LOCUS       NM_178797               3395 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus fatty acyl CoA reductase 2 (Far2), transcript variant
            2, mRNA.
ACCESSION   NM_178797
VERSION     NM_178797.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3395)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3395)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   3  (bases 1 to 3395)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 3395)
  AUTHORS   Otsuka,K., Sawai-Ogawa,M. and Kihara,A.
  TITLE     Formation of fatty alcohols-components of meibum lipids-by the
            fatty acyl-CoA reductase FAR2 is essential for dry eye prevention
  JOURNAL   FASEB J 36 (4), e22216 (2022)
   PUBMED   35238077
  REMARK    GeneRIF: Formation of fatty alcohols-components of meibum lipids-by
            the fatty acyl-CoA reductase FAR2 is essential for dry eye
            prevention.
REFERENCE   5  (bases 1 to 3395)
  AUTHORS   Sheehan,S., Mawe,S., Cianciolo,R.E., Korstanje,R. and Mahoney,J.M.
  TITLE     Detection and Classification of Novel Renal Histologic Phenotypes
            Using Deep Neural Networks
  JOURNAL   Am J Pathol 189 (9), 1786-1796 (2019)
   PUBMED   31220455
REFERENCE   6  (bases 1 to 3395)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (bases 1 to 3395)
  AUTHORS   Noordmans,G.A., Caputo,C.R., Huang,Y., Sheehan,S.M., Bulthuis,M.,
            Heeringa,P., Hillebrands,J.L., van Goor,H. and Korstanje,R.
  TITLE     Genetic analysis of mesangial matrix expansion in aging mice and
            identification of Far2 as a candidate gene
  JOURNAL   J Am Soc Nephrol 24 (12), 1995-2001 (2013)
   PUBMED   24009241
  REMARK    GeneRIF: Mouse strains with mesangial matrix expansion contain a
            9-bp sequence in the 5' untranslated region of Far2 that is absent
            in most of the strains without it.
REFERENCE   8  (bases 1 to 3395)
  AUTHORS   Patel,S., Xi,Z.F., Seo,E.Y., McGaughey,D. and Segre,J.A.
  TITLE     Klf4 and corticosteroids activate an overlapping set of
            transcriptional targets to accelerate in utero epidermal barrier
            acquisition
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18668-18673 (2006)
   PUBMED   17130451
REFERENCE   9  (bases 1 to 3395)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. II. Expression cloning of wax synthase
            cDNAs encoding a member of the acyltransferase enzyme family
  JOURNAL   J Biol Chem 279 (36), 37798-37807 (2004)
   PUBMED   15220349
  REMARK    GeneRIF: wax monoester synthesis in mammals involves a two step
            biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax
            synthase enzymes
REFERENCE   10 (bases 1 to 3395)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. I. Identification of two fatty
            acyl-Coenzyme A reductases with different substrate specificities
            and tissue distributions
  JOURNAL   J Biol Chem 279 (36), 37789-37797 (2004)
   PUBMED   15220348
  REMARK    GeneRIF: fatty alcohol synthesis in mammals is accomplished by two
            fatty acyl-CoA reductase isozymes that are expressed at high levels
            in tissues known to synthesize wax monoesters and ether lipids
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043388.1 and AK043589.1.
