LOCUS       NM_183221              16968 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus FAT atypical cadherin 4 (Fat4), mRNA.
ACCESSION   NM_183221 XM_006535484 XM_619892 XM_891240
VERSION     NM_183221.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 16968)
  AUTHORS   Wang,D., Wu,S., He,J., Sun,L., Zhu,H., Zhang,Y., Liu,S., Duan,X.,
            Wang,Y. and Xu,T.
  TITLE     FAT4 overexpression promotes antitumor immunity by regulating the
            beta-catenin/STT3/PD-L1 axis in cervical cancer
  JOURNAL   J Exp Clin Cancer Res 42 (1), 222 (2023)
   PUBMED   37658376
  REMARK    GeneRIF: FAT4 overexpression promotes antitumor immunity by
            regulating the beta-catenin/STT3/PD-L1 axis in cervical cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 16968)
  AUTHORS   Zhang,C.H., Gao,Y., Hung,H.H., Zhuo,Z., Grodzinsky,A.J. and
            Lassar,A.B.
  TITLE     Creb5 coordinates synovial joint formation with the genesis of
            articular cartilage
  JOURNAL   Nat Commun 13 (1), 7295 (2022)
   PUBMED   36435829
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 16968)
  AUTHORS   Wu,Y., Zhou,Y., Huang,J., Ma,K., Yuan,T., Jiang,Y., Ye,M. and Li,J.
  TITLE     The Role of Sorting Nexin 17 in Cardiac Development
  JOURNAL   Front Cardiovasc Med 8, 748891 (2021)
   PUBMED   34988124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 16968)
  AUTHORS   Weiss,A.C., Rivera-Reyes,R., Englert,C. and Kispert,A.
  TITLE     Expansion of the renal capsular stroma, ureteric bud branching
            defects and cryptorchidism in mice with Wilms tumor 1 gene deletion
            in the stromal compartment of the developing kidney
  JOURNAL   J Pathol 252 (3), 290-303 (2020)
   PUBMED   32715478
REFERENCE   5  (bases 1 to 16968)
  AUTHORS   Lodge,E.J., Xekouki,P., Silva,T.S., Kochi,C., Longui,C.A.,
            Faucz,F.R., Santambrogio,A., Mills,J.L., Pankratz,N., Lane,J.,
            Sosnowska,D., Hodgson,T., Patist,A.L., Francis-West,P.,
            Helmbacher,F., Stratakis,C. and Andoniadou,C.L.
  TITLE     Requirement of FAT and DCHS protocadherins during
            hypothalamic-pituitary development
  JOURNAL   JCI Insight 5 (23), 134310 (2020)
   PUBMED   33108146
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 16968)
  AUTHORS   Mao,Y., Mulvaney,J., Zakaria,S., Yu,T., Morgan,K.M., Allen,S.,
            Basson,M.A., Francis-West,P. and Irvine,K.D.
  TITLE     Characterization of a Dchs1 mutant mouse reveals requirements for
            Dchs1-Fat4 signaling during mammalian development
  JOURNAL   Development 138 (5), 947-957 (2011)
   PUBMED   21303848
  REMARK    GeneRIF: Dchs1 and Fat4 function as a ligand-receptor pair during
            murine development, and novel requirements for Dchs1-Fat4
REFERENCE   7  (bases 1 to 16968)
  AUTHORS   Ishiuchi,T., Misaki,K., Yonemura,S., Takeichi,M. and Tanoue,T.
  TITLE     Mammalian Fat and Dachsous cadherins regulate apical membrane
            organization in the embryonic cerebral cortex
  JOURNAL   J Cell Biol 185 (6), 959-967 (2009)
   PUBMED   19506035
  REMARK    GeneRIF: Results highlight the importance of the
            Fat4-Dachsous1-Pals1 complex in organizing the apical membrane
            architecture of neural progenitor cells.
REFERENCE   8  (bases 1 to 16968)
  AUTHORS   Qi,C., Zhu,Y.T., Hu,L. and Zhu,Y.J.
  TITLE     Identification of Fat4 as a candidate tumor suppressor gene in
            breast cancers
  JOURNAL   Int J Cancer 124 (4), 793-798 (2009)
   PUBMED   19048595
  REMARK    GeneRIF: Fat4 may be a breast tumor suppressor gene
REFERENCE   9  (bases 1 to 16968)
  AUTHORS   Saburi,S., Hester,I., Fischer,E., Pontoglio,M., Eremina,V.,
            Gessler,M., Quaggin,S.E., Harrison,R., Mount,R. and McNeill,H.
  TITLE     Loss of Fat4 disrupts PCP signaling and oriented cell division and
            leads to cystic kidney disease
  JOURNAL   Nat Genet 40 (8), 1010-1015 (2008)
   PUBMED   18604206
  REMARK    GeneRIF: Study shows that Fat4 is an essential gene that has a key
            role in vertebrate core planar cell polarity; loss of Fat4 disrupts
            oriented cell divisions and tubule elongation during kidney
            development, leading to cystic kidney disease.
