LOCUS       NM_025648               1846 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phenylalanyl-tRNA synthetase, alpha subunit (Farsa),
            transcript variant 1, mRNA.
ACCESSION   NM_025648
VERSION     NM_025648.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1846)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1846)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1846)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   4  (bases 1 to 1846)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB853717.1, AK031697.1, AK002577.1 and BP754226.1.
            
            On Dec 8, 2007 this sequence version replaced NM_025648.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006862.1, AK154629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BB853717.1         3-25
            24-1029             AK031697.1         2-1007
            1030-1764           AK002577.1         1005-1739
            1765-1846           BP754226.1         1-82                c
FEATURES             Location/Qualifiers
     source          1..1846
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.23 cM"
     gene            1..1846
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /note="phenylalanyl-tRNA synthetase, alpha subunit"
                     /db_xref="GeneID:66590"
                     /db_xref="MGI:MGI:1913840"
     exon            1..196
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1576
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /EC_number="6.1.1.20"
                     /note="phenylalanine-tRNA synthetase-like, alpha subunit;
                     phenylalanyl-tRNA synthetase alpha chain;
                     phenylalanine--tRNA ligase alpha chain"
                     /codon_start=1
                     /product="phenylalanine--tRNA ligase alpha subunit"
                     /protein_id="NP_079924.2"
                     /db_xref="CCDS:CCDS22480.2"
                     /db_xref="GeneID:66590"
                     /db_xref="MGI:MGI:1913840"
                     /translation="MADNPVLELLLRRLEVADGGLDSAELATQLGVEHQAVVGAVKSL
                     QALGEVIEAELRSTKCWELTTEGEEIAREGSHEARVFRSIPLEGLVQSELMHLPSGKV
                     GFSKAMSNKWIRVDKSAADGPRVFRVVDSIEDEVQKRLQLVQAGQAEKLAEKERNELR
                     KRKLLTEVILKTYWVSKGKAFSTSVSKQEAELSPEMISSGSWRDRPFKPYNFSARGVL
                     PDSGHLHPLLKVRSQFRQIFLEMGFTEMPTDNFIESSFWNFDALFQPQQHPARDQHDT
                     FFLRDPAEALQLPMGYVQRVKRTHSQGGYGSQGYKYTWKLEEARKNLLRTHTTAASAR
                     ALYQLAQKKPFTPAKYFSIDRVFRNETLDATHLAEFHQIEGVIADHGLTLGHLMGVLR
                     EFFTKLGITQLRFKPAYNPYTEPSMEVFSYHQGLKKWVEVGNSGVFRPEMLLPMGLPE
                     NVSVIAWGLSLERPTMIKYGINNIRELVGHKVNLQMVYDSPVCRLDIEPRSSKTQEAA
                     "
     exon            197..334
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /inference="alignment:Splign:2.1.0"
     exon            335..433
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /inference="alignment:Splign:2.1.0"
     exon            434..552
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /inference="alignment:Splign:2.1.0"
     exon            553..645
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /inference="alignment:Splign:2.1.0"
     exon            646..774
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /inference="alignment:Splign:2.1.0"
     exon            775..890
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /inference="alignment:Splign:2.1.0"
     exon            891..975
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1075
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1244
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1322
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1437
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1829
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1787..1792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /note="hexamer: AATAAA"
     polyA_site      1829
                     /gene="Farsa"
                     /gene_synonym="0610012A19Rik; Farsla; pheRS"
                     /note="major polyA site"
ORIGIN      
        1 cctagtcagg tccggcggcc tgcacacgcc aagcacgctg ggagtagcca tggcggataa
       61 tcccgttttg gagctgttgc tgcggcggct ggaggtagct gatggcggtc tggacagcgc
      121 ggagttggct acgcagctgg gtgtggagca ccaggcggtg gtgggcgcag tgaagagcct
      181 tcaagctctg ggtgaggtca ttgaggctga gcttcgttct accaagtgct gggagctgac
      241 tactgagggt gaggagattg cccgggaggg cagccatgag gcccgtgtgt ttagaagcat
      301 ccctctcgag ggcctggtgc agagtgagct catgcacctg cccagcggca aggtgggctt
      361 cagcaaggcc atgtccaaca agtggatccg agtggacaag agtgccgccg acgggccccg
      421 ggtgttccga gtggtggaca gtatagagga tgaagtgcag aagcggttgc agctggtcca
      481 ggcaggccag gctgagaagc tggctgaaaa ggaacggaat gagctcagga agaggaagct
      541 gctgacggaa gtgatcctga aaacctactg ggtgagcaag ggcaaggcct tcagcacaag
      601 cgtgtctaag caggaggcag agctgagccc agagatgatc tccagtggct cttggaggga
      661 ccgacctttc aaaccctaca acttctctgc ccgtggtgtg ctcccagata gtggccacct
      721 gcaccccttg ctcaaggtcc gctctcagtt ccgacaaatc ttcttggaga tggggttcac
      781 tgagatgcct acggacaatt tcattgagag ctccttctgg aactttgatg cactctttca
      841 gcctcagcag cacccagcac gtgaccaaca tgatactttc ttcctgcgag acccagctga
      901 ggccctgcag cttccaatgg gctatgtcca gcgcgtgaaa cggacccact cccagggtgg
      961 ctacggctca cagggctaca agtatacctg gaagctggaa gaggcccgga aaaacctgct
     1021 tcgcacacac accacagcag ccagcgcccg cgccctctac cagttagccc agaagaagcc
     1081 gtttacacca gccaagtact tctctattga tcgtgtgttt cggaatgaga cgctggacgc
     1141 cacgcacctg gcggagttcc accagattga gggtgtaata gcagaccatg gtctcaccct
     1201 aggccacctc atgggtgtgc tgagggagtt cttcaccaag ctgggaatca cgcagttgcg
     1261 cttcaaacca gcctacaacc cctacacaga gcccagcatg gaagtgttca gctaccacca
     1321 aggtctaaag aagtgggttg aagttggcaa ctctggggtc ttccgccctg agatgctcct
     1381 gcctatgggg ctccctgaga atgtgtctgt cattgcttgg ggtctctccc tggaacgccc
     1441 aacaatgatc aaatatggca tcaataacat ccgagaactg gtgggccaca aggtgaacct
     1501 gcagatggta tacgacagcc ctgtgtgccg actggatatt gagcccaggt cctcaaagac
     1561 acaggaggct gcatgatata ggctgttcca gagatccctg tctagtccct gtgcatctct
     1621 tggcagtgac ctactattta tgaggcctct gtgaggccag ctcactcccc ctgcctctcc
     1681 caccctgggg gcagggttct aagtatgggg agttcttatg ctggctttta gtggtgtgtg
     1741 tagtttgctt gtaagggtgg gtttggccct gcaggccagc tgttttaata aagtgggcac
     1801 attccctcat ttggtgcctt ttgttaggaa aaaaaaaaaa aaaaaa
//
