LOCUS       NM_010177               1935 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus Fas ligand (Fasl), transcript variant 1, mRNA.
ACCESSION   NM_010177
VERSION     NM_010177.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Krzyzowska,M., Patrycy,M., Chodkowski,M., Janicka,M., Kowalczyk,A.,
            Skulska,K., Thorn,K. and Eriksson,K.
  TITLE     Fas/FasL-Mediated Apoptosis and Inflammation Contribute to Recovery
            from HSV-2-Mediated Spinal Cord Infection
  JOURNAL   Viruses 16 (9), 1363 (2024)
   PUBMED   39339840
  REMARK    GeneRIF: Fas/FasL-Mediated Apoptosis and Inflammation Contribute to
            Recovery from HSV-2-Mediated Spinal Cord Infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   Albert,M.C., Uranga-Murillo,I., Arias,M., De Miguel,D., Pena,N.,
            Montinaro,A., Varanda,A.B., Theobald,S.J., Areso,I., Saggau,J.,
            Koch,M., Liccardi,G., Peltzer,N., Rybniker,J., Hurtado-Guerrero,R.,
            Merino,P., Monzon,M., Badiola,J.J., Reindl-Schwaighofer,R.,
            Sanz-Pamplona,R., Cebollada-Solanas,A., Megyesfalvi,Z., Dome,B.,
            Secrier,M., Hartmann,B., Bergmann,M., Pardo,J. and Walczak,H.
  TITLE     Identification of FasL as a crucial host factor driving COVID-19
            pathology and lethality
  JOURNAL   Cell Death Differ 31 (5), 544-557 (2024)
   PUBMED   38514848
  REMARK    GeneRIF: Identification of FasL as a crucial host factor driving
            COVID-19 pathology and lethality.
REFERENCE   3  (bases 1 to 1935)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   4  (bases 1 to 1935)
  AUTHORS   Wu,B., Wu,B., Benkaci,S., Shi,L., Lu,P., Park,T., Morrow,B.E.,
            Wang,Y. and Zhou,B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   5  (bases 1 to 1935)
  AUTHORS   Bernard-Bloch,R., Lebrault,E., Li,X., Sutra Del Galy,A., Garcia,A.,
            Doliger,C., Parietti,V., Legembre,P., Socie,G. and Karray,S.
  TITLE     Ambivalent role of FasL in murine acute graft-versus-host-disease
  JOURNAL   J Leukoc Biol 114 (3), 205-211 (2023)
   PUBMED   37013690
  REMARK    GeneRIF: Ambivalent role of FasL in murine acute
            graft-versus-host-disease.
REFERENCE   6  (bases 1 to 1935)
  AUTHORS   Giese,T. and Davidson,W.F.
  TITLE     Evidence for early onset, polyclonal activation of T cell subsets
            in mice homozygous for lpr
  JOURNAL   J Immunol 149 (9), 3097-3106 (1992)
   PUBMED   1383337
REFERENCE   7  (bases 1 to 1935)
  AUTHORS   Cohen,P.L. and Eisenberg,R.A.
  TITLE     The lpr and gld genes in systemic autoimmunity: life and death in
            the Fas lane
  JOURNAL   Immunol Today 13 (11), 427-428 (1992)
   PUBMED   1282318
  REMARK    Review article
            Erratum:[Immunol Today 1993 Feb;14(2):97]
REFERENCE   8  (bases 1 to 1935)
  AUTHORS   Mountz,J.D. and Edwards,C.K. 3rd.
  TITLE     Murine models of autoimmunity: T-cell and B-cell defects
  JOURNAL   Curr Opin Rheumatol 4 (5), 612-620 (1992)
   PUBMED   1419495
  REMARK    Review article
REFERENCE   9  (bases 1 to 1935)
  AUTHORS   Froidevaux,S., Rosenblatt,N. and Loor,F.
