LOCUS       NM_001146708             555 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus Fas cell surface death receptor (Fas), transcript
            variant 2, mRNA.
ACCESSION   NM_001146708
VERSION     NM_001146708.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 555)
  AUTHORS   Xiao,X., Du,Y., Sun,S., Su,X., Xing,J., Wang,G., Elzein,S.M.,
            Zou,D., Minze,L.J., Mao,Z., Ghobrial,R.M., Connor,A.A., Chen,W.,
            Zhang,Z. and Li,X.C.
  TITLE     Apex1 safeguards genomic stability to ensure a cytopathic T cell
            fate in autoimmune disease models
  JOURNAL   J Clin Invest (2024) In press
   PUBMED   39739423
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 555)
  AUTHORS   Zheng,X., Dozmorov,M.G., Espinoza,L., Bowes,M.M., Bastacky,S. and
            Sawalha,A.H.
  TITLE     Inducible deletion of Ezh2 in CD4+ T cells inhibits kidney T cell
            infiltration and prevents interstitial nephritis in MRL/lpr
            lupus-prone mice
  JOURNAL   iScience 27 (11), 111114 (2024)
   PUBMED   39498302
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 555)
  AUTHORS   Wueest,S., Scaffidi,C., van Krieken,P.P., Konrad,N.K., Koch,C.,
            Wiedemann,M.S.F., Goergen,A., Borsigova,M., Lempesis,I.G.,
            Fullin,J., Manolopoulos,K.N., Bottcher,S., Goossens,G.H., Bluher,M.
            and Konrad,D.
  TITLE     Fas (CD95) expression in adipocytes contributes to diet-induced
            obesity
  JOURNAL   Obesity (Silver Spring) 32 (10), 1812-1818 (2024)
   PUBMED   39020501
  REMARK    GeneRIF: Fas (CD95) expression in adipocytes contributes to
            diet-induced obesity.
REFERENCE   4  (bases 1 to 555)
  AUTHORS   Krzyzowska,M., Patrycy,M., Chodkowski,M., Janicka,M., Kowalczyk,A.,
            Skulska,K., Thorn,K. and Eriksson,K.
  TITLE     Fas/FasL-Mediated Apoptosis and Inflammation Contribute to Recovery
            from HSV-2-Mediated Spinal Cord Infection
  JOURNAL   Viruses 16 (9), 1363 (2024)
   PUBMED   39339840
  REMARK    GeneRIF: Fas/FasL-Mediated Apoptosis and Inflammation Contribute to
            Recovery from HSV-2-Mediated Spinal Cord Infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 555)
  AUTHORS   Gordon,R.A., Cosgrove,H.A., Marinov,A., Gingras,S., Tilstra,J.S.,
            Campbell,A.M., Bastacky,S.I., Kashgarian,M., Perl,A.,
            Nickerson,K.M. and Shlomchik,M.J.
  TITLE     NADPH oxidase in B cells and macrophages protects against murine
            lupus by regulation of TLR7
  JOURNAL   JCI Insight 9 (16), e178563 (2024)
   PUBMED   39042716
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 555)
  AUTHORS   Ohnishi-Inoue,Y., Yasumizu,R., Sugiura,K., Nagata,N., Fan,H.,
            Oyaizu,N., Inaba,M., Toki,J. and Ikehara,S.
  TITLE     Functional analyses of lpr gene in MRL/Mp-lpr/lpr mice. Role of
            lymph node stromal cells in lpr-lymphadenopathy
  JOURNAL   Immunobiology 186 (5), 449-465 (1992)
   PUBMED   1286883
REFERENCE   7  (bases 1 to 555)
  AUTHORS   Wang,W., Kobayashi,S. and Uede,T.
  TITLE     Dysregulated expression of cellular adhesion molecules in
            autoimmune-prone mice
  JOURNAL   J Dermatol 19 (11), 831-835 (1992)
   PUBMED   1284074
REFERENCE   8  (bases 1 to 555)
  AUTHORS   Cohen,P.L. and Eisenberg,R.A.
