LOCUS       NM_023229               1840 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Fas-activated serine/threonine kinase (Fastk), mRNA.
ACCESSION   NM_023229 XM_982275 XM_982306 XM_982335 XM_982369 XM_982404
            XM_982432 XM_982470 XM_982509
VERSION     NM_023229.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1840)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1840)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1840)
  AUTHORS   Zhang,F., Wang,K., Hu,G., Fu,F., Fan,R. Dr, Li,J., Yang,L., Liu,Y.,
            Feng,N., Gu,X., Jia,M., Chen,X. and Pei,J.
  TITLE     Genetic ablation of fas-activated serine/threonine kinase
            ameliorates alcoholic liver disease through modulating HuR-SIRT1
            mRNA complex stability
  JOURNAL   Free Radic Biol Med 166, 201-211 (2021)
   PUBMED   33610658
REFERENCE   4  (bases 1 to 1840)
  AUTHORS   Zhang,F., Wang,K., Zhang,S., Li,J., Fan,R., Chen,X. and Pei,J.
  TITLE     Accelerated FASTK mRNA degradation induced by oxidative stress is
            responsible for the destroyed myocardial mitochondrial gene
            expression and respiratory function in alcoholic cardiomyopathy
  JOURNAL   Redox Biol 38, 101778 (2021)
   PUBMED   33197770
  REMARK    GeneRIF: Accelerated FASTK mRNA degradation induced by oxidative
            stress is responsible for the destroyed myocardial mitochondrial
            gene expression and respiratory function in alcoholic
            cardiomyopathy.
REFERENCE   5  (bases 1 to 1840)
  AUTHORS   Zhang,F., Pei,J. and Chen,X.
  TITLE     Genetic ablation of Fas-activated serine/threonine kinase
            ameliorates obesity-related hepatic glucose and lipid metabolic
            disorders via sirtuin-1 signaling
  JOURNAL   Biochem Biophys Res Commun 529 (4), 1066-1072 (2020)
   PUBMED   32819566
  REMARK    GeneRIF: Genetic ablation of Fas-activated serine/threonine kinase
            ameliorates obesity-related hepatic glucose and lipid metabolic
            disorders via sirtuin-1 signaling.
REFERENCE   6  (bases 1 to 1840)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1840)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   8  (bases 1 to 1840)
  AUTHORS   Simarro,M., Gimenez-Cassina,A., Kedersha,N., Lazaro,J.B.,
            Adelmant,G.O., Marto,J.A., Rhee,K., Tisdale,S., Danial,N.,
            Benarafa,C., Orduna,A. and Anderson,P.
  TITLE     Fast kinase domain-containing protein 3 is a mitochondrial protein
            essential for cellular respiration
  JOURNAL   Biochem Biophys Res Commun 401 (3), 440-446 (2010)
   PUBMED   20869947
REFERENCE   9  (bases 1 to 1840)
  AUTHORS   Simarro,M., Giannattasio,G., De la Fuente,M.A., Benarafa,C.,
            Subramanian,K.K., Ishizawar,R., Balestrieri,B., Andersson,E.M.,
            Luo,H.R., Orduna,A., Boyce,J. and Anderson,P.
  TITLE     Fas-activated serine/threonine phosphoprotein promotes
            immune-mediated pulmonary inflammation
  JOURNAL   J Immunol 184 (9), 5325-5332 (2010)
   PUBMED   20363972
  REMARK    GeneRIF: In a well-established model of allergic pulmonary
            inflammation, FAST is a proinflammatory factor that modulates the
            function of lung resident hematopoietic cells to promote neutrophil
            recruitment and pulmonary inflammation.
REFERENCE   10 (bases 1 to 1840)
  AUTHORS   Simarro,M., Mauger,D., Rhee,K., Pujana,M.A., Kedersha,N.L.,
            Yamasaki,S., Cusick,M.E., Vidal,M., Garcia-Blanco,M.A. and
            Anderson,P.
