LOCUS       NM_198176               3131 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus FAST kinase domains 5 (Fastkd5), transcript variant 1,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_198176
VERSION     NM_198176.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3131)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3131)
  AUTHORS   Cheong,A., Archambault,D., Degani,R., Iverson,E., Tremblay,K.D. and
            Mager,J.
  TITLE     Nuclear-encoded mitochondrial ribosomal proteins are required to
            initiate gastrulation
  JOURNAL   Development 147 (10) (2020)
   PUBMED   32376682
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3131)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3131)
  AUTHORS   Simarro,M., Gimenez-Cassina,A., Kedersha,N., Lazaro,J.B.,
            Adelmant,G.O., Marto,J.A., Rhee,K., Tisdale,S., Danial,N.,
            Benarafa,C., Orduna,A. and Anderson,P.
  TITLE     Fast kinase domain-containing protein 3 is a mitochondrial protein
            essential for cellular respiration
  JOURNAL   Biochem Biophys Res Commun 401 (3), 440-446 (2010)
   PUBMED   20869947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731707.12.
            
            On Apr 10, 2019 this sequence version replaced NM_198176.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052898.1, SRR11927932.3672379.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AL731707.12        177177-177263       c
            88-234              AL731707.12        175750-175896       c
            235-3131            AL731707.12        161107-164003       c
FEATURES             Location/Qualifiers
     source          1..3131
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.24 cM"
     gene            1..3131
                     /gene="Fastkd5"
                     /gene_synonym="mKIAA1792"
                     /note="FAST kinase domains 5"
                     /db_xref="GeneID:380601"
                     /db_xref="MGI:MGI:2139469"
     exon            1..87
                     /gene="Fastkd5"
                     /gene_synonym="mKIAA1792"
                     /inference="alignment:Splign:2.1.0"
     exon            88..234
                     /gene="Fastkd5"
                     /gene_synonym="mKIAA1792"
                     /inference="alignment:Splign:2.1.0"
     exon            235..3131
                     /gene="Fastkd5"
                     /gene_synonym="mKIAA1792"
                     /inference="alignment:Splign:2.1.0"
     CDS             444..2732
                     /gene="Fastkd5"
                     /gene_synonym="mKIAA1792"
                     /codon_start=1
                     /product="FAST kinase domain-containing protein 5,
                     mitochondrial"
                     /protein_id="NP_937819.3"
                     /db_xref="CCDS:CCDS50713.2"
                     /db_xref="GeneID:380601"
                     /db_xref="MGI:MGI:2139469"
                     /translation="MSAALKLLEPLKYKAPCNPAYRAAQSVAHWHMGNITPHGGQTLP
                     ECNSSCHLARKVKNVGGTTLPRRTFTASSAHLGLEFNKASTLNASTLHPDSSSAGGGE
                     EDVEVFDSFEGTRVFLKLRPEYQLHSYNRSDTHQPIAASEVELILHKVTFYQNKLQPE
                     VITNYFYKLSSLPAEQNSVLLSSNSFALLCQLSVKNIQLFNTSDLISILKAFVDLRIP
                     PSLSMLDVYETRFCHQVWEMTLDQLLLVADLWRNLGRRVPRFFKIFFSYLNLHWRELS
                     LSQLIHLIYIIGENRQVPQDLMQRLESLILKYVDSVNLEEVGTICLGFFKSSSSLSEF
                     VMRKIGDLACANMQHLSSHTLVHILKMFRFTHVDHIHFMKQFGEIAPQRIPSLGVQGV
                     MHLTLACSALRILDERVMNAVAASLPPRVAHCRSKDVAKILWSFGTLNYKPPNTEEFY
                     SSLINEIHRKMPEFNQYPEHLLTCLIGLAFSEYFPVEFINVALSPGFVKLAQERSKFE
                     LTKELFTLDGTVAIECPDYKGNRLNSHLQQETSANLWNLASKDMRSKPEFLETLYLLE
                     TMLGGPQYIKHHMILPHTRSSDLEVQLDANMKPMPFNSEATPTEDGAQLRFKQVGVSL
                     TDDLMNQLLKGKAKRYFQGQIELETGQPPMELRKKTTVPLVNSGCNGTDRLGDGMVGL
                     CPLAHMQPPLVKLAIQFTNKNQYCYGSRALLGLHNMKRRQLVQIGYRVVELPHWEWLP
                     LLKRTRLEKLAYLHEKVFTSAL"
     regulatory      3112..3117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fastkd5"
                     /gene_synonym="mKIAA1792"
