LOCUS       NM_015792               3572 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus F-box DNA helicase 1 (Fbh1), transcript variant 1,
            mRNA.
ACCESSION   NM_015792
VERSION     NM_015792.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3572)
  AUTHORS   Simandlova,J., Zagelbaum,J., Payne,M.J., Chu,W.K., Shevelev,I.,
            Hanada,K., Chatterjee,S., Reid,D.A., Liu,Y., Janscak,P.,
            Rothenberg,E. and Hickson,I.D.
  TITLE     FBH1 helicase disrupts RAD51 filaments in vitro and modulates
            homologous recombination in mammalian cells
  JOURNAL   J Biol Chem 288 (47), 34168-34180 (2013)
   PUBMED   24108124
  REMARK    GeneRIF: FBH1 restraining RAD51 DNA binding under unperturbed
            growth conditions to prevent unwanted or unscheduled DNA
            recombination.
REFERENCE   2  (bases 1 to 3572)
  AUTHORS   Fugger,K., Chu,W.K., Haahr,P., Kousholt,A.N., Beck,H., Payne,M.J.,
            Hanada,K., Hickson,I.D. and Sorensen,C.S.
  TITLE     FBH1 co-operates with MUS81 in inducing DNA double-strand breaks
            and cell death following replication stress
  JOURNAL   Nat Commun 4, 1423 (2013)
   PUBMED   23361013
  REMARK    GeneRIF: FBH1 helicase activity is required to eliminate cells with
            excessive replication stress through the generation of
            MUS81-induced DNA double-strand breaks.
REFERENCE   3  (bases 1 to 3572)
  AUTHORS   Wang,Q., Chow,J., Hong,J., Smith,A.F., Moreno,C., Seaby,P.,
            Vrana,P., Miri,K., Tak,J., Chung,E.D., Mastromonaco,G., Caniggia,I.
            and Varmuza,S.
  TITLE     Recent acquisition of imprinting at the rodent Sfmbt2 locus
            correlates with insertion of a large block of miRNAs
  JOURNAL   BMC Genomics 12, 204 (2011)
   PUBMED   21510876
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3572)
  AUTHORS   Laulier,C., Cheng,A., Huang,N. and Stark,J.M.
  TITLE     Mammalian Fbh1 is important to restore normal mitotic progression
            following decatenation stress
  JOURNAL   DNA Repair (Amst) 9 (6), 708-717 (2010)
   PUBMED   20457012
  REMARK    GeneRIF: role of the F-box helicase 1 (Fbh1) protein during genome
            maintenance in mammalian cells
REFERENCE   5  (bases 1 to 3572)
  AUTHORS   Winston,J.T., Koepp,D.M., Zhu,C., Elledge,S.J. and Harper,J.W.
  TITLE     A family of mammalian F-box proteins
  JOURNAL   Curr Biol 9 (20), 1180-1182 (1999)
   PUBMED   10531037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845548.7, AK147829.1, AK003964.1 and AL831794.6.
            
            On Jan 24, 2017 this sequence version replaced NM_015792.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031393.1, AK147829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AL845548.7         32964-33038         c
            76-2952             AK147829.1         2-2878
            2953-2953           AK003964.1         456-456
            2954-3571           AK147829.1         2880-3497
            3572-3572           AL831794.6         3975-3975
FEATURES             Location/Qualifiers
     source          1..3572
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 9.01 cM"
     gene            1..3572
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /note="F-box DNA helicase 1"
                     /db_xref="GeneID:50755"
                     /db_xref="MGI:MGI:1354699"
     exon            1..154
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..3282
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /EC_number="5.6.2.4"
                     /note="isoform 1 is encoded by transcript variant 1; F-box
                     only protein 18; F-box protein 18; DNA 3'-5' helicase 1"
                     /codon_start=1
                     /product="F-box DNA helicase 1 isoform 1"
