LOCUS       NM_001378959            3093 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus filamin binding LIM protein 1 (Fblim1), transcript
            variant 4, mRNA.
ACCESSION   NM_001378959
VERSION     NM_001378959.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3093)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3093)
  AUTHORS   Miao,Q., Hill,M.C., Chen,F., Mo,Q., Ku,A.T., Ramos,C., Sock,E.,
            Lefebvre,V. and Nguyen,H.
  TITLE     SOX11 and SOX4 drive the reactivation of an embryonic gene program
            during murine wound repair
  JOURNAL   Nat Commun 10 (1), 4042 (2019)
   PUBMED   31492871
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3093)
  AUTHORS   Ishizuka,K., Tabata,H., Ito,H., Kushima,I., Noda,M., Yoshimi,A.,
            Usami,M., Watanabe,K., Morikawa,M., Uno,Y., Okada,T., Mori,D.,
            Aleksic,B., Ozaki,N. and Nagata,K.I.
  TITLE     Possible involvement of a cell adhesion molecule, Migfilin, in
            brain development and pathogenesis of autism spectrum disorders
  JOURNAL   J Neurosci Res 96 (5), 789-802 (2018)
   PUBMED   29114925
  REMARK    GeneRIF: Findings indicate that tightly regulated expression of
            migfilin is essential for neuronal development and that FBLIM1
            disruption may be related to the phenotypes associated with ASD and
            related neurodevelopmental disorders.
REFERENCE   4  (bases 1 to 3093)
  AUTHORS   Haubner,B.J., Moik,D., Schuetz,T., Reiner,M.F., Voelkl,J.G.,
            Streil,K., Bader,K., Zhao,L., Scheu,C., Mair,J., Pachinger,O. and
            Metzler,B.
  TITLE     In vivo cardiac role of migfilin during experimental pressure
            overload
  JOURNAL   Cardiovasc Res 106 (3), 398-407 (2015)
   PUBMED   25852081
  REMARK    GeneRIF: Suggest migfilin regulates cardiac hypertrophy in
            transverse aortic constriction.
REFERENCE   5  (bases 1 to 3093)
  AUTHORS   Brahme,N.N., Harburger,D.S., Kemp-O'Brien,K., Stewart,R.,
            Raghavan,S., Parsons,M. and Calderwood,D.A.
  TITLE     Kindlin binds migfilin tandem LIM domains and regulates migfilin
            focal adhesion localization and recruitment dynamics
  JOURNAL   J Biol Chem 288 (49), 35604-35616 (2013)
   PUBMED   24165133
  REMARK    GeneRIF: C-terminal LIM domains of migfilin dictate its focal
            adhesion localization, and these domains mediate an interaction
            with kindlin in vitro and in cells, demonstrating that kindlin is
            important for normal migfilin dynamics.
REFERENCE   6  (bases 1 to 3093)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 3093)
  AUTHORS   Akazawa,H., Kudoh,S., Mochizuki,N., Takekoshi,N., Takano,H.,
            Nagai,T. and Komuro,I.
  TITLE     A novel LIM protein Cal promotes cardiac differentiation by
            association with CSX/NKX2-5
  JOURNAL   J Cell Biol 164 (3), 395-405 (2004)
   PUBMED   14757752
  REMARK    GeneRIF: results suggest that a novel LIM protein Cal induces
            cardiomyocyte differentiation through its dynamic intracellular
            shuttling and association with CSX/NKX2-5
REFERENCE   8  (bases 1 to 3093)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3093)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 3093)
  AUTHORS   Skarnes,W.C., Auerbach,B.A. and Joyner,A.L.
