LOCUS       NM_010180               3359 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus fibulin 1 (Fbln1), transcript variant 1, mRNA.
ACCESSION   NM_010180
VERSION     NM_010180.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3359)
  AUTHORS   Tang,R., Jian,Y., Hu,Z., Li,L., Wang,H., Miao,P., Yang,Z. and
            Tang,M.
  TITLE     A Bioinformatics-Based Study on Methylation Alterations of the
            FBLN1 Gene in Hippocampal Tissue of Alzheimer's Disease Model DKO
            and DTG Mice
  JOURNAL   Int J Mol Sci 25 (16), 9036 (2024)
   PUBMED   39201719
  REMARK    GeneRIF: A Bioinformatics-Based Study on Methylation Alterations of
            the FBLN1 Gene in Hippocampal Tissue of Alzheimer's Disease Model
            DKO and DTG Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3359)
  AUTHORS   Feng,X., Molteni,H., Gregory,M., Lanza,J., Polsani,N., Gupta,I.,
            Wyetzner,R., Hawkins,M.B., Holmes,G., Hopyan,S., Harris,M.P. and
            Atit,R.P.
  TITLE     Apical expansion of calvarial osteoblasts and suture patency is
            dependent on fibronectin cues
  JOURNAL   Development 151 (7) (2024)
   PUBMED   38602508
REFERENCE   3  (bases 1 to 3359)
  AUTHORS   Ji,T., Yan,D., Huang,Y., Luo,M., Zhang,Y., Xu,T., Gao,S., Zhang,L.,
            Ruan,L. and Zhang,C.
  TITLE     Fibulin 1, targeted by microRNA-24-3p, promotes cell proliferation
            and migration in vascular smooth muscle cells, contributing to the
            development of atherosclerosis in APOE-/- mice
  JOURNAL   Gene 898, 148129 (2024)
   PUBMED   38184021
  REMARK    GeneRIF: Fibulin 1, targeted by microRNA-24-3p, promotes cell
            proliferation and migration in vascular smooth muscle cells,
            contributing to the development of atherosclerosis in APOE[-/-]
            mice.
REFERENCE   4  (bases 1 to 3359)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3359)
  AUTHORS   Wu,B., Wu,B., Benkaci,S., Shi,L., Lu,P., Park,T., Morrow,B.E.,
            Wang,Y. and Zhou,B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   6  (bases 1 to 3359)
  AUTHORS   Sasaki,T., Kostka,G., Gohring,W., Wiedemann,H., Mann,K., Chu,M.L.
            and Timpl,R.
  TITLE     Structural characterization of two variants of fibulin-1 that
            differ in nidogen affinity
  JOURNAL   J Mol Biol 245 (3), 241-250 (1995)
   PUBMED   7844816
REFERENCE   7  (bases 1 to 3359)
  AUTHORS   Zhang,H.Y., Chu,M.L., Pan,T.C., Sasaki,T., Timpl,R. and Ekblom,P.
  TITLE     Extracellular matrix protein fibulin-2 is expressed in the
            embryonic endocardial cushion tissue and is a prominent component
            of valves in adult heart
  JOURNAL   Dev Biol 167 (1), 18-26 (1995)
   PUBMED   7851641
REFERENCE   8  (bases 1 to 3359)
  AUTHORS   Mattei,M.G., Pan,T.C., Zhang,R.Z., Timpl,R. and Chu,M.L.
  TITLE     The fibulin-1 gene (FBLN1) is located on human chromosome 22 and on
            mouse chromosome 15
  JOURNAL   Genomics 22 (2), 437-438 (1994)
   PUBMED   7806231
REFERENCE   9  (bases 1 to 3359)
  AUTHORS   Pan,T.C., Kluge,M., Zhang,R.Z., Mayer,U., Timpl,R. and Chu,M.L.
  TITLE     Sequence of extracellular mouse protein BM-90/fibulin and its
            calcium-dependent binding to other basement-membrane ligands
  JOURNAL   Eur J Biochem 215 (3), 733-740 (1993)
   PUBMED   8354280
REFERENCE   10 (bases 1 to 3359)
  AUTHORS   Kluge,M., Mann,K., Dziadek,M. and Timpl,R.
  TITLE     Characterization of a novel calcium-binding 90-kDa glycoprotein
            (BM-90) shared by basement membranes and serum
  JOURNAL   Eur J Biochem 193 (3), 651-659 (1990)
   PUBMED   2249686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK086451.1, AK083573.1, AK159646.1, AA017744.1 and AK085989.1.
