LOCUS       NM_001413776            5810 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus fibulin 5 (Fbln5), transcript variant 3, mRNA.
ACCESSION   NM_001413776 XM_006515865
VERSION     NM_001413776.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5810)
  AUTHORS   Ramachandra,A.B., Mikush,N., Sauler,M., Humphrey,J.D. and
            Manning,E.P.
  TITLE     Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice
  JOURNAL   J Biomech Eng 144 (8) (2022)
   PUBMED   35171214
  REMARK    GeneRIF: Compromised Cardiopulmonary Function in Fibulin-5
            Deficient Mice.
REFERENCE   2  (bases 1 to 5810)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (bases 1 to 5810)
  AUTHORS   Wu,Y., Zhou,Y., Huang,J., Ma,K., Yuan,T., Jiang,Y., Ye,M. and Li,J.
  TITLE     The Role of Sorting Nexin 17 in Cardiac Development
  JOURNAL   Front Cardiovasc Med 8, 748891 (2021)
   PUBMED   34988124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5810)
  AUTHORS   Negretti,N.M., Plosa,E.J., Benjamin,J.T., Schuler,B.A.,
            Habermann,A.C., Jetter,C.S., Gulleman,P., Bunn,C., Hackett,A.N.,
            Ransom,M., Taylor,C.J., Nichols,D., Matlock,B.K., Guttentag,S.H.,
            Blackwell,T.S., Banovich,N.E., Kropski,J.A. and Sucre,J.M.S.
  TITLE     A single-cell atlas of mouse lung development
  JOURNAL   Development 148 (24) (2021)
   PUBMED   34927678
REFERENCE   5  (bases 1 to 5810)
  AUTHORS   Clark-Patterson,G.L., Roy,S., Desrosiers,L., Knoepp,L.R., Sen,A.
            and Miller,K.S.
  TITLE     Role of fibulin-5 insufficiency and prolapse progression on murine
            vaginal biomechanical function
  JOURNAL   Sci Rep 11 (1), 20956 (2021)
   PUBMED   34697337
  REMARK    GeneRIF: Role of fibulin-5 insufficiency and prolapse progression
            on murine vaginal biomechanical function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5810)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   7  (bases 1 to 5810)
  AUTHORS   Schiemann,W.P., Blobe,G.C., Kalume,D.E., Pandey,A. and Lodish,H.F.
  TITLE     Context-specific effects of fibulin-5 (DANCE/EVEC) on cell
            proliferation, motility, and invasion. Fibulin-5 is induced by
            transforming growth factor-beta and affects protein kinase cascades
  JOURNAL   J Biol Chem 277 (30), 27367-27377 (2002)
   PUBMED   12021267
  REMARK    GeneRIF: FBLN-5 is a novel TGF-beta-inducible target gene that
            regulates cell growth and motility in a context-specific manner and
            affects protein kinase activation by TGF-beta.
REFERENCE   8  (bases 1 to 5810)
  AUTHORS   Nakamura,T., Lozano,P.R., Ikeda,Y., Iwanaga,Y., Hinek,A.,
            Minamisawa,S., Cheng,C.F., Kobuke,K., Dalton,N., Takada,Y.,
            Tashiro,K., Ross,J. Jr., Honjo,T. and Chien,K.R.
  TITLE     Fibulin-5/DANCE is essential for elastogenesis in vivo
  JOURNAL   Nature 415 (6868), 171-175 (2002)
   PUBMED   11805835
REFERENCE   9  (bases 1 to 5810)
  AUTHORS   Yanagisawa,H., Davis,E.C., Starcher,B.C., Ouchi,T., Yanagisawa,M.,
            Richardson,J.A. and Olson,E.N.
  TITLE     Fibulin-5 is an elastin-binding protein essential for elastic fibre
            development in vivo
  JOURNAL   Nature 415 (6868), 168-171 (2002)
   PUBMED   11805834
  REMARK    GeneRIF: Fibulin-5 is a calcium-dependent, elastin-binding protein
            that localizes to the surface of elastic fibres in vivo.
REFERENCE   10 (bases 1 to 5810)
  AUTHORS   Nakamura,T., Ruiz-Lozano,P., Lindner,V., Yabe,D., Taniwaki,M.,
            Furukawa,Y., Kobuke,K., Tashiro,K., Lu,Z., Andon,N.L., Schaub,R.,
            Matsumori,A., Sasayama,S., Chien,K.R. and Honjo,T.
  TITLE     DANCE, a novel secreted RGD protein expressed in developing,
            atherosclerotic, and balloon-injured arteries
  JOURNAL   J Biol Chem 274 (32), 22476-22483 (1999)
   PUBMED   10428823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122473.4.
