LOCUS       NM_007992               4477 bp    mRNA    linear   ROD 11-NOV-2023
DEFINITION  Mus musculus fibulin 2 (Fbln2), transcript variant 1, mRNA.
ACCESSION   NM_007992
VERSION     NM_007992.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4477)
  AUTHORS   Li S, Jiang H, Wang S, Li Y, Guo D, Zhan J, Li Q, Meng H, Chen A,
            Chen L, Dai X, Li X, Xing W, Li L and Fei J.
  TITLE     Fibulin-2: A potential regulator of immune dysfunction after bone
            trauma
  JOURNAL   Immun Inflamm Dis 11 (5), e846 (2023)
   PUBMED   37249292
  REMARK    GeneRIF: Fibulin-2: A potential regulator of immune dysfunction
            after bone trauma.
REFERENCE   2  (bases 1 to 4477)
  AUTHORS   Kurz J, Weiss AC, Ludtke TH, Deuper L, Trowe MO, Thiesler H,
            Hildebrandt H, Heineke J, Duncan SA and Kispert A.
  TITLE     GATA6 is a crucial factor for Myocd expression in the visceral
            smooth muscle cell differentiation program of the murine ureter
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35905011
REFERENCE   3  (bases 1 to 4477)
  AUTHORS   Ahuja N, Hiltabidle MS, Rajasekhar H, Voss S, Lu SZ, Barlow HR,
            Cowdin MA, Daniel E, Vaddaraju V, Anandakumar T, Black E, Cleaver O
            and Maynard C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (bases 1 to 4477)
  AUTHORS   Meuser M, Deuper L, Rudat C, Aydogdu N, Thiesler H, Zarnovican P,
            Hildebrandt H, Trowe MO and Kispert A.
  TITLE     FGFR2 signaling enhances the SHH-BMP4 signaling axis in early
            ureter development
  JOURNAL   Development 149 (1) (2022)
   PUBMED   35020897
REFERENCE   5  (bases 1 to 4477)
  AUTHORS   Ma Y, Nenkov M, Schroder DC, Abubrig M, Gassler N and Chen Y.
  TITLE     Fibulin 2 Is Hypermethylated and Suppresses Tumor Cell
            Proliferation through Inhibition of Cell Adhesion and Extracellular
            Matrix Genes in Non-Small Cell Lung Cancer
  JOURNAL   Int J Mol Sci 22 (21), 11834 (2021)
   PUBMED   34769264
  REMARK    GeneRIF: Fibulin 2 Is Hypermethylated and Suppresses Tumor Cell
            Proliferation through Inhibition of Cell Adhesion and Extracellular
            Matrix Genes in Non-Small Cell Lung Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4477)
  AUTHORS   Sasaki T, Mann K, Murphy G, Chu ML and Timpl R.
  TITLE     Different susceptibilities of fibulin-1 and fibulin-2 to cleavage
            by matrix metalloproteinases and other tissue proteases
  JOURNAL   Eur J Biochem 240 (2), 427-434 (1996)
   PUBMED   8841408
REFERENCE   7  (bases 1 to 4477)
  AUTHORS   Naylor SL, Carritt B, Boileau C, Beroud C, Alexander C, Allderdice
            P, Alimov A, Ashworth T, Bonifas J, Bugert P, Buys CH, Chipperfield
            MA, Deng G, Drabkin H, Gemmill RM, Grompe M, Joensuu T, Jonasdottir
            A, Gizatullin R, Krols L, Leach RJ, Lott ST, Killary A, Martinsson
            T, Messiaen L et al.
  TITLE     Report of the sixth international workshop on human chromosome 3
            mapping 1995
  JOURNAL   Cytogenet Cell Genet 72 (4), 255-270 (1996)
   PUBMED   8641130
REFERENCE   8  (bases 1 to 4477)
  AUTHORS   Zhang HY, Chu ML, Pan TC, Sasaki T, Timpl R and Ekblom P.
  TITLE     Extracellular matrix protein fibulin-2 is expressed in the
            embryonic endocardial cushion tissue and is a prominent component
            of valves in adult heart
  JOURNAL   Dev Biol 167 (1), 18-26 (1995)
   PUBMED   7851641
REFERENCE   9  (bases 1 to 4477)
  AUTHORS   Zhang RZ, Pan TC, Zhang ZY, Mattei MG, Timpl R and Chu ML.
  TITLE     Fibulin-2 (FBLN2): human cDNA sequence, mRNA expression, and
            mapping of the gene on human and mouse chromosomes
  JOURNAL   Genomics 22 (2), 425-430 (1994)
   PUBMED   7806230
REFERENCE   10 (bases 1 to 4477)
  AUTHORS   Pan TC, Sasaki T, Zhang RZ, Fassler R, Timpl R and Chu ML.
