LOCUS       NM_177244               2877 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus FAST kinase domains 1 (Fastkd1), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_177244 XM_909181 XM_921193 XM_921202
VERSION     NM_177244.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2877)
  AUTHORS   Marshall,K.D., Klutho,P.J., Song,L., Krenz,M. and Baines,C.P.
  TITLE     The novel cyclophilin-D-interacting protein FASTKD1 protects cells
            against oxidative stress-induced cell death
  JOURNAL   Am J Physiol Cell Physiol 317 (3), C584-C599 (2019)
   PUBMED   31268778
  REMARK    GeneRIF: FASTKD1 supports mitochondrial homeostasis and plays a
            critical role against oxidant-induced death.
REFERENCE   2  (bases 1 to 2877)
  AUTHORS   Simarro,M., Gimenez-Cassina,A., Kedersha,N., Lazaro,J.B.,
            Adelmant,G.O., Marto,J.A., Rhee,K., Tisdale,S., Danial,N.,
            Benarafa,C., Orduna,A. and Anderson,P.
  TITLE     Fast kinase domain-containing protein 3 is a mitochondrial protein
            essential for cellular respiration
  JOURNAL   Biochem Biophys Res Commun 401 (3), 440-446 (2010)
   PUBMED   20869947
REFERENCE   3  (bases 1 to 2877)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC075689.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_909181.1, XM_921193.1, XM_921202.1, NM_177244.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075689.1, SRR1660817.239186.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 40.93 cM"
     gene            1..2877
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /note="FAST kinase domains 1"
                     /db_xref="GeneID:320720"
                     /db_xref="MGI:MGI:2444596"
     exon            1..480
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..2635
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /codon_start=1
                     /product="FAST kinase domain-containing protein 1,
                     mitochondrial"
                     /protein_id="NP_796218.2"
                     /db_xref="CCDS:CCDS16096.1"
                     /db_xref="GeneID:320720"
                     /db_xref="MGI:MGI:2444596"
                     /translation="MFRLRSISLLSWRAFPLRPFSCESLITQMQKCTNEEQVFDLIET
                     NTATLSEQQVGCAFNVLWQFQKQKTVLEKNVDHVRNHPQFLTLCSITTNHIPAMSDAT
                     LVDVLYSIKQFAVESHHPLIEALVTEAWKRLERFDTNVLSIFSTCLADQHLYFSPLMG
                     KIADIVNRRLETIQDLRALSVLMVSISSLISPCFQERLVIRTELLFDTVNSSKVNIAR
                     RILLFLRNVKYSHYPLLERCNQVFIRNMSHLDLESISKILNLYQFLQFHSFEFVEAAR
                     GRLAEMTLPSDHPESFVRLFAALGPVARPEIKKQLKSTILLLSEELSSQQALIVLGAM
                     EDMESRNSHLLKKIVSVLYKHLDNYKSIELLKIIQALTFLHFQSKELFMKLRELLLSR
                     LEASVIPSEISVLVSALSMLPHPHLSETAVSRIEAVLPQCDFRELNDLVVYLMRWIQS
                     DLVCLASTTGKQLDLLQKLDQLGRHRLQQSTNLDLLWEELKSLKGEWLHESLVEESIA
                     ALLRFMDEIDYSNIAKVASFLSRTNYLNTLLLDRIASVAIQQVEKIHPFSVLAIILPF
                     SILNYDPPQKDEFFGACVQCCNSYLGTLDPGTLVFLGFSLAVLEYFPEDLLKKMFNIE
                     FLARLDSQLEILPSSLSARIQFRLMELNRAVCLECPELQVPWFHDRFCQRQFNKDTGV
                     MNGAQQQIYKMLAEVLGGHQCVKPSALSPYYHTVGFECILDKRKKPLPYESHSIAPRK
                     SLGMHWDSRVEPRLPPEAERIAIELLDVRAFCSNIPHLKGKSAMKKRHLEILGYRVIQ
                     IPYFEWNSMAMSTKDARMDYLREHLFGEGKS"
     exon            481..549
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /inference="alignment:Splign:2.1.0"
     exon            550..675
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /inference="alignment:Splign:2.1.0"
     exon            676..1074
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1185
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1317
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1804
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1919
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2048
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2180
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2294
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2424