REFERENCE   10 (bases 1 to 16968)
  AUTHORS   Rock,R., Schrauth,S. and Gessler,M.
  TITLE     Expression of mouse dchs1, fjx1, and fat-j suggests conservation of
            the planar cell polarity pathway identified in Drosophila
  JOURNAL   Dev Dyn 234 (3), 747-755 (2005)
   PUBMED   16059920
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161228.7 and AC122841.4.
            
            On or before Dec 20, 2022 this sequence version replaced
            XM_006535484.5, NM_183221.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14777535.1238131.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-860               AC161228.7         87803-88662         c
            861-6054            AC161228.7         82246-87439         c
            6055-6186           AC161228.7         31440-31571         c
            6187-6448           AC161228.7         24678-24939         c
            6449-6799           AC161228.7         23007-23357         c
            6800-7722           AC161228.7         16785-17707         c
            7723-7897           AC161228.7         15805-15979         c
            7898-8078           AC161228.7         3574-3754           c
            8079-8329           AC122841.4         76615-76865
            8330-12679          AC122841.4         78999-83348
            12680-12784         AC122841.4         90982-91086
            12785-13092         AC122841.4         95244-95551
            13093-13178         AC122841.4         98420-98505
            13179-13358         AC122841.4         99458-99637
            13359-13483         AC122841.4         100461-100585
            13484-13701         AC122841.4         102109-102326
            13702-13963         AC122841.4         106440-106701
            13964-16968         AC122841.4         108329-111333
FEATURES             Location/Qualifiers
     source          1..16968
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 18.72 cM"
     gene            1..16968
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /note="FAT atypical cadherin 4"
                     /db_xref="GeneID:329628"
                     /db_xref="MGI:MGI:3045256"
     exon            1..860
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            861..6054
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            6055..6186
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            6187..6448
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            6449..6799
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            6800..7722
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            7723..7897
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            7898..8078
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            8079..8329
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            8330..12679
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            12680..12784
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            12785..13092
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            13093..13178
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            13179..13358
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            13359..13483
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            13484..13701
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            13702..13963
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     exon            13964..16968
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      16949..16954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /note="hexamer: ATTAAA"
