LOCUS       NM_134082               4857 bp    mRNA    linear   ROD 06-SEP-2023
DEFINITION  Mus musculus FERM, ARH/RhoGEF and pleckstrin domain protein 1
            (Farp1), mRNA.
ACCESSION   NM_134082
VERSION     NM_134082.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4857)
  AUTHORS   Klockner I, Schutt C, Gerhardt T, Boettger T and Braun T.
  TITLE     Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is
            essential for neuromuscular junction function
  JOURNAL   Nat Commun 13 (1), 3180 (2022)
   PUBMED   35676269
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4857)
  AUTHORS   Rinschen MM, Godel M, Grahammer F, Zschiedrich S, Helmstadter M,
            Kretz O, Zarei M, Braun DA, Dittrich S, Pahmeyer C, Schroder P,
            Teetzen C, Gee H, Daouk G, Pohl M, Kuhn E, Schermer B, Kuttner V,
            Boerries M, Busch H, Schiffer M, Bergmann C, Kruger M, Hildebrandt
            F, Dengjel J, Benzing T and Huber TB.
  TITLE     A Multi-layered Quantitative In Vivo Expression Atlas of the
            Podocyte Unravels Kidney Disease Candidate Genes
  JOURNAL   Cell Rep 23 (8), 2495-2508 (2018)
   PUBMED   29791858
REFERENCE   3  (bases 1 to 4857)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   4  (bases 1 to 4857)
  AUTHORS   Cheadle L and Biederer T.
  TITLE     The novel synaptogenic protein Farp1 links postsynaptic
            cytoskeletal dynamics and transsynaptic organization
  JOURNAL   J Cell Biol 199 (6), 985-1001 (2012)
   PUBMED   23209303
  REMARK    GeneRIF: It was shown that Farp1 regulates dendritic filopodial
            dynamics in immature neurons. Later in development, Farp1 is
            postsynaptic and FARP1's 4.1 protein/ezrin/radixin/moesin domain
            binds SynCAM 1, assembling a synaptic complex.
REFERENCE   5  (bases 1 to 4857)
  AUTHORS   Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P,
            Eppig JJ, Solter D and Knowles BB.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   6  (bases 1 to 4857)
  AUTHORS   Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, Falco
            G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG, Hamatani T,
            Aiba K, Akutsu H, Sharova L, Tanaka TS, Kimber WL, Yoshikawa T,
            Jaradat SA, Pantano S, Nagaraja R, Boheler KR, Taub D, Hodes RJ,
            Longo DL, Schlessinger D, Keller J, Klotz E, Kelsoe G, Umezawa A,
            Vescovi AL, Rossant J, Kunath T, Hogan BL, Curci A, D'Urso M, Kelso
            J, Hide W and Ko MS.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   7  (bases 1 to 4857)
  AUTHORS   Luo ZG, Je HS, Wang Q, Yang F, Dobbins GC, Yang ZH, Xiong WC, Lu B
            and Mei L.
  TITLE     Implication of geranylgeranyltransferase I in synapse formation
  JOURNAL   Neuron 40 (4), 703-717 (2003)
   PUBMED   14622576
REFERENCE   8  (bases 1 to 4857)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF537427.1, CN535003.1, CN456176.1, CK389990.1, DV655111.1,
            BB840008.1 and AK034903.1.
            
            [WARNING] On Nov 27, 2023 this sequence was replaced by
            NM_134082.4.