  TITLE     Structure and expression of fibulin-2, a novel extracellular matrix
            protein with multiple EGF-like repeats and consensus motifs for
            calcium binding
  JOURNAL   J Cell Biol 123 (5), 1269-1277 (1993)
   PUBMED   8245130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131764.3 and AC121990.3.
            
            [WARNING] On Jan 17, 2024 this sequence was replaced by
            NM_007992.3.
            
            On Feb 7, 2007 this sequence version replaced NM_007992.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X75285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AC131764.3         52146-52282         c
            138-1426            AC131764.3         30695-31983         c
            1427-1538           AC131764.3         14077-14188         c
            1539-1668           AC131764.3         12473-12602         c
            1669-1849           AC131764.3         10425-10605         c
            1850-2059           AC131764.3         8602-8811           c
            2060-2173           AC131764.3         8053-8166           c
            2174-2275           AC131764.3         7220-7321           c
            2276-2416           AC131764.3         5276-5416           c
            2417-2551           AC131764.3         1573-1707           c
            2552-2689           AC131764.3         210-347             c
            2690-2833           AC121990.3         35767-35910
            2834-2962           AC121990.3         36005-36133
            2963-3088           AC121990.3         36364-36489
            3089-3205           AC121990.3         38587-38703
            3206-3334           AC121990.3         39137-39265
            3335-3458           AC121990.3         40013-40136
            3459-4477           AC121990.3         41571-42589
FEATURES             Location/Qualifiers
     source          1..4477
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 40.42 cM"
     gene            1..4477
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /note="fibulin 2"
                     /db_xref="GeneID:14115"
                     /db_xref="MGI:MGI:95488"
     exon            1..137
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            138..1426
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..3816
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="fibulin-2 isoform a precursor"
                     /protein_id="NP_032018.2"
                     /db_xref="CCDS:CCDS39566.1"
                     /db_xref="GeneID:14115"
                     /db_xref="MGI:MGI:95488"
                     /translation="MLLQESAGVWLALALVTALTPSPSMAVPWQDCTGAECPLLENCI
                     EEALEPGACCATCVQQGCACEGYQYYDCVQGGFVDGRVPAGQSYFVDFGSTECSCPPG
                     GGKISCQFMLCPELPPNCIEAVVVADSCPQCGQVGCVHSGRKYAAGHTVHLSSCRACH
                     CPDAGGELICYQLPGCHGNFSDAEEGDSERQYEDPYSYDQEVAEAEATTAIVNEVQAG
                     AEGPPAALGGGNLPPSSIRVTPWPVALPRPTAAAALGPPAPVQAKARRVTLDTEEDEE
                     EEEEETLVTEPPTAGSPGRLDSLPTRSPARPGFPVQEKEAEAKAGPEENLIPDAQVTP
                     RSVMQEGAAPLPRSGLAALSPSLATDSSSEDPVKPSDHPTLSTLPPDRAQVSPSPETP
                     EEIPQHPQLLPRFRAEEDIDPNSVHSVPRGDLDGSTKDLIETCCAAGQQWAIDNDECQ
                     EIPENGAQSDICRIAQRQCCISYLKEKSCVAGVMGAKEGETCGAEDNDTCGVSLYKQC
                     CDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEGEEPLIVPEVRRPPEPEAAPRR
                     VSEMEMASREALSLGTEAELPNSLPGDDQDECLMLPGELCQHLCINTVGSYRCACFPG
                     FELQGDGRTCRPDRGAPQLDTARESAPRSESAQVSPNTIPLPVPQPNTCKDNGPCRQV
                     CRVVGDTAMCSCFPGYAIMADGVSCEDQDECLMGTHDCSWKQFCVNTLGSFYCVNHTV