     polyA_site      16968
                     /gene="Fat4"
                     /gene_synonym="6030410K14Rik; 9430004M15"
                     /note="major polyA site"
ORIGIN      
        1 actggagtcc gggagcaccg aggggcgagc aaagtttctc agtcctgctc gcgatcgcgg
       61 acaaccctcc ccctccgtgt gtgcgcgcgt gtgtgcgagt gcttgtgtgc gcgcagcggg
      121 gaaggggcgg ggagagtgcg agggaccagg agaggcagcg ggggactcgc cgggctccag
      181 atacgtcgaa gtgccacctc ggagtcccgg ctgcaaagga gcgcgtccac acggcgcacc
      241 gagcagctgc cccgcacctc cgtgccccca tcgcccgcgg ggaccgcgac ggagggaccc
      301 accccactcc aaacacaaag cctggaggat tacaaagtga aactgacccg ggacaataaa
      361 agcacagatc ccaggacaag ggcgaggagc gctcgggggc gctggtgccc gctgacgccc
      421 ggggaagagc ccctggcatg gtgaggggag gggactccgg gaccaagcgc tgccgctgct
      481 gtccgacccc cgtggcgctg aggaggaagg gaaacccgcg ctcagtggac ttacaaatga
      541 tgccggcgcg gaggtgaagg atgcggagca gtgcctgcgg cagcctgggc tggacctcgg
      601 gcttcgaccc gcggcgagag caaaggcagc ccgggctgcc cgcagaggca cggagctgag
      661 agctgcggga gtggggaagc ggagccctgg cagcctccgc tgcaggggga aggagcccga
      721 cccacagacc accttccagg ctcgcccgga acgaaaccag agaagagtct tcgcagctag
      781 cttcgggctc tcccggctgt ctccagggtg caggggctct gtggcccttg gccctgcgct
      841 ttttggcgtc ccgttccggg gttcctggaa actaggacca tgaacttggc cgcaaaccgg
      901 gctcctggcc gcaggcggct cccgctacct tctccatctc tgtgccagct cctgagagtc
      961 tgggggctgc tatcactgct ccccggctcc gcccgagtcc aagcggccga acagcgccag
     1021 gtgttccagg tgatggaaga gcagccccca gggactctgg tgggcaccat cccaacgcgt
     1081 cctggcttta cctatcgtct cagtgaaagc cacgccctgt tcgcgattaa cagcagcacc
     1141 ggagcgctgt acaccaccgc taccatcgac cgcgagagcc tgcccagcga tgtggtcaac
     1201 ctggtggtcc tttccagctc ccccacatac cctaccgagg tgcgagtgct ggtgcgtgac
     1261 ctcaatgaca acgccccagt cttcccagac ccttcgatcg tggtcacctt caaggaggac
     1321 agtggtagcg ggcgtcaggt cattctggac accgccacgg actctgacat cggctccaac
     1381 ggtgtggacc accactccta ccgcatcgtc agcggcaacg aggcgggccg ctttcggctg
     1441 gacatcacct tgaaccccag tggcgaggga gcgttcctgc acctggtatc caagggcggg
     1501 ctggaccgcg aagtcacacc tcagtaccag ctcctggtgg aggtggagga caagggtgag
     1561 ccaaagcggc ggggttacct tcaggtcaac gtaactgtac aggacattaa cgacaatccc
     1621 ccggtgtttg gcagttccca ttaccaggcg ggggtgcctg aagacgcagt tgtgggctcc
     1681 agtgtcctgc aggtggcggc ggcggacgca gacgagggca ccaatgcaga catccgttac
     1741 cggctgcaag atgagggaac ccccttccag atggacccag agacggggct catcaccgtg
     1801 agagagccgc tagatttcga ggcccggcga cagtattcgc taacagttca ggccacggac
     1861 cggggcgtgc cctctctcac cgggcgcgcc gaagcgttta tccagttgtt agatgtcaat
     1921 gacaacgacc cggtagtgaa gtttcgctac ttccctgcca cctcgcgcta tgcttcggtg
     1981 gatgagaacg cgcaggtggg tacagtggtg gctctgctca ccgtgactga cgctgactcc
     2041 ccagcagcca acggaaacat ttcagtgcag attctcgggg gcaatgagca gcgccacttt
     2101 gaggtgcaga ggagcaaggt gcccaacctg agcctcatca aggtggccag cgccctggac
     2161 cgggagcgca tcccttcata caacctcaca gtctcggtct cggataactc cggggcgccc
     2221 cctaccgccg aggtccaggc tcgttcgtct gtggccagct tggtgatttt tgtcaatgac
     2281 atcaatgatc accctccggt ctttgagcag caagtataca gagtgaacct gagcgaggag
     2341 gtgcctccgg ggagctacgt gagtggggtg tcggccaccg atggcgactc tggtctgaat
     2401 gctaacctgc gttacagcat tgtctccgga aatgggttgg gctggtttca cattagtgag
     2461 cacagtggac tggtgactac cagtgctgcc gggggccttg accgtgaact tgcttcccag
     2521 attgtactaa atattagtgc ccgagaccag ggggtccacc ccaaggtatc ctatgcccag
     2581 cttgtggtaa ctgtcctgga tgtcaatgat gaaaagccgg tgtttagcca gcctgaaggt
     2641 tatgaggtgt ctgtggttga aaatgctcca actgggacag agttgctggt tctcggggca