            
            On Nov 8, 2022 this sequence version replaced XM_006515865.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.5344216.1,
                                           SRR17253011.9100290.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AC122473.4         147297-147598       c
            303-357             AC122473.4         143606-143660       c
            358-406             AC122473.4         141218-141266       c
            407-661             AC122473.4         138780-139034       c
            662-784             AC122473.4         100309-100431       c
            785-901             AC122473.4         97457-97573         c
            902-1021            AC122473.4         94220-94339         c
            1022-1144           AC122473.4         90866-90988         c
            1145-1271           AC122473.4         89765-89891         c
            1272-1467           AC122473.4         86320-86515         c
            1468-5810           AC122473.4         75625-79967         c
FEATURES             Location/Qualifiers
     source          1..5810
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 51.29 cM"
     gene            1..5810
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /note="fibulin 5"
                     /db_xref="GeneID:23876"
                     /db_xref="MGI:MGI:1346091"
     exon            1..302
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1629
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; FIBL-5; developmental arteries and neural crest
                     EGF-like protein"
                     /codon_start=1
                     /product="fibulin-5 isoform 3 precursor"
                     /protein_id="NP_001400705.1"
                     /db_xref="GeneID:23876"
                     /db_xref="MGI:MGI:1346091"
                     /translation="MGPRSFEPMHSGLCRQRRMILTVTILALWLPHPGNAQQCTNGFD
                     LDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTSYSG
                     PYPAAAPPVPASNYPTISRPLVCRFGYQMDEGNQCVDVDECATDSHQCNPTQICINTE
                     GGYTCSCTDGYWLLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNDDGRSCQ
                     DVNECETENPCVQTCVNTYGSFICRCDPGYELEEDGIHCSDMDECSFSEFLCQHECVN
                     QPGSYFCSCPPGYVLLDDNRSCQDINECEHRNHTCTSLQTCYNLQGGFKCIDPISCEE
                     PYLLIGENRCMCPAEHTSCRDQPFTILYRDMDVVSGRSVPADIFQMQATTRYPGAYYI
                     FQIKSGNEGREFYMRQTGPISATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVIR
                     LRIYVSQYPF"
     exon            303..357
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            358..406
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            407..661
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            662..784
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            785..901
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1021
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1144
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1271
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1467
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..5810
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2417..2422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /note="hexamer: ATTAAA"
     regulatory      2429..2434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /note="hexamer: AAGAAA"
     polyA_site      2434
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /note="major polyA site"
     polyA_site      2450
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
     regulatory      3432..3437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /note="hexamer: ATTAAA"
     polyA_site      3456
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
