LOCUS       NP_001334445             515 aa            linear   ROD 18-JUN-2024
DEFINITION  fatty acyl-CoA reductase 2 isoform 1 [Mus musculus].
ACCESSION   NP_001334445 XP_006507132
VERSION     NP_001334445.1
DBSOURCE    REFSEQ: accession NM_001347516.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 515)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 515)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   3  (residues 1 to 515)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (residues 1 to 515)
  AUTHORS   Otsuka,K., Sawai-Ogawa,M. and Kihara,A.
  TITLE     Formation of fatty alcohols-components of meibum lipids-by the
            fatty acyl-CoA reductase FAR2 is essential for dry eye prevention
  JOURNAL   FASEB J 36 (4), e22216 (2022)
   PUBMED   35238077
  REMARK    GeneRIF: Formation of fatty alcohols-components of meibum lipids-by
            the fatty acyl-CoA reductase FAR2 is essential for dry eye
            prevention.
REFERENCE   5  (residues 1 to 515)
  AUTHORS   Sheehan,S., Mawe,S., Cianciolo,R.E., Korstanje,R. and Mahoney,J.M.
  TITLE     Detection and Classification of Novel Renal Histologic Phenotypes
            Using Deep Neural Networks
  JOURNAL   Am J Pathol 189 (9), 1786-1796 (2019)
   PUBMED   31220455
REFERENCE   6  (residues 1 to 515)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (residues 1 to 515)
  AUTHORS   Noordmans,G.A., Caputo,C.R., Huang,Y., Sheehan,S.M., Bulthuis,M.,
            Heeringa,P., Hillebrands,J.L., van Goor,H. and Korstanje,R.
  TITLE     Genetic analysis of mesangial matrix expansion in aging mice and
            identification of Far2 as a candidate gene
  JOURNAL   J Am Soc Nephrol 24 (12), 1995-2001 (2013)
   PUBMED   24009241
  REMARK    GeneRIF: Mouse strains with mesangial matrix expansion contain a
            9-bp sequence in the 5' untranslated region of Far2 that is absent
            in most of the strains without it.
REFERENCE   8  (residues 1 to 515)
  AUTHORS   Patel,S., Xi,Z.F., Seo,E.Y., McGaughey,D. and Segre,J.A.
  TITLE     Klf4 and corticosteroids activate an overlapping set of
            transcriptional targets to accelerate in utero epidermal barrier
            acquisition
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18668-18673 (2006)
   PUBMED   17130451
REFERENCE   9  (residues 1 to 515)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. II. Expression cloning of wax synthase
            cDNAs encoding a member of the acyltransferase enzyme family
  JOURNAL   J Biol Chem 279 (36), 37798-37807 (2004)
   PUBMED   15220349
  REMARK    GeneRIF: wax monoester synthesis in mammals involves a two step
            biosynthetic pathway catalyzed by fatty acyl-CoA reductase and wax
            synthase enzymes
REFERENCE   10 (residues 1 to 515)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. I. Identification of two fatty
            acyl-Coenzyme A reductases with different substrate specificities
            and tissue distributions
  JOURNAL   J Biol Chem 279 (36), 37789-37797 (2004)
   PUBMED   15220348
  REMARK    GeneRIF: fatty alcohol synthesis in mammals is accomplished by two
            fatty acyl-CoA reductase isozymes that are expressed at high levels
            in tissues known to synthesize wax monoesters and ether lipids
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137298.1, BC055759.1 and AW048109.1.
            
            On Nov 30, 2016 this sequence version replaced XP_006507132.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137298.1, SRR1660819.195503.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 78.49 cM"
     Protein         1..515
                     /product="fatty acyl-CoA reductase 2 isoform 1"
                     /EC_number="1.2.1.84"
                     /note="male sterility domain-containing protein 1"
                     /calculated_mol_wt=59036
     Region          11..315
                     /region_name="FAR-N_SDR_e"
                     /note="fatty acyl CoA reductases (FARs), extended (e)
                     SDRs; cd05236"
                     /db_xref="CDD:187547"
     Site            order(17,19..22,44..46,111..113,130,151..153,204,208,
                     229..232)
                     /site_type="other"
                     /note="putative NAD(P) binding site [chemical binding]"
                     /db_xref="CDD:187547"
     Site            order(131,153,204,208)
                     /site_type="active"
                     /db_xref="CDD:187547"
     Site            order(153,204,231,243,259,265)
                     /site_type="other"
                     /note="putative substrate binding site [chemical binding]"
                     /db_xref="CDD:187547"
     Region          357..447
                     /region_name="Sterile"
                     /note="Male sterility protein; pfam03015"
                     /db_xref="CDD:460779"
     Site            465..484
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNT2.1)"
     CDS             1..515
                     /gene="Far2"
                     /gene_synonym="A230046P18; Mlstd1"
                     /coded_by="NM_001347516.1:135..1682"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS85188.1"
                     /db_xref="GeneID:330450"
                     /db_xref="MGI:MGI:2687035"
ORIGIN      
        1 msmiaafysn ksilitgatg flgkvlmekl frtsphlkvi yilvrpksgq tlqervfqil
       61 nsklfekvke vcpnvhekir pisadlnqrd faiskedvqe llsctniifh caatvrfdah
      121 lreavqlnvt atqqlllmas qmpkleafih istafsncnl shideviypc pveprkiids
      181 mewlddsiie eitpkligdr pntytytkal geivvqqesg nlnvaivrps ivgatwqepf
      241 pgwvdnlngp sgliiatgkg flrsikatpm avadvipvdt vvnltiavgw ytavhrpkst
      301 liyhstsgnl npcnwykmgl qvlatiekip fesafrrpna dfttsnftth ywntvshrvp
      361 aiiydfylrl tgrkprmlkl mnrllktism leyfinhswe wstnntemll selspedqrv
      421 fnfdvrqlnw leyienyvlg vkkyllkedl agipkakqhl rrlrnihylf ntalfliiwr
      481 lliarsqmar nvwffivsfc ykfisyfras stlkv
//
