LOCUS       NM_007991               1488 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus fibrillarin (Fbl), transcript variant 1, mRNA.
ACCESSION   NM_007991 XM_030242131
VERSION     NM_007991.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1488)
  AUTHORS   Zhang,Y., Kang,H.R., Jun,Y., Kang,H., Bang,G., Ma,R., Ju,S.,
            Yoon,D.E., Kim,Y., Kim,K., Kim,J.Y. and Han,K.
  TITLE     Neurodevelopmental disorder-associated CYFIP2 regulates
            membraneless organelles and eIF2alpha phosphorylation via protein
            interactors and actin cytoskeleton
  JOURNAL   Hum Mol Genet 33 (19), 1671-1687 (2024)
   PUBMED   38981622
REFERENCE   2  (bases 1 to 1488)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1488)
  AUTHORS   Dash,S., Lamb,M.C., Lange,J.J., McKinney,M.C., Tsuchiya,D., Guo,F.,
            Zhao,X., Corbin,T.J., Kirkman,M., Delventhal,K., Moore,E.L.,
            McKinney,S., Shiang,R. and Trainor,P.A.
  TITLE     rRNA transcription is integral to phase separation and maintenance
            of nucleolar structure
  JOURNAL   PLoS Genet 19 (8), e1010854 (2023)
   PUBMED   37639467
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1488)
  AUTHORS   Gregorio,I., Mereu,M., Contarini,G., Bello,L., Semplicini,C.,
            Burgio,F., Russo,L., Sut,S., Dall'Acqua,S., Braghetta,P.,
            Semenza,C., Pegoraro,E., Papaleo,F., Bonaldo,P. and Cescon,M.
  TITLE     Collagen VI deficiency causes behavioral abnormalities and cortical
            dopaminergic dysfunction
  JOURNAL   Dis Model Mech 15 (9) (2022)
   PUBMED   35946603
REFERENCE   5  (bases 1 to 1488)
  AUTHORS   Wu,Q., Shichino,Y., Abe,T., Suetsugu,T., Omori,A., Kiyonari,H.,
            Iwasaki,S. and Matsuzaki,F.
  TITLE     Selective translation of epigenetic modifiers affects the temporal
            pattern and differentiation of neural stem cells
  JOURNAL   Nat Commun 13 (1), 470 (2022)
   PUBMED   35078993
  REMARK    GeneRIF: Selective translation of epigenetic modifiers affects the
            temporal pattern and differentiation of neural stem cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1488)
  AUTHORS   Baran,V., Vesela,J., Rehak,P., Koppel,J. and Flechon,J.E.
  TITLE     Localization of fibrillarin and nucleolin in nucleoli of mouse
            preimplantation embryos
  JOURNAL   Mol Reprod Dev 40 (3), 305-310 (1995)
   PUBMED   7772340
REFERENCE   7  (bases 1 to 1488)
  AUTHORS   Ferreira,J. and Carmo-Fonseca,M.
  TITLE     The biogenesis of the coiled body during early mouse development
  JOURNAL   Development 121 (2), 601-612 (1995)
   PUBMED   7768196
REFERENCE   8  (bases 1 to 1488)
  AUTHORS   Turley,S.J., Tan,E.M. and Pollard,K.M.
  TITLE     Molecular cloning and sequence analysis of U3 snoRNA-associated
            mouse fibrillarin
  JOURNAL   Biochim Biophys Acta 1216 (1), 119-122 (1993)
   PUBMED   8218401
REFERENCE   9  (bases 1 to 1488)
  AUTHORS   Okano,Y., Steen,V.D. and Medsger,T.A. Jr.
  TITLE     Autoantibody to U3 nucleolar ribonucleoprotein (fibrillarin) in
            patients with systemic sclerosis
  JOURNAL   Arthritis Rheum 35 (1), 95-100 (1992)
   PUBMED   1731817
REFERENCE   10 (bases 1 to 1488)
  AUTHORS   Aris,J.P. and Blobel,G.
  TITLE     cDNA cloning and sequencing of human fibrillarin, a conserved
            nucleolar protein recognized by autoimmune antisera
  JOURNAL   Proc Natl Acad Sci U S A 88 (3), 931-935 (1991)
   PUBMED   1846968
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141883.4.
