LOCUS       NM_001347516            3339 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus fatty acyl CoA reductase 2 (Far2), transcript variant
            1, mRNA.
ACCESSION   NM_001347516 XM_006507069
VERSION     NM_001347516.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3339)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3339)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   3  (bases 1 to 3339)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 3339)
  AUTHORS   Otsuka,K., Sawai-Ogawa,M. and Kihara,A.
  TITLE     Formation of fatty alcohols-components of meibum lipids-by the
            fatty acyl-CoA reductase FAR2 is essential for dry eye prevention
  JOURNAL   FASEB J 36 (4), e22216 (2022)
   PUBMED   35238077
  REMARK    GeneRIF: Formation of fatty alcohols-components of meibum lipids-by
            the fatty acyl-CoA reductase FAR2 is essential for dry eye
            prevention.
REFERENCE   5  (bases 1 to 3339)
  AUTHORS   Sheehan,S., Mawe,S., Cianciolo,R.E., Korstanje,R. and Mahoney,J.M.
  TITLE     Detection and Classification of Novel Renal Histologic Phenotypes
            Using Deep Neural Networks
  JOURNAL   Am J Pathol 189 (9), 1786-1796 (2019)
   PUBMED   31220455
REFERENCE   6  (bases 1 to 3339)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (bases 1 to 3339)
  AUTHORS   Noordmans,G.A., Caputo,C.R., Huang,Y., Sheehan,S.M., Bulthuis,M.,
            Heeringa,P., Hillebrands,J.L., van Goor,H. and Korstanje,R.
  TITLE     Genetic analysis of mesangial matrix expansion in aging mice and
            identification of Far2 as a candidate gene
  JOURNAL   J Am Soc Nephrol 24 (12), 1995-2001 (2013)
   PUBMED   24009241
  REMARK    GeneRIF: Mouse strains with mesangial matrix expansion contain a
            9-bp sequence in the 5' untranslated region of Far2 that is absent
            in most of the strains without it.
REFERENCE   8  (bases 1 to 3339)
  AUTHORS   Patel,S., Xi,Z.F., Seo,E.Y., McGaughey,D. and Segre,J.A.
  TITLE     Klf4 and corticosteroids activate an overlapping set of
            transcriptional targets to accelerate in utero epidermal barrier
            acquisition
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18668-18673 (2006)
   PUBMED   17130451
REFERENCE   9  (bases 1 to 3339)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. II. Expression cloning of wax synthase
            cDNAs encoding a member of the acyltransferase enzyme family
  JOURNAL   J Biol Chem 279 (36), 37798-37807 (2004)
   PUBMED   15220349
  REMARK    GeneRIF: wax monoester synthesis in mammals involves a two step
            biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax
            synthase enzymes
REFERENCE   10 (bases 1 to 3339)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. I. Identification of two fatty
            acyl-Coenzyme A reductases with different substrate specificities
            and tissue distributions
  JOURNAL   J Biol Chem 279 (36), 37789-37797 (2004)
   PUBMED   15220348
  REMARK    GeneRIF: fatty alcohol synthesis in mammals is accomplished by two
            fatty acyl-CoA reductase isozymes that are expressed at high levels
            in tissues known to synthesize wax monoesters and ether lipids
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137298.1, BC055759.1 and AW048109.1.