     2701 acagacaggg atctgggtga caatgggaca gtgcgcttct ccctgcaaga ggcagagaat
     2761 gaccaaaggc tcttccgcct ggatccggta tctgggaggc tgagcactgc ctcctccctg
     2821 gacagagagg aacaagcctt ctactgtcta tcgattctag ccacagacct gggttcccct
     2881 ccccagtcgt ccacagctca ggtaaatgtc agtcttctgg atataaacga taacagccct
     2941 gtgttctacc cagtccaata ctttgctcat atccaggaaa atgagcctgg aggtagctat
     3001 gtcaccacag tgtctgctac cgacccagac atgggtccca acggaactgt taagtacagt
     3061 atatcagctg gggacaggtc tcggtttcag attcatgcga agagtggggt catttctaca
     3121 aaaatggccc tagatagaga agagaaaaca gcataccagc tgcaagtagt ggccacagat
     3181 gggggcaatc tacagtctcc caaccaggcc atcgtaactg tcacagtgtt agacacacaa
     3241 gacaacccac ctgtgttcag ccaggctgcc tacagctttg tggtctttga gaacgtggct
     3301 ctggggtatc atgtgggcag tgtttctgca actacaatgg acctcaatgc caacatcagt
     3361 tatctcatca ctaccgggga ccagcgaggg atgtttgcta tgaatcctgt cacagggcag
     3421 ctgaccacag caagtgtcat tgacagggaa gaacagtcct tttatcagct gaaaatagtg
     3481 gccagtgggg gagccgtcac gggagacact gtggttaaca tcacagtgaa agatttgaac
     3541 gacaacgccc cccacttcct ccaggcagtg gaaagcataa atgctgtgga gaactggcag
     3601 gcgggacaca gcatcttcca ggccaaagcc gtggacccgg atgagggtgt caacggtagg
     3661 gtgctctata gtctgaagca gaaccccaag aacctgttta ctattaatga gcagaatggt
     3721 aacattagtc tgctgggggc cctagatgtc cacgctggct cataccaggt agaaatcgtg
     3781 gcctctgata tgggtgtccc tcagctgtcc tccagtatcc ttctgacagt ttacgtgcat
     3841 gatgtaaatg acaacccacc agtgtttgat cagatttcct acgaggtcac actctccgag
     3901 tcagagcctg tgaattctcg attcttcaag gtacaagctt cagacaaaga ttctggagca
     3961 aatggggaaa tagcatacac gatcacagat gggaacaacg gggatgcctt tggcatattc
     4021 ccagatggcc agctgtatat aaaaagtgaa ctggatcgtg aacttcagga cagatatgtg
     4081 ttactggttg ttgcctctga ccgggcagtg gagcctctaa gtgctactgt gaatgtcact
     4141 gtgcttttag aagatgtgaa tgacaacagg cctttgttta atagcaccaa ttacacattt
     4201 tacttcgaag aggagcagag agctgggtcc ttcgtaggca aagtcagtgc tgtggacaaa
     4261 gacttcgggc caaatgggga agtcaggtat gcttttgagg tgacacagcc aaatttcgag
     4321 ttgcacgctg tcactgggga gatcaccagc actcacaagt ttgataggga gtccctcatg
     4381 aggagaaggg ggacagcagt attcagcttc acagtgacag ccatggatcg gggcctccct
     4441 cagcccctca aggaccaggc cactgtgcat gtctacatga aggacatcaa cgacaatgcc
     4501 cctaagtttc taaaagactt ttaccaagct acagtatccg agacggcgac caatctgacc
     4561 caggtcttac gagtgtctgc ctccgacgtg gacgagggaa gcaacggtct cattcattac
     4621 tctatcctca aaggaaacga agaaagacag tttgccatag acagcttctc tggacaggtg
     4681 actcttgtag gcaagctaga ctatgaagca acctcagcct actctctcct catccaggca
     4741 gtggattcag gggccattcc cctcaactca acctgcaccc tgagtatcga tattttggat
     4801 gagaatgata acaccccctc tttcccaaag tcaacactat tcgtggatgt tttggaaaac
     4861 atgaggattg gcgaacttgt atcctccgtc actgccactg actctgactc gggtgtcaat
     4921 gctgacctac actacactat tacagggtca aacaaccatg ggacttttag tattagcccc
     4981 aacactggga gtatctttct ggccaaaaag ttggactttg agacacagtc tttatataaa
     5041 ttaaacataa cagcgaaaga ccaggggcgg cctcctcgat cgtccacgat gtcagtggtg
     5101 atccaggtac gggacttcaa tgacaacccc cccagctttc ctccgggaga catttttaag
     5161 tcaatagtgg agaacatccc ccttggtacg tctgttattt ccgtgacagc gcatgaccca
     5221 gatgcagata tcaacgggca gctgtcttac gccatcatcc aacagatgcc ccgaggcaac
     5281 cacttcagca tagacgaagt caaaggaacc atctacacca gtgctgagat cgaccgggaa
     5341 tttgccaacc tcttcgagtt aacggtgaaa gccaatgacc aagcagtgcc gatagaaacc
     5401 aggaggtacg ctctgaaaaa tgtgaccatt ttggtgaccg acctcaatga caatgtccca
     5461 atgtttatat ctcaaaatgc actggctgca gacccgtcag ccatgattgg ttctgtcctg