  TITLE     Adoptive transfer of the generalized lymphoproliferative disease
            (gld) syndrome in nude beige mice
  JOURNAL   Immunology 75 (4), 693-699 (1992)
   PUBMED   1592442
REFERENCE   10 (bases 1 to 1935)
  AUTHORS   Shimizu,M., Sekine,K., Matsuzawa,A. and Iwaguchi,T.
  TITLE     Cell electrophoretic characterization of abnormally expanded
            lymphocytes in autoimmune lprcg, lpr, gld and Yaa mice, and of
            thymocyte subsets
  JOURNAL   Electrophoresis 13 (3), 136-142 (1992)
   PUBMED   1592043
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040139.1.
            
            On Apr 5, 2011 this sequence version replaced NM_010177.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040139.1, AK141268.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1935              AK040139.1         1-1935
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 69.95 cM"
     gene            1..1935
                     /gene="Fasl"
                     /gene_synonym="APT1LG1; CD178; CD95-L; CD95L; Fas-L;
                     Faslg; gld; Tnfsf6; Tnlg1a"
                     /note="Fas ligand"
                     /db_xref="GeneID:14103"
                     /db_xref="MGI:MGI:99255"
     exon            1..552
                     /gene="Fasl"
                     /gene_synonym="APT1LG1; CD178; CD95-L; CD95L; Fas-L;
                     Faslg; gld; Tnfsf6; Tnlg1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1050
                     /gene="Fasl"
                     /gene_synonym="APT1LG1; CD178; CD95-L; CD95L; Fas-L;
                     Faslg; gld; Tnfsf6; Tnlg1a"
                     /note="isoform 1 is encoded by transcript variant 1; Fas
                     ligand (TNF superfamily, member 6); tumor necrosis factor
                     ligand superfamily member 6; CD95 ligand; generalized
                     lymphoproliferative disease; Fas antigen ligand; tumor
                     necrosis factor ligand 1a"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     6 isoform 1"
                     /protein_id="NP_034307.1"
                     /db_xref="CCDS:CCDS15418.1"
                     /db_xref="GeneID:14103"
                     /db_xref="MGI:MGI:99255"
                     /translation="MQQPMNYPCPQIFWVDSSATSSWAPPGSVFPCPSCGPRGPDQRR
                     PPPPPPPVSPLPPPSQPLPLPPLTPLKKKDHNTNLWLPVVFFMVLVALVGMGLGMYQL
                     FHLQKELAELREFTNQSLKVSSFEKQIANPSTPSEKKEPRSVAHLTGNPHSRSIPLEW
                     EDTYGTALISGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNQPLNHKVYMRNSKYPE
                     DLVLMEEKRLNYCTTGQIWAHSSYLGAVFNLTSADHLYVNISQLSLINFEESKTFFGL
                     YKL"
     exon            553..598
                     /gene="Fasl"
                     /gene_synonym="APT1LG1; CD178; CD95-L; CD95L; Fas-L;
                     Faslg; gld; Tnfsf6; Tnlg1a"
                     /inference="alignment:Splign:2.1.0"
     exon            599..655
                     /gene="Fasl"
                     /gene_synonym="APT1LG1; CD178; CD95-L; CD95L; Fas-L;
                     Faslg; gld; Tnfsf6; Tnlg1a"
                     /inference="alignment:Splign:2.1.0"
     exon            656..1935
                     /gene="Fasl"
                     /gene_synonym="APT1LG1; CD178; CD95-L; CD95L; Fas-L;
