LOCUS       NM_007988               9938 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus fatty acid synthase (Fasn), mRNA.
ACCESSION   NM_007988
VERSION     NM_007988.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9938)
  AUTHORS   Kang,J., Wu,J., Liu,Q., Jiang,H., Li,W., Li,Y., Li,X., Ni,C.,
            Wu,L., Liu,M., Liu,H., Deng,L., Lin,Z., Wu,X., Zhao,Y. and Ren,J.
  TITLE     FASN regulates STING palmitoylation via malonyl-CoA in macrophages
            to alleviate sepsis-induced liver injury
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167299 (2024)
   PUBMED   38878833
  REMARK    GeneRIF: FASN regulates STING palmitoylation via malonyl-CoA in
            macrophages to alleviate sepsis-induced liver injury.
REFERENCE   2  (bases 1 to 9938)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   3  (bases 1 to 9938)
  AUTHORS   Drury,J., Geisen,M.E., Tessmann,J.W., Rychahou,P.G., Kelson,C.O.,
            He,D., Wang,C., Evers,B.M. and Zaytseva,Y.Y.
  TITLE     Overexpression of Fatty Acid Synthase Upregulates
            Glutamine-Fructose-6-Phosphate Transaminase 1 and O-Linked
            N-Acetylglucosamine Transferase to Increase O-GlcNAc Protein
            Glycosylation and Promote Colorectal Cancer Growth
  JOURNAL   Int J Mol Sci 25 (9), 4883 (2024)
   PUBMED   38732103
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9938)
  AUTHORS   Xu,S., Wu,X., Wang,S., Xu,M., Fang,T., Ma,X., Chen,M., Fu,J.,
            Guo,J., Tian,S., Tian,T., Cheng,X., Yang,H., Zhou,J., Wang,Z.,
            Yin,Y., Xu,W., Xu,F., Yan,J., Wang,Z., Luo,S., Zhang,X.J., Ji,Y.X.
            and Weng,J.
  TITLE     TRIM56 protects against nonalcoholic fatty liver disease by
            promoting the degradation of fatty acid synthase
  JOURNAL   J Clin Invest 134 (5), e166149 (2024)
   PUBMED   38206764
  REMARK    GeneRIF: TRIM56 protects against nonalcoholic fatty liver disease
            by promoting the degradation of fatty acid synthase.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9938)
  AUTHORS   Wei,H., Weaver,Y.M., Yang,C., Zhang,Y., Hu,G., Karner,C.M.,
            Sieber,M., DeBerardinis,R.J. and Weaver,B.P.
  TITLE     Proteolytic activation of fatty acid synthase signals pan-stress
            resolution
  JOURNAL   Nat Metab 6 (1), 113-126 (2024)
   PUBMED   38167727
  REMARK    GeneRIF: Proteolytic activation of fatty acid synthase signals
            pan-stress resolution.
REFERENCE   6  (bases 1 to 9938)
  AUTHORS   Semenkovich,C.F., Coleman,T. and Fiedorek,F.T. Jr.
  TITLE     Human fatty acid synthase mRNA: tissue distribution, genetic
            mapping, and kinetics of decay after glucose deprivation
  JOURNAL   J Lipid Res 36 (7), 1507-1521 (1995)
   PUBMED   7595075
REFERENCE   7  (bases 1 to 9938)
  AUTHORS   Myohanen,S., Wahlfors,J., Alhonen,L. and Janne,J.
  TITLE     Nucleotide sequence of mouse spermidine synthase cDNA
  JOURNAL   DNA Seq 4 (5), 343-346 (1994)
   PUBMED   7803821
REFERENCE   8  (bases 1 to 9938)
  AUTHORS   Hsu,D.K., Donohue,P.J., Alberts,G.F. and Winkles,J.A.
  TITLE     Fibroblast growth factor-1 induces phosphofructokinase, fatty acid
            synthase and Ca(2+)-ATPase mRNA expression in NIH 3T3 cells
  JOURNAL   Biochem Biophys Res Commun 197 (3), 1483-1491 (1993)
   PUBMED   7506544
REFERENCE   9  (bases 1 to 9938)
  AUTHORS   Paulauskis,J.D. and Sul,H.S.
