LOCUS       NM_172422               3205 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus FAST kinase domains 2 (Fastkd2), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_172422
VERSION     NM_172422.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3205)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3205)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 3205)
  AUTHORS   Simarro,M., Gimenez-Cassina,A., Kedersha,N., Lazaro,J.B.,
            Adelmant,G.O., Marto,J.A., Rhee,K., Tisdale,S., Danial,N.,
            Benarafa,C., Orduna,A. and Anderson,P.
  TITLE     Fast kinase domain-containing protein 3 is a mitochondrial protein
            essential for cellular respiration
  JOURNAL   Biochem Biophys Res Commun 401 (3), 440-446 (2010)
   PUBMED   20869947
REFERENCE   4  (bases 1 to 3205)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035322.1, AK148224.1 and AK084971.1.
            
            On Apr 17, 2008 this sequence version replaced NM_172422.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084971.1, AK148224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AK035322.1         2-17
            17-1743             AK148224.1         1-1727
            1744-2285           AK035322.1         1744-2285
            2286-3205           AK084971.1         2261-3180
FEATURES             Location/Qualifiers
     source          1..3205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.31 cM"
     gene            1..3205
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /note="FAST kinase domains 2"
                     /db_xref="GeneID:75619"
                     /db_xref="MGI:MGI:1922869"
     exon            1..67
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            68..889
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2224
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /codon_start=1
                     /product="FAST kinase domain-containing protein 2,
                     mitochondrial"
                     /protein_id="NP_766010.1"
                     /db_xref="CCDS:CCDS15001.1"
                     /db_xref="GeneID:75619"
                     /db_xref="MGI:MGI:1922869"
                     /translation="MNSKARSLLWTIRRFSTLLPRSRALRIDPLGTCRPEVIHSKWNP
                     RNHRLNVFDEGLQPSVRYLFQDIFISKSVDGCIQTKGISHSAVFKPDRLLCPRRLSFD
                     AKHSFVSDGTSDHDLKKINFHHTSSEDVFTKKVRPTPVNYKKLAQECNSLSDVLDTFS
                     KAPTFPGSNYFLAMWIIAKRISEDKRRFERQLMFSHPAFNQLCEQMMREAKIMHYDHL
                     LFSLNAIVKLGIPQNTLMVQTLLRTIQERINECDERCLSILSTALVSMEPCMNVNALR
                     AGLRILVDQQVWNIKHVFTLQTVMKCIGKDAPSALKKKLEMKALKELGRFSILNSQHM
                     FEVLAAMDLRSVVLLNECSKVVIDNVHGCPFKVLISILQSCRDLRYQNEDLFKSIAEY
                     VATTFDIWKLKQVIFFLLLFETLGFRPPGLMDKLMEKVVQEPGSLNVKNIVSILHVYS
                     SLNHVHKIHNREFLEALASALTGCLHHISSESLLNAVHSFCMMNYFPLAPINQLIKEN
                     IINELLTSGDTEKNIHKLHVLNTCLKLDESTYKSVHIPLPQLPLSASQPNEKLAEVLS
                     RLLEGEGRFSRNVPLPHNYHIDFEIRMDTNRTQVFSFSDVDASSATNMQRVAVLCVPK
                     SVYCLNSCHPRGLMAMKIRHLNVMGFHVILIHNWELKKLKMEDAVTFVRKKIYSDEVL
                     PTADTTV"
     exon            890..993
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1102
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1226
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1366
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1539
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1703
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1916
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2001
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2116
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..3205
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2265..2270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2286
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
                     /note="major polyA site"
     polyA_site      2360
                     /gene="Fastkd2"
                     /gene_synonym="2810421I24Rik"
ORIGIN      