                     /protein_id="NP_056607.1"
                     /db_xref="CCDS:CCDS15688.1"
                     /db_xref="GeneID:50755"
                     /db_xref="MGI:MGI:1354699"
                     /translation="MRRFKRKHLTVVDCHHLARSHLAVTQPFSQRWTNRDPNHGLYPR
                     PRTKGRNRGRGCQRYISEFFLAGHQHCTNDMAKSNSVGQDSCQDAEGDMILTAESSCT
                     LPQVDNGEARLGSSGSAQPARKRAHCFEEATESGQWDGVTKKTPRHRLFPSCSRLREA
                     RQGAEDSLSQCSPVPGEAGRDIEDIGPDPLPDSYYGLLGMLPCQEVPSHICRLPSEVL
                     RHIFAFLPVEDLYWNLSLVCHLWREIINDPLFIPWKKLYHRYLINEEQAVSKVDGILS
                     SHGIEKDSDLCVLNLIRYTATTKCSPSVDPERVLWSLRDHPLLLEAEACMRQQLPDLY
                     AAAGGINVWALVAAMVLLSSCVNDIQHLLFCLRRPSSTVTMPDVTETLYCIAVLLYAM
                     REKGINISNRIHYNIFYCLYLQENSCTQATKVTEEPSVWPGKKTSIQLTHEQQLILNH
                     KMEPLQVVKIMAFAGTGKTSTLVKYAEKWSQSRFLYVTFNKSIAKQAELVFPSNVICK
                     TFHSMAYSHVGRKYQLKKKLNLFKLTPFMVNSVLAEGKGGFIRAKLVCKTLENFFASA
                     DEELTIDHVPIWCKNSHGQRVMVEQSEKLNGVLEASRLWDNMRKLGECKEEAYQMTHD
                     GYLKLWQLSKPLLASFDAIFVDEAQDCTPAIMNIVLSQPCGKIFVGDPHQQIYTFRGA
                     VNALFTVPHTHVFYLTQSFRFGVEIAYVGATILDVCKRVRKKTLVGGNHQSGIRGDIK
                     GQVALLSRTNANVFDEAVRVTEGESPARIHLIGGIKSFGLDRIIDIWTLLQPEEERRK
                     RDLIIKDRFIRRWVHKEGFSGFKRYVTAAEDKELEAKIAVVEKYNIRIPELVERIERC
                     HIDDLDFAEYILGTVHKAKGLEFDTVHVLDDFVKVPCARHNLAQLPHFRVESFSEDEW
                     NLLYVAVTRAKKRLIMTKSLENILTLAGEYFLQAELTSNVLKTGVVHCCVGQCNNTIP
                     VDTILTMKKLPITYSNRKENKGGYLCHSCAEQRIGPLAFLTASPEQVRAMERTVEDIV
                     LPRQEALLFLVF"
     exon            155..310
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            311..900
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1031
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1167
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1358
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1451
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1546
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1715
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1938
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2026
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2113
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2250
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2350
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2472
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2548
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2746
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..2872
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2979
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3111
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3572
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3531..3536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /note="hexamer: ATTAAA"
     polyA_site      3572
                     /gene="Fbh1"
                     /gene_synonym="Fbx18; Fbxo18"
                     /note="major polyA site"
ORIGIN      
        1 ggcagcgaag aggcggagct cgcggaggaa gtctgcagtc gtctgtgctc gctgtctggg
       61 ccgaaggagg ggcttgctgg tcggggaaag gctgaatgtc cggcggcatc gcctgggtgg
      121 tgtcgccgcc ggggtcctgg gccgggccgc catatgagac ggtttaagcg gaagcatctt
      181 acagtggtcg actgccatca tttggcccgg agtcatttgg ctgtgactca gcccttcagt
      241 cagagatgga caaacagaga ccctaaccat ggtctctatc ctagacccag aacaaaagga
      301 cggaataggg gtcgaggatg tcagagatat atttctgagt tcttcctagc tggccaccag
      361 cactgtacca atgacatggc caaaagcaat tctgttggcc aggacagctg tcaggacgct
      421 gagggtgaca tgattttaac tgcagagagc agttgtactc tgcctcaggt ggataatgga
      481 gaagcgaggc tgggctcatc aggatctgca cagcctgcca ggaagcgggc tcactgcttt