  TITLE     Structure of mouse fatty acid synthase mRNA. Identification of the
            two NADPH binding sites
  JOURNAL   Biochem Biophys Res Commun 158 (3), 690-695 (1989)
   PUBMED   2920037
REFERENCE   10 (bases 1 to 9938)
  AUTHORS   Paulauskis,J.D. and Sul,H.S.
  TITLE     Cloning and expression of mouse fatty acid synthase and other
            specific mRNAs. Developmental and hormonal regulation in 3T3-L1
            cells
  JOURNAL   J Biol Chem 263 (15), 7049-7054 (1988)
   PUBMED   2452820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ125823.1, AK147694.1, AF127033.1, AK080374.1 and AK078721.1.
            
            On Apr 21, 2006 this sequence version replaced NM_007988.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147694.1, AK147214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               CJ125823.1         2-239
            239-4722            AK147694.1         2-4485
            4723-8820           AF127033.1         4240-8337
            8821-9766           AK080374.1         3718-4663
            9767-9938           AK078721.1         1196-1367
FEATURES             Location/Qualifiers
     source          1..9938
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.56 cM"
     gene            1..9938
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /note="fatty acid synthase"
                     /db_xref="GeneID:14104"
                     /db_xref="MGI:MGI:95485"
     exon            1..518
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            519..654
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             528..8042
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /EC_number="2.3.1.85"
                     /EC_number="2.3.1.38"
                     /EC_number="2.3.1.39"
                     /EC_number="2.3.1.41"
                     /EC_number="3.1.2.14"
                     /EC_number="4.2.1.59"
                     /EC_number="1.1.1.100"
                     /EC_number="1.3.1.39"
                     /note="type I Fatty Acid Synthase"
                     /codon_start=1
                     /product="fatty acid synthase"
                     /protein_id="NP_032014.3"
                     /db_xref="CCDS:CCDS25759.1"
                     /db_xref="GeneID:14104"
                     /db_xref="MGI:MGI:95485"
                     /translation="MEEVVIAGMSGKLPESENLQEFWANLIGGVDMVTDDDRRWKAGL
                     YGLPKRSGKLKDLSKFDASFFGVHPKQAHTMDPQLRLLLEVSYEAIVDGGINPASLRG
                     TNTGVWVGVSGSEASEALSRDPETLLGYSMVGCQRAMMANRLSFFFDFKGPSIALDTA
                     CSSSLLALQNAYQAIRSGECPAALVGGINLLLKPNTSVQFMKLGMLSPDGTCRSFDDS
                     GSGYCRSEAVVAVLLTKKSLARRVYATILNAGTNTDGSKEQGVTFPSGEVQEQLICSL
                     YQPAGLAPESLEYIEAHGTGTKVGDPQELNGITRSLCAFRQAPLLIGSTKSNMGHPEP
                     ASGLAALTKVLLSLEHGVWAPNLHFHNPNPEIPALLDGRLQVVDRPLPVRGGNVGINS
                     FGFGGSNVHVILQPNTRQAPAPTAHAALPHLLHASGRTLEAVQDLLEQGRQHSQDLAF
                     VSMLNDIAATPTAAMPFRGYTVLGVEGRVQEVQQVSTNKRPLWFICSGMGTQWRGMGL
                     SLMRLDSFRESILRSDEAVKPLGVKVSDLLLSTDERTFDDIVHAFVSLTAIQIALIDL