  TITLE     A gene trap approach in mouse embryonic stem cells: the lacZ
            reported is activated by splicing, reflects endogenous gene
            expression, and is mutagenic in mice
  JOURNAL   Genes Dev 6 (6), 903-918 (1992)
   PUBMED   1592261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670446.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AL670446.8         102372-102505       c
            135-188             AL670446.8         100184-100237       c
            189-444             AL670446.8         99513-99768         c
            445-626             AL670446.8         94233-94414         c
            627-744             AL670446.8         93587-93704         c
            745-914             AL670446.8         88985-89154         c
            915-1093            AL670446.8         87343-87521         c
            1094-1211           AL670446.8         85272-85389         c
            1212-3093           AL670446.8         80351-82232         c
FEATURES             Location/Qualifiers
     source          1..3093
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 74.64 cM"
     gene            1..3093
                     /gene="Fblim1"
                     /gene_synonym="2410043F08Rik; Cal; Fblp1; Gt10; migfilin;
                     migfilin(s)"
                     /note="filamin binding LIM protein 1"
                     /db_xref="GeneID:74202"
                     /db_xref="MGI:MGI:1921452"
     exon            1..134
                     /gene="Fblim1"
                     /gene_synonym="2410043F08Rik; Cal; Fblp1; Gt10; migfilin;
                     migfilin(s)"
                     /inference="alignment:Splign:2.1.0"
     exon            135..188
                     /gene="Fblim1"
                     /gene_synonym="2410043F08Rik; Cal; Fblp1; Gt10; migfilin;
                     migfilin(s)"
                     /inference="alignment:Splign:2.1.0"
     exon            189..444
                     /gene="Fblim1"
                     /gene_synonym="2410043F08Rik; Cal; Fblp1; Gt10; migfilin;
                     migfilin(s)"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1325
                     /gene="Fblim1"
                     /gene_synonym="2410043F08Rik; Cal; Fblp1; Gt10; migfilin;
                     migfilin(s)"
                     /note="isoform 1 is encoded by transcript variant 4;
                     CSX-associated LIM; FBLP-1"
                     /codon_start=1
                     /product="filamin-binding LIM protein 1 isoform 1"
                     /protein_id="NP_001365888.1"
                     /db_xref="GeneID:74202"
                     /db_xref="MGI:MGI:1921452"
                     /translation="MASKPEKRVASSVFITLAPPRRDVAVSEEVGQAACEARRARPWE
                     MLPTKTPGAAVGRSPKTWTPSGKTNASLSGVTPQLSNGGCSLPPPSLNEEDLDLPPPP
                     PPPSAYLPLPEEEPPVLPGKSLISDLEQLHLPPPPPPPPPQAPSKGSSVHPPPGHAIP
                     SEEELPPPPEEPVTLPEREVSTDVCGFCHKPVSPRELAVEAMKRQYHAQCFTCRTCRR
                     QLAGQRFYQKDGRPLCEPCYQDTLEKCGKCGEVVQEHVIRALGKAFHPPCFTCVTCAR
                     CISDESFALDSQNQVYCVADFYRKFAPVCSICENPIIPRDGKDAFKIECMGRNFHENC
                     YRCEDCSVLLSVEPTDQGCYPLNDHLFCKPCHLKRSAAGCC"
     exon            445..626
                     /gene="Fblim1"
                     /gene_synonym="2410043F08Rik; Cal; Fblp1; Gt10; migfilin;
                     migfilin(s)"
                     /inference="alignment:Splign:2.1.0"
     exon            627..744
                     /gene="Fblim1"
                     /gene_synonym="2410043F08Rik; Cal; Fblp1; Gt10; migfilin;
                     migfilin(s)"
                     /inference="alignment:Splign:2.1.0"
     exon            745..914
                     /gene="Fblim1"
                     /gene_synonym="2410043F08Rik; Cal; Fblp1; Gt10; migfilin;
                     migfilin(s)"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1093
                     /gene="Fblim1"
                     /gene_synonym="2410043F08Rik; Cal; Fblp1; Gt10; migfilin;
                     migfilin(s)"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1211
                     /gene="Fblim1"
                     /gene_synonym="2410043F08Rik; Cal; Fblp1; Gt10; migfilin;
                     migfilin(s)"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..3093
                     /gene="Fblim1"
                     /gene_synonym="2410043F08Rik; Cal; Fblp1; Gt10; migfilin;