     5521 actaccatca tggctgcaga cccggatgaa ggtgccaatg gcgaggtcga gtatgagata
     5581 ctcaatgggg acacagacac ctttactgtg gatcgttaca gtggggatct tcgagtggct
     5641 tctgccttgg tgccttcaca gctcatctac aaccttatcg tatcagccac agacctgggc
     5701 ccagagcgga ggaagtcaac cacagagcta actgtcattc tccagggcct agatgggcct
     5761 gttttcacac agaccaagta cataaccatc ttgaaggaag gggaacccat tggcaccaat
     5821 gtcatctcca tagaagcagc cagccccaga gggtcagaag ctccagtgga atattacatc
     5881 gtttctgttc gttgtgaaga gaagactgtc ggacgtctct ttaccattgg acggcagacg
     5941 ggtgtcattc aaactgcagc cattttggac cgggagcagg gtgcgtgtct ctacctggtg
     6001 gatgtttatg ccatagagaa gtcctctgcc tttcccagga cacagagagc agaggtagaa
     6061 ataacacttc aagatatcaa tgacaaccca ccggtgtttc caacagacac cctggatctc
     6121 accgtggaag agaacattgg agatggctca aagattatgc agctgactgc catggatgct
     6181 gatgagggtg ccaacgctct ggtcacgtat gctctcatta gtggagctga tgacagcttc
     6241 cgaattgatc ctgagtctgg agacctgata gccaccaaga ggttggacag ggagcacagg
     6301 tccaagtact cattgctggt tcgtgcagac gatggcctcc agtcctcaga catgaggata
     6361 aatatcacca tcagcgacgt gaatgaccac acccccagat tctccaggcc cgtgtactct
     6421 ttcgacatcc cagaagacac aacccctggt tccctggtgg cagctatttt agcaacagat
     6481 gatgactctg gtgtgaatgg agagatcagc tatgtggtgg aggaggatga cggggatggc
     6541 gtgttctttc tgaatctggt cactggtgtc ttcaacctga cccgagcact ggactatgaa
     6601 acacagcagt attacatcct cacagtccgt gcggaggatg gtgggggtca gtccaccacc
     6661 atccgagctt acttcaacat tcttgatgtc aacgacaatc cacctgtctt cagcatgagc
     6721 tcctacagca catccttaat ggaaaacctg cctctcggat ccacggtcct tgtgtttaac
     6781 gtcaccgatg cagatgatgg tgtcaactct cagctgtcct acagcattgc ttcaggtgac
     6841 agccttgggc agtttgcagt ggataagcac ggagtcctca aaaccctcaa agctttggac
     6901 cgggaaagcc agtccttcta caacctggtc attcaggtcc atgacttgcc ccagcctcct
     6961 acctccaggt tcaccagcac agcccaagtt tctatcatct tgttagatgt caatgataac
     7021 ccacctatgt ttctttcccc caagttgaca tacattccag aaaacacacc cattgatact
     7081 gttgtcttca aggctcaagc gacagaccca gacagtggcc ccaacagcta tattgagtat
     7141 actctcctga acccttcagg aaacaagttc agcattggga ccattgatgg tgaagtgcat
     7201 cttacaggag agctggacag agaggaagtt tccaattaca gcctgacagt ggtggccaca
     7261 gacaaagggc agccacctct gtcgtcctct actgaggttg tggttatggt ccttgacatc
     7321 aatgataaca accctgtttt tgctcaggct atgtaccgag tgcagattaa ggagaacata
     7381 ctcactggaa cagatataat ccaagtgtct gcagcagaca atgatgaagg taccaacgga
     7441 caggttcgct acggcatcgt gggtggaaac acacatcaag agttcaggat cgactcagtg
     7501 acaggggcca tcacagtggc taagtctttg gatagagaga cgacccctgc ttacacttta
     7561 actgttcagg ccacagatcg gggcagtagc cccagaacgg actcctgcac agtcgccatc
     7621 actttacttg acatgaatga ttttgtccct gtatttgagt tgtctccgta ttctgtgaat
     7681 gttcctgaaa atttagggac cctgcccaga gccattcttc aggtggtggc aagagacgat
     7741 gatcaaggtc caaatagcca gctctcatat gttttgcttg gtggaaatga agacaatgct
     7801 tttgtcctca cggccagtgg cgagcttcgg gtgacccaga gtctggaccg ggaagcaaga
     7861 gatcacttcg tcctggttgt cacagctgct gatgcaggat ccccagcctt gacgggaaca
     7921 ggaacaatca acatcattgt agatgatatc aacgacaacg tccccacttt tgccaataac
     7981 atgtacttaa cttcaattgc cgaggatgcc cggacgggga cagatgtcct gttggtgaat
     8041 gcctcggatg cagatgctgc ggcaaatgct gtcatcagtt acagtatcat cggtggaaac
     8101 tcgcagttca ccatcaaccc atccacggga cagatcatca ctagtgcttt gctggacaga
     8161 gaaaccaaag ataattacac tttggtcgtg gttgccagtg atgctgggtc tccagagtct
     8221 ctttccagct ctactagtgt gcttgtgacc atcactgatg ttaatgacaa cccaccccgg
     8281 ttccaacatc acccatacgt cacacacatc ccatctccta ctcctccagg ttcctttgtt
     8341 tttgctgtca cagtcaccga cgcggacata ggatctaatt ctgaactcca ttactcactc