                     LTSVGLKPDGIIGHSLGEVACGYADGCLSQREAVLAAYWRGQCIKDAHLPPGSMAAVG
                     LSWEECKQRCPAGVVPACHNSEDTVTISGPQAAVNEFVEQLKQEGVFAKEVRTGGLAF
                     HSYFMEGIAPTLLQALKKVIREPRPRSARWLSTSIPEAQWQSSLARTSSAEYNVNNLV
                     SPVLFQEALWHIPEHAVVLEIAPHALLQAVLKRGVKSSCTIIPLMKRDHKDNLEFFLT
                     NLGKVHLTGINVNPNALFPPVEFPAPRGTPLISPHIKWDHSQTWDVPVAEDFPNGSSS
                     SSATVYSIDASPESPDHYLVDHCIDGRVIFPGTGYLCLVWKTLARSLGLSLEETPVVF
                     ENVSFHQATILPKTGTVALEVRLLEASHAFEVSDTGNLIVSGKVYLWEDPNSKLFDHP
                     EVPTPPESASVSRLTQGEVYKELRLRGYDYGPQFQGICEATLEGEQGKLLWKDNWVTF
                     MDTMLQVSILGSSQQSLQLPTRVTAIYIDPATHRQKVYRLKEDTQVADVTTSRCLGIT
                     VSGGIHISRLQTTATSRRQQEQLVPTLEKFVFTPHMEAECLSESTALQKELQLCKGLA
                     RALQTKATQQGLKAAMLGQEDPPQHGLPRLLAAACQLQLNGNLQLELGEALAQERLLL
                     PEDPLISGLLNSQALKACVDTALENLSTLKMKVAEVLAGEGHLYSRIPALLNTQPMLQ
                     LEYTATDRHPQALKDVQTKLQQHDVAQGQWNPSDPAPSSLGALDLLVCNCALATLGDP
                     ALALDNMVAALKEGGFLLVHTVLKGHALGETLACLPSEVQPAPSLLSQEEWESLFSRK
                     ALHLVGLKRSFYGTALFLCRRAIPQEKPIFLSVEDTSFQWVDSLKSTLATSSSQPVWL
                     TAMDCPTSGVVGLVNCLRKEPGGHRIRCILLSNLSNTSHAPKLDPGSPELQQVLKHDL
                     VMNVYRDGAWGAFRHFQLEQDKPKEQTAHAFVNVLTRGDLASIRWVSSPLKHTQPSSS
                     GAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWASRDCMLGMEFSGRDRCGRRVMGLV
                     PAEGLATSVLLSSDFLWDVPSSWTLEEAASVPVVYTTAYYSLVVRGRIQRGETVLIHS
                     GSGGVGQAAISIALSLGCRVFTTVGSAEKRAYLQARFPQLDDTSFANSRDTSFEQHVL
                     LHTGGKGVDLVLNSLAEEKLQASVRCLAQHGRFLEIGKFDLSNNHPLGMAIFLKNVTF
                     HGILLDALFEEANDSWREVAALLKAGIRDGVVKPLKCTVFPKAQVEDAFRYMAQGKHI
                     GKVLVQVREEEPEAVLPGAQPTLISAISKTFCPAHKSYIITGGLGGFGLELARWLVLR
                     GAQRLVLTSRSGIRTGYQAKHIREWRRQGIQVLVSTSNVSSLEGARALIAEATKLGPV
                     GGVFNLAMVLRDAMLENQTPELFQDVNKPKYNGTLNLDRATREACPELDYFVAFSSVS
                     CGRGNAGQTNYGFANSTMERICEQRRHDGLPGLAVQWGAIGDVGIVLEAMGTNDTVIG
                     GTLPQRISSCMEVLDLFLNQPHAVLSSFVLAEKKAVAHGDGDTQRDLVKAVAHILGIR
                     DLAGINLDSTLADLGLDSLMGVEVRQILEREHDLVLPMREVRQLTLRKLQEMSSKTDS
                     ATDTTAPKSRSDTSLKQNQLNLSTLLVNPEGPTLTQLNSVQSSERPLFLVHPIEGSTT
                     VFHSLAAKLSVPTYGLQCTQAAPLDSIPNLAAYYIDCIKQVQPEGPYRIAGYSFGACV
                     AFEMCSQLQAQQGPAPTHNNLFLFDGSHTYVLAYTQSYRAKMTPGCEAEAEAEALCFF
                     IKQFLDVEHSKVLEALLPLKSLEDRVAASVDLITKSHHSLDRRELSFAAVSFYHKLRA
                     ADQYKPKAKYHGNVTLLRAKTGGTYGEDLGADYNLSQVCDGKVSVHIIEGDHRTLLEG
                     SGLESIINIIHSSLAEPRVSVREG"
     exon            655..807
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            808..981
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1182
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1305
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1421
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1556
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..2019