            
            On or before Sep 29, 2022 this sequence version replaced
            XM_030242131.2, NM_007991.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.1179328.1,
                                           SRR13422601.1009781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AC141883.4         114699-114845
            148-393             AC141883.4         115404-115649
            394-576             AC141883.4         120335-120517
            577-684             AC141883.4         120616-120723
            685-779             AC141883.4         120815-120909
            780-950             AC141883.4         121686-121856
            951-1083            AC141883.4         122974-123106
            1084-1196           AC141883.4         124036-124148
            1197-1342           AC141883.4         124729-124874
            1343-1488           AC141883.4         124962-125107
FEATURES             Location/Qualifiers
     source          1..1488
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.67 cM"
     gene            1..1488
                     /gene="Fbl"
                     /gene_synonym="FIB; FLRN; RNU3IP1"
                     /note="fibrillarin"
                     /db_xref="GeneID:14113"
                     /db_xref="MGI:MGI:95486"
     exon            1..147
                     /gene="Fbl"
                     /gene_synonym="FIB; FLRN; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            148..393
                     /gene="Fbl"
                     /gene_synonym="FIB; FLRN; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..1367
                     /gene="Fbl"
                     /gene_synonym="FIB; FLRN; RNU3IP1"
                     /note="isoform 1 is encoded by transcript variant 1; rRNA
                     2'-O-methyltransferase fibrillarin; nucleolar protein 1;
                     histone-glutamine methyltransferase; U6 snRNA
                     2'-O-methyltransferase fibrillarin"
                     /codon_start=1
                     /product="rRNA 2'-O-methyltransferase fibrillarin isoform
                     1"
                     /protein_id="NP_032017.2"
                     /db_xref="CCDS:CCDS21036.1"
                     /db_xref="GeneID:14113"
                     /db_xref="MGI:MGI:95486"
                     /translation="MKPGFSPRGGGFGGRGGFGDRGGRGGGRGGRGGFGGGRGGFGGG
                     GRGRGGGGGGFRGRGGGGGRGGGFQSGGNRGRGGGRGGKRGNQSGKNVMVEPHRHEGV
                     FICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQ
                     IHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIP
                     VIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCID
                     STASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN"
     exon            394..576
                     /gene="Fbl"
                     /gene_synonym="FIB; FLRN; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..684
                     /gene="Fbl"
                     /gene_synonym="FIB; FLRN; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..779
                     /gene="Fbl"
                     /gene_synonym="FIB; FLRN; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..950
                     /gene="Fbl"
                     /gene_synonym="FIB; FLRN; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1083
                     /gene="Fbl"
                     /gene_synonym="FIB; FLRN; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1196
                     /gene="Fbl"
                     /gene_synonym="FIB; FLRN; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1342
                     /gene="Fbl"
                     /gene_synonym="FIB; FLRN; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1488
                     /gene="Fbl"
                     /gene_synonym="FIB; FLRN; RNU3IP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1463..1468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbl"
                     /gene_synonym="FIB; FLRN; RNU3IP1"
                     /note="hexamer: ATTAAA"
     polyA_site      1488
                     /gene="Fbl"
                     /gene_synonym="FIB; FLRN; RNU3IP1"
                     /note="major polyA site"
ORIGIN      
        1 aacactgggc cttctgcaac agttgttgct cgactgatgt gatctttatc agtagggtgg
       61 gctgaattca tgacctgaag aggaggaaca gaggcagaaa caactgcaaa ccagcagtgg
      121 cctgggagca gctgcgacaa catttgggaa aaagtgagga gcgtagagac acgacagagc
      181 cggaaaagga ttcagaactc ccacccaagg ggccgactcc gacttccggg agacgggacg
      241 cgcgtctaag gggcgtggtt acgcgcttcc gtcactcgcc gtgcgtcacc gcgcgcaggc
      301 gctcctttcc acgtgcgaaa gcctgagact cgtggagtcg gggacgccgc aggttgcctg
      361 aatcgcgcga ccagaacgca gtaatgaagc caggtttcag cccccgtggg ggtggctttg
      421 gtggcagagg cggctttggt gacagaggcg gtagaggagg tggaagagga ggccgaggag
      481 gctttggcgg tggacgagga ggctttggcg gtggaggtcg aggtcgaggc ggagggggtg
      541 gtggcttcag gggacgagga ggtggcggtg gccgaggtgg gggcttccag tctgggggca
      601 accggggtcg aggtggtggc cggggaggca agagaggaaa ccagtcaggg aagaatgtga
      661 tggtggagcc gcatcgtcat gaaggtgtct ttatctgtcg cggaaaggag gatgcccttg
      721 tcacaaagaa tctggtccct ggagagtctg tgtatggaga gaagagagtc tctatttcag
      781 aaggagatga caaaattgag tacagagcct ggaacccctt ccgctccaag ctggcagcag
      841 ctatcctggg cggcgtagac cagatccaca tcaagccagg agccaaggtg ctctaccttg
      901 gggcagcctc aggcaccacc gtctcccacg tctctgatat tgtcggcccg gatggtctgg
      961 tctacgcagt tgagttctcc caccgctctg gccgtgacct catcaacttg gccaagaaga
     1021 ggactaacat tattcctgta attgaagatg ctcgacaccc acacaaatac cgcatgctta
     1081 tcgcaatggt ggatgtcatc tttgccgatg tggcccagcc agaccaaacc cgaattgtgg
     1141 ccctgaacgc ccacaccttc ctgcggaatg gaggacactt tgtgatttcc attaaggcca
     1201 actgcattga ctccactgcg tcagcagagg ctgtgtttgc atctgaagtg aagaagatgc
     1261 agcaggagaa catgaagccg caggagcagc tgacgctaga gccttatgag cgagaccacg
     1321 ccgtggttgt cggtgtgtac aggccacctc ccaaggtgaa gaactgaaac tcagagctgt
     1381 ctggattgaa gagatgtgtg ttgttactgt tgcacgtgtg gcttgtgatt ttttgggggc
     1441 gggggagttg ttttgttttt ctattaaaag actcatctgt ctcccctg
//