  TITLE     The lpr and gld genes in systemic autoimmunity: life and death in
            the Fas lane
  JOURNAL   Immunol Today 13 (11), 427-428 (1992)
   PUBMED   1282318
  REMARK    Review article
            Erratum:[Immunol Today 1993 Feb;14(2):97]
REFERENCE   9  (bases 1 to 555)
  AUTHORS   Theofilopoulos,A.N., Eisenberg,R.A., Bourdon,M., Crowell,J.S. Jr.
            and Dixon,F.J.
  TITLE     Distribution of lymphocytes identified by surface markers in murine
            strains with systemic lupus erythematosus-like syndromes
  JOURNAL   J Exp Med 149 (2), 516-534 (1979)
   PUBMED   762500
REFERENCE   10 (bases 1 to 555)
  AUTHORS   Andrews,B.S., Eisenberg,R.A., Theofilopoulos,A.N., Izui,S.,
            Wilson,C.B., McConahey,P.J., Murphy,E.D., Roths,J.B. and Dixon,F.J.
  TITLE     Spontaneous murine lupus-like syndromes. Clinical and
            immunopathological manifestations in several strains
  JOURNAL   J Exp Med 148 (5), 1198-1215 (1978)
   PUBMED   309911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY348234.1 and AK086933.1.
            
            Transcript Variant: This variant (2) has multiple differences in
            the presence and absence of exons at its 3' end, compared to
            variant 1. These differences produce a unique 3' UTR and a protein
            (isoform 2) with a shorter and distinct C-terminus, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB531014.2, BB605773.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY348234.1         2-26
            26-555              AK086933.1         3-532
FEATURES             Location/Qualifiers
     source          1..555
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.48 cM"
     gene            1..555
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /note="Fas cell surface death receptor"
                     /db_xref="GeneID:14102"
                     /db_xref="MGI:MGI:95484"
     exon            1..86
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..248
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; Fas (TNF receptor superfamily member); apo-1
                     antigen; FASLG receptor; apoptosis-mediating surface
                     antigen FAS; lymphoproliferation; Fas antigen; Fas (TNF
                     receptor superfamily member 6)"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 6 isoform 2 precursor"
                     /protein_id="NP_001140180.1"
                     /db_xref="CCDS:CCDS50420.1"
                     /db_xref="GeneID:14102"
                     /db_xref="MGI:MGI:95484"
                     /translation="MLWIWAVLPLVLAGSQLRVHTQGTNSISESLKLRRRVRETDKNC
                     SEGLYQGGPFCCQPCQPEN"
     exon            87..240
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            241..555
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      523..528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /note="hexamer: ATTAAA"
     polyA_site      547
                     /gene="Fas"
                     /gene_synonym="APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6"
                     /note="major polyA site"
ORIGIN      
        1 gggtggggcc gcaggctgcc cacacaggcc gcccgctgtt ttcccttgct gcagacatgc
       61 tgtggatctg ggctgtcctg cctctggtgc ttgctggctc acagttaaga gttcatactc
      121 aaggtactaa tagcatctcc gagagtttaa agctgaggag gcgggttcgt gaaactgata
      181 aaaactgctc agaaggatta tatcaaggag gcccattttg ctgtcaacca tgccaacctg
      241 aaaactaggc tgagcatttt ggagaccatc agaaattcag cccgttggag tgattcaact
      301 ttcttttcat caaaaagaag agaattggga gaagggggtg gggtgggtaa agaagccaaa
      361 cggaaattgc agggggtgat ttgggtggat gcaactttaa tgaagagact ataactcatc
      421 tctatgtcaa acgattgaca tacttatgga gagactcttt aaaatgaaaa cacaatatag
      481 acttttccag tgattccatc tgtgaactgg tgcttttgat tgattaaaat acactgtatg
      541 cttacagcaa ttttt
//