     8401 tcaggtagaa actctgaaaa atttcacatt gaccccctga ggggggcaat catggcagct
     8461 gggccactaa gtggagcttc ggaggtgacg ttctctgtcc atgtgaaaga tggtggctca
     8521 tttccaaaga cagattctac tacagtgact gttaggtttg ccaacaaggc agatttcccc
     8581 aaagtcagag ccaaagaaca aacattcatg tttccagaaa accagccagt gggcactctg
     8641 gtcaccacta tcacagggtc ctctttgaga ggagaaactt tgtcttacta catcgcaagt
     8701 ggaaacctgg gcgacacttt ccaaattgat ccactaacag gacaggtgtc catcagccag
     8761 cctctggact ttgagaagat acaaaaatac gttgtttgga tcgaagctag agatggaggc
     8821 ttccctccct tctcttctta tgagaagctt gacatcacgg tgctggatat caatgacaat
     8881 gctccaacat ttgaagaaga cccatttgta tctgagatcc tggaaaacct atcccctcgg
     8941 aaaatcctta ccgtctcagc aacggacaag gacagtggtc ccaatggaca actagactat
     9001 gagattgtga atggcaacca ggagagcagt ttcaccatca atcatgctac aggtgaaatc
     9061 agaagcattc ggccactaga cagagaaaaa atatcccact atgaactcac tgtgaaatct
     9121 tcagacaaag ggtccccttc tcagagcacc tccgtaaaag tgatcatcag tattttagat
     9181 gaaaacgata acgcacctag gttttcacag atattcagtg cctatgtttc tgaaaactcc
     9241 cccttgggat acacagttac ccgtgtaaca acttctgatg aagacattgg gataaatgca
     9301 attagtagat attccatagt ggacacaagt cttccattta ctattaaccc caacacagga
     9361 gatattgtca tcagtcgacc tttaaacaga gaagatacag acagatacag gatccgagtg
     9421 tccgcacatg attctggctg gactgtaagt accgatgtca ccatatttgt gactgacatc
     9481 aatgacaaca ctccaagatt tagcagaccc tcttattatt tagattgccc tgaacttcct
     9541 gagcttggct ccagagtgac tcaagtgtct gccacagatc ctgatgaggg gtcaaatggg
     9601 caggtgtttt atttcataaa gtcgcagtca gagtatttca gaatcaatgc caccactgga
     9661 gagattttca acaagcaggt gttaaaatac caaaatgtca gtggcttcag taatgtgaac
     9721 atcaacaggc acagtttcat tgtgacagct tctgaccgag gcaacccctc cttactcagc
     9781 gagaccacag ttaccatcaa cacggtggat agcaacgaca acccacctca gtttctccaa
     9841 aataaatact ttaccccagt taccaaaaac gttaaagttg gtactaagtt aatcaaagtg
     9901 actgcggtgg atgacaaaga ctttggatta aactctgaag tggagtattt cgtgtcggat
     9961 gggaaccacc tagggaagtt taagttagac aacgatactg ggtggatttc aatagcctct
    10021 tccttggttt ctgacctaaa tcaaaacttc ctgatcagag tcacagcaaa ggacaaaggg
    10081 aaccccccac tttcctccca agcagtcgtt cacatcacag tcactgaaga gaactaccac
    10141 acccctgaat tttcccagaa ccatataagt gccaccatcc ctgagagcca cagcattggg
    10201 tctgtggtca gaactgtctc tgccagagat cgtgacaccg ccatgaatgg tctgatcagt
    10261 tacaacatta tttcggggaa tgaagagggc atctttgcaa tcaattcctc aacaggtgtg
    10321 gtaaccctag ccaaagccct tgattatgag atgagctcaa agcacgagat gaccattagt
    10381 gccacagatg gaggatgggt tgcgaggact ggctactgca gcctgactgt gagtgtgatc
    10441 gatgtgaatg acaattcccc agtgtttgtt cctgatgaat ttttcccaac tgttatggag
    10501 aacgccccaa gtgggaccac tgttatccac ctaaacgcaa cagacgctga ctcgggagcc
    10561 aatgctgtga ttgcgtacac tgtgcagtca tcagacagtg acctgtttgt tattgacccc
    10621 aacatgggag tcatcaccac tcaaggcttc ttggattttg aaaccaagca gagctaccac
    10681 ctcacagtga aagccttcaa cgtccccgac gaggaaaagt gcagctttgc cactgtggat
    10741 atccagttga aggggacgaa cgagtatgtg cctcgctttg tttctaagct ctactacttt
    10801 gaggtgtcgg aagcggcttc tagggggact gctgttgggg aagtgtttgc cagtgacagg
    10861 gacatgggtg ctgatggaga agtacactat ttgatttttg gaaatagtag gaaaaagggc
    10921 ttccagatca acaagatgac agggcagatc tacgtgtctg ggcttcttga tagagagaaa
    10981 gaagaaaggg tgtctttgaa agtgttagcc aagaactttg gcaacattcg aggtgcagat
    11041 atcgatgaag tcacagtaaa tatcactgtg cttgatgcta atgacccgcc agtgtttagt
    11101 ctgagcacct atagagtcca gatcagtgaa ggggtcccta ttgggaccca cgtgaccttt
    11161 gtgagtgcct ttgactcaga ttccatcccg agctggagca ggttctcata cttcattggg
    11221 tccgggaatg aaaatggtgc cttttccatt aacccacaga cagggcagat cacagttacc