      541 gaggaagcca cagagagcgg ccagtgggat ggcgttacta agaagacacc gcgccatcgt
      601 ttgttcccat cgtgttcaag gcttagggag gccaggcaag gggcagagga cagtttgtcc
      661 cagtgctccc cagtgccggg ggaagctggc cgagacattg aggacattgg tcctgatccc
      721 ttgcctgact catactatgg gcttcttgga atgttgcctt gtcaggaagt gcccagccac
      781 atttgcaggc tgccaagtga agtgctgaga cacatctttg ctttcctgcc agtggaggac
      841 ctctactgga atctcagcct ggtgtgccac ctgtggaggg aaataatcaa tgacccgctg
      901 ttcattcctt ggaagaagct atatcatcga tacttgatca atgaagagca ggctgtcagc
      961 aaagtggatg gcattctctc gagccatggc atagaaaagg attcggacct atgtgtgctg
     1021 aacctcatac gatacacggc caccaccaaa tgctccccaa gtgttgaccc tgagagggtg
     1081 ctgtggagcc tgagggatca tcctctactt ttggaggctg aggcgtgcat gcggcaacaa
     1141 ctacctgacc tctatgcagc tgctgggggc attaacgtct gggccttggt ggcagccatg
     1201 gtgctcctct ccagctgtgt gaacgacatc cagcatctgc tcttctgcct caggagaccc
     1261 agctccacag tgaccatgcc agatgtcacc gagaccttat actgcatagc tgtgctcctt
     1321 tatgccatga gggagaaggg gattaacatc agcaatagga ttcactacaa cattttctat
     1381 tgcctatatc ttcaggagaa ttcctgtact caggccacca aagttacaga ggagccatct
     1441 gtctggccag gcaagaaaac atctatccag ctaacacatg aacaacagct gattctgaac
     1501 cataagatgg agcctctcca ggtggtaaaa attatggcat ttgcaggcac cgggaagact
     1561 tctaccctgg tcaagtatgc tgagaagtgg tctcagagca ggtttctgta tgtcacgttc
     1621 aacaagagca tcgcaaagca ggcagagctt gtcttcccca gcaacgtcat ctgcaagacc
     1681 ttccattcca tggcctacag tcacgtcggg cggaagtacc agctgaagaa gaagttgaat
     1741 ctcttcaagt tgacaccctt tatggttaac tccgtccttg ctgaaggaaa aggtggattt
     1801 ataagggcca agttagtgtg taagacttta gaaaacttct ttgcatcagc tgatgaagag
     1861 ctaactatcg atcatgtgcc catttggtgc aagaatagcc acgggcagag agtcatggtg
     1921 gagcagagtg agaaactgaa tggtgtcctt gaagcaagcc gactctggga caacatgcgg
     1981 aagctggggg aatgcaaaga agaggcatac caaatgacac atgatggcta tttgaaactc
     2041 tggcagctga gcaaaccttt gcttgcctct tttgacgcca tctttgtgga tgaggcccag
     2101 gactgtaccc cagctatcat gaacatagtt ctgtctcagc catgtgggaa gatctttgta
     2161 ggggaccccc accagcagat ctataccttc cgaggtgcag tgaatgctct gttcacagtt
     2221 ccccacaccc acgtcttcta tctcacacag agttttagat ttggtgtgga aatagcctat
     2281 gtgggagcta ccattttgga tgtctgcaag agagtcagga agaagacgtt ggttggaggg
     2341 aaccatcaga gtggcataag aggtgacata aagggacaag tagctctgct gtccaggacc
     2401 aatgccaatg tgtttgacga ggctgtccgg gtaacagaag gagaatcccc tgcaaggata
     2461 catttgattg gggggattaa atcgtttgga ttggacagaa tcattgacat ttggaccctt
     2521 cttcagccag aggaagaacg gaggaaacga gacctcatca ttaaagacag gttcatcaga
     2581 agatgggtgc ataaagaagg cttcagtggc ttcaagaggt atgtgactgc tgccgaggac
     2641 aaggaactgg aagcgaagat tgcggtagtt gaaaaataca atatcaggat tccagaactg
     2701 gtagaaagga tagagagatg ccacatagac gatttggact ttgcagagta cattttgggc
     2761 accgtgcaca aagccaaagg gttagagttt gacactgtgc acgttttgga tgatttcgtg
     2821 aaagtgcctt gtgccaggca taatcttgcc cagcttcctc acttcagagt tgagtcgttt
     2881 tctgaggatg aatggaattt actgtatgtt gctgttactc gtgccaagaa gcggctcata
     2941 atgaccaaat ccctggagaa catcctgact ctggctgggg agtatttctt gcaagcagag
     3001 ttgacaagta acgttttgaa aacaggagtg gtccactgct gtgtggggca gtgcaacaac
     3061 accatccctg tggacaccat ccttaccatg aagaaactgc ctatcactta tagcaacagg
     3121 aaggaaaaca agggtggcta cctctgccac tcatgtgcag agcagcgcat cgggcctttg
     3181 gcattcctga ctgcctcccc agagcaggtg cgtgccatgg aacgcactgt ggaagacata
     3241 gtgctgccca ggcaggaggc cctgctcttc cttgtcttct gaggctgtga ctccacgtgc
     3301 taaaggagcc attctgggct gcatttctgc tcacaggaga ctctgagttc aatcacagca
     3361 tctctgagga ggaagatagc aaccagagtt ggacctgcca tttccccgtt ccttacagag
     3421 agccagttcc cacttgcctg tcctccaaat gcctcaggcc agggaactgg aagaagttct
     3481 tttgataaaa aaatcatttt atgtatttaa acttttatta caaggtttca attaaacagg
     3541 tattgagcag tggcgtgcca ctgtgaagtc ta
//