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2207
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2397
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2492
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2627
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2831
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2947
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3120
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3312
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3393
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3573
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            3574..3753
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..3957
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            3958..4244
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            4245..4631
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            4632..4796
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            4797..4915
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            4916..5070
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            5071..5274
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            5275..5425
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            5426..5604
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            5605..5724
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            5725..5847
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            5848..6071
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            6072..6273
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            6274..6425
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            6426..6517
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            6518..6669
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            6670..6915
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            6916..7104
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            7105..7332
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            7333..7553
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            7554..7652
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            7653..7904
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     exon            7905..9938
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8801..8806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /note="hexamer: ATTAAA"
     polyA_site      8820
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /note="major polyA site"
     polyA_site      8853
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
     regulatory      9750..9755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
                     /note="hexamer: AATAAA"
     polyA_site      9767
                     /gene="Fasn"
                     /gene_synonym="A630082H08Rik; FAS"
ORIGIN      
        1 gtggaatcgc agcgacacgg acctgtcccc ccgcgtggcc ctggtgtcct cctcagtgca
       61 gagtttccag tgtgaccaag cacgcccgac ccacactgcg cgcgcacagt gcacacctgg
      121 caccggccgc gagggggtgg gggtgggagg acagagatga gggcgtcggg atgagccccg
      181 cgtggcccgc gcgaggccgg gggcggggac ggaagcaggc gggggctgcg cgttccttgt
      241 gctccagcgc gcgcccgtgc agggtcccgg ctgggggcgg cgcgcgcggg catcacccca
      301 ccggcggcgg cgcgccgggt cccggggcgc agccccgacg ctcattggcc tgggcggcgc
      361 agccaagctg tcagcccatg tggcgtggcc gcgcggggat ggccgcggtt taaatagcgc
      421 cggcgcggcc tagagggagc cagagagacg gcagcggcgt cccgtccagt tcgcctgccg
      481 cgctcctcgc ttgtcgtctg cctccagagc ccagacagag aagagccatg gaggaggtgg
      541 tgatagccgg tatgtcgggg aagttgcccg agtcagagaa cctacaggag ttctgggcca
      601 acctcattgg tggtgtggac atggtcacag atgatgacag gagatggaag gctgggctct
      661 atggattacc caagcggtct ggaaagctga aggatctctc caagttcgac gcctcctttt
      721 ttggggtcca ccccaagcag gcacacacaa tggaccccca gcttcggctg ctgttggaag
      781 tcagctatga agcaattgtg gatggaggta tcaacccagc ctcactccga ggaacgaaca
      841 ctggcgtctg ggtgggtgtg agtggttcag aggcatccga ggcccttagc agagatcccg
      901 agacgcttct gggctacagc atggtgggct gccagcgtgc aatgatggcc aaccggctct
      961 ctttcttctt cgacttcaaa ggaccaagca ttgccctgga cacagcctgc tcctccagct
     1021 tgctggcact acagaatgcc taccaggcca tccgtagtgg ggaatgcccc gcggcccttg
     1081 tgggtgggat caacctgctc ctgaagccga acacctctgt gcagttcatg aagctgggca
     1141 tgctcagccc ggacggcacc tgcagatcct ttgatgattc agggagtgga tattgtcgct
     1201 ctgaggctgt tgtagcagtt ctgctgacta agaagtccct ggctcggcgg gtctatgcca
     1261 cgattctgaa tgccggcacc aatacagatg gcagcaagga gcaaggtgta acattcccct
     1321 ctggagaagt ccaagaacaa ctcatctgct ctctgtatca gccagctggt ctggccccgg
     1381 agtcgcttga gtatattgaa gcccatggca cgggcaccaa ggtgggtgac ccccaggaac
     1441 tgaatggcat tactcggtcc ctgtgcgcct tccgccaggc ccctctgtta attggctcca
     1501 ccaaatccaa catgggacac cctgagcctg cctctgggct tgcagccctg accaaggtgc
     1561 tgttatccct ggagcatggg gtctgggccc ctaacctgca cttccacaac cccaaccctg
     1621 agatcccagc acttcttgat gggcggctgc aggtggtcga taggcccctg cctgttcgtg
     1681 gtggcaacgt gggcatcaac tcatttggct tcggaggctc caatgttcat gtcatcctcc
     1741 agcccaacac acggcaggcc cctgcgccca ctgcacacgc tgcccttccc catttgctgc
     1801 acgccagtgg acgcacctta gaggcagtgc aggacctgct ggaacagggc cgccagcaca
     1861 gccaggacct ggcctttgtg agcatgctca atgacattgc ggcaacccct acagcagcca
     1921 tgcccttcag gggttacact gtgctaggtg ttgagggccg tgtccaagaa gtgcagcaag
     1981 tgtccaccaa caagcgccca ctctggttca tctgctcagg gatgggcacg cagtggcgcg
     2041 ggatggggct gagcctcatg cgcctggaca gcttccgtga gtctatcctg cgctccgatg
     2101 aggctgtgaa gccgttggga gtgaaagtgt cagatctgct gttgagcaca gatgagcgca
     2161 cctttgatga catcgtgcat gcctttgtga gcctcactgc catccagatt gccctcatcg
     2221 acctactgac ttctgtggga ctgaaacctg acggcatcat tgggcactcc ttgggagagg
     2281 ttgcctgtgg ctatgcagat ggctgtctct cccagagaga ggctgtgctt gcagcttact
     2341 ggcgaggcca gtgcatcaaa gatgcccacc tcccgcctgg atccatggca gctgttggtt
     2401 tgtcctggga ggaatgtaaa cagcgctgcc ccgctggcgt ggtgcctgcc tgccacaact
     2461 ctgaggacac cgtgaccatc tctggacctc aggctgcagt gaatgaattt gtggagcagc
     2521 taaagcaaga aggtgtgttt gccaaggagg tacgaacagg aggcctggct ttccactcct
