LOCUS       NM_007987               1486 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus Fas cell surface death receptor (Fas), transcript
            variant 1, mRNA.
ACCESSION   NM_007987
VERSION     NM_007987.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1486)
  AUTHORS   Xiao,X., Du,Y., Sun,S., Su,X., Xing,J., Wang,G., Elzein,S.M.,
            Zou,D., Minze,L.J., Mao,Z., Ghobrial,R.M., Connor,A.A., Chen,W.,
            Zhang,Z. and Li,X.C.
  TITLE     Apex1 safeguards genomic stability to ensure a cytopathic T cell
            fate in autoimmune disease models
  JOURNAL   J Clin Invest (2024) In press
   PUBMED   39739423
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1486)
  AUTHORS   Zheng,X., Dozmorov,M.G., Espinoza,L., Bowes,M.M., Bastacky,S. and
            Sawalha,A.H.
  TITLE     Inducible deletion of Ezh2 in CD4+ T cells inhibits kidney T cell
            infiltration and prevents interstitial nephritis in MRL/lpr
            lupus-prone mice
  JOURNAL   iScience 27 (11), 111114 (2024)
   PUBMED   39498302
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1486)
  AUTHORS   Wueest,S., Scaffidi,C., van Krieken,P.P., Konrad,N.K., Koch,C.,
            Wiedemann,M.S.F., Goergen,A., Borsigova,M., Lempesis,I.G.,
            Fullin,J., Manolopoulos,K.N., Bottcher,S., Goossens,G.H., Bluher,M.
            and Konrad,D.
  TITLE     Fas (CD95) expression in adipocytes contributes to diet-induced
            obesity
  JOURNAL   Obesity (Silver Spring) 32 (10), 1812-1818 (2024)
   PUBMED   39020501
  REMARK    GeneRIF: Fas (CD95) expression in adipocytes contributes to
            diet-induced obesity.
REFERENCE   4  (bases 1 to 1486)
  AUTHORS   Krzyzowska,M., Patrycy,M., Chodkowski,M., Janicka,M., Kowalczyk,A.,
            Skulska,K., Thorn,K. and Eriksson,K.
  TITLE     Fas/FasL-Mediated Apoptosis and Inflammation Contribute to Recovery
            from HSV-2-Mediated Spinal Cord Infection
  JOURNAL   Viruses 16 (9), 1363 (2024)
   PUBMED   39339840
  REMARK    GeneRIF: Fas/FasL-Mediated Apoptosis and Inflammation Contribute to
            Recovery from HSV-2-Mediated Spinal Cord Infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1486)
  AUTHORS   Gordon,R.A., Cosgrove,H.A., Marinov,A., Gingras,S., Tilstra,J.S.,
            Campbell,A.M., Bastacky,S.I., Kashgarian,M., Perl,A.,
            Nickerson,K.M. and Shlomchik,M.J.
  TITLE     NADPH oxidase in B cells and macrophages protects against murine
            lupus by regulation of TLR7
  JOURNAL   JCI Insight 9 (16), e178563 (2024)
   PUBMED   39042716
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1486)
  AUTHORS   Ohnishi-Inoue,Y., Yasumizu,R., Sugiura,K., Nagata,N., Fan,H.,
            Oyaizu,N., Inaba,M., Toki,J. and Ikehara,S.
  TITLE     Functional analyses of lpr gene in MRL/Mp-lpr/lpr mice. Role of
            lymph node stromal cells in lpr-lymphadenopathy
  JOURNAL   Immunobiology 186 (5), 449-465 (1992)
   PUBMED   1286883
REFERENCE   7  (bases 1 to 1486)
  AUTHORS   Wang,W., Kobayashi,S. and Uede,T.
  TITLE     Dysregulated expression of cellular adhesion molecules in
            autoimmune-prone mice
  JOURNAL   J Dermatol 19 (11), 831-835 (1992)
   PUBMED   1284074
REFERENCE   8  (bases 1 to 1486)
  AUTHORS   Cohen,P.L. and Eisenberg,R.A.
  TITLE     The lpr and gld genes in systemic autoimmunity: life and death in
            the Fas lane
  JOURNAL   Immunol Today 13 (11), 427-428 (1992)
   PUBMED   1282318
  REMARK    Review article
            Erratum:[Immunol Today 1993 Feb;14(2):97]
REFERENCE   9  (bases 1 to 1486)
  AUTHORS   Theofilopoulos,A.N., Eisenberg,R.A., Bourdon,M., Crowell,J.S. Jr.
            and Dixon,F.J.
  TITLE     Distribution of lymphocytes identified by surface markers in murine
            strains with systemic lupus erythematosus-like syndromes
  JOURNAL   J Exp Med 149 (2), 516-534 (1979)
   PUBMED   762500
REFERENCE   10 (bases 1 to 1486)
  AUTHORS   Andrews,B.S., Eisenberg,R.A., Theofilopoulos,A.N., Izui,S.,
            Wilson,C.B., McConahey,P.J., Murphy,E.D., Roths,J.B. and Dixon,F.J.
