LOCUS       NM_027123               2476 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus FAST kinase domains 3 (Fastkd3), transcript variant 2,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_027123
VERSION     NM_027123.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2476)
  AUTHORS   Simarro,M., Gimenez-Cassina,A., Kedersha,N., Lazaro,J.B.,
            Adelmant,G.O., Marto,J.A., Rhee,K., Tisdale,S., Danial,N.,
            Benarafa,C., Orduna,A. and Anderson,P.
  TITLE     Fast kinase domain-containing protein 3 is a mitochondrial protein
            essential for cellular respiration
  JOURNAL   Biochem Biophys Res Commun 401 (3), 440-446 (2010)
   PUBMED   20869947
  REMARK    GeneRIF: these results introduce FASTKD3 as an essential component
            of mitochondrial respiration that may modulate energy balance in
            cells exposed to adverse conditions by functionally coupling
            mitochondrial protein synthesis to respiration.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT033781.12, AK033189.1 and CJ265660.1.
            
            On Aug 25, 2016 this sequence version replaced NM_027123.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033189.1, AK148902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                CT033781.12        157413-157450
            39-2400             AK033189.1         2-2363
            2401-2476           CJ265660.1         585-660
FEATURES             Location/Qualifiers
     source          1..2476
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 35.55 cM"
     gene            1..2476
                     /gene="Fastkd3"
                     /gene_synonym="2310010B21Rik"
                     /note="FAST kinase domains 3"
                     /db_xref="GeneID:69577"
                     /db_xref="MGI:MGI:1916827"
     exon            1..141
                     /gene="Fastkd3"
                     /gene_synonym="2310010B21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            142..1605
                     /gene="Fastkd3"
                     /gene_synonym="2310010B21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2150
                     /gene="Fastkd3"
                     /gene_synonym="2310010B21Rik"
                     /codon_start=1
                     /product="FAST kinase domain-containing protein 3,
                     mitochondrial"
                     /protein_id="NP_081399.3"
                     /db_xref="CCDS:CCDS36719.1"
                     /db_xref="GeneID:69577"
                     /db_xref="MGI:MGI:1916827"
                     /translation="MAFITLRRAFCHKSILWIPGAVVALKIHPASHAPKAVTDRLSVC
                     FCSLQPELFRVRFHHAYCKNFHSEKGNDFHPVGEPWSSQAQEWNQPGQSLQNEDEEML
                     FRRLSYFTSFEEVLSFISALDTLPVPLAMAALLRICEIGRRDGEQRLPEGVLENRAFQ
                     ALCLRCERDPSHLTNAGLVTALQSLLTLLPADPQSSLMLSLVAECQRRLQRGNLEVHH
                     LCVLGESLAMLQGASCETLKLVVRQLQSKSVETFAPEEITSVYRILQVCPEEVDKHQM
                     FLNTLNNFSISVVPYLSPKSISHVLTALVALDQTHALPLLIKLGKYVVRYIPRFTNEE
                     LRKVLEAFVYFGHSDRFFTEALEQHVSALCFSLDPAVASSVMGYCSRKRILSKPIFDV
                     VSEIVVCQWDRLSPSQIAELIEPFGKLNYVPPNAPALFRKVENVLCARLHHFPPKMLL
                     RLLHSCALIERHPVNFMSKLFSPFFLQRLQGKESYLDRLSLAQLTQLFLTSVLECPFY
                     KGPKLLPKYQVKSFLTPCCSLETPLDLHLYKSVVIGLIDLLGSRLYFASKVLTPYYYT
                     IDVEVKLDEDGFVLPCTVDEDIHKRVALCIDGPQRFCLDSKHLLGKEATKQRHLRLLG
                     YQVVQLPYHELELLTSRLELVDYLQRKLFSQSSAVHW"
     exon            1606..1691
                     /gene="Fastkd3"
                     /gene_synonym="2310010B21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1866
                     /gene="Fastkd3"
                     /gene_synonym="2310010B21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1936
                     /gene="Fastkd3"
                     /gene_synonym="2310010B21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2051
                     /gene="Fastkd3"