            
            On Nov 30, 2016 this sequence version replaced XM_006507069.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137298.1, SRR1660819.195503.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AK137298.1         1-22
            23-2621             BC055759.1         1-2599
            2622-3266           AK137298.1         2623-3267
            3267-3339           AW048109.1         1-73                c
FEATURES             Location/Qualifiers
     source          1..3339
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 78.49 cM"
     gene            1..3339
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /note="fatty acyl CoA reductase 2"
                     /db_xref="GeneID:330450"
                     /db_xref="MGI:MGI:2687035"
     exon            1..97
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            98..323
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1682
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /EC_number="1.2.1.84"
                     /note="isoform 1 is encoded by transcript variant 1; male
                     sterility domain-containing protein 1"
                     /codon_start=1
                     /product="fatty acyl-CoA reductase 2 isoform 1"
                     /protein_id="NP_001334445.1"
                     /db_xref="CCDS:CCDS85188.1"
                     /db_xref="GeneID:330450"
                     /db_xref="MGI:MGI:2687035"
                     /translation="MSMIAAFYSNKSILITGATGFLGKVLMEKLFRTSPHLKVIYILV
                     RPKSGQTLQERVFQILNSKLFEKVKEVCPNVHEKIRPISADLNQRDFAISKEDVQELL
                     SCTNIIFHCAATVRFDAHLREAVQLNVTATQQLLLMASQMPKLEAFIHISTAFSNCNL
                     SHIDEVIYPCPVEPRKIIDSMEWLDDSIIEEITPKLIGDRPNTYTYTKALGEIVVQQE
                     SGNLNVAIVRPSIVGATWQEPFPGWVDNLNGPSGLIIATGKGFLRSIKATPMAVADVI
                     PVDTVVNLTIAVGWYTAVHRPKSTLIYHSTSGNLNPCNWYKMGLQVLATIEKIPFESA
                     FRRPNADFTTSNFTTHYWNTVSHRVPAIIYDFYLRLTGRKPRMLKLMNRLLKTISMLE
                     YFINHSWEWSTNNTEMLLSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYLLKEDL
                     AGIPKAKQHLRRLRNIHYLFNTALFLIIWRLLIARSQMARNVWFFIVSFCYKFISYFR
                     ASSTLKV"
     exon            324..499
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..679
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..857
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..902
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1021
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1089
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1261
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1391
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1519
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..3323
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2603..2608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /note="hexamer: AATAAA"
     polyA_site      2621
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
     regulatory      3304..3309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /note="hexamer: AATAAA"
     polyA_site      3323
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /note="major polyA site"
ORIGIN      
        1 gagagcagag gcgcggttca gaaaagctcg agtgcctcct tcatctccgg gaggaccgtg
       61 accaccagcc ggcaagtcaa ccgcactgaa gcagcaggac tctcttccca gaaccataca
      121 ggaacggagg aatcatgtcc atgatcgcag ctttctacag caacaagtct atcctcatca
      181 caggggccac aggcttcctg ggcaaggtgc tcatggagaa gttattccgt accagccccc
      241 acttgaaagt catttacatc ctcgtgagac ccaagtctgg acagacactg caggaaaggg
      301 ttttccagat cctcaacagt aagctgtttg agaaagtcaa agaagtctgt ccaaatgtgc
      361 atgagaagat cagacccatc tccgcagacc tcaaccagcg tgacttcgcc atcagcaagg