     2581 acttcatgga aggaattgcc cccacattgc tgcaggctct caagaaggtg atccgggaac
     2641 cacggccgcg ctcggctcga tggctcagca cctctatccc tgaggcccag tggcagagca
     2701 gcctggcccg cacatcttct gccgagtaca atgtcaacaa cctggtgagc cctgtgctct
     2761 tccaggaagc actgtggcac atccctgagc atgccgtggt gctggagatt gcgccccacg
     2821 cactgttgca ggctgtcctg aagcgaggcg tgaagtccag ctgcaccatc attcccttga
     2881 tgaagaggga tcataaagat aacttggagt tctttctcac caaccttggc aaggtgcacc
     2941 tcacaggcat caatgtcaac cctaacgcct tgttcccacc tgtggagttc ccggctcccc
     3001 gagggactcc tctcatctcc cctcacatca agtgggacca cagtcagact tgggatgtcc
     3061 cggttgctga ggacttccca aacggctcca gctcctcctc tgctacagtc tacagcatcg
     3121 acgccagtcc tgagtcgccc gaccactacc tggtagacca ctgcattgac ggccgggtca
     3181 tcttccctgg cactggctac ctgtgcctgg tgtggaagac actggctcgc agcctgggct
     3241 tgtccctaga agagacccct gtggtatttg agaatgtgtc gtttcatcag gccactatac
     3301 tacccaagac aggaaccgtg gcgctggagg tgaggctgct agaggcctcc catgcctttg
     3361 aggtgtctga cactggcaat ctgattgtga gcggaaaagt gtacctgtgg gaagacccga
     3421 actccaagtt attcgaccac ccagaagtcc caacaccccc tgagtctgca tcggtctccc
     3481 gcctgaccca gggagaagta tacaaggagc tgcggctgcg tggctatgat tatggccctc
     3541 agttccaggg catctgtgag gccacccttg aaggtgaaca aggcaagctg ctctggaaag
     3601 ataactgggt gaccttcatg gacacaatgc tgcaggtatc cattctgggt tctagccagc
     3661 agagtctaca gctacctacc cgtgtgaccg ccatctatat cgaccctgcc acccaccgtc
     3721 agaaggtgta caggctgaag gaggacactc aagtggctga tgtgacaacg agccgctgtc
     3781 tgggcataac ggtctctggt ggtatccaca tctcaagact acagacgaca gcaacctcac
     3841 ggcggcagca agaacagctg gtccccacct tggaaaagtt cgttttcaca ccgcacatgg
     3901 aggctgagtg cctgtctgag agcactgccc tgcagaagga gctgcaactg tgcaagggtc
     3961 tggcacgggc tctgcagacc aaggccaccc agcaagggct gaaggcggca atgcttgggc
     4021 aagaggaccc tccacagcac gggctgcctc gactcctggc agctgcttgc cagttgcagc
     4081 tcaacgggaa cctgcagctg gagctgggag aagcgctggc tcaagagagg ctcctgctgc
     4141 cagaagaccc tctgatcagt ggcctcctca actcccaggc cctcaaggcc tgcgtagaca
     4201 cagccctgga gaacttgtct actctcaaga tgaaggtggc agaggtgctg gctggagaag
     4261 gccacttgta ttcccgaatc ccggcactgc tcaacaccca gcccatgcta caactggaat
     4321 acacagccac cgaccggcac ccccaggccc tgaaggatgt tcagaccaaa ctgcagcagc
     4381 atgatgtggc gcagggccag tggaaccctt ccgaccctgc gcccagcagc ctgggtgccc
     4441 ttgaccttct ggtgtgcaac tgtgcattag ccaccctggg ggatccagcc ttggccctgg
     4501 acaacatggt agctgccctc aaggaaggtg gtttcctgct agtgcacaca gtgctcaaag
     4561 gacatgccct tggggagacc ctggcctgcc taccctctga ggtgcagcct gcgcccagcc
     4621 tcctaagcca ggaggagtgg gagagcctgt tctcgaggaa ggcactacac ctggtgggcc
     4681 ttaaaaggtc cttctacggt actgcgctgt tcctgtgccg gcgagccatc ccacaggaga
     4741 aacctatctt cctgtctgtg gaggatacca gcttccagtg ggtggactct ctgaagagca
     4801 ctctggccac gtcctcctcc cagcctgtgt ggctaacggc catggactgc cccacctcgg
     4861 gtgtggtggg tttggtgaat tgtctccgaa aagagccggg tggacaccgg attcggtgta
     4921 tcctgctgtc caacctcagc aacacatctc acgcccccaa gttggaccct ggctctccag
     4981 agctacagca ggtgctaaag catgacctcg tgatgaacgt gtaccgggac ggggcctggg