            
            On Jul 14, 2006 this sequence version replaced NM_134082.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-433               CF537427.1         1-433
            434-1088            CN535003.1         1-655
            1089-1611           CN456176.1         155-677
            1612-2068           CK389990.1         4-460
            2069-2405           DV655111.1         430-766
            2406-2848           BB840008.1         7-449
            2849-4857           AK034903.1         152-2160
FEATURES             Location/Qualifiers
     source          1..4857
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 64.86 cM"
     gene            1..4857
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /note="FERM, ARH/RhoGEF and pleckstrin domain protein 1"
                     /db_xref="GeneID:223254"
                     /db_xref="MGI:MGI:2446173"
     exon            1..352
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            353..546
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..3522
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /note="FERM, RhoGEF and pleckstrin domain-containing
                     protein 1; FERM, RhoGEF (Arhgef) and pleckstrin domain
                     protein 1 (chondrocyte-derived)"
                     /codon_start=1
                     /product="FERM, ARHGEF and pleckstrin domain-containing
                     protein 1"
                     /protein_id="NP_598843.3"
                     /db_xref="CCDS:CCDS37015.1"
                     /db_xref="GeneID:223254"
                     /db_xref="MGI:MGI:2446173"
                     /translation="MGEIEQKPTPASRLGAPENSGISTLERGQKPPPTPSGKLMTVKI
                     QMLDDTQEAFEVPQRAPGKVLFDAVCNHLNLVEGDYFGLEFPDHRKIVVWLDLLKPIV
                     KQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLI
                     SHIVQSEIGDFDEALDREHLAKNKYVPQQDALEDRIMEFHHSHVGQTPAESDFQLLEV
                     ARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRF
                     LIKLRPDVNSSYQDTLEFLMAGRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRG
                     SSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSTRSLVSQPTAPNSEVPKQSPQS
                     ASLTFGEGTESPGGQSCQQAKETKACTLELGPHQSPALPKSPPGSKAADGTTVVPPEE
                     EEEEEGGKDGIRPSNPQPPQPSTGSLTGSPHLSELSINSQGGAAPANVTLSPNLSPDN
                     KQASPLISPLLNDQACPRTDDEEEGRRKRFPTDKAYYIAKEVSTTERTYLKDLEVIAS
                     WFQSTVSKEDSMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAHVRGDYQ
                     RIGDVMLKNIQGMKHLAAHLWKHSEALEALETSIKGSRRLEHFCRDFELQKVCYLPLN
                     TFLLRPLHRLMHYKHVLERLCKHHPPNHADFRDCRAALAEITEMVAQLHGTMIKMENF
                     QKLHELKKDLIGIDNLVTPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTA
                     SNQFKVHGQLPLYGMTIEESEEEWGVPHCLTLRGQRQSIIVAASSRSEMEKWMEDIQM
                     AIDLAEKSNGPTPELLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTM
                     VHVCWHRSTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQD
                     SHPLASLPLLGYSLTIPSESENIHKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSA
                     TSSASRAHILSHKESHLY"
     exon            547..651
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            652..694
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            695..773
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            774..871
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            872..986
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1134
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1230
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1394