      421 aagacgtgca agaacttctg tcctgtacca atattatctt ccactgtgca gccacagtgc
      481 gctttgatgc acatctgaga gaagctgtgc agctgaacgt cacggccacc cagcagctcc
      541 tgctaatggc cagccagatg ccaaagctgg aagccttcat ccacatctcc actgcctttt
      601 ccaactgcaa cctgagccac attgatgagg tcatctaccc atgccctgtg gagccaagaa
      661 agatcattga ctccatggag tggttagatg actctatcat tgaagagatc actcctaagc
      721 tgattgggga ccggcccaat acctacacct acaccaaagc cttgggagag atagtagtgc
      781 agcaagagag cggaaacctg aatgtggcca ttgtcaggcc atccatagtg ggagcaacct
      841 ggcaggagcc tttcccgggt tgggttgata atctaaatgg acccagcgga ctcattattg
      901 cgactgggaa aggatttctt cggtccataa aagcgactcc catggcagtg gcagatgtga
      961 ttccagttga cacagttgtt aatctcacca tagcagtagg atggtatact gcagttcata
     1021 ggcctaaatc aacattaatc taccattcca catctggtaa tctcaatccc tgtaactggt
     1081 ataaaatggg attacaggtc ttggcgacca tcgaaaagat cccatttgag agtgctttca
     1141 gaaggccaaa tgctgacttc accaccagca atttcaccac ccattattgg aacaccgtca
     1201 gccaccgggt cccagccatc atctatgact tctatctgag gcttactgga aggaaaccca
     1261 gaatgctgaa gctcatgaac cggctgctaa aaaccatttc catgctggag tatttcatca
     1321 accacagttg ggaatggagc acaaacaaca cggagatgct tctgtcagag ctcagtcctg
     1381 aagaccagag agtattcaac tttgatgtgc gtcagttgaa ctggctcgaa tacattgaaa
     1441 attacgtttt gggggttaag aagtatctac taaaagagga tctggccggt atccccaaag
     1501 caaagcaaca cctaagaagg ctccggaaca ttcactacct ctttaacact gccctgtttc
     1561 ttatcatctg gcgcctcctc attgcaaggt ctcagatggc tcggaacgtc tggttcttca
     1621 ttgtaagctt ctgttacaag ttcatctcct actttcgggc ctccagcaca ctcaaggtct
     1681 aagaacatta taccagccca tcatctggaa cctcagatac ctctaaggca gtaaactggg
     1741 tcttaagcta gaaagtaaca agaagcactc ccaagcttcc agtcaaagtt gccattccac
     1801 cttcttccct attctttgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgcgcg
     1861 tgcgcgcgtg cgcatgcgtg taggattgct tgtttggtgt tttgtttttg ttttagtgag
     1921 gaaagtccat ctctaactgc atacatttac agaaacgtaa cttccagatt atatcctgac
     1981 accaccactc cacactatca cacaggaagc atgaaagcac tccttttcct ttatttagct
     2041 acttcccgac aaaactaatt taaactcact aaagatggaa gaacacgtgg cagaagtcta
     2101 aataggctag agaaaggcag caccaagcag ggaagcatgc tcagtaccaa ggcaagagct
     2161 tccaaccatt gtgaactgcg cagctcaacc tcctcacaat acaacacaag tagccttctg
     2221 tgttaaacac tacagtcctg gttgaattga ggggaagtag gctcatgcct atcctgtttc
     2281 tcacctctgt ccccagctta atgctaaaag gaacaaacgg tgtagatgag tacacaccaa
     2341 atgagaacac aatcatacat gcaccaggga gtcttgtgta cttcacttat aacatgattt
     2401 ggacatccct tactctgcgt ttttcatcac cattgttctg aaagcttcaa gtcctcttct
     2461 tacttaatga cgttgccaaa gcccttctac ttaagtgttt cactcaggcc tcagtcagaa
     2521 aggatgatgg ggagggtgac gttcctagac tcgaaccatg aaaaccctcc tgacctttac
     2581 cagtgaggga agcaaaactt caaataaaat gtaaagtttt agtttctgtc ttcatgtgtg
     2641 gagttgggag gagcacattc ctggtcaccc aaggcccttg tacctcagtt aacccagtca
     2701 cacaccttag ttaactctat aatgtacagt ggtcaaaaca acaaagagta aagcctttgg
     2761 cttaagcatt ttaaatacaa atagaaacct ttaaacagtc acaaattctc atacccataa
     2821 gatggcactc agttttgctc atatttgaga tgagggcatc ctggactgca ggatctctgc
     2881 atggtaacaa tgaaatagtc aaataaaagt aaagtccaca caaatcactg aaaattgcac
     2941 acaagcagct aacatgtgta tgcttacatt ctgatggctg aagtgtggcc attacggagg
     3001 tctcctcaga accatgaaga atatgttggg aaaacccttt ctggcagttt ctgcaaattt
     3061 gattaaggtc agtgactact gtccaggcag aaaactcaac tctgaaataa agtacctgtg
     3121 ggtttcccta tgtgagacat ctgcaagact tgtgagttac atgaaagaca ccagctaagg
     3181 atacagtaat aggaactcaa caggcaggaa gagactaaca ggacagttct aaagatttac
     3241 taccttttga tcattgtatc atcaatccaa gatctccagc gactgagttt gaacttcaga
     3301 ttaaataaaa ctctgaatta ctaaaaaaaa aaaaaaaaa
//