                     /gene_synonym="2310010B21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2459
                     /gene="Fastkd3"
                     /gene_synonym="2310010B21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2381..2386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fastkd3"
                     /gene_synonym="2310010B21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2403
                     /gene="Fastkd3"
                     /gene_synonym="2310010B21Rik"
                     /note="major polyA site"
     regulatory      2441..2446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fastkd3"
                     /gene_synonym="2310010B21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2459
                     /gene="Fastkd3"
                     /gene_synonym="2310010B21Rik"
ORIGIN      
        1 ggatgtgggt gggtgggtgg ccttagtgcc gcgcacgcgc cggaatgttc tccaggtaag
       61 gggcagcgtc cgtgtacgga cgctcccagg gctcggaagc tccgtgtctg tcctgtcccg
      121 ggtgcggctt ggagccgctc gtcacatgtt gtgaattcta tggcatggcg ttcatcaccc
      181 tgcggagggc cttttgtcat aagtccattc tttggatacc tggagctgtg gttgctctga
      241 aaattcaccc tgccagtcat gccccaaagg cagtcacaga tcgcctgagt gtgtgcttct
      301 gctccctaca acctgagctg ttcagggtca gattccatca cgcatactgt aaaaacttcc
      361 actcagaaaa gggaaatgac tttcatcccg tgggcgagcc atggtcctcc caggcgcagg
      421 aatggaacca gccaggacag agtcttcaaa acgaggatga agagatgctt ttcaggagac
      481 taagctactt cacttccttt gaggaagtgc tgagtttcat aagtgccctg gacaccctgc
      541 ctgtccctct ggcaatggca gctctactca ggatctgtga gatagggagg agggatggtg
      601 agcaaaggct gccagaagga gtgctggaga accgtgcctt ccaggctctt tgcctccggt
      661 gtgagcgaga cccctcacac ctgaccaatg ctggtttggt gacagctttg caatctctgc
      721 ttacgttgtt gcctgcagat cctcaaagta gcctgatgct gagcctggtg gcagaatgcc
      781 aacgtcgtct ccaaagaggc aacctcgaag tccaccatct ttgtgtcctt ggggaaagtc
      841 tggccatgct tcaaggtgcg agttgtgaga ccctgaagct ggttgtccgt caacttcaaa
      901 gtaaaagtgt ggaaacattt gctccagagg agatcacgtc cgtttatagg attctgcagg
      961 tgtgtcctga agaagtagac aaacaccaga tgttcttaaa cacattaaac aacttctcca
     1021 tttcagtagt tccctacctg agccctaaat ccattagcca tgtcctcacc gccttagtgg
     1081 ccctggacca gactcacgca ctcccactgc ttataaagct gggcaagtac gttgtgagat
     1141 acatcccccg ttttaccaac gaagagctca ggaaggtctt ggaggcgttt gtctatttcg
     1201 gacacagtga caggttcttc acagaggcct tagagcaaca tgtgtccgcc ctgtgcttct
     1261 ccctggaccc cgctgtggcc agctccgtga tggggtactg cagcaggaaa cggattctct
     1321 ccaagcccat cttcgacgta gtctcagaga tcgttgtttg ccagtgggac agactttcac
     1381 ctagtcagat tgccgagcta attgagccat ttggaaagct caattacgtg ccaccaaacg
     1441 cccctgccct gtttaggaag gtagaaaatg tgctctgtgc ccgtttacat cacttcccac
     1501 caaagatgct actgaggctc cttcattcat gtgcgctgat tgagcgacat cccgtcaact
     1561 tcatgtcaaa actattcagc ccctttttcc ttcagcggct gcaaggtaaa gagtcatatt
     1621 tggacagatt gagcctggca cagctgaccc aacttttcct aacctccgtc ctagagtgtc
     1681 cgttctataa gggccccaaa cttcttccta aatatcaagt gaagtcattt ctcactccat
     1741 gctgctcctt agagacgccc ctggatctcc atctgtataa gtctgtggtg attggactga
     1801 ttgatctttt aggatcaaga ctgtattttg cttcaaaggt gttgacgccc tattactaca
     1861 ctatagatgt tgaagttaaa ttagatgaag atggatttgt attgccgtgt acagtggatg
     1921 aggatatcca caaaagggtg gcgctgtgta ttgatgggcc acagcgattt tgcttggaca
     1981 gtaaacactt acttggaaaa gaggctacta agcagagaca cctgcggtta cttggttacc
     2041 aggttgttca gcttccctat catgagctgg agctgcttac atcaagactt gagttggtgg
     2101 actatttaca aaggaagctg ttttctcaaa gctccgctgt ccactggtaa tagaggaaac
     2161 tggcttcagg attctcggtg aaaaagatga tatttgtaag agagacagtt taatctgtga
     2221 attagccact ctatggaaat tatgtttaca gacttgggat ctgaaaaggg tctgcggttt
     2281 ttcttatacc atgtatatgt gtattggtgg taaatttgga attaatttaa tgctagtatc
     2341 ttagatgcct tcaccgcatc gagcaggatt attcaaatgc aataaagcaa tgtaacaagt
     2401 aaatgttaat tgtccgtctt gtttttaaga gttatctgct aataaaagta tgctttttaa
     2461 aaaaaaaaaa aaaaaa
//