                     LCAEGYILNAHRKCVDINECVTDLHTCTRAEHCVNTPGSFQCYKALTCEPGYVLTDGE
                     CTDVDECVTGTHNCQAGFSCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLLE
                     PCRSGFSCINTVGSYTCQRNPLVCGRGYHANEEGSECVDVNECETGVHRCGEGQLCYN
                     LPGSYRCDCKPGFQRDAFGRTCIDVNECWVSPGRLCQHTCENTPGSYRCSCAAGFLLA
                     ADGKHCEDVNECETRRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGIL
                     CTFRCVNVPGSYQCACPEQGYTMMANGRSCKDLDECALGTHNCSEAETCHNIQGSFRC
                     LRFDCPPNYVRVSETKCERTTCQDITECQTSPARITHYQLNFQTGLLVPAHIFRIGPA
                     PAFAGDTISLTITKGNEEGYFVTRRLNAYTGVVSLQRSVLEPRDFALDVEMKLWRQGS
                     VTTFLAKMYIFFTTFAP"
     exon            1427..1538
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1668
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1849
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2059
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2173
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2275
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2416
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2551
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2689
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2833
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2962
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3088
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3205
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3334
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..3458
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..4477
                     /gene="Fbln2"
                     /gene_synonym="5730577E14Rik; FIBL-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgtggggc ggggtctcaa ggcctggcta gtcccgctct tctccaaccc cgagccgcgc
       61 gccacccgga ctctggattc accgacggcg ggtgcgcgga cagactgacg gcggcgcagc
      121 tcaacacaga gcaccgggga ctcctgagac atgctgctcc aggaatctgc aggagtgtgg
      181 ctggccttgg ctctggtcac agctctgact ccgagcccaa gcatggccgt cccgtggcag
      241 gattgcacag gtgctgagtg tcccctgctg gagaactgca tcgaggaggc gttggagcca
      301 ggagcctgct gtgctacctg tgtgcagcag ggctgtgcct gcgaaggcta ccagtactac
      361 gactgcgtac aaggagggtt tgtggatggc cgtgtaccag ccggccagtc ctactttgtg
      421 gactttggca gcaccgagtg ctcctgccca cccggtggtg gcaagatcag ctgccagttc
      481 atgctgtgcc ctgagctacc acccaactgc attgaagctg tagtagtagc cgacagctgc
      541 ccgcagtgtg gccaggtggg ctgtgtccac agtggccgta agtatgctgc tggccatacc
      601 gtccacctct catcctgccg ggcttgccac tgtcctgacg ctggtggtga gctcatttgc
      661 taccagcttc ctggttgcca tgggaacttc tcggatgctg aggagggtga ctctgagagg
      721 cagtatgaag acccctacag ctatgaccag gaggtggcag aggcagaagc tactacggcc
      781 attgtgaacg aggtccaggc aggtgcagag ggccccccag ctgctctggg aggagggaat
      841 ctgccaccgt cctccatcag agtaacaccc tggccagttg cccttcccag acccacagca
      901 gctgctgccc tgggtccccc agcacctgtg caggccaaag ccaggagagt gacattggac
      961 actgaagagg atgaggaaga agaagaggag gagacactag tcactgagcc accaacagca
     1021 ggcagtcctg gaaggctgga cagcctgccc acaagatccc cagccagacc tggtttccct
     1081 gtccaggaga aggaggctga agctaaggca gggcctgagg aaaaccttat tcctgatgcc
     1141 caggtcactc ctcgaagtgt catgcaggag ggtgctgcac ctctgccaag gtcaggcctg
     1201 gctgctctca gtccatctct ggccactgac agctcttcag aggacccagt aaagcccagc
     1261 gatcacccca ctctatctac actgccacct gaccgagccc aggtctcccc ctccccagag
     1321 acacctgaag aaatacccca gcatccacag ttgctacctc gattccgggc agaagaagac
     1381 atagacccca actcagtaca ttctgtcccc agaggtgatc ttgatggctc caccaaggac
     1441 ctaatcgaga cctgttgtgc agcgggccag cagtgggcca tcgacaatga tgagtgccag
     1501 gagatccccg agaatggtgc ccagagtgac atctgtagga tagcccagag gcaatgctgc