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2539
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2860
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2826..2831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
                     /note="hexamer: AATAAA"
     polyA_site      2843
                     /gene="Fastkd1"
                     /gene_synonym="5330408N05Rik; mKIAA1800"
ORIGIN      
        1 gcaaataaag cacgtgaatg aaagccagat tttatattgt cacattatac ctgacttcta
       61 gtgtagatgc tttttttttt taaccaaaga aaaaattgtg ctaaggaaaa gaaacctcta
      121 ttttggagcc ccgtccgtta taaatatgtt ccggctacga agcatctctt tactctcttg
      181 gagagcattt ccgctccgcc ccttcagttg tgagtcatta attactcaga tgcagaagtg
      241 tacaaacgaa gaacaagtgt ttgaccttat tgagacgaat acggcaacgc tctccgaaca
      301 gcaagtgggc tgtgcgttta atgtactttg gcagtttcag aagcagaaga ccgtcttgga
      361 aaaaaacgtt gaccatgtta gaaaccatcc tcagtttctt actctttgca gcattacaac
      421 aaatcacatc ccagcaatga gtgatgctac cctggtggat gtgttataca gcataaagca
      481 gtttgcagtt gaatcccatc acccactaat cgaagcactg gttacagaag catggaaaag
      541 actggaaagg ttcgatacta atgtgctgtc catattttcc acttgcttgg ccgatcagca
      601 tctgtatttc agtccattaa tgggaaaaat agctgatatt gtaaatagga gactggaaac
      661 catccaggac ttaagggcct tatctgtctt aatggtcagc atttcttcat taatatcacc
      721 gtgtttccag gaacgactgg tgatcagaac agaacttctt tttgacactg taaattcttc
      781 caaagtcaac attgcaagaa ggatattact gtttcttcga aatgtcaaat acagtcatta
      841 cccactgtta gagaggtgta atcaagtgtt tataaggaac atgagccatc ttgatctgga
      901 gtccatcagt aaaatcctta acctgtatca gtttctacag ttccacagct ttgaatttgt
      961 tgaagcagct cgagggaggc tggctgagat gaccctccct tctgatcatc ctgaaagctt
     1021 tgtccggttg tttgccgctc tggggccggt ggccagacct gagataaaga aacagcttaa
     1081 atcaactata ctactgctgt cagaggagct gagcagccag caagcgctga tcgtgttggg
     1141 agcaatggaa gatatggaaa gcagaaattc acacttgctt aaaaagattg tttctgttct
     1201 gtacaaacat ttggataact ataaatcgat agagctattg aagataatac aagcattgac
     1261 ttttctacat tttcaaagta aggagctttt tatgaaactc agagaattac ttctcagtcg
     1321 tttggaagct agtgtcatac ccagtgagat ttctgttctg gtctctgctc tgtccatgct
     1381 tccacatccg cacctcagtg aaacagcggt ctcccggatt gaagcagttc taccacagtg
     1441 tgacttcagg gaactgaatg acttggtagt atatctcatg cgctggattc agagtgatct
     1501 cgtctgcctg gctagtacta ctggaaagca actggacctc cttcaaaaac tagatcaact
     1561 gggccgtcac cggctgcaac agagcaccaa cttggatctt ctgtgggagg agctcaagtc
     1621 tttgaaggga gaatggcttc acgaatcctt agttgaagaa tccatcgctg ctttactgcg
     1681 tttcatggat gaaatagatt acagcaatat tgccaaggtc gcgtcttttc tttccagaac
     1741 taactacctc aacactctgc tgctggatag gatcgcttca gtggccattc agcaggttga
     1801 aaagatccat cccttttcag tccttgctat tattctccca ttcagcattc tgaactatga
     1861 tccacctcaa aaggatgaat tctttggagc gtgtgtccaa tgctgtaatt cttacttagg
     1921 tacattggat cctggtacat tagtgtttct tggtttttct ttggccgtac ttgaatattt
     1981 tccagaagat ctgctaaaga aaatgtttaa catcgagttc cttgccagat tagattccca
     2041 gcttgaaatt ttaccttcaa gtctgagtgc aaggatccag ttccgcctca tggagttaaa
     2101 tagagcagtc tgcttggagt gccccgagct gcaggttcca tggtttcatg accgcttttg
     2161 tcagcgacag tttaacaaag acactggtgt tatgaacgga gcccaacaac agatctataa
     2221 aatgttagca gaggtcctgg gaggacacca atgtgtgaag ccttccgctc tttcaccgta
     2281 ttaccacaca gtgggttttg aatgcatttt ggataaacga aaaaaacctc tgccttatga
     2341 aagccatagc atagctccca gaaaatccct gggcatgcac tgggattcaa gagttgagcc
     2401 aaggcttcca ccagaagctg agaggattgc tatagaactt ttggatgtaa gagccttttg
     2461 ttcaaacatt cctcacttaa aaggaaaatc tgctatgaaa aagcggcatt tggaaatctt
     2521 gggctaccgt gttattcaga tcccttactt tgagtggaac tctatggcaa tgtcaacgaa
     2581 ggatgcacgg atggactacc tgagagaaca tctatttggg gaaggcaaat catgactgta
     2641 gttttcattt aaaatgactg tggtggactg gagaggtggc acagaggaaa agaacactgg
     2701 ctgctcttgc agagatccta agttcaatcc ccagcaccca catggcggct cataaccatc
     2761 tataatgtga tctgggaccc tcttctggcc tgcaggcata catgcaggca gaacactgta
     2821 tacataataa ataaataaat aaataaatct ttttaaaaaa aaaaaaaaaa aaaaaaa
//