     regulatory      5787..5792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
                     /note="hexamer: AATACA"
     polyA_site      5810
                     /gene="Fbln5"
                     /gene_synonym="A55; DANCE; EVEC"
ORIGIN      
        1 aacagcgtca ggagtcagca tctcgagaga ggcagcagac aacctctcta ggtcatttct
       61 ctttcttttt ggaaagggca gcaacgttgt gcgcagttta taaactatca cactacatgt
      121 tttttaaatt tgggagactg ctgactacgg caccagcaat tgctttgctg caacggctgt
      181 gagacaagca gaagtctccg aacacttctg tctgcgtttg ctctatgtgt gtgatttaca
      241 gagggaatgg gacctagaag tttcgagcca atgcacagtg gactctgcag acagagacgc
      301 atgatactca ctgttaccat cttggcactc tggcttccac atcctgggaa tgcacagcag
      361 tgcacaaacg gctttgacct ggaccgccag tcaggacagt gtctagatat tgatgaatgc
      421 cggaccatcc ctgaggcttg tcgtggggac atgatgtgtg tcaaccagaa tggcgggtat
      481 ttgtgcatcc ctcgaaccaa cccagtgtat cgagggcctt actcaaatcc ctactctaca
      541 tcctactcag gcccataccc agcagcggcc ccaccagtac cagcttccaa ctaccccacg
      601 atttcaaggc ctcttgtctg ccgctttggg tatcagatgg atgaaggcaa ccagtgtgtg
      661 gatgtggacg agtgtgcaac agactcacac cagtgcaacc ctacccagat ctgtatcaac
      721 actgaaggag gttacacctg ctcctgcacc gatgggtact ggcttctgga agggcagtgc
      781 ctagatattg atgaatgtcg ctatggttac tgccagcagc tctgtgcaaa tgttccagga
      841 tcctattcct gtacatgcaa ccctggtttc accctcaacg acgatggaag gtcttgccaa
      901 gatgtgaacg agtgcgaaac tgagaatccc tgtgttcaga cctgtgtcaa cacctatggc
      961 tctttcatct gccgctgtga cccaggatat gaacttgagg aagatggcat tcactgcagt
     1021 gatatggacg agtgcagctt ctccgagttc ctctgtcaac acgagtgtgt gaaccagccg
     1081 ggctcatact tctgctcgtg ccctccaggc tacgtcctgt tggatgataa ccgaagctgc
     1141 caggatatca atgaatgtga gcaccgaaac cacacgtgta cctcactgca gacttgctac
     1201 aatctacaag ggggcttcaa atgtattgat cccatcagct gtgaggagcc ttatctgctg
     1261 attggtgaaa accgctgtat gtgtcctgct gagcacacca gctgcagaga ccagccattc
     1321 accatcctgt atcgggacat ggatgtggtg tcaggacgct ccgttcctgc tgacatcttc
     1381 cagatgcaag caacaacccg ataccctggt gcctattaca ttttccagat caaatctggc
     1441 aacgagggtc gagagttcta tatgcggcaa acagggccta tcagtgccac cctggtgatg
     1501 acacgcccca tcaaagggcc tcgggacatc cagctggact tggagatgat cactgtcaac
     1561 actgtcatca acttcagagg cagctccgtg atccgactgc ggatatatgt gtcgcagtat
     1621 ccgttctgag cctctggcta aggcctctga cactgccttt caccagcacc gagggacggg
     1681 aggagaaagg aaaccagcaa gaatgagagc gagacagaca ttgcaccttt cctgctgaat
     1741 atctcctggg ggcatcagcc tagcatcttg acccatatct gtactattgc agatggtcac
     1801 tctgaaggac accctgccct cagttcctat gatgcagtta tccaaaagtg ttcatcttag
     1861 cccctgatat gaggttgcca gtgactcttc aaagccttcc atttatttcc atcgttttat
     1921 aaaaaagaaa atagattaga tttgctgggg tatgagtcct cgaaggttca aaagactgag
     1981 tggcttgctc tcacctcttc ctctccttcc tccatctctt gctgcattgc tgctttgcaa
     2041 aagtcctcat gggctcgtgg gaaatgctgg gaatagctag tttgcttctt gcatgttctg
     2101 agaaggctat gggaacacac cacagcagga tcgaaggttt ttatagagtc tattttaaaa
     2161 tcacatctgg tattttcagc ataaaagaaa ttttagttgt ctttaaaatt tgtatgagtg
     2221 tttaaccttt tcttattcat tttgaggctt cttaaagtgg tagaattcct tccaaaggcc
     2281 tcagatacat gttatgttca gtctttccaa cctcatcctt tcctgcatct tagcccagtt
     2341 tttacataga ccccttaatc atgctttctt aagagttttt acccaactgt gttggaagac
     2401 agaggtatcc agactgatta aatatttgaa gaaatcttgt gtttggttaa ttatgactcc
     2461 atggataatt tagtgcttgg ggttggtttt gatctatgca gtggcttgga aagttctctg
     2521 aggggctgaa acctccttca taactgaatc aagatggcaa aagatgggga actgagaaat
     2581 gaggatggtg gagaagtgag ggccagcatc caccccaaga ttttttatag atgctttctt
     2641 atgtggtctg ttgtgggttg tctccaaggg cagagggcag agggcagagg acacaggaca
     2701 cagggccaag gatactaagg atacaggcca gaacatactc aaatccctgt aaaccagtga
     2761 gtggcccctg accctctgta gagggaagcc tgattaagca ggaaccatcc ccagaaactg