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1463
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1539
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1795
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1983
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2073
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2207
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2289
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2527
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2658
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2727
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2817
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2900
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3013
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3180
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3288
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            3289..3440
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..4857
                     /gene="Farp1"
                     /gene_synonym="Cdep"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4823..4828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Farp1"
                     /gene_synonym="Cdep"
     polyA_site      4844
                     /gene="Farp1"
                     /gene_synonym="Cdep"
ORIGIN      
        1 ctcggaggcg gctggtcccg gcgcgggcgc agcggctgcg gggagcgggg agcccggaga
       61 aggtgcgggg cggggacgcg gccaccgccc gctctgcgcc gctcctcccc acgcgagtgg
      121 cgctcgggcc gggcgtcgag gcggccgcgg cgacccggag ctcgctcccc acccaccccg
      181 cctgctccgc cctcccctcc gccccgcgcc acctttgatg gctcggacct cggccggccg
      241 ccgcctgcct agctcgcgcg cccgccgccc gcggggaccc ctcgctcgcc gccgccgcgc
      301 cctcgccagc cttgcagccc gcagcccgca gcccggaccc ggagccaccg agatcttata
      361 taagttcctt tcatcatggg agaaatagag cagaagccca ccccagcatc acgtctgggg
      421 gccccagaga actcggggat cagcaccttg gaacgaggac agaaaccacc gcccacacct
      481 tcaggaaaac ttatgactgt caaaattcag atgctggacg acacccagga ggcctttgaa
      541 gttccacaac gagcgccagg gaaggttctg tttgacgccg tgtgcaacca cctcaacctt
      601 gtggagggcg actacttcgg cctggagttc cctgaccaca ggaagatcgt ggtgtggctg
      661 gatctcctga agcccattgt gaagcagatt cgaagaccga agcacgtcgt tgttaaattt
      721 gttgtgaaat tcttccctcc cgaccacaca cagctccagg aagaacttac caggtacctg
      781 ttcgctctgc aggtgaagca ggacttggct caaggcaggc tgacgtgtaa cgacaccagt
      841 gccgctctct tgatctcaca cattgtacag tcggagattg gggatttcga tgaagctttg
      901 gacagagaac acttagcaaa aaataagtac gtacctcaac aggatgcgct ggaagacaga
      961 atcatggagt tccaccacag ccacgttgga caaaccccgg cagagtcaga tttccagctc
     1021 ctagaggtgg cccgtcggct agagatgtac ggaatccggt tacaccctgc caaggacagg
     1081 gaaggcacca agatcaacct ggctgtcgcc aacactggaa ttctagtgtt tcagggcttc
     1141 acgaagatca atgcttttaa ctgggccaag gtgcggaagc tgagcttcaa gcggaagcgc
     1201 tttcttatca agctcagacc tgacgtgaat agctcatacc aggacacctt ggagttcctg
     1261 atggccggcc gagacttctg caagtctttc tggaaaatat gtgtggagca ccatgccttc
     1321 ttcagactct tcgaagaacc taagccaaag ccaaagcctg ttctcttcag ccgagggtcg
     1381 tccttccggt ttagtggtcg gactcagaag caagttcttg attatgttaa agaaggcggc
     1441 cacaagaagg tgcagtttga aagaaagcac agcaagatcc actccaccag gagcctggtc
     1501 tcacagccca cagcaccgaa ttcagaagtg ccaaaacagt ctccacagag cgcaagcctt
     1561 acgtttggag aaggtaccga gtctccgggt ggccagagct gccagcaagc gaaggaaaca
     1621 aaagcctgta ccttggagtt gggacctcac caaagccccg ccctccctaa gagccctcca
     1681 gggagcaaag ctgcagatgg aaccaccgtg gtgccgcctg aggaagaaga ggaggaagag
     1741 ggtggcaagg acggcatccg gccaagtaac cctcagcccc cgcagccaag cacaggctcc
     1801 ctgactggta gccctcacct ttcagagctg tccatcaact cacagggagg agccgcccca
     1861 gccaacgtga ccctgtctcc caacctgagt cctgacaaca agcaggcctc tcccctgatc