            
            On Jan 18, 2018 this sequence version replaced NM_178797.3.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1. These differences cause a
            translation frameshift and result in an isoform (2) with a shorter
            and distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043589.1, AK038584.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2872              AK043388.1         1-2872
            2873-3395           AK043589.1         2872-3394
FEATURES             Location/Qualifiers
     source          1..3395
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 78.49 cM"
     gene            1..3395
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /note="fatty acyl CoA reductase 2"
                     /db_xref="GeneID:330450"
                     /db_xref="MGI:MGI:2687035"
     exon            1..97
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            98..323
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1643
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /EC_number="1.2.1.84"
                     /note="isoform 2 is encoded by transcript variant 2; male
                     sterility domain-containing protein 1"
                     /codon_start=1
                     /product="fatty acyl-CoA reductase 2 isoform 2"
                     /protein_id="NP_848912.1"
                     /db_xref="CCDS:CCDS39718.1"
                     /db_xref="GeneID:330450"
                     /db_xref="MGI:MGI:2687035"
                     /translation="MSMIAAFYSNKSILITGATGFLGKVLMEKLFRTSPHLKVIYILV
                     RPKSGQTLQERVFQILNSKLFEKVKEVCPNVHEKIRPISADLNQRDFAISKEDVQELL
                     SCTNIIFHCAATVRFDAHLREAVQLNVTATQQLLLMASQMPKLEAFIHISTAFSNCNL
                     SHIDEVIYPCPVEPRKIIDSMEWLDDSIIEEITPKLIGDRPNTYTYTKALGEIVVQQE
                     SGNLNVAIVRPSIVGATWQEPFPGWVDNLNGPSGLIIATGKGFLRSIKATPMAVADVI
                     PVDTVVNLTIAVGWYTAVHRPKSTLIYHSTSGNLNPCNWYKMGLQVLATIEKIPFESA
                     FRRPNADFTTSNFTTHYWNTVSHRVPAIIYDFYLRLTGRKPRMLKLMNRLLKTISMLE
                     YFINHSWEWSTNNTEMLLSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYLLKEDL
                     AGIPKAKQHLRRLRNIHYLFNTALFLIIWRLLIARSQMARNVWFFICPLFKL"
     exon            324..499
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..679
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..857
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..902
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1021
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1089
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1261
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1391
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1519
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1622
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..3395
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagcagag gcgcggttca gaaaagctcg agtgcctcct tcatctccgg gaggaccgtg
       61 accaccagcc ggcaagtcaa ccgcactgaa gcagcaggac tctcttccca gaaccataca
      121 ggaacggagg aatcatgtcc atgatcgcag ctttctacag caacaagtct atcctcatca
      181 caggggccac aggcttcctg ggcaaggtgc tcatggagaa gttattccgt accagccccc
      241 acttgaaagt catttacatc ctcgtgagac ccaagtctgg acagacactg caggaaaggg
      301 ttttccagat cctcaacagt aagctgtttg agaaagtcaa agaagtctgt ccaaatgtgc
      361 atgagaagat cagacccatc tccgcagacc tcaaccagcg tgacttcgcc atcagcaagg
      421 aagacgtgca agaacttctg tcctgtacca atattatctt ccactgtgca gccacagtgc
      481 gctttgatgc acatctgaga gaagctgtgc agctgaacgt cacggccacc cagcagctcc