                     /note="hexamer: AATAAG"
     polyA_site      3131
                     /gene="Fastkd5"
                     /gene_synonym="mKIAA1792"
                     /note="major polyA site"
ORIGIN      
        1 gtggagcggt tgatgcagga gtctgtgcat tgacttaccc ggggcggccc gggactggag
       61 ttagggagct gccttcgcgg gcttcagtgc tggaggaggc cagaagaggg cgttggatct
      121 cctgggactt gaattaaggt tgattgtgag ccacagtgtg agcgctggaa atcaaacccc
      181 aatcctctgg aagagcagcc agtactctta aacactgagc aatctctcca gccagtagaa
      241 gccactcatt cttcatctac ccttttttca gtatctggca ccaattctgg ccccatcatt
      301 tgtggcccat ggctcttgtg gtatgccgaa gatttacagg cagtttctgt ggaacatttc
      361 cctgtccacc tctaatgaag ccccgtcaaa caagaacatg tgattttgct ctgactgcca
      421 agaagatcag cacagactcc agaatgtcag ccgctctcaa gctattagaa cctttaaagt
      481 acaaagcacc ttgtaatcct gcttaccgtg cagcccaaag cgtggcccat tggcacatgg
      541 gaaacatcac gccacacggg ggacagacgc tccctgaatg taatagctcc tgccatcttg
      601 ccagaaaagt gaagaacgtt ggtggtacca cccttcctcg gagaaccttc acagccagca
      661 gtgcccacct gggtttggag ttcaacaaag cttctaccct taatgccagc acactgcatc
      721 cagactcatc cagtgctgga ggaggtgaag aggatgtaga ggtctttgat tccttcgaag
      781 gaacccgagt tttcttaaag ctaaggccag agtaccagct tcacagctat aacagaagtg
      841 acactcacca acccatagct gcttcagaag ttgaactaat tttgcacaaa gtcacattct
      901 accaaaataa actccagcca gaagtcataa ctaattattt ttataagctc agctctttgc
      961 cagcagaaca gaattctgtt ttgctatcca gtaacagctt tgctttgctc tgccagctga
     1021 gtgtgaaaaa catacagctc tttaacacct ccgatctgat cagtattttg aaagcctttg
     1081 ttgacttaag aattcccccc tccctgtcca tgctagatgt gtatgaaacc agattttgcc
     1141 atcaggtatg ggagatgact ctagatcagc ttctcctagt agctgatctt tggcggaact
     1201 taggccgcag agtgcctcgt ttttttaaaa ttttttttag ttatcttaat ttacactgga
     1261 gagagctatc tttgtctcag ctgattcact taatttatat tataggtgaa aatcgtcaag
     1321 taccacagga cctgatgcaa agactagaat cactgatcct taagtatgta gattcagtca
     1381 atttagagga agttggtaca atctgtttgg ggttttttaa atcaagtagt agtctctctg
     1441 aatttgtcat gcggaaaatt ggagatctag cttgtgctaa catgcagcat ctgagtagcc
     1501 acaccttagt tcatattctt aaaatgttcc gcttcactca tgtagatcat atacatttta
     1561 tgaagcagtt tggagaaatt gctcctcaga gaattccttc cttgggggtt cagggtgtta
     1621 tgcacctcac acttgcctgc tcagccttac gcatcctgga tgaaagagta atgaacgcag
     1681 tagctgcctc tttgcctccg agggtagcac actgtcgaag taaagatgtt gccaaaattc
     1741 tgtggtcctt tggaactctg aattataagc cacccaacac agaagaattt tattccagtc
     1801 tcataaatga aatccacaga aagatgcctg aattcaacca gtacccagag caccttctca
     1861 cctgcctgat tggcttggca ttttctgaat actttccagt tgagttcata aatgttgctc
     1921 tgagcccagg atttgtcaag ttagctcaag agagaagtaa gtttgaactc actaaggaac
     1981 tgtttactct tgatggtaca gttgccattg aatgtccaga ttacaagggc aaccgtctta
     2041 attctcacct tcaacaagaa acatctgcaa atctgtggaa tctagcaagt aaggatatga
     2101 gatcaaagcc tgaattccta gaaactctct atttacttga gaccatgttg ggtggccccc
     2161 agtacattaa gcaccatatg attttgcctc atacccgctc ttctgactta gaggttcagc
     2221 ttgatgctaa catgaaacca atgcccttta atagtgaagc gacaccaact gaagatggag
     2281 ctcaattacg gtttaagcaa gtgggagtca gccttacaga tgatttgatg aatcagttgc
     2341 tgaagggaaa agccaagagg tatttccagg ggcaaattga gttagagact ggccagccac
     2401 ccatggagtt aagaaagaag acaactgtac ccttggtgaa ctctggttgc aatgggacag
     2461 atagattggg ggatgggatg gttggcttgt gccctctagc ccacatgcag cccccattag
     2521 tgaagctagc tatccagttc acaaacaaga accaatactg ctatggttcc agggctctac
     2581 ttggattgca caatatgaag aggaggcagc tagttcaaat tgggtaccgt gtggtagaat
     2641 taccccactg ggaatggctt ccactactaa aaagaactcg cttagagaag ctagcatacc
     2701 tccatgagaa agtgttcacc tctgctctct gaagggcact cgtggacatt tatcctcata
     2761 aaaggaatag gtgcatacct tctacctgta agttgagcat ccttaaccag aaaatcaaag
     2821 tcaaatatta aaaaacctgg aactgagtac tgacagatgt cagatcaagg atattcaagt
     2881 ggtaggtagt ctatgtagat accctggact tcaaatctca aacacctcta gtctcaagta
     2941 tttgataccg ggattctcaa cctgtcctcc aagtaattat aaaagccaca gtgtaggtgg
     3001 gtaataaccg tctgttgagt agccatgggt gcagtgcctg tagcaattat atattacgac
     3061 aggttttgtg taaccctggt tgtactctag ttgtatgttt tgctcagaat aaataagcat
     3121 cttcaaaatg a
//