    11281 tcagggctgg accgggaaag cctgcctgtt tataatctca ctgtcctggc tgtagactca
    11341 gggactccct ctgccacagg aagtgcttcc ttggtagtta ccctggaaga catcaatgac
    11401 aatggcccag tgttgactgt cagtgaaggg gaagttctag aaaacaaacg accaggaact
    11461 ctagtgatga ccctgcagtc cacagatcct gacctccctc caaatcaagg ccccttcaat
    11521 tattacctgc tgagcacagg ccccgctact aattatttca gtctcagtac cgctggcgtt
    11581 ctaagcacaa cccgggagat cgacagagag cagattgcgg acttctattt gtctgtggtc
    11641 accagggatt ctggggctcc tcaaatgtca tccacaggaa ctgtgcacat cactgttcta
    11701 gatcaaaatg acaacccctc acagtcccgc acagtggaga tatttgttaa ttattacggc
    11761 aacttatttc ctggtggcac tctgggctct gtgaagcccc aggacccgga tgtgttagac
    11821 agtttccact gctccctcac ttcaggagtc accagcctct tcagtatccc agcgggcagc
    11881 tgtgacctga gttcccagcc cagatccaca gatggcacct ttgatctgac tgttgtcagc
    11941 agcgatgggg ttcacagcac agtcaccaac aatattcgag ttttctttgc aggattctcc
    12001 aatgctacga tagataacag catcttgctt cgtgttggtg ttcccacagt caaggacttc
    12061 ctgactaatc actaccttca ctttctgcgc attgctagtt cccagcttac gggcctgggc
    12121 acggcagtgc agctgtatgc tgcctatgag gagaacaaca gaacgtttct tttagcagct
    12181 gtgaaacgaa ataataacca gtatgtgaac cccagtggtg tagccacgtt cttcgaaagc
    12241 atcaaagaga tcctcctccg tcagagtggt gtcaaggtcg aatctgtgga tcacgaccca
    12301 tgcattcatg ggccgtgtca gaacggaggc agctgccttc gaagacttgc cgtgggctct
    12361 gcgctgaaga ttcaggagag tctgcctgtc atcattgtgg ccaacgagcc tctgcagcct
    12421 tcccagtgca agtgtgtgcc aggctatgct ggaagctggt gcgaggtgga tattgatgaa
    12481 tgcctcccag ccccttgcca caatgggggc acctgccaca acttagttgg gggattttca
    12541 tgcagctgcc cagagggctt cactgggaga gcctgtgaga gagacatcaa tgaatgtttg
    12601 cccagccctt gcaagcatgg ggccgtctgt caaaatttcc cagggggatt caactgcgtg
    12661 tgcaaaactg gatacacagg aaaaatgtgt gaatcttcag tcaattactg tgaatgcaac
    12721 ccctgcttca atggtggttc ctgtcagagt ggtgtggagt cctattactg tcactgtcca
    12781 ttcggcgtct ttggcaagca ctgtgagctg aacagttatg gatttgagga actgtcatac
    12841 atggagtttc ccagcctgga ccccaacaac aactatattt atgtcaagtt tgccaccatc
    12901 aaaagccatg ctttattgct ttataactat gacaaccaga cgggagagag ggcagagttc
    12961 ctggctctgg agattgccga agaaagactc agattctcat acaatctggg cagtgggacg
    13021 tacaaactga ccaccatgaa gaaggtgtcg gatggacagt tccacacagt gattgcacgg
    13081 cgagcaggca tggcagcttc tttaactgtg gactcctgct cagagaatca agagccaggc
    13141 tattgcactg tcagtaatgt ggcggtttca gacgactgga ctcttgatgt tcagccaaac
    13201 cgagtcactg ttggaggaat cagatcacta gagccaatcc ttcagaggag ggggcatgtg
    13261 gagagccacg attttgtggg ctgtgtaatg gagtttgctg tcaatggacg acccctggag
    13321 cccagccagg ctctggcagc acaaggcatt cttgaccagt gtcctagatt ggaaggcacg
    13381 tgtgctcgca acccctgcca gcatggtggc acctgtgtgg acttctggtc atggcagcag
    13441 tgtcagtgca tggagggtct gactgggaag tactgtgaaa aatctgtcac tccagacact
    13501 gccttgtcac tagaaggcaa aggacgcctg gactaccaca tgagccagag tgagaagcgg
    13561 gaatacttgc tgacccagag catacgggac accacattgg agccttttgg ggtcaatagc
    13621 ctggaagtaa aattcaggac tcggagtgag aatggcattt tgatccatat ccaggaaagc
    13681 agcaattata ccacagtgaa gattaagaat ggcaaagtgc actttacatc ggatgcaggt
    13741 gttgctggga aggtggagcg aatcatccca gaagcataca ttgcagatgg ccattggcat
    13801 accttccgga tctcaaagaa tggaagcatc actgtgctgt ctgtagacag gatacacaac
    13861 agagacatcg tccaccccac tcaggacttt ggtggcattg aggtgctttc catgtctctg
    13921 ggaggaatcc cccccaacca agcccatcga gacactcaga caggttttaa tggctgcatt
    13981 gcctcagtgc tctatggtgg agagagcctc cccttcagtg ggaagcacag cttggcgtcc
    14041 atctccaaaa cagacccttc agtgaagatc ggctgtcggg gccctaacat ctgtgccagc