     1921 agcccgctcc tgaacgacca agcgtgccca aggaccgacg acgaagaaga gggccggcga
     1981 aagagattcc caaccgacaa ggcgtactac attgctaagg aagtctccac cacagagcgc
     2041 acgtacctga aggaccttga ggtcattgct tcgtggtttc agagcacagt cagcaaagag
     2101 gactccatgc ccgaagcctt gaagagtctc atattcccaa attttgaacc tttgcacaag
     2161 ttccatacca attttctgaa ggaaattgag caacgacttg ccctgtggga aggccgctca
     2221 aatgcccacg tcagaggaga ttaccaaaga atcggggacg tcatgctgaa aaacattcag
     2281 ggcatgaagc acctggcggc ccacctgtgg aagcacagtg aggccctgga ggccctggag
     2341 acctccatca agggctcgcg gcggctggaa catttctgcc gagacttcga gctgcagaag
     2401 gtgtgttacc tgccgctcaa caccttcctc ctgcgcccgc tgcaccggct catgcactat
     2461 aagcatgtcc tggagaggct gtgcaagcac cacccaccaa accacgccga cttcagggac
     2521 tgcagagctg cgctggcgga gatcacagag atggtggcac agctgcatgg taccatgatc
     2581 aagatggaga acttccagaa gctgcatgag ctcaagaaag atctgatcgg cattgacaat
     2641 cttgtgaccc caggaaggga gttcatccgc ctgggcagcc tcagcaagct ctccgggaag
     2701 gggcttcagc agcgcatgtt cttcctgttc aacgatgtct tgctgtatac cagccgggga
     2761 ctgacggcat ctaatcagtt taaagtccac ggacagctcc cactctatgg catgacgatc
     2821 gaggagagtg aggaggagtg gggtgtgccc cactgcctga ccctgcgggg ccagcggcaa
     2881 tctatcatcg tggctgccag ttcccggtca gagatggaaa aatggatgga ggacatccag
     2941 atggccattg acctggcaga gaaaagcaat ggacccaccc ccgagctcct tgccagcagc
     3001 ccccctgaca acaagtcccc ggatgaagcc acagcggctg accaggagtc agaggatgac
     3061 ctgagtgcct ctcggacatc gctggagcgc caggcccctc accgtggcaa cacgatggtg
     3121 cacgtgtgct ggcatcgcag caccagtgtc tccatggtgg acttcagcat tgctgtggag
     3181 aaccagctct ctgggaactt gctgagaaag ttcaagaaca gcaatggctg gcagaagctg
     3241 tgggtggtat tcaccaactt ctgcctgttc ttctacaaat cacaccagga cagtcacccc
     3301 cttgccagcc tgcctctgct gggctactcc ctcaccatcc cctctgagtc tgagaacatc
     3361 cacaaggact atgtgttcaa gctgcatttc aagtcccacg tgtactactt cagggctgaa
     3421 agcgaataca catttgaaag gtggatggaa gtgatccgaa gtgccaccag ctcagcctct
     3481 cgggcccaca tcttgagtca caaagaatct cacctgtact gacggctgga cacgcccact
     3541 ggctgcgcca gccacggatg ctttcctgga ggatagaatg aagcctagca aaatccacac
     3601 ctgtgtgaac acgttgaaga tctgcagtgg ttcttgccca catcccttca tgggcctatc
     3661 tccaaacatt gtcttcccca taccaacctc tttggacagc ctttccctcc aggcctaggg
     3721 ggtgggaggg cggtgtcttg ccattctcca ggggcgcttt agtttgtgcc actactgaca
     3781 cattgtcatc aagagtgcca aacgacagtc tcgtcctgca gcatggccag cgcagggcca
     3841 tacatccgtt cacctgcaga ctgctgtttc ccaaacggat ttttccagtg ttcacaacac
     3901 atggcgcagt cttaagtaaa tgagatcatt ttggatttca tttttttttc caatctttct
     3961 acttttataa taggacattc gtaggactca acttttctca gataagcaac ttgtggagta
     4021 ctccattcca ccgaaggggt gggctccagc gagaccctgg tcgccacacc tactttcttg
     4081 gcggaagttg accaagctgt ttgtgattcc tatttacaag atgtagtggg gttgttttct
     4141 gtggagaagc agatacccag tgcaatacgt gggcgtcagc gccctgtgcg tggcgtgtac
     4201 agtggcggct cctaggccgt gatgttttgc tgtctgtttc acaagcatga gaagctgtat
     4261 gtcgttgact ggggtcgtct gtgctgttac atggggggca ttgagtgagc ttctcgggag
     4321 aagcatcgta tggtaatggt acgtagtccc agccccagtg attggcccca attccctgca
     4381 aggccgtggt ttggtttgaa cctgcacatt ctctagtagt atctattgta cctgtctcca
     4441 agtctttctc tttttatact cattccttct gggcatgggg tacagacagg atgacagccc
     4501 acatcctgga cagactcctc tgggggacct ggctgccaaa cactacctga gcctcccagt
     4561 ggaaaactgt ttgcctgttc tctagggcag ctgggtcgct gtcattccct tcatgcatag
     4621 aatcctctat aacgcaagct ggccaggtct gcagtcccct ctccctgtgc cctatacccc
     4681 agcaagggcc ttcttacctg aaaacaaccc atcaacattg aggggtcgtg actagtgtca
     4741 gagattcaca tggataagga gtaagatgta tcaatcattt gccttacaat gtaccagatg
     4801 gttctaagta ctaacaaaag ggaataaaaa tacctcacac catgatccag cacatac
//