                     migfilin(s)"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3075..3080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fblim1"
                     /gene_synonym="2410043F08Rik; Cal; Fblp1; Gt10; migfilin;
                     migfilin(s)"
                     /note="hexamer: AATAAA"
     polyA_site      3093
                     /gene="Fblim1"
                     /gene_synonym="2410043F08Rik; Cal; Fblp1; Gt10; migfilin;
                     migfilin(s)"
                     /note="major polyA site"
ORIGIN      
        1 aggttgctgg atcctctgaa aggattccaa gcctgctgga gggccaagaa aatccactct
       61 aagtcttgtt gggactgcgt gacagaggct ccctacagct gaggtttgaa ggctgagctc
      121 tcgactctat aaattggagc tggcctgaac tttggacctt gtcttccagt aggaaatcag
      181 tctctcagaa ggcgatcatg gcctccaagc ctgagaaaag ggtggcctcc tctgtcttca
      241 tcaccctggc accgccacgc cgagatgtag ccgtgagtga ggaagtgggc caggcagctt
      301 gtgaagccag acgcgctcgg ccctgggaga tgcttcccac aaagacacct ggggccgcag
      361 tgggcaggag ccccaagacc tggacgccct ctggcaagac caatgcctca ctctctggag
      421 tcacacctca gctctccaat ggaggatgct ctctcccacc tccttccctg aatgaggagg
      481 acctagacct cccgcctcct ccaccgcccc cttctgccta cctgcctctc ccagaagagg
      541 agcctcctgt cttaccaggg aagtcgctca tttccgactt ggagcaactg cacctgcccc
      601 cacccccgcc tccacccccg ccacaggctc catcaaaggg atcgtctgtc caccctccgc
      661 ctggtcacgc cataccctcg gaagaggagc ttcctcctcc tccagaagag cctgtcacac
      721 ttccagagag agaagtgtcc acggatgtct gtggtttctg tcacaagcct gtgtctcctc
      781 gagagctggc tgttgaggcc atgaagaggc agtaccacgc ccagtgcttc acctgtcgta
      841 cctgccgccg ccagttggct ggacagagat tctaccagaa ggatgggcgc cccctgtgcg
      901 aaccctgcta ccaggatact ctggagaagt gtggcaagtg cggagaggtg gtccaagagc
      961 acgtgatccg ggccctgggc aaggccttcc acccaccctg cttcacctgc gtgacctgtg
     1021 cccgctgcat cagcgacgag agctttgcgc tggacagcca gaaccaggtg tactgtgtgg
     1081 ctgatttcta caggaaattt gcccccgtgt gcagcatctg cgagaatccc atcatccccc
     1141 gagacgggaa ggacgccttc aaaatcgagt gcatgggaag gaatttccac gagaactgtt
     1201 accgctgtga ggactgcagc gtgctcctgt ctgtggaacc taccgaccaa ggctgctacc
     1261 cactgaatga ccacctcttc tgcaagccct gtcacctgaa gcggagtgct gctggttgct
     1321 gctgaagagt cccgatagct ggcccttccc tgacttggtt tcccctcctg acttttcttg
     1381 agtactttct ttttgaacct cactgggcac cagcacactg ctcagcccat agtgtctaaa
     1441 tgcacagaca ggcttgagac actgggcttt ggcctcctag tacacagcac cccccacccc
     1501 cagactttct actcctctcc cttcattgac caggaggcct ctcaccacca gactgcaacc
     1561 ctggtccatc tctagtgctg ccctgacatg tttatgggga caggtctcag gatgatacct
     1621 gtgtctctga ccatgatgct tagctgccta gcagaaggcg ctgagacctc agcttagatt
     1681 gtagagctaa gttgtttgaa gtgcgccttc tcagccactc caaaaagtat tttttgagaa
     1741 tataagtgtg tagtagacat gatagcacac acctttaatc ccagcacttg ggaggcagag
     1801 gcaggtggat ttctatgttc aatctagtct gatctactaa aagattcaaa acaatattct
     1861 ttggatttgg gggagagaaa tctttgaatt tttctctttt tctttttttg gtggggtaaa
     1921 atcagtaaac atcttccctt ggttcagggg ctgcgaagat ggctcggtga tgaagagcga
     1981 gctcttgctc ctcttgcgga ggaccagagt tcatttccca gcatccctca tggaggctca
     2041 taactacctg tcctgcaact ccagtttccg gagagctggc gccctctgct ggcctccttg
     2101 gaaccttaat gcatgtggtg tacacgctta cactcaggca cacacacata cattaaaaaa
     2161 aaaaaaacaa tttagccatg tctaatggca aacaccttta atctcagtac ttgggaggca
     2221 gagacacatg gatctctgca tttgaaggca gccacagcta caatcttaaa atgcacaaac
     2281 tactggggtt tggtggtgca aatctgtgat cccagtgctg ggggaaattg ccagaagctt
     2341 gcgacctgct tagacttcat agaattccca atcagttttg gccacattca gagatttgtc
     2401 tcagaaaata ataataaatc ataagtgcat agaacgtgag gtagcggcga cccagccttc
     2461 cttcctgtag aatccgtgct gagctgggct caggatggga gggaggatgg tcacgtgcct
     2521 ctgcttgctt ccacaccctg tgagctcctg tgaggggctc ccagacctgg attaagagcc
     2581 tttgatttgc taaggaacaa gttcgaggct gagcctcctt cctccagact ttactggggc
     2641 tctggcctct acaagtgcgc gcacgcgcgc acacacacac acacacacac acaccaaaga
     2701 ggctagggaa agaagtcaca tctctttggt ctcccatgtg tgccacccag cctccacttc
     2761 agctttgctg ctaggctgcc cgtaaccact gtctctgtga agccacacct agaacattct
     2821 ccctcttaag gaaattcact ttaaggcagg caagatgatt cagctggtag aggtgctggc
     2881 ttccaagtct gatggccgga gtcctgtctc tgggacccac agtgaaggag agagccaatt
     2941 ctataagttg tcctctggtt tacacctgca taccaagata cacgtttgtg cacacacatc
     3001 taatagagat aaaatgtaaa gtagaaaaaa aatcattttt gtgctttgta acttctaagt
     3061 tgcacacaga aaaaaataaa catatgttct ttc
//