     2821 ttgctattga tcctgggtgg ggcctgagaa tcaagatttg ttaaagagga ataaatagca
     2881 aagttgagga tgaaatgtca gaggtggggg gaagtggcta gtgtggccca agtttgggtt
     2941 accttgcctt cagcacctgt atagtttctt ccagaacttt taaatcttgt catcccttcg
     3001 atggtcagga gctccgggtt tctccccagg cagatgtaaa gagcacaagg cacagagaag
     3061 agatcaggtt agatggctgc ccacatgaca ttctcaggaa tggataggag acaacaggag
     3121 gagaaaatgt gttccttaag acccgaagac acacctgaag gaccaggctc ctatcctacc
     3181 tcttggtgat aaattcctcc aagataccca ggtctgtacc ctggaccccc aggctagtag
     3241 gcaacagatt aggttttttt ttgtgtgtgt gtgttttgat ggtaggcata gactgtgtgt
     3301 gtgtgttttg tttatttggt ttttttgaga cagaatcttt ctatgtatcc ttgattggcc
     3361 tcaaattcac tatgtagact aggttggtct tgagtttaga gatctgattt cgtttacctc
     3421 cttgtgctgg gattaaaagt gtatactacc cccaaatcca taggctttct tcagcagagg
     3481 caaaaaagca ttaccaccta catctgagca gccccagcct ttcttaacca gagtgtgtct
     3541 cacgccacaa cacatctctg cctcactttt cccccctaac taaaaccaag tccattctaa
     3601 accatgtcca tcagtgagcc ttctggcagg ctcaggtaac attagtaaca cctacccagg
     3661 tggcggagag gattctattt ggaagcttgg agaaagggac aaatcccttc agctaggctt
     3721 tctagagctc aaggctagaa ggcaccctct aattcaggca tcctgagttt gaggagtctt
     3781 aggagttaag gacagggcag agtagagacg ctaagtgcca gcactcagag catccacaac
     3841 cattggccca ggctcagcac agcatgggct caacttgcgt cacacagagg ctgaggagct
     3901 tggccttgta gtttctgaac ccattgcttt ccaaggtgct atatttggaa ctagactccg
     3961 agtaagtcct tagggtttac tttttagttg tcattgtcta aatgtggctt cctgcttcga
     4021 agaaaaaagg cacccaaagg ctccacaaaa gcaggctcaa aaggcctctt ggccattgga
     4081 ttgctctttc aaaacatcac tgatgagttc agtttaaatg aataagaagc atgtaggatg
     4141 aatttatctt aagatacact tgggcctaga agttcaagag gagaatggcc tgtggcagag
     4201 tgtgtactgg aggaccaaac ccaaaatatt cagaatggtt ctagaggctc ccagaaccca
     4261 aaaggctgct tgttttaccc acttgttgga aacagttgga tttttttttc ctcccatggc
     4321 taagggggcg gaggttggcc tgctggcaga attacagcat tgtactctaa agtggggtct
     4381 agtggattgg ctgttttgga agccctaata tatcagggct ctccaggctc gtctcttgtc
     4441 agtatggctg catcctggag ctgaagtctt ccaagtcaac cctggttcca tcagatccca
     4501 aagaatgaag caatctatga agagagggta ccagacaaag atccaagaca ccagcccaaa
     4561 tcctgtgttc ccaccacctg actgactgag ttccccacag gtgaatactt ccatttagct
     4621 gcttctgact ctaacgttct cagaggcccc aggatgtact ttggggatga cagccagcat
     4681 ttccattaaa gtgcagtttt ggagtttcac agaagcgtgc caatcttaac acacttccta
     4741 attggcacag aatccttcta cctgttaccc ttcaggctcc ggtaacacac tcagtttttc
     4801 tttaggtaac agtcttggac tcaggagtgt tatttgccca gatggtgaaa tgtttaagga
     4861 ggtctgatta tttcattttc aatggtttaa atgtattttt gtggtctcag tgtgaactct
     4921 actgtgcaca aattgtttat tctgagccaa agagccactc agagagactg actgcaagac
     4981 acaggggcga ctaccatttc ttctcatctt tccagatgaa atccaagtgg taaaaggtct
     5041 tcacttaaga gagtaccatg ctttattgtt tacaaatgtt tttccatatt catgagagta
     5101 atacatgtat accatgaagt atgaccacac tcctcccatt tctcctctct ttattcttcc
     5161 aatctatcct cctcccagct tagtgtcttc tttaaaattt ttagttttga taacccacaa
     5221 agtcaaatta gcattgccca catgtgcatg gtgttcagct ctctactgga ggatgggaaa
     5281 tctaccagta gccacaccct aaaagaggaa tgattctccc ttacctgctc cagcagctat
     5341 cagctgccag tagctcccca atacagatgg gggctgtgaa gcacctttct tgaccttgct
     5401 gaaatttcaa ctggcttgcc cttgtacagg tcttgtgtag gtcatatcag ctgctttgag
     5461 ctcattagtg tggtagccgc attctgactg gaagacagca tttcacagct ctcttcctca
     5521 gcttcaggct tttcccacct cctcttccac agagaaagaa cttaggttga acttattgct
     5581 ggactcagaa ccatggtgca ccgttcactg gggacacatt tatctgacta tctatgaatc
     5641 accagacaaa actagaacat gacctctttt agttagagtt tagtaattac taagccatat
     5701 ctattttgta caaccaaaaa ctctcatgag cattcatggg catgcatttg aaatttataa
     5761 taaatgccct ttgtttgaaa ccattaaata catttaatag aaaaccaaaa
//