            
            On Feb 23, 2008 this sequence version replaced NM_010180.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085989.1, AK137511.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1198              AK086451.1         2-1199
            1199-1829           AK083573.1         1202-1832
            1830-2104           AK159646.1         1785-2059
            2105-2534           AA017744.1         50-479
            2535-3359           AK085989.1         2480-3304
FEATURES             Location/Qualifiers
     source          1..3359
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 40.27 cM"
     gene            1..3359
                     /gene="Fbln1"
                     /note="fibulin 1"
                     /db_xref="GeneID:14114"
                     /db_xref="MGI:MGI:95487"
     exon            1..205
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2244
                     /gene="Fbln1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; BM-90; FIBL-1; basement-membrane protein 90;
                     BM-90/fibulin extracellular matrix glyroprotein"
                     /codon_start=1
                     /product="fibulin-1 isoform 1 precursor"
                     /protein_id="NP_034310.2"
                     /db_xref="CCDS:CCDS27719.1"
                     /db_xref="GeneID:14114"
                     /db_xref="MGI:MGI:95487"
                     /translation="MERPVPSRLVPLPLLLLSSLSLLAARANADISMEACCTDGNQMA
                     NQHRDCSLPYTSESKECRMVQEQCCHNQLEELHCATGINLASEPEGCASLHSYNSSLE
                     TIFIKRCCHCCMLGKASLARDQTCEPIVMISYQCGLVFRACCVKARENSDFVQGNGAD
                     LQDPAKIPDEEDQEDPYLNDRCRGGGPCKQQCRDTGDEVICSCFVGYQLQSDGVSCED
                     INECITGSHNCRLGESCINTVGSFRCQRDSSCGTGYELTEDNNCKDIDECETGIHNCP
                     PDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPVGQTCINTEGSY
                     TCQKNVPNCGRGYHLNEEGTRCVDVDECSPPAEPCGKGHHCLNSPGSFRCECKAGFYF
                     DGISRTCVDINECQRYPGRLCGHKCENTPGSFHCSCSAGFRLSVDGRSCEDVNECLNS
                     PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ
                     CSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGSFRCLSFECPENYRRSA
                     DTFRQEKTDTVRCIKSCRPNDEACVRDPVHTVSHTVISLPTFREFTRPEEIIFLRAVT
                     PLYPANQADIIFDITEGNLRDSFDIIKRYEDGMTVGVVRQVRPIVGPFYAVLKLEMNY
                     VLGGVVSHRNVVNVHIFVSEYWF"
     exon            206..311
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..447
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..619
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..676
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..778
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..916
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1054
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1198
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1327
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1453
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1573
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1705
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1829
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1972
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2104
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..3359
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2756
                     /gene="Fbln1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcctcctc cgggcgggat aattgaacgc ggcgcgcagg agcctcgcgt tggctgccca
       61 ggcctggctc gagcgtgtag ccgctgcccg ccgtgccttt gtccgccgcc ggagcccgcc
      121 agccccatgg agcgccccgt gccgtcgcgc ctcgtcccgc tgccgctgct gctgctcagc
      181 agcctctcgc tgctggcagc ccgagcgaat gcagacatct ccatggaggc ttgctgcacg
      241 gatggaaatc agatggctaa ccagcacagg gactgctcgc tgccgtacac ctcagaatcc