      541 tgctaatggc cagccagatg ccaaagctgg aagccttcat ccacatctcc actgcctttt
      601 ccaactgcaa cctgagccac attgatgagg tcatctaccc atgccctgtg gagccaagaa
      661 agatcattga ctccatggag tggttagatg actctatcat tgaagagatc actcctaagc
      721 tgattgggga ccggcccaat acctacacct acaccaaagc cttgggagag atagtagtgc
      781 agcaagagag cggaaacctg aatgtggcca ttgtcaggcc atccatagtg ggagcaacct
      841 ggcaggagcc tttcccgggt tgggttgata atctaaatgg acccagcgga ctcattattg
      901 cgactgggaa aggatttctt cggtccataa aagcgactcc catggcagtg gcagatgtga
      961 ttccagttga cacagttgtt aatctcacca tagcagtagg atggtatact gcagttcata
     1021 ggcctaaatc aacattaatc taccattcca catctggtaa tctcaatccc tgtaactggt
     1081 ataaaatggg attacaggtc ttggcgacca tcgaaaagat cccatttgag agtgctttca
     1141 gaaggccaaa tgctgacttc accaccagca atttcaccac ccattattgg aacaccgtca
     1201 gccaccgggt cccagccatc atctatgact tctatctgag gcttactgga aggaaaccca
     1261 gaatgctgaa gctcatgaac cggctgctaa aaaccatttc catgctggag tatttcatca
     1321 accacagttg ggaatggagc acaaacaaca cggagatgct tctgtcagag ctcagtcctg
     1381 aagaccagag agtattcaac tttgatgtgc gtcagttgaa ctggctcgaa tacattgaaa
     1441 attacgtttt gggggttaag aagtatctac taaaagagga tctggccggt atccccaaag
     1501 caaagcaaca cctaagaagg ctccggaaca ttcactacct ctttaacact gccctgtttc
     1561 ttatcatctg gcgcctcctc attgcaaggt ctcagatggc tcggaacgtc tggttcttca
     1621 tttgtccctt gttcaagctg tgagtgacac ctgttacaca tcatagcaag tatatacctg
     1681 ggccttagga aacttcacct tagttttcta aggctcaacc ttcaacagtc aggaaagtca
     1741 gcaactggag ttcaaaggaa tgcagtgacc ttcatcagaa ccccaaactg gacaacacca
     1801 tcttgtcaat atggcttaat attaatatgg ctgtaacaca gggccagtcc ctgtttcctt
     1861 tattaaccat gtgagctgat tacagttttt ttaaagtcta gactagtttt ccatatgttt
     1921 tacacatttt attctgacat ctttaaaaac aaaggacgca cacatttgca tttatcaatg
     1981 cccttttctt taaactcggg ttgacgtcca tcctctagga tctgctttcc atattgtctg
     2041 tttgctggga ggcatcagag gtgctgtctt cacctggcac tgttggctgg gctgactctc
     2101 cagttagctg cataatttct tctatgacat ttgtaacaga cacaacatat acaagacgac
     2161 tgcagtttgt tgttttcctt ggctgttttt ttctttttta aatatgtttc cgggttctca
     2221 tattttcttt ttctttgaat atattgcaca acatgttatt attagaaaag gctttatgtc
     2281 tcaggcaaaa agtttttctc cacccacaag gtactaatgt gtgttgttct ctaaaagagg
     2341 taagtggttg tctgtgtggc catccgcaaa ggggacctga gaggggaagg aaggcaagac
     2401 gagagtgtta gttccactct acaggatgtc tctaatcaca ggctttataa ggggcaatcc
     2461 tttctattta gacataacac caccaccagc acttaagaca agcaccacct gcagtaccac
     2521 ttacagaacg gacaggcttg taggatccaa gtctgaaacg acagcaaatt atttccacta
     2581 taaattttcc aattccatgt aacatgcctg caataaataa gttcaagttt ttcattaagt
     2641 tgcctttgaa attgctatgt gagaatcaaa agctgtacca actgtagagg gttagaccac
     2701 aaaaggaatg aagccaagcc gtctgtggct gcctctgagg ctcaaggtac tctcaagggt
     2761 tacatttaaa aacaaacatt tcatcaagat cataatccac acacacaata cacacctgat
     2821 ataacctacc caagactttc ttacataatt ttgtaagtaa cagatttaaa tgaaaaaagc
     2881 aaaagaactg tgtaaggaca gctgctcatt tgtaccagag atatgaatga aaacaaggtg
     2941 gggctccaaa aacacaacta tctagcttgg agtaaccaat ggctcaagat gaagctccca
     3001 aaaaaattcc agaatcttga acaaaaacca aaagcattac tgattaaatc aaaccaccac
     3061 catcatgact tcatagtgta cagggaaaaa aatttcaata catctgtgat gcttcctggg
     3121 cattttcttg tttaactcta caatacactt acaaaccaga taattacaat tcataaaagg
     3181 taagtgaact atctaaggac taccaagtca gtagtggaac acagattctg ttctagctct
     3241 gtctgtaatt aatacacagg atgtatgtgg cttaccaata atcttcctta cgttactgat
     3301 tcctgtgaat tggatgtgct tacaggatat gaaatatatt ttagagcttt agaattcaaa
     3361 gaagttccaa atattaaaac atgaaaatgt gacta
//