    14101 aacccctgct ggggcgatct tctgtgtatc aaccagtggt atgcctacaa atgtgtccct
    14161 cctggtgact gtgcatccca cccttgccag aatggaggta gctgtgaacc aggtctgctc
    14221 tccggctaca cttgcagctg tccagagtcg cacacaggga ggacctgtga gacggtggtg
    14281 gcctgcctcg gtgttctctg tcctcagggc aaggtgtgca aggctggaag tccaggggga
    14341 cacgtgtgtg tccagagtca gggtccagat gagatatcct tacctctgtg ggcagtgcct
    14401 gcaattgtgg gcagctgtgc cacagcccta gcgctgctgg tcctcagttt gattctatgc
    14461 aaccagtgca ggggaaagat gcccaaaaac cccaaagagg agaagaagcc gaaggagaag
    14521 aagaaaaagg gcagtgagaa tgtagctttt gatgacccag acaacatccc tccctatggg
    14581 gatgacctag ctgttaggaa gcaacctgag gggaatccca agccggacat catagagcga
    14641 gagaacccct atctaatctt cgatgagact gacatccccc acaactcaga gaccatccct
    14701 agtgccccgc tggcttcccc tgagcaggag attgagcact atgacatcga caatgccagc
    14761 agtatcgcgc cctcagatgc agacatcatc cagcactaca aacagttccg aagccacacg
    14821 cctaagtttt ccatccagag gcacagtcct ctgggcttcg ccaggcagtc ccctatgccc
    14881 ttgggagcaa gcagtctgac ctaccagcct tcttcatatg gccaagggtt aagaaccagc
    14941 tcccttagcc actcggcctg ccccactccc aaccctctgt ccaggcacag cccagctcct
    15001 ttctccaaac catctgcctt ctacaggaac agcccagccc gggaactgca tcttcctctg
    15061 agggatgggg gtacgctgga aatgcatggg gacccctgcc agcctggcat gttcaactat
    15121 gccaccaggc tagggagaag aagtaagagc cctcaggcca tggcatctca tggatcgaga
    15181 ccagggagtc gcctcaaaca gcccatagca cagatccctc tagaatcttc tcctcccgtg
    15241 ggactctcca tagaggaggt agagaggctc aacacccctc gacccagaaa ccccagcatc
    15301 tgcagtgcag accatgggag gtcctcttct gaagaagact gtagaaggcc cctgtccaga
    15361 accaggaacc cagcagatgg catccctgcc ccagaatcgt cttctgacag tgactcccat
    15421 gattctttca cgtgctcaga aatggaatac gacagggaga agcccgtggt ctacacttcc
    15481 aggatgccca agttatctca agtcaacgaa tccgatgcag atgacgaaga taattatgga
    15541 gccagactga aacccagaag gtaccatgga cgcagggctg aggggggacc agtgggtacc
    15601 cctgcagcag cgtctggggc tgcagacagc accctgaagc tggggcagca ggcaggcaac
    15661 ttcaactggg acaacctttt gaactggggc ccaggctttg gtcattatgt ggatgtcttt
    15721 aaagatttgg cctctctccc agaaaaagca gctggtaacg aagaaggtaa aagtggggca
    15781 gctaaaccag ccgccaaaga tggggaggca gaacagtatg tgtgaggtgt atgtgtgggc
    15841 aagaaacact caaagcacgg tgtggcttcc caccagcggg ggtcaccttt gtaaaacagg
    15901 ccagtataga ccggtggcca gggacacatt taaagttaac cacaaagctg ctcacataga
    15961 ctccaaacga ctgactcttt aatttaaatg tgctcagtgg aacggaatga tcctcctgca
    16021 tgcatcttgt tttgtgatga gttttggggc atgcaacatt gggaagtgtt gctttgtgtt
    16081 tggtttgtgg ttttttgccg tttataccat tgcagttgta gactcgagct tgtgctttca
    16141 cagtggggtt gcttgtttcc attgtagtgt tacggttgtg ttttaccttg caagatcatt
    16201 taagtttagc caacccgtgt ggagtgcagg aaggaggact tcccaccttg gagggatgaa
    16261 aggctgcaca tttaacactc ttcagatgaa tagattcata tgtgatgtcg ctcagacaca
    16321 ataagggctt gttttacatg acggtgggta ctaagaataa gtcattttgt tccgcacttt
    16381 aaagctttct taaaaactgt gttgacactt gtgtgtctcc gtgcgaacag tcatggcctc
    16441 ctgacttacc tcaggcttcc aggaagaaca agatgaccac atactgtccc cagaacactg
    16501 ccacctttcc tcttccggga taacattctc agcgcacttc taagagacaa tttttaaagt
    16561 tatttattga agaaaaaaag ttctatgctt ttaacattgt aacaaattga cctatgcagg
    16621 ccctaattgg ttttattttc tatccattca acatttaccc caagtaccca gtttttataa
    16681 tttatataaa gtcagattgc aatgtttctt actttccgtc gttttgtaga tcattttttt
    16741 aatactgtgt aaaacttttt tttttttttt tttacacctg agctgtggtt ttgatactga
    16801 tattttccta tgccggaaac ttttcttgct ttcagggaag gtaagaaaat gtgtttttta
    16861 catttgttac ttatgtaaca ttcatatttt cacagtttga tatctgtaac atactgtatg
    16921 ctttctacct gtaaatgcca acaatagaat taaaatattt atttaaaa
//