      301 aaggagtgca ggatggtcca ggagcaatgt tgtcacaacc aactggaaga gctgcactgt
      361 gccacgggca tcaacctggc cagcgagcca gaaggctgcg cctcgctcca cagctacaac
      421 agtagccttg agaccatctt cataaagagg tgctgccact gttgcatgct gggaaaggca
      481 tccctggccc gagaccagac ctgtgaaccc attgtcatga taagctacca gtgtgggctg
      541 gtgttccgtg cctgctgtgt gaaggcccgg gagaattcag actttgtcca aggcaacggt
      601 gcagaccttc aggacccagc taagattcct gacgaggagg accaagaaga cccgtacctg
      661 aatgaccgct gtcgaggtgg cgggccctgt aagcagcagt gccgtgacac tggggacgag
      721 gtgatctgct cttgctttgt gggctaccag ctgcagtcgg atggtgtctc ctgcgaagat
      781 atcaatgaat gcatcacagg cagccataac tgccggctgg gagaatcctg catcaataca
      841 gtgggctctt tccgctgcca gcgggacagc agctgtggga ctggctatga gctcacagag
      901 gataataact gcaaagatat tgacgaatgt gagactggta ttcataactg cccccccgat
      961 tttatctgtc agaatactct gggatccttc cgttgcagac cgaagctgca gtgcaagagc
     1021 ggcttcatac aggatgctct aggcaactgc attgatatca atgagtgttt aagtatcagt
     1081 gctccatgcc ctgtggggca gacatgcatc aatacagagg gctcctacac atgccagaag
     1141 aatgtgccca actgtggccg tggttatcat ctcaatgaag aggggacccg ctgtgttgat
     1201 gtggatgagt gctccccacc agcggagccc tgtgggaagg gacaccactg cctgaactcc
     1261 cccggcagct tccgctgcga gtgcaaggct ggcttctatt ttgatggcat cagcaggacc
     1321 tgcgtggata tcaacgagtg ccagcgctat cccgggcgcc tgtgtggcca caagtgtgag
     1381 aacacgccag gctccttcca ctgcagctgc tccgccggct tccggctgtc tgtggacggc
     1441 cggtcttgtg aagatgtgaa cgagtgtctc aacagccctt gcagccagga gtgtgctaat
     1501 gtctatggct cctaccagtg ctattgccga cgaggttacc agctcagtga cgtggatggg
     1561 gtcacctgcg aagatattga tgagtgtgcc ctgcccactg gaggtcacat ctgctcctac
     1621 cgctgcatca acatccccgg aagcttccag tgcagctgcc cctcatctgg ctacaggcta
     1681 gctcccaatg gccgcaactg ccaagacatt gatgagtgtg tgaccggcat ccataactgt
     1741 tccatcaatg agacttgctt caacatccag ggcagcttcc gctgtctgtc ctttgaatgc
     1801 cccgagaact atcgccgctc cgcagacacc ttccgccaag agaaaacaga caccgtccgc
     1861 tgcatcaagt cttgccgtcc caacgatgag gcctgcgtgc gggaccctgt acataccgtc
     1921 tcccacaccg tcatctcgct gcccaccttt cgagagttca cccgtcctga ggagatcatc
     1981 tttctgaggg ctgtcacacc gctgtacccc gccaaccagg ccgacatcat cttcgacatc
     2041 acagaaggga accttcgaga ctcctttgat atcatcaagc gctatgagga cggcatgact
     2101 gtgggtgtcg tgcgccaagt gcggcccatc gtgggcccgt tttacgctgt cctgaagctg
     2161 gagatgaact acgtgttggg aggcgtagtt tcccaccgga acgtcgtcaa tgtacacatc
     2221 ttcgtctccg agtactggtt ctgagggcag gttgtggctc agccaggagt gtaccccgcc
     2281 ccctggctac gcccttgctg ccagtgacag ccaggtgcct gtctctaccc ctcgggcctc
     2341 ccttgatgtt tcatattggt ttgtatggcc acgtgcatta ggctgagccg catcacttaa
     2401 gtccagctgg tgtactgtgg cgtttaaaca tggctcagct gggtggttga atccttgctt
     2461 ttttttttaa atgcaaaggc caaatcggaa ttttgttccc tttctctacc tgtgagctag
     2521 gcattgctaa ggaccaattg aaggagtttt caaagcagca ctccacccaa aagccgaggt
     2581 agttctcact gagtctgcat gaggattggc attttggtac tttttttttt ttttttttaa
     2641 ccaacggggc tctttgtgtt tcaagttgat ggctgctgta gagtggcaca taaataaatg
     2701 tacaataaat tctccccaga agcagctgac aagcatgcct cgggggcact tggaaagtgg
     2761 attgcaattt tgttcaaagg agggcccctt ggtaaagatg tgagctgcaa ggtttgtgtg
     2821 tggcctggta tggctgtggg gaaggctggg atgtcccagt gtgtctgggg tggctggtgt
     2881 ctcccagtgt gtccatgggg gtggctggtg catccctatc tgtttgtgag ggtggccagt
     2941 atgtcccagt gtgtctatgg gggtggctgg tgtgtcccca tgtgtctgta gagatggctg
     3001 gtgtgtccct gtgtgtctgt agaagtgtct ggtgtgtttc agtgtgtcca tagaggtggc
     3061 tggctttctt tgtaccctga agctgccttt cctcacaaga gtaaacaggc ttttgtgatc
     3121 ttcctgacaa cctactatac actctccgga tggggcttct gctagctcag aggtcttcca
     3181 tgagctggag gactgcaaat ctctcctaaa gccaatttca aagtctcccc tgcccccata
     3241 gctccagcta aggggttgca aaagcttccc agtctggaat cgttgttgtc atattgtctt
     3301 gttgctatga caaaatacta aaagctgggc tatttataaa gaataaatgt ttacttagc
//