  TITLE     Fas-activated serine/threonine phosphoprotein (FAST) is a regulator
            of alternative splicing
  JOURNAL   Proc Natl Acad Sci U S A 104 (27), 11370-11375 (2007)
   PUBMED   17592127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK152369.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_982509.1, XM_982306.1, XM_982470.1, XM_982432.1, XM_982335.1,
            XM_982369.1, XM_982404.1, XM_982275.1, NM_023229.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152369.1, AK038596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1840              AK152369.1         2-1841
FEATURES             Location/Qualifiers
     source          1..1840
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 11.78 cM"
     gene            1..1840
                     /gene="Fastk"
                     /gene_synonym="0610011K02Rik; 610011K02Rik"
                     /note="Fas-activated serine/threonine kinase"
                     /db_xref="GeneID:66587"
                     /db_xref="MGI:MGI:1913837"
     exon            1..170
                     /gene="Fastk"
                     /gene_synonym="0610011K02Rik; 610011K02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1726
                     /gene="Fastk"
                     /gene_synonym="0610011K02Rik; 610011K02Rik"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.8"
                     /note="FAST kinase"
                     /codon_start=1
                     /product="fas-activated serine/threonine kinase"
                     /protein_id="NP_075718.2"
                     /db_xref="CCDS:CCDS19120.1"
                     /db_xref="GeneID:66587"
                     /db_xref="MGI:MGI:1913837"
                     /translation="MRRPRGEPGSRAPRPAERVTYAGPGESWSPPPSSMLRILLSAQT
                     SPARLSGLLLIPPVQPCCLGPSKSGDRPFGGGPVQGLQRLLEQARSPGELLRWLSQNP
                     TKVRAHHYPVALRRLGQLLVSQPRPSPVEQATLQDLSQLIIRNCPSFDVHTIHVCLHL
                     AVLLGFPSDGPLLCALEQERRSRLPPKPPSPHRPAIYGGQRLEVALSCPRFLQYPRQH
                     LIRSLAEARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQEAQLNSKVVQKL
                     VLPFGRLNYMPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLQCLPFRALQFVFS
                     PSFINHINGTPPSLIVRRYLSLLDTAVELELPGYQGPRLPQRQRVPIFPQPLITDRAR
                     CKYSHKDMVAEGLRQLLGEENYRQNLTVPPGYCTDFLLCVSSSGAVLPMRTQDPFLPY
                     PPRSCQQDQANFNSTTQDPAQRVVLMLRERWHFCRDGRVLLGSRALRERHLGLMGYQL
                     LPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG"
     exon            171..581
                     /gene="Fastk"
                     /gene_synonym="0610011K02Rik; 610011K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            582..761
                     /gene="Fastk"
                     /gene_synonym="0610011K02Rik; 610011K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            762..901
                     /gene="Fastk"
                     /gene_synonym="0610011K02Rik; 610011K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1115
                     /gene="Fastk"
                     /gene_synonym="0610011K02Rik; 610011K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1275
                     /gene="Fastk"
                     /gene_synonym="0610011K02Rik; 610011K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1367
                     /gene="Fastk"
                     /gene_synonym="0610011K02Rik; 610011K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1503
                     /gene="Fastk"
                     /gene_synonym="0610011K02Rik; 610011K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1618
                     /gene="Fastk"
                     /gene_synonym="0610011K02Rik; 610011K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1840
                     /gene="Fastk"
                     /gene_synonym="0610011K02Rik; 610011K02Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1840
                     /gene="Fastk"
                     /gene_synonym="0610011K02Rik; 610011K02Rik"
                     /note="putative"
ORIGIN      
        1 gtctccgccg ccctggcgct ggactgcgat tggcgtctgg gggcgatccg ggggctgctg
       61 ggaagatggc ggactcggtg gcccgctgat gaggaggccg cggggggagc ccggctcccg
      121 ggccccaaga ccagctgaga gagtgaccta cgcggggccc ggggagtcat ggtctccacc
      181 acccagctcc atgcttcgaa tcctgctctc tgcccagact tcccctgctc ggctgtctgg
      241 tttgctgctc atcccaccag tacagccctg ttgtttggga cccagcaagt ccggggaccg
      301 gccttttgga ggaggccctg tgcaaggcct tcaacggctt ctggaacagg cacggagccc
      361 tggggagcta ctgcgatggc tgagccagaa ccccaccaag gtgcgagctc atcactaccc
      421 tgtggcactc cggcgtctgg gccagctctt ggtgtctcag cctaggccct ctcctgtgga
      481 gcaggccaca ctgcaggact tgagtcagct catcatccga aactgcccct cctttgacgt
      541 tcacaccatc catgtgtgtc tccaccttgc agtgttactt ggctttccat cagatggacc
      601 actcctgtgt gccctcgagc aggagcgcag gtcccgtctc cctccaaagc caccctcccc
      661 acatcggcct gccatctatg gtggtcaaag gttggaagtg gccctgagct gcccccgttt
      721 cctgcagtac cctcgtcagc atctgatcag aagcctggca gaggcaaggc cagaagaact
      781 gactcctcac gtaatggtgc ttctggccca acacctggcc cggcaccgct tgcgggaacc
      841 ccaacttctg gaagccattg ctcatttcct ggtggttcag gaagcccagc tcaacagcaa
      901 ggtggtacag aagttggtcc tgccctttgg gaggttgaac tacatgcccc tggagcagca
      961 atttatgccc tgccttgaga ggatcctggc tcgggaagca ggggtggcac ccttggccac
     1021 agtcaacatt ttgatgtcgc tgtgccagct gcagtgcctg cccttcagag ccctgcagtt
     1081 tgtcttttct cccagtttta tcaaccacat caatggcacc cctccttctc tgattgtgcg
     1141 acgctacctc tctctactcg atacggctgt ggagcttgaa ctcccaggat accaaggccc
     1201 ccgccttccc cagaggcagc gagtgcccat cttcccacag cccctcatca ctgaccgtgc
     1261 ccgctgcaaa tacagtcaca aggacatggt cgctgagggg ctgcgccagc tattagggga
     1321 agaaaactac cgtcagaatc tgactgtacc tccgggctac tgcacagact ttctactctg
     1381 tgtgagtagt tctggtgctg tgctgcctat gaggacacaa gaccccttcc tgccctaccc
     1441 accacggtcc tgccaacagg accaggcaaa ctttaactcc acaacccaag accctgccca
     1501 aagggtggtg ctgatgctga gagaacgctg gcatttctgc cgagacggca gggtgctgct
     1561 gggctcgcgg gccttgaggg agcggcacct gggcctaatg ggctaccaac tcctaccgct
     1621 gccatttgaa gagctggagt ctcaaagagg cctgccccag ctcaagagct acctgaggca
     1681 aaagcttcag gccttaggtc ttcgctgggg acctgagggt gggtgaggag gtacacacag
     1741 ggctcaggat ggatccccta tggggaggag ggcagacaat ttgcactttg gcttcctgtt
     1801 attattatta tttttttcat taaaacccct ttccttcctg
//