     5041 gtgccttccg tcacttccag ttagagcagg acaagcccaa ggagcagaca gcgcatgcct
     5101 ttgtaaacgt cctcacccga ggggacctcg cctccatccg ctgggtctcc tcccccctga
     5161 agcacacgca gccctcgagc tcaggagcac agctctgcac tgtctactac gcctcactga
     5221 acttccgaga catcatgctg gccacgggca agctgtcccc tgatgccatt ccaggtaaat
     5281 gggccagccg agactgcatg ctcggcatgg agttctcagg ccgggatagg tgtggccggc
     5341 gtgtgatggg gctggttcct gcagaaggcc tggccacctc agtcctgcta tcatctgact
     5401 tcctctggga tgtaccctcc agctggaccc tggaggaggc ggcctctgtg cccgtcgtct
     5461 ataccactgc ttactactcg ttagtggttc gcgggcgcat ccagcgtggg gagaccgtgc
     5521 tcatccactc aggttcaggt ggtgtgggcc aagcggccat ttccattgcc ctcagtctgg
     5581 gctgccgcgt cttcaccact gtgggctctg cagagaagcg agcatacctc caggccaggt
     5641 tccctcagct tgatgacacc agctttgcca actcgaggga cacatcattt gagcagcacg
     5701 tgttactgca cacaggtggc aaaggggtcg acctggtcct caactcactg gcagaagaga
     5761 agctgcaggc cagtgtgcgg tgcttggctc agcatggtcg cttcttagag attggcaaat
     5821 ttgatctttc taacaaccac cctctgggca tggctatctt cttgaagaac gtcactttcc
     5881 atgggatcct gctggacgcc ctttttgagg aggccaatga cagctggcgg gaggtggcgg
     5941 cactcctgaa ggctggcatt cgtgatggag tcgtgaagcc cctcaagtgc acagtgtttc
     6001 ccaaggccca ggtggaagat gccttccgct acatggctca ggggaaacac attggcaaag
     6061 tccttgtcca ggtacgggag gaggagcctg aggctgtgct gccaggggct cagcccaccc
     6121 tgatttctgc catctccaag accttctgcc cagcccataa gagttacatc atcactggtg
     6181 gcctaggtgg ctttggcctg gagctggccc ggtggctcgt gcttcgcgga gcccagaggc
     6241 ttgtgctgac ttcccgatct ggaatccgca ccggctacca agccaagcac attcgggagt
     6301 ggagacgcca gggcatccaa gtgctcgtgt caacaagcaa cgtgagctca ctggaggggg
     6361 cccgtgctct catcgccgaa gccacaaagc tggggcccgt tgggggtgtc ttcaacctgg
     6421 ccatggtttt gagggatgcc atgctggaga accagacccc agagctcttc caggatgtca
     6481 acaagcccaa atacaatggc accctgaacc ttgacagggc aacccgggaa gcctgccctg
     6541 agctggacta ctttgtggcc ttctcctctg taagctgcgg gcgtggtaat gctggccaaa
     6601 ctaactacgg cttcgccaac tctaccatgg agcgtatatg tgaacagcgc aggcacgatg
     6661 gcctcccagg ccttgccgtg cagtggggtg ccattggtga cgtgggcatt gtcctggaag
     6721 cgatgggcac caatgacaca gtcatcggag gtacgctgcc tcagcgcatc tcctcctgca
     6781 tggaggtact ggacctcttc ctgaatcagc cccacgcagt cctgagcagc tttgtgctgg
     6841 cagagaagaa agctgtggcc catggggacg gggacaccca gagggatctg gtgaaagctg
     6901 tagcacacat cctaggcatc cgagacctcg caggtattaa cctggacagc acgctggcag
     6961 acctcggcct ggactcgctc atgggtgtgg aagttcgtca gatcctggaa cgagaacacg
     7021 atctggtgct gcccatgcgt gaggtgcggc agctcacgct gcggaaactt caggaaatgt
     7081 cctccaagac tgactcggct actgacacga cagcccccaa gtccaggagt gacacgtctc
     7141 tgaagcagaa ccaactgaac ctgagcacac tgctggtgaa ccctgagggt cctaccctaa
     7201 cccagctcaa ctcggtgcag agctctgagc ggcctctgtt ccttgtgcac cccattgagg
     7261 gttccaccac cgtgttccac agtctggctg ccaagctcag tgtgcccacc tacggcctgc
     7321 agtgcaccca agctgccccc ctggatagca ttccgaacct ggctgcctac tacatagatt
     7381 gcatcaagca agtgcagcct gagggaccct accgcatagc tgggtactca tttggagcct
     7441 gtgtagcctt cgagatgtgc tcccagctgc aggcccagca gggcccagcc ccgacccaca