                     Faslg; gld; Tnfsf6; Tnlg1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1776..1781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fasl"
                     /gene_synonym="APT1LG1; CD178; CD95-L; CD95L; Fas-L;
                     Faslg; gld; Tnfsf6; Tnlg1a"
                     /note="hexamer: AATAAA"
     polyA_site      1799
                     /gene="Fasl"
                     /gene_synonym="APT1LG1; CD178; CD95-L; CD95L; Fas-L;
                     Faslg; gld; Tnfsf6; Tnlg1a"
                     /note="major polyA site"
     regulatory      1882..1887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fasl"
                     /gene_synonym="APT1LG1; CD178; CD95-L; CD95L; Fas-L;
                     Faslg; gld; Tnfsf6; Tnlg1a"
                     /note="hexamer: AATAAA"
     polyA_site      1905
                     /gene="Fasl"
                     /gene_synonym="APT1LG1; CD178; CD95-L; CD95L; Fas-L;
                     Faslg; gld; Tnfsf6; Tnlg1a"
ORIGIN      
        1 tgaggcttct cagcttcaga tgcaagtgag tgggtgtctc acagagaagc aaagagaaga
       61 gaacaggaga aaggtgtttc ccttgactgc ggaaacttta taaagaaaac ttagcttctc
      121 tggagcagtc agcgtcagag ttctgtcctt gacacctgag tctcctccac aaggctgtga
      181 gaaggaaacc ctttcctggg gctgggtgcc atgcagcagc ccatgaatta cccatgtccc
      241 cagatcttct gggtagacag cagtgccact tcatcttggg ctcctccagg gtcagttttt
      301 ccctgtccat cttgtgggcc tagagggccg gaccaaagga gaccgccacc tccaccacca
      361 cctgtgtcac cactaccacc gccatcacaa ccactcccac tgccgccact gacccctcta
      421 aagaagaagg accacaacac aaatctgtgg ctaccggtgg tatttttcat ggttctggtg
      481 gctctggttg gaatgggatt aggaatgtat cagctcttcc acctgcagaa ggaactggca
      541 gaactccgtg agttcaccaa ccaaagcctt aaagtatcat cttttgaaaa gcaaatagcc
      601 aaccccagta caccctctga aaaaaaagag ccgaggagtg tggcccattt aacagggaac
      661 ccccactcaa ggtccatccc tctggaatgg gaagacacat atggaaccgc tctgatctct
      721 ggagtgaagt ataagaaagg tggccttgtg atcaacgaaa ctgggttgta cttcgtgtat
      781 tccaaagtat acttccgggg tcagtcttgc aacaaccagc ccctaaacca caaggtctat
      841 atgaggaact ctaagtatcc tgaggatctg gtgctaatgg aggagaagag gttgaactac
      901 tgcactactg gacagatatg ggcccacagc agctacctgg gggcagtatt caatcttacc
      961 agtgctgacc atttatatgt caacatatct caactctctc tgatcaattt tgaggaatct
     1021 aagacctttt tcggcttgta taagctttaa aagaaaaagc attttaaaat gatctactat
     1081 tctttatcat gggcaccagg aatattgtct tgaatgagag tcttcttaag acctattgag
     1141 attaattaag actacatgag ccacaaagac ctcatgaccg caaggtccaa caggtcagct
     1201 atccttcatt ttctcgaggt ccatggagtg gtccttaatg cctgcatcat gagccagatg
     1261 gaaggaggtc tgtgactgag ggacataaag ctttgggctg ctgtgtgaca atgcagaggc
     1321 acagagaaag aactgtctga tgttaaatgg ccaagagaat tttaaccatt gaagaagaca
     1381 cctttacact cacttccagg gtgggtctac ttactacctc acagaggccg tttttgagac
     1441 atagttgtgg tatgaatata caagggtgag aaaggaggct catttgactg ataagctaga
     1501 gactgaaaaa aagacagtgt ctcattggca ccatctttac tgttacctaa tgttttctga
     1561 gccgaccttt gatcctaacg gagaagtaag agggatgttt gaggcacaaa tcattctcta
     1621 catagcatgc atacctccag tgcaatgatg tctgtgtgtt tgtatgtatg agagcaaaca
     1681 gattctaagg agtcatataa ataaaatatg tacattatgg agtacatatt agaaacctgt
     1741 tacatttgat gctagatatc tgaatgtttc ttggcaataa actctaatag tcttcaaaat
     1801 cttttattat cagctactga tgctgttttt ctttaataca actagtattt atgctctgaa
     1861 catcctaatg aggaaaagac aaataaaatt atgttataga atacagaaat gccttaagga
     1921 catagacttt ggaaa
//
