 tcaatggttt aaatgtattt ttgtggtctc agtgtgaact ctactgtgca caaattgttt
     5221 attctgagcc aaagagccac tcagagagac tgactgcaag acacaggggc gactaccatt
     5281 tcttctcatc tttccagatg aaatccaagt ggtaaaaggt cttcacttaa gagagtacca
     5341 tgctttattg tttacaaatg tttttccata ttcatgagag taatacatgt ataccatgaa
     5401 gtatgaccac actcctccca tttctcctct ctttattctt ccaatctatc ctcctcccag
     5461 cttagtgtct tctttaaaat ttttagtttt gataacccac aaagtcaaat tagcattgcc
     5521 cacatgtgca tggtgttcag ctctctactg gaggatggga aatctaccag tagccacacc
     5581 ctaaaagagg aatgattctc ccttacctgc tccagcagct atcagctgcc agtagctccc
     5641 caatacagat gggggctgtg aagcaccttt cttgaccttg ctgaaatttc aactggcttg
     5701 cccttgtaca ggtcttgtgt aggtcatatc agctgctttg agctcattag tgtggtagcc
     5761 gcattctgac tggaagacag catttcacag ctctcttcct cagcttcagg cttttcccac
     5821 ctcctcttcc acagagaaag aacttaggtt gaacttattg ctggactcag aaccatggtg
     5881 caccgttcac tggggacaca tttatctgac tatctatgaa tcaccagaca aaactagaac
     5941 atgacctctt ttagttagag tttagtaatt actaagccat atctattttg tacaaccaaa
     6001 aactctcatg agcattcatg ggcatgcatt tgaaatttat aataaatgcc ctttgtttga
     6061 aaccattaaa tacatttaat agaaaaccaa aa
//