     1561 atctcctact tgaaagagaa gagctgtgtg gctggggtca tgggagccaa ggagggtgag
     1621 acctgtggag cagaggacaa tgatacctgc ggcgtctcac tctacaagca atgctgtgac
     1681 tgctgtggcc tgggactccg agtgcgggct gagggccagt cctgtgagtc caaccccaac
     1741 ctgggctatc cctgcaacca tgtcatgctc tcctgctgtg aaggtgaaga gcccctcata
     1801 gtgcctgagg tccgccggcc accagagccc gaggctgctc ctcgcagagt ttcagagatg
     1861 gagatggcaa gccgggaggc cctgtcactg ggcacagagg ctgaactgcc caatagcctg
     1921 ccgggagatg accaggatga gtgcctgatg ctccctgggg agctttgcca gcatctttgc
     1981 atcaacaccg tcggctccta ccgctgtgcc tgcttccctg gattcgagct gcagggtgat
     2041 ggccgtacct gccgcccaga tagaggtgcc ccacagttgg acactgcacg agagtctgca
     2101 ccgaggtctg agtctgccca ggtatctccc aacaccatcc cactgccggt gccacagccc
     2161 aacacctgca aagacaatgg gccctgccgt caggtgtgtc gtgttgttgg ggacacagct
     2221 atgtgctcct gcttccctgg ctacgccatc atggcagatg gtgtgtcctg tgaagaccaa
     2281 gacgagtgtt tgatgggcac tcacgattgt agctggaaac agttctgtgt gaacaccctg
     2341 ggatccttct actgtgtcaa ccacacagtg ctgtgtgcag agggctatat cctcaacgca
     2401 cataggaagt gtgtggacat caatgagtgt gtgacagacc tgcacacgtg cacccgggcc
     2461 gagcactgtg tgaacacgcc aggttccttc caatgctaca aggcgctcac ctgtgagcca
     2521 ggctatgtcc tcacagatgg tgaatgcaca gacgtggacg aatgtgtgac gggcacacac
     2581 aactgccagg caggcttctc atgccagaac accaagggct ccttctactg ccaggcccgg
     2641 caacgctgca tggatggctt cttgcaggac cccgagggca actgtgtgga catcaacgaa
     2701 tgcacatcgt tactggagcc ttgccgctca gggttcagct gcatcaacac agtgggctcc
     2761 tacacctgtc agaggaaccc actggtctgc ggtcgcggtt accatgctaa cgaggagggc
     2821 tctgaatgtg tggatgtgaa tgagtgtgag acaggtgtgc atcgctgtgg cgagggccaa
     2881 ctgtgctata acctccctgg atcctaccgc tgtgactgca agcccggctt ccagagggat
     2941 gcattcggca ggacttgcat tgatgtgaac gaatgctggg tctcgccggg ccgcctgtgc
     3001 cagcacacat gtgagaacac accgggctcc taccgctgct cctgcgctgc tggcttcctt
     3061 ttggccgcag atggcaaaca ttgtgaagat gtgaacgagt gcgagactcg gcgctgcagc
     3121 caggaatgtg ccaacatcta tggctcctat cagtgctact gccgtcaggg ctaccagctg
     3181 gcagaggatg ggcatacctg cacagacatc gatgagtgtg cacagggcgc gggcattctc
     3241 tgtaccttcc gctgtgtcaa cgtgcctggg agctaccagt gtgcatgccc agagcaaggg
     3301 tatacaatga tggccaacgg gaggtcctgc aaggacctgg atgagtgtgc actgggcacc
     3361 cacaactgct ctgaggctga gacctgccac aatatccagg ggagtttccg ctgcctgcgc
     3421 tttgattgtc cacccaacta tgtccgtgtc tcagaaacga agtgcgagcg caccacatgc
     3481 caggatatca cggaatgtca aacctcacca gctcgcatca cgcactacca gctcaatttc
     3541 cagacaggcc tactggtacc tgcacatatc ttccgcatcg gccctgctcc cgcctttgct
     3601 ggggacacca tctccctgac catcacgaag ggcaatgagg agggctactt cgtcacacgc
     3661 agactcaatg cctacactgg tgtggtatcc ctgcagcggt ctgttctgga gccgcgggac
     3721 tttgccctag atgtggagat gaagctttgg cgccagggct ctgtcactac cttcctggcc
     3781 aagatgtaca tcttcttcac cacttttgcc ccatgaggtg acatgtcagg caatccctcc
     3841 aggtgatgcc tgggcggtgg gcagctgcgc cactcctaag tggctttttg ctgtgactct
     3901 gtaacttaac ttaatcatgc tgagctggtt ggtcttgagt ctctacccta gagggaggga
     3961 gatgcacccc agcaggcact gagtacaggc cagggtcacc cgaggctaga tggtgacctg
     4021 caaactggaa acagccatag ggggcttctg aactccactc ctcaactatg gctacagctg
     4081 acattccatt ccttcatcca ctgtgttcct caattaaaaa aaaaaatcag ctgtgcatgg
     4141 tagcacagac ctttaatcct agcactgggg aggcagaggt aggtagatct ctgagttcca
     4201 ggccagcctg gtctacactg ggagttctaa ccagccagag ctacatagag agaccctatc
     4261 tcaacaagga aaaaacgaaa gaaatctctg tgagttccag gccagcctgg tctacgctgg
     4321 gagttctaac cagccagagc tacatagaga gatcctatct caacaaggaa aaatgaaaga
     4381 aatcatttta aaaggttttt ttttttgctg ttgttgttta atgataagag tagcacatat
     4441 acattattaa aaatgatcaa atagcacaga aaggtta
//