  TITLE     Spontaneous murine lupus-like syndromes. Clinical and
            immunopathological manifestations in several strains
  JOURNAL   J Exp Med 148 (5), 1198-1215 (1978)
   PUBMED   309911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY348234.1 and BC061160.1.
            
            On Apr 9, 2009 this sequence version replaced NM_007987.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M83649.1, DQ846748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BY348234.1         2-28
            28-1486             BC061160.1         1-1459
FEATURES             Location/Qualifiers
     source          1..1486
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.48 cM"
     gene            1..1486
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /note="Fas cell surface death receptor"
                     /db_xref="GeneID:14102"
                     /db_xref="MGI:MGI:95484"
     exon            1..86
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1040
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Fas (TNF receptor superfamily member); apo-1
                     antigen; FASLG receptor; apoptosis-mediating surface
                     antigen FAS; lymphoproliferation; Fas antigen; Fas (TNF
                     receptor superfamily member 6)"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 6 isoform 1 precursor"
                     /protein_id="NP_032013.2"
                     /db_xref="CCDS:CCDS29758.1"
                     /db_xref="GeneID:14102"
                     /db_xref="MGI:MGI:95484"
                     /translation="MLWIWAVLPLVLAGSQLRVHTQGTNSISESLKLRRRVRETDKNC
                     SEGLYQGGPFCCQPCQPGKKKVEDCKMNGGTPTCAPCTEGKEYMDKNHYADKCRRCTL
                     CDEEHGLEVETNCTLTQNTKCKCKPDFYCDSPGCEHCVRCASCEHGTLEPCTATSNTN
                     CRKQSPRNRLWLLTILVLLIPLVFIYRKYRKRKCWKRRQDDPESRTSSRETIPMNASN
                     LSLSKYIPRIAEDMTIQEAKKFARENNIKEGKIDEIMHDSIQDTAEQKVQLLLCWYQS
                     HGKSDAYQDLIKGLKKAECRRTLDKFQDMVQKDLGKSTPDTGNENEGQCLE"
     exon            87..240
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            241..378
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            379..487
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            488..549
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            550..603
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            604..683
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            684..708
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            709..1486
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtggggcc gcaggctgcc cacacaggcc gcccgctgtt ttcccttgct gcagacatgc
       61 tgtggatctg ggctgtcctg cctctggtgc ttgctggctc acagttaaga gttcatactc
      121 aaggtactaa tagcatctcc gagagtttaa agctgaggag gcgggttcgt gaaactgata
      181 aaaactgctc agaaggatta tatcaaggag gcccattttg ctgtcaacca tgccaacctg
      241 gtaaaaaaaa agttgaggac tgcaaaatga atgggggtac accaacctgc gccccatgca
      301 cagaagggaa ggagtacatg gacaagaacc attatgctga taaatgcaga agatgcacac
      361 tctgcgatga agagcatggt ttagaggtgg aaacaaactg caccctgacc cagaatacca
      421 agtgcaagtg caaaccagac ttctactgcg attctcctgg ctgtgaacac tgtgttcgct
      481 gcgcctcgtg tgaacatgga acccttgagc cgtgcacagc aaccagcaat acaaactgca
      541 ggaaacaaag tcccagaaat cgcctatggt tgttgaccat ccttgttttg ttaattccac
      601 ttgtatttat atatcgaaag taccggaaaa gaaagtgctg gaaaaggaga caggatgacc
      661 ctgaatctag aacctccagt cgtgaaacca taccaatgaa tgcctcaaat cttagcttga
      721 gtaaatacat cccgagaatt gctgaagaca tgacaatcca ggaagctaaa aaatttgctc
      781 gagaaaataa catcaaggag ggcaagatag atgagatcat gcatgacagc atccaagaca
      841 cagctgagca gaaagtccag ctgctcctgt gctggtacca atctcatggg aagagtgatg
      901 catatcaaga tttaatcaag ggtctcaaaa aagccgaatg tcgcagaacc ttagataaat
      961 ttcaggacat ggtccagaag gaccttggaa aatcaacccc agacactgga aatgaaaatg
     1021 aaggacaatg tctggagtga aaactacctc agttccagcc atgaagagag gagagagcct
     1081 gccacccatg atggaaacaa aatgaatgcc aactgtattg acattggcaa ctcctggtgt
     1141 gttctctttg ccagcaaatg gtagttgata ctcagtgagg gtcaaatgac tagcaggttc
     1201 cagggactgc ttctgttatt ctctgcagtt gctgagatga accattttct ctgtctactg
     1261 caatttttac attcaaatgt ccatgaaatt tgtattaaat gtgaagtgga atctgcagtg
     1321 tttgtgttta tattcatata ctatgaactg aggagaatta taaactgaaa caaatactcg
     1381 cagttaattg aagaccttcc attgatggac agttcttttc ctctctatgt ggaaatgtat
     1441 aatagaagaa ataattttta aattaaagta tctctttttg catttc
//