     7501 acaacctctt cctgtttgac ggctcacaca cctacgtgtt ggcctacacc cagagctacc
     7561 gggcaaagat gaccccaggc tgtgaagccg aggccgaggc tgaggcctta tgcttcttca
     7621 taaagcagtt tcttgatgtg gaacacagca aggtgctgga ggccctgctg ccactgaaga
     7681 gcctggaaga tcgggtggct gcctccgtgg accttatcac taagagtcac cacagcctgg
     7741 accgccgaga gctgagcttt gctgccgtgt ccttctacca caagctccgg gcagctgatc
     7801 agtataagcc caaggccaag taccatggca acgtgacact gctgcgtgcc aagacaggcg
     7861 gcacctatgg cgaggacttg ggtgctgact acaacctctc ccaggtgtgt gacgggaagg
     7921 tgtctgtgca catcattgag ggtgaccacc gcacactgct ggagggcagt ggcctggaat
     7981 ccatcatcaa catcatccat agctccctgg ctgagccacg agtgagtgta cgggagggct
     8041 agacctgccg accaccatga agccacgctc cacacctgcc accagagatg ctccgatccc
     8101 caccacaccc tgagtgcagg aactggggag ggtcctgctg gtgggacccc tccccccagt
     8161 ggcccagcac cacccgctcc cctggtggct gctacaaaca gaccatcacg cgtgtgtttc
     8221 ccagccgcgt agtggggttc ccagagccac tgacttggag acaccctggt ctgtgaagag
     8281 tcagtggagg caggagccaa actgagcctt ttctaccgtg tggcatttgc cacgctggtc
     8341 gtttctccat taaattctca tatttattgc attgctggga aagaccccca ggggtgactc
     8401 attccagaac cccctaaaat gggagaagcc atgtggggaa gatttctggg aaagtttcta
     8461 gactcaatac acaggctgct ggctggagcc cctttttgtc ttgtcctgtc cctgctcact
     8521 gcagggcagg atatggagag ggctggttcc cagggaacaa ggaccccagc agacactgta
     8581 gcccgtggcc cttggtcccc agcatccccg gctgccccat gatgcagggc catcctgact
     8641 ctgcggaccg caccgggcac tgactgtctg ttttccaaga cgaaaatgat gcttgggttt
     8701 tgacttttct gcagctgtca gtgtgaagaa gtgtctggac tgtgtcattt ttacaccaac
     8761 ctggtaaaaa tgctgctctt gatgctctcc tgatcccaca attaaactgc acgtgagcga
     8821 gcactgcctt cggttcagtc tctttccagt ccaggcccgg cttcaggctc tgatacttat
     8881 gggtattccc cacaagtggc ctccacagct cttccagtga gactccttgg agggtgtgcc
     8941 attctgtcag tataagggga gtatgctaaa atgtgtttca gcatggaggg ctggctggag
     9001 gccttgccac tgtagtacaa gcagaatttg tccaccttta agttgccctg agggcatcag
     9061 cttagtcaca gccccgcccc agcggtagag aatagcatca tcctctactt gtagtcaact
     9121 gagtgttggt gcaagccctc tagagaaaaa cgtaagcagt atgtgaccac tgtgagaagc
     9181 atgtccctgg aaacaggtga catgacgaga gcagagggcc tgagtcacac agaactgacc
     9241 atgtgtgtaa gcagaggagt ggaggttgct tggaagagga ggatcaagag aaaagtaggc
     9301 tcagtttagt ggacccacag tagcagccaa tgtaattaca ttggcttgga gctaaggcat
     9361 ggtgggtcct gcagggtggc ttgttggact aggcaaagtc ccctggcttg agggtccagg
     9421 agagactgtc acaaggccgc agcattcgat cacatccaga gaggagcatc cagaggacaa
     9481 ctgcattggt agggtacaaa ggtgttcaga ggatcccagt ctgagtgatt agcctaagac
     9541 tgaagcatct ggttggctct agtcacactt agaaaaattc ttacagcact cgtcatgagt
     9601 tgtccattcc tggaaaggac ctgcccaatc tctatagtgt ctctacctag ttagagttta
     9661 ctgactcaag ggagcagatt tataaacttg cagaaaggcc cgactccctt acgaggctgt
     9721 gtggtcctta gaattcatgg atgagaggca ataaaacctt gaggttcctt cctgttcttt
     9781 gtgattgcct aacaagacat aaactgggtg tgatgagatt gctcagtgga tagagcgctg
     9841 tgcagcctga gtttgatcac tggaacccat gcagcagtag aaaagactaa gttgtcctct
     9901 gacctccaca catctgttga gtggaacaag actgaaat
//