        1 agacgcgccg cttgaggagg aactgtcatg gctgcgccta tgtgtagtca cggggttctg
       61 ttcgaaggac agtccacagc atgtgctctt ttttagaaag acggcaactt gcgttgcatc
      121 ttgggtattt gaaagtgtgc caatagatag cagaatgaat agcaaagcac gttccttgtt
      181 atggaccatc cgacgattca gtacgttact tccaagaagc agagctttga ggatagatcc
      241 attgggaact tgcagaccag aggttattca ttcaaaatgg aacccaagaa accatcggct
      301 aaatgttttt gatgagggat tgcaaccatc tgttagatac ctctttcagg atatatttat
      361 ttctaaatca gtagatggtt gtattcaaac taaaggcata agccattcag ccgtttttaa
      421 acctgatagg ctgctttgtc ctagaagact gtcctttgat gcaaaacatt cttttgtctc
      481 tgatgggaca tctgatcatg atttaaagaa aataaacttt catcatacct ccagtgaaga
      541 tgtgttcacc aagaaagtaa gaccaacccc tgtgaattat aaaaagctag cccaggagtg
      601 taactctctg agtgatgtgc tggacacatt ttcaaaagca cctacatttc ctggtagtaa
      661 ctatttctta gcaatgtgga taattgccaa aaggatatct gaagacaaga ggcgctttga
      721 gagacagctg atgttcagtc accctgcctt taaccagctg tgtgagcaga tgatgagaga
      781 agccaagatt atgcactatg accacctctt gttcagcctt aatgctatag tgaagctggg
      841 aatccctcag aacactctta tggtacagac tttgctgagg acgattcagg agcgcatcaa
      901 tgagtgtgat gagagatgtc tttcaatttt gtcaaccgct ttagtgtcaa tggagccatg
      961 catgaatgtg aatgcgcttc gagcagggtt gcgaatccta gttgatcagc aagtttggaa
     1021 cataaaacat gtcttcacct tacaaacagt gatgaaatgt attgggaaag acgcaccatc
     1081 tgcacttaag aagaaattgg agatgaaagc cttgaaggag ttaggcagat tttccatctt
     1141 gaatagccag cacatgtttg aagtcttagc agctatggat ctccgctctg ttgtccttct
     1201 gaatgaatgc agtaaggttg tcatagataa tgtccatggg tgtcctttta aagtattgat
     1261 cagcatactg cagtcctgta gagacctccg ataccaaaat gaagatctct tcaaaagcat
     1321 agcagaatat gtggctacaa cctttgacat ctggaagttg aaacaagtta tctttttcct
     1381 cttattattt gaaactcttg gttttcgacc tcctggtttg atggacaagc ttatggagaa
     1441 agtagtacag gagcctggct ctctaaacgt gaagaacatc gtttctatcc tgcatgtgta
     1501 ttcttctctc aatcatgttc acaaaatcca caacagagag ttcctagaag ctctggcgag
     1561 tgctctgact ggctgtcttc accacatttc ttctgaaagc ctgttgaatg ctgtgcattc
     1621 gttttgcatg atgaattatt tccctctggc ccctattaac cagcttatca aagagaatat
     1681 catcaacgaa ctgctgactt cgggtgacac agagaagaat attcataagc ttcatgtttt
     1741 gaatacttgt ctgaaacttg atgaaagtac ttacaaatct gtgcacatac cgttgccaca
     1801 gctgccactg tcagcatcac agccaaacga gaagcttgca gaggtcctca gcaggcttct
     1861 ggaaggggaa ggacgcttct cgagaaatgt gccattgcca cataattatc acattgattt
     1921 tgaaatcaga atggatacta acaggaccca agtattttca ttttctgatg tagatgcaag
     1981 ttctgccaca aacatgcaga gagtagcagt gctgtgtgtt cctaagtctg tttactgttt
     2041 aaattcatgc caccccagag gattgatggc catgaaaatc cgacatttga atgtaatggg
     2101 cttccatgtg atcttgatcc ataactggga gctgaagaaa ctaaagatgg aggatgcggt
     2161 cacatttgtg aggaagaaga tctattcaga tgaagtgctt cccactgctg acacaaccgt
     2221 gtaaagcttg actacatcag aacacacagt tgtaaaatga ttttaataaa ggctgtgatt
     2281 cagttattcg tggatcagct ggctgatcac tgcaacaatg gtattttcag gttgggttaa
     2341 agatgacttt aagaatggaa gatgtgttgt cattggtatt ttggaacaca ctggaaacac
     2401 ttcagaagag ccatttttcc aacagcatct gctcctctga ctgtgcagat gcttaatatg
     2461 tccaagagct gtcgctgtac tttttctcat gggctttggt gtgttaaaag ctgctttctt
     2521 agttgtgtta tgataggtca catgtaagtt tgtgttggga gtttgaagtc tgaatattta
     2581 tatttcttct gtcagctgtt gtgagactta ggatttatat ttcagatcat tcaaacagta
     2641 gctaggcagc atttcgacca agttctcaag ccgtaggtca tgcaagagtt ggtgaggtag
     2701 catgtgaaat gtgagtgcgg ggcctgggga tggttcagtg atgatggtgt ctggtgtgca
     2761 gatattaccc atgttaaagc cagatgtgga tggttatcca ccaataacct tggaagatgt
     2821 gaatggttat ccaccagtat ccttggaaga tatggatggt tatccaccag taatcttggc
     2881 agaccctagg agcccactgg ccagatatat tggccaagac ctgctgaccg taacctctgg
     2941 cttccacatg cacacacctc tcatccacac atgcacacag cagatgagga tgccgtgcac
     3001 atatgtagca agcactgcaa gtggaggtgt gtcctgggct gcaacaggag gtaaaaggag
     3061 aagcgaagtc atccgtgttt gttaaaatgg ataggctgtc cattgacata agttttgcca
     3121 tttttgagac taatttcttt gtccttgcct ctcccaccat tgcatgagac ttccaaaatt
     3181 taaatatatt gccaaactgt gaact
//
